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| 1 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 2 | Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals显示文摘 | Scheid J F Mouquet H Feldhahn N Seaman M S Velinzon K Pietzsch J Ott R G Anthony R M Zebroski H Hurley A Phogat A Chakrabarti B Li Y Connors M Pereyra F Walker B D Wardemann H Ho D Wyatt R T Mascola J R Ravetch J V Nussenzweig M C | 2009 | Nature2009，458，7238： | 1 |
| 3 | Pho- tocatalytic degradation of 17-β-oestradiol on immobilised TiO2 显示文摘 | Coleman H M Eggins B R Anthony Byrne J | 2000 | Appl Catal B : Environ2000，24，1： | 1 |
| 4 | The effect of hydrogen peroxide on a CST under cesium ion exchange conditions显示文摘 | KIN S H PHILIP M ANTHONY R G | 2003 | Separation Science and Technology2003，38，1213： | 1 |
| 5 | The diagnostic accuracy of mammography in the evaluation of male breast disease 显示文摘 | Evans G F Anthony T Tumage R H et at | 2001 | Am J Surg2001，181，2： | 1 |
| 6 | Flavonoid antioxida- nts: chemistry, metabolism and structure-activity relation- ships 显示文摘 | Kelly E H Anthony R T Dennis J B | 2002 | Nutritional Biochemistry2002，13，： | 1 |
| 7 | Albaflavenone, a sesquiterpene ketone with a zizaene skeleton produced by a streptomycete with a new rope morphology显示文摘 | Gtirtler H Pedersen R Anthoni U | 1994 | The Journal of Antibiotics1994，47，4： | 1 |
| 8 | The effect of harmonics on the capillary instability of liquid jets显示文摘 | Cline H E Anthony T R | 1978 | J Appl Phys1978，49，： | 1 |
| 9 | Kinetic studies of upgrading pine pyrolytic oil by hydrotreatment显示文摘 | Sheu Y H E Anthony R G Sohes E J | 1988 | Fuel Processing Technology1988，，19： | 1 |
| 10 | Extradural pneumatocele-an unusual cause of pulsatile tinnitus显示文摘 | Wilbur H Anthony R Charles T | 1997 | Skull base surgery1997，7，： | 1 |
| 11 | Polymorphic microsatellite markers identified in individual Plasmodium falciparum oocysts from wild-caught Anopheles mosquitoes显示文摘 | Trueman H E Harbach R E | 2000 | Parasitology2000，121，2： | 1 |
| 12 | Pharmacokinetics and tumor retention of ^125 I-labeled RGD peptide are improved by PEGylation 显示文摘 | Chen XY Park R Anthony H | 2004 | Nuclear Medicine and Biology2004，31，： | 1 |
| 13 | Immune response to secondary immunization with live or inactivated VZV vaccine in elderly adults 显示文摘 | Anthony R H Kim B Myron J L | 1994 | Vir Immun1994，7，： | 1 |
| 14 | Increased sperm nuclear DNA damage in normozoospermic infertile men: a prospective study显示文摘 | Ramadan A Saleh Ashok Agarwal David R Nelson Essam A Nada Mohammed H El-Tonsy Juan G Alvarez Anthony J Thomas Rakesh K Sharma | 2002 | Fertility and Sterility2002，，2： | 1 |
| 15 | ^18F-labeled RGD peptide: initial evaluation for imaging brain tumor angiogenesis 显示文摘 | Chen XY Parka R Anthony H | 2004 | Nuclear Medicine and Biology2004，31，： | 1 |
| 16 | Extraintestinal Manifestations of Pediatric Inflammatory Bowel Disease and Their Relation to Disease Type and Severity显示文摘 | Jennifer L Dotson Jeffrey S Hyams James Markowitz Neal S LeLeiko David R Mack Jonathan S Evans Marian D Pfefferkorn Anne M Griffiths Anthony R Otley Athos Bousvaros Subra Kugathasan Joel R Rosh David Keljo Ryan S Carvalho Gitit Tomer Petar Mamula Marsha H | 2010 | Journal of Pediatric Gastroenterology and Nutrition2010，，2： | 1 |
| 17 | Microbial Conversion of Tall Oil Sterols to C19 Steroids 显示文摘 | Anthony H C Muneo N John W R | 1976 | Applied and environmental microbiology1976，32，： | 1 |
| 18 | Microbial conversion of tall oil sterols to C19 steroids 显示文摘 | Anthony H C Muneo N John W R | 1976 | Applied and Environmental Microbiology1976，32，： | 1 |
| 19 | The effects of a high animal fat diet on the induction of aberrant crypt foci in the colons of male F344/N rats exposed to trihalomethanes in the drinking water显示文摘 | David R Geter Michael H George Tanya M Moore Steve R Kilburn Gloria Huggins-Clark Anthony B DeAngelo | 2003 | Toxicology Letters2003，，： | 1 |
| 20 | Tests of X-and K-Joints in CHS stainless steel tubes 显示文摘 | Kim J R R Anthony S H | 2001 | Journal of Structure Engineering2001，127，10： | 1 |
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