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| 1 | Soluble interleukin-6 receptor is elevated during influenza A virus infection and mediates the IL-6 and IL-32 inflammatory cytokine burst显示文摘流行性感冒 A 病毒(IAV ) 感染是一个主要全球公共的健康问题。然而,因素在调停包含了煽动性的反应到这感染和他们糟糕理解的关系遗体。这里,我们证明 IAV 感染刺激可溶的 IL-6 受体(sIL-6R ) 的表示,涉及 IL-6 发信号的多功能的蛋白质。有趣地, sIL-6R 表示 upregulated 它的自己的 ligand,支持 inflammatory cytokine IL-32 的 IL-6 和那些的层次。调停 shRNA sIL-6R 击倒压制的 IL-6 和 IL-32,显示这条规定在 IAV 感染期间依赖于 sIL-6R。而且,我们的结果证明 IL-32 参予禁止 sIL-6R 的一个否定反馈环当时 upregulating IL-6 表示在 IAV 感染期间。因此,我们证明 sIL-6R 是涉及对病毒的感染的尖锐煽动性的反应的一个关键细胞的因素。 | Jun Wang Qing Wang Tao Han Yong-Kui Li Sheng-Li Zhu Fang Ao Jian Feng Ming-Zhen Jing Li Wang Lin-Bai Ye Ying Zhu | 2015 | Cellular & Molecular Immunology2015，12，5： | 6 |
| 2 | Pathological changes in the lungs and lymphatic organs of 12 COVID-19 autopsy cases显示文摘Systematic autopsy and comprehensive pathological analyses of COVID-19 decedents should provide insights into the disease characteristics and facilitate the development of novel therapeutics.In this study,we report the autopsy findings from the lungs and lymphatic organs of 12 COVID-19 decedents—findings that evaluated histopathological changes;immune cell signature and inflammatory factor expression in the lungs,spleen and lymph nodes.Here we show that the major pulmonary alterations included diffuse alveolar damage,interstitial fibrosis and exudative inflammation featured with extensive serous and fibrin exudates,macrophage infiltration and abundant production of inflammatory factors(IL-6,IP-10,TNFo?and IL-I f).The spleen and hilar lymph nodes contained lesions with tissue structure disruption and immune cell dysregulation,including lymphopenia and macrophage accumulation.These findings provide pathological evidence that links injuries of the lungs and lymphatic organs with the fatal systematic respiratory and immune malfunction in critically ill COVID-19 patients. | Qian Liu Yu Shi Jun Cai Yaqi Duan Rongshuai Wang Hongyan Zhang Qiurong Ruan Jiansha Li Lei Zhao Yifang Ping Rong Chen Liang Ren Xiaochun Fei Heng Zhang Rui Tang Xi Wang Tao Luo Xindong Liu Xuequan Huang Zhenhua Liu Qilin Ao Yong Ren Jing Xiong Zhicheng He Haibo Wu Wenjuan Fu Pengnan Zhao Xinwei Chen Guoqiang Qu Yunyun Wang Xi Wang Jia Liu Dongfang Xiang Sanpeng Xu Xiaowei Zhou Qingrui Li Jinghong Ma Heng Li Jie Zhang Sizhe Huang Xiaohong Yao Yiwu Zhou Chaofu Wang Dingyu Zhang Guoping Wang Liang Liu Xiu-Wu Bian | 2020 | National Science Review2020，7，12： | 6 |
| 3 | Time correction of the ocean bottom seismometers deployed at the southwest Indian ridge using ambient noise cross-correlation显示文摘Seismic monitoring using ocean bottom seismometers(OBS) is an efficient method for investigating earthquakes in mid-ocean ridge far away from land. Clock synchronization among the OBSs is difficult without direct communication because electromagnetic signals cannot propagate efficiently in water. Time correction can be estimated through global positioning system(GPS) synchronization if clock drift is linear before and after the deployment. However, some OBSs in the experiments at the southwest Indian ridge(SWIR) on the Chinese DY125-34 cruise had not been re-synchronized from GPS after recovery. So we attempted to estimate clock drift between each station pairs using time symmetry analysis(TSA) based on ambient noise cross-correlation. We tested the feasibility of the TSA method by analyzing daily noise cross-correlation functions(NCFs) that extract from the data of another OBS experiment on the Chinese DY125-40 cruise with known clock drift and the same deployment site. The results suggest that the NCFs' travel time of surface wave between any two stations are symmetrical and have an opposite growing direction with the date. The influence of different band-pass filters,different components and different normalized methods was discussed. The TSA method appeared to be optimal for the hydrophone data within the period band of 2–5 s in dozens of km-scale interstation distances. A significant clock drift of ~2 s was estimated between OBSs sets through linear regression during a 108-d deployment on the Chinese cruise DY125-34. Time correction of the OBS by the ambient noise cross-correlation was demonstrated as a practical approach with the appropriate parameters in case of no GPS re-synchronization. | LIU Yunlong LIU Cai TAO Chunhui YAO Huajian QIU Lei WANG Ao RUAN Aiguo WANG Hanchuang ZHOU Jianping LI Huaiming DONG Chuanwan | 2018 | Acta Oceanologica Sinica2018，37，5： | 5 |
| 4 | Balance Control of a Biped Robot on a Rotating Platform Based on Efficient Reinforcement Learning显示文摘In this work,we combined the model based reinforcement learning(MBRL)and model free reinforcement learning(MFRL)to stabilize a biped robot(NAO robot)on a rotating platform,where the angular velocity of the platform is unknown for the proposed learning algorithm and treated as the external disturbance.Nonparametric Gaussian processes normally require a large number of training data points to deal with the discontinuity of the estimated model.Although some improved method such as probabilistic inference for learning control(PILCO)does not require an explicit global model as the actions are obtained by directly searching the policy space,the overfitting and lack of model complexity may still result in a large deviation between the prediction and the real system.Besides,none of these approaches consider the data error and measurement noise during the training process and test process,respectively.We propose a hierarchical Gaussian processes(GP)models,containing two layers of independent GPs,where the physically continuous probability transition model of the robot is obtained.Due to the physically continuous estimation,the algorithm overcomes the overfitting problem with a guaranteed model complexity,and the number of training data is also reduced.The policy for any given initial state is generated automatically by minimizing the expected cost according to the predefined cost function and the obtained probability distribution of the state.Furthermore,a novel Q(λ)based MFRL method scheme is employed to improve the policy.Simulation results show that the proposed RL algorithm is able to balance NAO robot on a rotating platform,and it is capable of adapting to the platform with varying angular velocity. | Ao Xi Thushal Wijekoon Mudiyanselage Dacheng Tao Chao Chen | 2019 | IEEE/CAA Journal of Automatica Sinica2019，6，4： | 5 |
| 5 | Tourism sectorization opportunity spectrum model and space partition of tourism urbanization area:a case of the Mayangxi ecotourism area,Fujian province,China显示文摘Nowadays, tourism has become an increasingly significant driving force of modern urbanization in China. However, it has caused varieties of problems, such as resource unreasonable utilization, society unfair play, and environment pollution, etc. Thus, the establishment of an efficient and sustainable space partition model for tourism urbanization, from the geographical perspective, is highly necessary and urgent. Herein, a new evaluation model of tourist town space, referred to as Tourism Sectorization Opportunity Spectrum(TSOS), is established on the relationships between productionliving-ecology spaces. TSOS is a kind of quantitative evaluation model involving such factors as urban living area, ecological conservation area and the tourism industry. Furthermore, the analysis of quantitative production-living-ecology spatial overlap has been utilized for space division in a tourism urbanization area. This paper, using both the TSOS model and GIS technology, analyzes the spatial restructure of the Mayangxi ecotourism area. Theresult demonstrates that tourism industrial space takes the Shanchong Village as a core which shows a pattern of local regional agglomeration and a fuzzy edge extending along the entire Mayangxi River. The urban living area should be consolidated in the Shili village with the supporting facilities and living space for tourism. In addition, Tianzhu Mountain forest park should be the key environmental protection area. The case study on the Mayangxi ecotourism area verifies that the TSOS model has strong operability. Therefore, TSOS model provides a scientific foundation for the space reconstruction of new urbanization area, and an effective tool for optimizing the space partition of a tourism urbanization area. | TAO Hui LIU Jia-ming DENG Yu DU Ao | 2017 | Journal of Mountain Science2017，14，3： | 4 |
| 6 | Energy-efficient recovery of tetrahydrofuran and ethyl acetate by triple-column extractive distillation:entrainer design and process optimization显示文摘An energy-efficient triple-column extractive distillation process is developed for recovering tetrahydrofuran and ethyl acetate from industrial effluent.The process development follows a rigorous hierarchical design procedure that involves entrainer design,thermodynamic analysis,process design and optimization,and heat integration.The computer-aided molecular design method is firstly used to find promising entrainer candidates and the best one is determined via rigorous thermodynamic analysis.Subsequently,the direct and indirect triple-column extractive distillation processes are proposed in the conceptual design step.These two extractive distillation processes are then optimized by employing an improved genetic algorithm.Finally,heat integration is performed to further reduce the process energy consumption.The results indicate that the indirect extractive distillation process with heat integration shows the highest performance in terms of the process economics. | Ao Yang Yang Su Tao Shi Jingzheng Ren Weifeng Shen Teng Zhou | 2022 | Frontiers of Chemical Science and Engineering2022，16，2： | 3 |
| 7 | A specific aggregation-induced emission-conjugated polymer enables visual monitoring of osteogenic differentiation显示文摘Osteogenic differentiation is the basis of bone growth and repair related to many diseases,in which evaluating the degree and ability of osteogenic transformation is quite important and highly desirable.However,fixing or stopping the growth of cells is required for conventional methods to monitor osteogenic differentiation,which cannot realize the full investigation of the dynamic process.Herein,a new anion conjugated polymer featuring aggregation-induced emission(AIE)characteristics is developed with excellent solubility for in-situ monitoring the process of osteogenic differentiation.This novel polymer can bind with osteogenic differentiated cells,and the intracellular fluorescence increases gradually with the enhancement of osteogenic differentiation.Moreover,it possesses good biosafety with negligible effect on cell activity and osteogenic differentiation,which cannot be realized by the typical method of Alizarin Red S staining.Further study shows that the polymer crosses the cell membrane through endocytosis and enriches in lysosomes,whereas no obvious fluorescence is detected with other cells,including non-differentiated osteoblast cells,under the same conditions,demonstrating the high selectivity.This is the first fluorescent probe with excellent specificity to realize real-time observation of the process of osteogenic differentiation.Therefore,PTB-EDTA shows great promise in the study of osteogenic differentiation and related applications. | Zhenyu Zheng Taotao Zhou Rong Hu Minjun Huang Xiang Ao Jun Chu Tao Jiang Anjun Qin Zhongmin Zhang | 2020 | Bioactive Materials2020，5，4： | 3 |
| 8 | Genome-wide analysis of the B3 transcription factors reveals that RcABI3/VP1 subfamily plays important roles in seed development and oil storage in castor bean(Ricinus communis)显示文摘The B3 transcription factors(TFs)in plants play vital roles in numerous biological processes.Although B3 genes have been broadly identified in many plants,little is known about their potential functions in mediating seed development and material accumulation.Castor bean(Ricinus communis)is a non-edible oilseed crop considered an ideal model system for seed biology research.Here,we identified a total of 61 B3 genes in the castor bean genome,which can be classified into five subfamilies,including ABI3/VP1,HSI,ARF,RAV and REM.The expression profiles revealed that RcABI3/VP1 subfamily genes are significantly up-regulated in the middle and later stages of seed development,indicating that these genes may be associated with the accumulation of storage oils.Furthermore,through yeast one-hybrid and tobacco transient expression assays,we detected that ABI3/VP1 subfamily member RcLEC2 directly regulates the transcription of RcOleosin2,which encodes an oil-body structural protein.This finding suggests that RcLEC2,as a seed-specific TF,may be involved in the regulation of storage materials accumulation.This study provides novel insights into the potential roles and molecular basis of B3 family proteins in seed development and material accumulation. | Wen-Bo Wang Tao Ao Yan-Yu Zhang Di Wu Wei Xu Bing Han Ai-Zhong Liu | 2022 | Plant Diversity2022，44，2： | 2 |
| 9 | A hydrothermal investigation system for the Qianlong-Ⅱ autonomous underwater vehicle显示文摘Qianlong-Ⅱ is a fully autonomous underwater vehicle designed for the investigation of submarine resources,particularly polymetallic sulfides. It was used to successfully explore hydrothermal fields on the Southwest Indian Ridge. Here, we summarized the exploration of hydrothermal systems using Qianlong-Ⅱ, including detailed descriptions of its implementation along with the systems used for data management and fast mapping. We also introduced a method to remove platform magnetic interference using magnetic data while Qianlong-Ⅱ is spinning. Based on hydrothermal anomalies collected by Qianlong-Ⅱ, we developed a rapid method for locating hydrothermal vents. Taking one dive as an example, we systemically demonstrated the process for analyzing hydrothermal survey data to locate hydrothermal vents. | Tao Wu Chunhui Tao Jinhui Zhang Ao Wang Guoyin Zhang Jianping Zhou Xianming Deng | 2019 | Acta Oceanologica Sinica2019，38，3： | 2 |
| 10 | Sterilization and disinfection methods for decellularized matrix materials:Review,consideration and proposal显示文摘Sterilization is the process of killing all microorganisms,while disinfection is the process of killing or removing all kinds of pathogenic microorganisms except bacterial spores.Biomaterials involved in cell experiments,animal experiments,and clinical applications need to be in the aseptic state,but their physical and chemical properties as well as biological activities can be affected by sterilization or disinfection.Decellularized matrix(dECM)is the low immunogenicity material obtained by removing cells from tissues,which retains many inherent components in tissues such as proteins and proteoglycans.But there are few studies concerning the effects of sterilization or disinfection on dECM,and the systematic introduction of sterilization or disinfection for dECM is even less.Therefore,this review systematically introduces and analyzes the mechanism,advantages,disadvantages,and applications of various sterilization and disinfection methods,discusses the factors influencing the selection of sterilization and disinfection methods,summarizes the sterilization and disinfection methods for various common dECM,and finally proposes a graphical route for selecting an appropriate sterilization or disinfection method for dECM and a technical route for validating the selected method,so as to provide the reference and basis for choosing more appropriate sterilization or disinfection methods of various dECM. | Meihan Tao Tianrang Ao Xiaoyan Mao Xinzhu Yan Rabia Javed Weijian Hou Yang Wang Cong Sun Shuang Lin Tianhao Yu Qiang Ao | 2021 | Bioactive Materials2021，6，9： | 2 |
| 11 | Two new nonacosanetriols from the pollen of Typha angustifolia显示文摘Chemical investigation of the pollen of Typha angustifolia Linn.has led to the isolation of two new nonacosanetriols,7,8,10- nonacosanetriol(1) and 7,9,10-nonacosanetriol(2).Their structures were elucidated by chemical reaction and spectral analysis. Compounds 1 and 2 exhibited weak activity of antiplatelet aggregation in vitro. | Tao, Wei Wei Yang, Nian Yun Duan, Jin Ao Wu, De Kang Shang, Er Xin Qian, Da Wei Tang, Yu Ping | 2010 | Chinese Chemical Letters2010，21，2： | 2 |
| 12 | Photocatalytic properties of P25-doped TiO_2 composite film synthesized via sol–gel method on cement substrate显示文摘TiO_2 films have received increasing attention for the removal of organic pollutants via photocatalysis. To develop a simple and effective method for improving the photodegradation efficiency of pollutants in surface water, we herein examined the preparation of a P25-TiO_2 composite film on a cement substrate via a sol–gel method. In this case, Rhodamine B(Rh B)was employed as the target organic pollutant. The self-generated TiO_2 film and the P25-TiO_2 composite film were characterized by X-ray diffraction(XRD), N_2 adsorption/desorption measurements, scanning electron microscopy(SEM), transmission electron microscopy(TEM), and diffuse reflectance spectroscopy(DRS). The photodegradation efficiencies of the two films were studied by Rh B removal in water under UV(ultraviolet) irradiation. Over 4 day exposure, the P25-TiO_2 composite film exhibited higher photocatalytic performance than the self-generated TiO_2 film. The photodegradation rate indicated that the efficiency of the P25-TiO_2 composite film was enhanced by the addition of the rutile phase Degussa P25 powder. As such, cooperation between the anatase TiO_2 and rutile P25 nanoparticles was beneficial for separation of the photo-induced electrons and holes. In addition, the influence of P25 doping on the P25-TiO_2 composite films was evaluated. We found that up to a certain saturation point, increased doping enhanced the photodegradation ability of the composite film. Thus, we herein demonstrated that the doping of P25 powders is a simple but effective strategy to prepare a P25-TiO_2 composite film on a cement substrate, and the resulting film exhibits excellent removal efficiency in the degradation of organic pollutants. | Xiang Guo Lei Rao Peifang Wang Chao Wang Yanhui Ao Tao Jiang Wanzhong Wang | 2018 | Journal of Environmental Sciences2018，30，4： | 2 |
| 13 | Molecular Design of Host Materials Based on Triphenylamine/oxadiazole Hybrids for Excel- lent Deep-red Phosphorescent Organic Light-emitting Diodes显示文摘 | Tao Y Wang Q Ao L | 2010 | J Mater Chem2010，20，9： | 1 |
| 14 | Zircon U-Pb ages and Hf isotopic characteristics of the Dehe biotite monzonitic gneiss pluton in the North Qinling orogen and their geological significance显示文摘The Dehe granitic pluton intruded the Xiahe Group which is in the core complex of the North Qinling Orogenic Belt(NQOB).It shows gneissic bedding and possesses typical S-type granite minerals such as muscovite and garnet.LA-ICP-MS U-Pb isotopic dating of the Dehe granite yielded a weighted average age of 925±23 Ma which represents the emplacement age of the pluton.Most of the εHf(t) values are negative,and the two-stage model ages are consistent with the age of the Qinling Group.The isotope data show that the Dehe granite was formed in the following geological setting:in the syn-collision setting of the NQOB in the Neoproterozoic,crustal thickening induced partial melting of materials derived from the Qinling complex,and then the maga upwelled and intruded into the Xiahe Group.The formation of the Dehe S-type granite implied the occurrence of a convergent event in the QOB during the Neoproterozoic. | Wang, Fei Zhu, Laimin Li, Jiming Lee, Ben Gong, Hujun Yang, Tao Wang, Wei Xu, Ao | 2011 | Chinese Journal Of Geochemistry2011，30，2： | 1 |
| 15 | Synthesis and electrochemical properties of LiNi_(0.8)Al_(0.2-x)Ti_xO_2 cathode materials by an ultrasonic-assisted co-precipitation method显示文摘A new co-precipitation route was proposed to synthesize LiNi0.8Al0.2-xTixO2 (x=0.0-0.20) cathode materials for lithium ion batteries, with Ni(NO3)2, Al(NO3)3, LiOH.H2O, and TiO2 as the starting materials. Ultrasonic vibration was used during preparing the precursors, and the precursors were protected by absolute ethanol before calcination in the air. The influences of doped-Ti content, calcination temperature and time, additional Li content, and ultrasonic vibration on the structure and properties of LiNi0.8Al0.2-xTixO2 were investigated by X-ray diffraction (XRD), scanning electron microscopy (SEM), and charge-discharge tests, respectively. The results show that the optimal molar fraction of Ti, calcination temperature and time, and additional molar fraction of Li for LiNi0.8Al0.2-xTixO2 cathode materials are 0.1, 700°C, 20 h, and 0.05, respectively. Ti doping facilitates the formation of the α-NaFeO2 layered structure, and ultrasonic vibration improves the electrochemical performance of LiNi0.8Al0.2-xTixO2. | Meng Chen Wen-le Ao Chang-song Dai Tao Tao Jun Yang | 2009 | International Journal of Minerals,Metallurgy and Materials2009，16，4： | 1 |
| 16 | Association of Comorbid Asthma and the Efficacy of Bioabsorbable Steroid-eluting Sinus Stents Implanted After Endoscopic Sinus Surgery in Patients with Chronic Rhinosinusitis with Nasal Polyps显示文摘Objective To identify factors affecting the efficacy of steroid-eluting sinus stents implanted after endoscopic sinus surgery(ESS)in patients with chronic rhinosinusitis with nasal polyps(CRSwNP).Methods We performed a post-hoc analysis of a randomized self-controlled clinical trial on post-operative implantation of bioabsorbable steroid-eluting stents in patients with CRSwNP.Univariate logistic regression analysis was conducted to identify which of the following factors affect the response to post-operative stent implantation:sex,serum eosinophil levels,history of prior surgery,endoscopic scores,and comorbid conditions(asthma and allergic rhinitis).The primary outcome was the rate of post-operative intervention on day 30,and the secondary outcome was the rate of polypoid tissue formation(grades 2–3)on days 14,30,and 90.Results A total of 151 patients with CRSwNP were included in the post-hoc analysis.Asthma was identified as the only risk factor for a poor response to steroid-eluting sinus stents on post-operative day 30,with an odds ratio of 23.71(95%CI,2.81,200.16;P=0.004)for the need for post-operative intervention and 19(95%CI,2.20,164.16;P=0.003)for moderate-to-severe polypoid tissue formation.In addition,the asthmatic group showed higher rates of post-operative intervention and polypoid tissue formation than the non-asthmatic group on post-operative day 30.Blood eosinophil levels were not identified as a risk factor for poor outcomes after stent implantation.Conclusion Comorbid asthma,but not blood eosinophil level,impairs the efficacy of steroid-eluting sinus stents in the short term after ESS in patients with CRSwNP. | Ao HUANG Tao LI Min-shan LI Zhen-xiao HUANG De-hui WANG Lei CHENG Bing ZHOU Heng WANG Zheng LIU | 2023 | Current Medical Science2023，43，5： | 1 |
| 17 | Antioxidant activity of vin- egar melanoidins显示文摘 | XU Qingping TAO Wenyi AO Zonghua | 2007 | Food Chemistry2007，102，3： | 1 |
| 18 | Characterization of volatile compounds from Daqu-a traditional Chinese liquor fermentation starter 显示文摘 | Zhang CL Ao ZH Chui WQ Shen CH Tao WY Zhang SY | 2011 | Food Sci Technol Intern2011，46，： | 1 |
| 19 | Antioxidant activity of vinegar melanoidins显示文摘 | XU Q P TAO W Y AO Z H | 2007 | Food Chemistry2007，102，3： | 1 |
| 20 | DOA estimation of incoherently distributed sources using importance sampling maximum likelihood显示文摘In this paper, an importance sampling maximum likelihood(ISML) estimator for direction-of-arrival(DOA) of incoherently distributed(ID) sources is proposed. Starting from the maximum likelihood estimation description of the uniform linear array(ULA), a decoupled concentrated likelihood function(CLF) is presented. A new objective function based on CLF which can obtain a closed-form solution of global maximum is constructed according to Pincus theorem. To obtain the optimal value of the objective function which is a complex high-dimensional integral,we propose an importance sampling approach based on Monte Carlo random calculation. Next, an importance function is derived, which can simplify the problem of generating random vector from a high-dimensional probability density function(PDF) to generate random variable from a one-dimensional PDF. Compared with the existing maximum likelihood(ML) algorithms for DOA estimation of ID sources, the proposed algorithm does not require initial estimates, and its performance is closer to CramerRao lower bound(CRLB). The proposed algorithm performs better than the existing methods when the interval between sources to be estimated is small and in low signal to noise ratio(SNR)scenarios. | WU Tao DENG Zhenghong HU Xiaoxiang LI Ao XU Jiwei | 2022 | Journal of Systems Engineering and Electronics2022，33，4： | 1 |
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