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| 1 | 欧洲新生儿呼吸窘迫综合征防治指南-2010版显示文摘呼吸窘迫综合征(RDS)是由于肺表面活性物质(PS)缺乏及肺结构发育不成熟所致,多见于早产儿,自然病程为生后当时或很快发病,并在生后2d内进行性恶化,如不及时治疗,因进行性缺氧和呼吸衰竭而死亡,存活者,在生后2—4d病情开始改善。胎龄越小,RDS发生率越高,2006年EuroNeoStat的数据显示:胎龄23~25周的早产儿RDS发生率为91%, | Sweet DG Carnielli V Greisen G Hallman M Ozek E Plavka R Saugstad OD Simeoni U Speer CP Halliday HL 袁琳(翻译) 陈超(审校) | 2011 | 中华儿科杂志2011，49，1： | 137 |
| 2 | 欧洲新生儿呼吸窘迫综合征防治共识指南:2016版显示文摘新生儿呼吸窘迫综合征(RDS)是早产儿的重要疾病,尽管治疗手段不断成熟,低龄早产儿存活率逐渐增高,但支气管肺发育不良(BPD)发病率也随之升高,其中部分原因是减少了出生后激素的使用.2006年以来,来自欧洲许多国家的新生儿专家每3年一次回顾最新文献,就RDS或有RDS风险早产儿的防治达成共识,立志于改善欧洲新生儿的预后.欧洲RDS防治指南2007年开始发布,2010年和2013年进行了更新,期间获得了欧洲围产医学学会的大力支持.RDS是由于肺表面活性物质(PS)缺乏导致生后早期出现呼吸窘迫,典型临床表现随着防治手段的改进发生了巨大变化. | DavidG.Sweet Virgilio Carnielli Gorm Greisen Mikko Hallman Eren Ozek Richard Plavka Ola Didrik Saugstad Umberto Simeoni Christian P. Speer Maximo Vento Gerard H. A. Visser Henry L. Halliday | 2017 | 中华儿科杂志2017，55，3： | 90 |
| 3 | 欧洲早产儿呼吸窘迫综合征防治共识指南(2013版)显示文摘本次指南更新包括了自2010年以来Cochrane系统评价和医学文献中的最新证据,并采纳了一种新的证据评估分级系统(GRADE)。以往关于早期肺表面活性物质和持续气道正压通气治疗的推荐目前拥有了更坚定的循证依据。对产房复苏、稳定生命体征等内容进行了较大扩充。生命体征稳定后的氧疗目前仍存在一定的争议,但是在获得更多的证据之前,血氧饱和度的目标范围不应低于90%,支持治疗对于超早早产儿仍然极为重要。指南对其他注意事项进行了缩减。 | Sweet D Carnielli V Greisen G Hallman M Ozek E Plavka R Saugstad OD Simeoni U Speer CP Halliday HL 王敏婕 袁琳 陈超 | 2014 | 中华儿科杂志2014，52，10： | 34 |
| 4 | Q&P钢热处理工艺的开发进展(英文)显示文摘Q&P钢的工艺概念已提出了有些年了,它作为一种热处理工艺,生产的组织具有马氏体和富C的亚稳残余奥氏体。工艺包括:控制淬火形成部分的马氏体,然后热处理以使C从过饱和的马氏体中转移到残余奥氏体中。潜在的应用包括具有好的成型性和抗断裂的高强度钢。应用该工艺可生产薄板和厚板,以及用从长锻材生产热处理元件,甚至于铸铁。自2003年一直在实验室研究,早期的工作结果已有发表。近期的研究主要集中于机理方面的细节。国际范围的独立团队在此研究领域也有很多进展。 | John G Speer David K Matlock | 2009 | 世界钢铁2009，9，1： | 21 |
| 5 | 欧洲新生儿呼吸窘迫综合征防治共识显示文摘呼吸窘迫综合征(RDS)是由于肺表面活性物质(PS)缺乏及肺结构发育不成熟所致,多见于早产儿,自然病程为出生当时或生后很快发病,并在生后2d内进行性恶化,如不及时治疗,因进行性缺氧和呼吸衰竭而死亡。存活者出生后2—4d病情开始改善。RDS临床表现早期出现呼吸窘迫如紫绀、呻吟、吸凹和呼吸急促,然后进一步发展为呼吸衰竭,血气分析结果可提示呼吸衰竭的严重性。胸部X线典型的毛玻璃样改变和支气管充气征可以确诊。Vermont Oxford新生儿协作网对RDS的定义为: | Sweet D Bevilacqua G Carnielli V Greisen G Plavka R Didrik Saugstad O Simeoni U Speer CP Valls-I-Soler A Halliday H 袁琳(译) 陈超(译) 杜立中(校) | 2008 | 中华儿科杂志2008，46，1： | 17 |
| 6 | 汽车用钢的最新研究进展显示文摘为满足提高燃油效率及汽车'轻量化'等方面持续的需求,学术界及工业领域一直都很重视钢铁及其替代材料的研发,这两类材料之间的竞争始终十分激烈。对汽车用钢在北美的研究现状进行了概述,并重点介绍了几种冷轧和热轧汽车用钢的研究进展及其生产情况。新一代先进高强钢的发展将依然令人关注并充满机遇。 | John G Speer David K Matlock Emmanuel de Moor Grant A Thomas 周澍(译) 李晟(校) | 2013 | 世界钢铁2013，，5： | 10 |
| 7 | CYP24A1 inhibition facilitates the anti-tumor effect of vitamin D3 on colorectal cancer cells显示文摘AIM:The effects of vitamin D3 have been investigated on various tumors, including colorectal cancer (CRC). 25-hydroxyvitamin-D3-24-hydroxylase (CYP24A1), the enzyme that inactivates the active vitamin D3 metabolite 1,25-dihydroxyvitamin D3 (1,25-D3), is considered to be the main enzyme determining the biological halflife of 1,25-D3. During colorectal carcinogenesis, the expression and concentration of CYP24A1 increases significantly, suggesting that this phenomenon could be responsible for the proposed efficacy of 1,25-D3 in the treatment of CRC. The aim of this study was to investigate the anti-tumor effects of vitamin D3 on the human CRC cell line Caco-2 after inhibition of the cytochrome P450 component of CYP24A1 activity. METHODS:We examined the expression of CYP24A1 mRNA and the effects of 1,25-D3 on the cell line Caco-2 after inhibition of CYP24A1. Cell viability and proliferation were determined by means of sulforhodamine-B staining and bromodeoxyuridine incorporation, respectively, while cytotoxicity was estimated via the lactate dehydrogenase content of the cell culture supernatant. CYP24A1 expression was measured by realtime reverse transcription polymerase chain reaction. A number of tetralone compounds were synthesized to investigate their CP24A1 inhibitory activity. RESULTS:In response to 1,25-D3, CYP24A1 mRNA expression was enhanced significantly, in a time- and dose-dependent manner. Caco-2 cell viability and proliferation were not influenced by the administration of 1,25-D3 alone, but were markedly reduced by coadministration of 1,25-D3 and KD-35, a CYP24A1-inhibiting tetralone. Our data suggest that the mechanism of action of co-administered KD-35 and 1,25-D3 does not involve a direct cytotoxic effect, but rather the inhibition of cell proliferation. CONCLUSION:These findings demonstrate that the selective inhibition of CYP24A1 by compounds such as KD-35 may be a new approach for enhancement of the anti-tumor effect of 1,25-D3 on CRC. | János P Kósa Péter Horváth János Wlfling Dóra Kovács Bernadett Balla Péter Mátyus Evelin Horváth Gábor Speer István Takács Zsolt Nagy Henrik Horváth Péter Lakatos | 2013 | World Journal of Gastroenterology2013，19，17： | 5 |
| 8 | 环境战略与中国城市发展(英文)显示文摘可持续发展理论已越来越受到社会广泛关注 ,但如何将可持续发展理论从书斋引向实践一直是大家渴望看到而未如愿的事情。作者结合上海张江高科技园区规划实践论述了城市发展进程中应如何保护生态环境 ,为城市可持续发展创造条件。他指出 ,一、降低城市积聚区密度是改善城市发展环境的基本方法 ;二、超大城市中心区内的开敞空间和一定面积的绿化对补偿建成区土地利用带来的负面影响是一个关键要素 ;三、协调通畅的交通组织必须贯彻公交优先原则 ;四、基础设施网络化是城市可持续发展不可或缺的条件 ;五、与开发商的密切合作才能实现城市管理和金融资源合理有效地利用。 | Prof.Dipl.-lng.Albert Speer | 2001 | 城市发展研究2001，8，2： | 4 |
| 9 | Austenite stabilization through manganese enrichment显示文摘 | Emmanuel De Moor David K. Matlock John G. Speer Matthew J. Merwin | 2010 | Scripta Materialia2010，，： | 3 |
| 10 | Quantitative measurement of deformation-induced martensite in 304 stainless steel by X-ray diffraction显示文摘 | Amar K. De David C. Murdock Martin C. Mataya John G. Speer David K. Matlock | 2004 | Scripta Materialia2004，，12： | 3 |
| 11 | 支气管肺发育不良的防治——证据及临床应用显示文摘 | Wolfgang THOMAS Christian P SPEER 钱莉玲 邓芳明 | 2007 | 中国当代儿科杂志2007，9，3： | 3 |
| 12 | Biparental behavior in the burying beetle Nicrophorus orbicollis: a role for dopamine?显示文摘 | S. Carmen PANAITOF Jazmine D. W. YAEGER Jarod P. SPEER Kenneth J. RENNER | 2016 | Current Zoology2016，62，3： | 3 |
| 13 | Carbon partitioning into austenite after martensite transformation显示文摘 | J. Speer D.K. Matlock B.C. De Cooman J.G. Schroth | 2003 | Acta Materialia2003，，9： | 3 |
| 14 | Carbon partitioning into austenite after martensite transformation显示文摘 | J. Speer D.K. Matlock B.C. De Cooman J.G. Schroth | 2003 | Acta Materialia2003，，9： | 3 |
| 15 | European Consensus Guidelines on the Management of Neonatal Respiratory Distress Syndrome in Preterm Infants - 2013 Update显示文摘 | Sweet David G Carnielli Virgilio Greisen Gorm Hallman Mikko Ozek Eren Plavka Richard Saugstad Ola D Simeoni Umberto Speer Christian P Vento Maximo Halliday Henry L | 2013 | Neonatology2013，，4： | 3 |
| 16 | 应用分子生物学技术探讨慢性肺疾病和呼吸窘迫综合征的炎症反应机制显示文摘目的 应用分子生物学技术探讨慢性肺疾病 (CLD)和呼吸窘迫综合征 (RDS)患儿肺部的炎症反应机制。方法 应用原位基因杂交技术 (insitu hybridzation) ,结合免疫组织化学染色技术和常规组织染色技术检测尸解肺组织的炎性细胞浸润和细胞因子基因表达情况 ,结果用中位数 (M)表示。结果 新生儿RDS患儿肺内IL 8mRNA基因表达为 2 7/ 5mm2 ,明显高于对照组的 2 / 5mm2 ,差异有显著性 (U =3 2 3,P <0 0 1) ;CLD患儿肺内IL 8mRNA基因表达为 5 6 / 5mm2 ,也明显高于对照组的4 / 5mm2 ,差异有显著性 (U =5 7 3,P <0 0 1)。RDS组肺间质CD68阳性巨噬细胞 (14 5 / 5mm2 )、白细胞弹性蛋白酶 (N elastase)阳性多核粒细胞 (133/ 5mm2 )均明显高于对照组 (CD68细胞 18/ 5mm2 ,N elastase细胞 2 8/ 5mm2 )。CLD组肺间质CD68阳性巨噬细胞 (中位数为 15 3/ 5mm2 )、N elastase阳性的多核粒细胞 (182 / 5mm2 )均明显高于对照组 (CD68细胞 31/ 5mm2 ,N elastase细胞 37/ 5mm2 )。CD+ 3 淋巴细胞在RDS新生儿肺组织增加不明显 (2 1/ 5mm2 和 17/ 5mm2 ,P >0 0 5 ) ,而在CLD组肺组织中明显高于对照组 (41/ 5mm2 和 5 / 5mm2 ,P <0 0 1)。结论 RDS和CLD可引起肺组织细胞因子基因表达增加 。 | 曹蕾 Schmidt Bease Speer Christian P | 2001 | 中华儿科杂志2001，39，11： | 3 |
| 17 | Quenching and partitioning martensite—A novel steel heat treatment显示文摘 | D.V. Edmonds K. He F.C. Rizzo B.C. De Cooman D.K. Matlock J.G. Speer | 2006 | Materials Science & Engineering A2006，，： | 2 |
| 18 | Abnormal High-Density Lipoprotein Induces Endothelial Dysfunction via Activation of Toll-Like Receptor-2显示文摘 | Thimoteus Speer Lucia Rohrer Przemyslaw Blyszczuk Rukshana Shroff Kira Kuschnerus Nicolle Kr?nkel Gabriela Kania Stephen Zewinger Alexander Akhmedov Yi Shi Tina Martin Damir Perisa Stephan Winnik Maja F. Müller Urban Sester Gabriel Wernicke Andreas Jung U | 2013 | Immunity2013，，： | 2 |
| 19 | Partitioning of carbon from supersaturated plates of ferrite, with application to steel processing and fundamentals of the bainite transformation显示文摘 | John G. Speer David V. Edmonds Fernando C. Rizzo David K. Matlock | 2004 | Current Opinion in Solid State & Materials Science2004，，3： | 2 |
| 20 | Effect of intercritical annealing on microstructure,mechanical properties,and work-hardening behavior of ultrahigh-strength dual-phase steels with different silicon contents显示文摘In this study,three kinds of dual-phase( DP) steels were used to investigate the influence of silicon content and intercritical annealing temperature on their microstructures,mechanical properties,and work-hardening behaviors. By adding silicon and matching the critical annealing temperature,a new DP steel( 1. 0Si and intercritically annealed at 790 ℃) that exhibits an excellent combination of ultrahigh strength and adequate ductility was obtained. Variations in the strength,elongation,and fracture mechanism of the specimens with respect to different intercritical annealing temperatures were correlated to microstructural features. With an increase in the silicon content,there is no significant change in the martensitic band structure or ferrite morphology. At the same annealing temperature,the yield strength and yield strength ratio of the specimens decreased,but at different annealing temperatures,the tensile strength was reduced. The Hollomon analysis results indicate that the workhardening behavior obeys a two-stage work-hardening mechanism. With an increasing intercritical annealing temperature,the 'transition strain'shifts to the left,and with an increasing silicon content,the 'transition strain'shifts to the right. The surface exhibits ductile fractures characterized by a high density of microvoid dimples. With an increase in the silicon content,the average dimple size on the fracture surface decreases and the plasticity of the material increases. | LI Wei1 John G SPEER ZHU Xiaodong LI Wei | 2018 | Baosteel Technical Research2018，12，4： | 2 |
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