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| 1 | Comparison of PPIs and H_2-receptor antagonists plus prokinetics for dysmotility-like dyspepsia显示文摘AIM:To compare efficacy of proton pump inhibitors(PPIs)with H2-receptor antagonists(H2RAs)plus prokinetics(Proks)for dysmotility-like symptoms in functional dyspepsia(FD).METHODS:Subjects were randomized to receive openlabel treatment with either rabeprazole 10 mg od(n= 57)or famotidine 10 mg bid plus mosapride 5 mg tid(n=57)for 4 wk.The primary efficacy endpoint was change(%)from baseline in total dysmotility-like dyspepsia symptom score.The secondary efficacy endpoint was patient satisfaction with treatment.RESULTS:The improvement in dysmotility-like dyspep-sia symptom score on day 28 was significantly greater in the rabeprazole group(22.5%±29.2%of baseline) than the famotidine+mosapride group(53.2%± 58.6%of baseline,P<0.0001).The superior benefit of rabeprazole treatment after 28 d was consistent regardless of Helicobacter pylori status.Significantly more subjects in the rabeprazole group were satisfied or very satisfied with treatment on day 28 than in the famotidine+mosapride group(87.7%vs 59.6%,P= 0.0012).Rabeprazole therapy was the only significant predictor of treatment response(P<0.0001),defined as a total symptom score improvement≥50%.CONCLUSION:PPI monotherapy improves dysmotility-like symptoms significantly better than H2RAs plus Proks,and should be the treatment of first choice for Japanese FD. | Masahiro Sakaguchi Miyuki Takao Yasuo Ohyama Hiroshi Oka Hiroshi Yamashita Takumi Fukuchi Kiyoshi Ashida Masahiro Murotani Masuyo Murotani Kazuo Majima Hiroshi Morikawa Takashi Hashimoto Keisuke Kiyota Hirohiko Esaki Kanji Amemoto Gouhei Isowa Fumiyuki Takao | 2012 | World Journal of Gastroenterology2012，18，13： | 8 |
| 2 | Nuclear survivin expression predicts poorer prognosis in glioblastoma显示文摘 | Katsuyuki Shirai Yoshiyuki Suzuki Kuniyuki Oka Shin-ei Noda Hiroyuki Katoh Yoshihiko Suzuki Jun Itoh Hideaki Itoh Shogo Ishiuchi Hideyuki Sakurai Masatoshi Hasegawa Takashi Nakano | 2009 | Journal of Neuro - Oncology2009，，3： | 1 |
| 3 | Hepatic maturation in differentiating embryonic stem cells in vitro显示文摘 | Takashi Hamazaki Yasuhiko Iiboshi Masahiro Oka Philip J. Papst Amy M. Meacham Leonard I. Zon Naohiro Terada | 2001 | FEBS Letters2001，，1： | 1 |
| 4 | Thin-layer chromatography/direct analysis in real time time-of-flight mass spectrometry and isotope dilution to analyze organophosphorus insecticides in fatty foods显示文摘 | Osamu Kiguchi Kazuko Oka Masafumi Tamada Takashi Kobayashi Jun Onodera | 2014 | Journal of Chromatography A2014，，： | 1 |
| 5 | Real-time manipulation of texture-mapped surfaces 显示文摘 | Oka M K Akio O Yoshitaka K Takashi T | 1987 | Computer Graphics1987，21，4： | 1 |
| 6 | Poly(vinyl alcohol)hydrogel as an artificial articular cartilage: Evaluation of biocompatibility显示文摘 | Takao Yamamuro Takashi Noguchi Masanori Oka | 1991 | Journal of Applied Biomaterials1991，2，2： | 1 |
| 7 | Current status and future perspectives of endoscopic diagnosis and treatment of diminutive colorectal polyps显示文摘 | Takahisa Matsuda Hiroshi Kawano Takashi Hisabe Hiroaki Ikematsu Nozomu Kobayashi Kenichi Mizuno Shiro Oka Yoji Takeuchi Naoto Tamai Toshio Uraoka David Hewett Han‐Mo Chiu | 2014 | Digestive Endoscopy2014，，： | 1 |
| 8 | Interactive effects of carbon footprint information and its accessibility on value and subjective qualities of food products 显示文摘 | Atsushi Kimura Yuji Wada Akiko Kamada Tomohiro Ma- suda Masako Okamoto Sho - ichi Goto Daisuke Tsuzuki Dongsheng Cai Takashi Oka Ippeita Dan | 2010 | Appetite2010，55，： | 1 |
| 9 | Randomized, controlled study on adjuvant immunochemotherapy with PSK? in curatively resected colorectal cancer显示文摘 | Toshio Mitomi M.D. Shuji Tsuchiya M.D. Noboru Iijima M.D. Koichi Aso M.D. Kaisuke Suzuki M.D. Kiyoshi Nishiyama M.D. Tomishige Amano M.D. Toshitake Takahashi M.D. Norihisa Murayama M.D. Hisashi Oka M.D. Kazumitsu Oya M.D. Dr. Takashi Noto M.D. Nobuya Ogaw | 1992 | Diseases of the Colon & Rectum1992，，2： | 1 |
| 10 | Randomized Phase II Trial of Irinotecan with Paclitaxel or Gemcitabine for Non-small Cell Lung Cancer: Association of UGT1A1*6 and UGT1A1*27 with Severe Neutropenia显示文摘 | Yoichi Nakamura Hiroshi Soda Mikio Oka Akitoshi Kinoshita Minoru Fukuda Masaaki Fukuda Hiroshi Takatani Seiji Nagashima Yoshifumi Soejima Takashi Kasai Katsumi Nakatomi Noriyuki Masuda Kazuhiro Tsukamoto Shigeru Kohno | 2011 | Journal of Thoracic Oncology2011，，1： | 1 |
| 11 | Germ cell tumor of the colon with an adenocarcinomatous component显示文摘 | Masaki Kawahara Atushi Takada Akihiko Tachibana Takashi Kodama Hiroaki Kobayashi Youko Takino Takeo Sugishita Yasuo Oono Teruaki Oka | 2009 | International Journal of Clinical Oncology2009，，6： | 1 |
| 12 | Folylpolyglutamate synthase and γ-glutamyl hydrolase regulate leucovorin-enhanced 5-fluorouracil anticancer activity显示文摘 | Etsuko Sakamoto Sayaka Tsukioka Shinji Oie Takashi Kobunai Hiroaki Tsujimoto Kazuki Sakamoto Yoshihiro Okayama Yoshikazu Sugimoto Toshinori Oka Masakazu Fukushima Tatsuzo Oka | 2007 | Biochemical and Biophysical Research Communications2007，，4： | 1 |
| 13 | Tu1469 Recommendations About Training for Colorectal Endoscopic Submucosal Dissection in the Western World. Results of a Survey to Experts显示文摘 | Adolfo Parra-Blanco Yutaka Saito Naohisa Yahagi Mainor R. Antillon Pierre H. Deprez Shusei Fukunaga Takemasa Hayashi Kinichi Hotta Takeshi Nakajima Takashi Toyonaga Shiro Oka Yoshiro Tamegai Takahisa Matsuda Toshio Uraoka | 2011 | Gastrointestinal Endoscopy2011，，4： | 1 |
| 14 | Immunological evaluation of personalized peptide vaccination for patientswith pancreatic cancer显示文摘 | Koutaro Yamamoto Takashi Mine Kazuko Katagiri Nobuaki Suzuki Toru Kawaoka Tomio Ueno Satoko Matsueda Akira Yamada Kyogo Itoh Hideaki Yamana Masaaki Oka | 2005 | Oncology Reports2005，，5： | 1 |
| 15 | Clinicopathological features of minute pharyngeal lesions diagnosed by narrow-band imaging endoscopy and biopsy显示文摘AIM:To evaluate the utility of magnified narrow-band imaging(NBI) endoscopy for diagnosing and treating minute pharyngeal neoplasia.METHODS:Magnified NBI gastrointestinal examinations were performed by the first author.A magnification hood was attached to the tip of the endoscope for quick focusing.Most of the examinations were performed under sedation.Magnified NBI examinations were performed for all of the pharyngeal lesions that had noticeable brownish areas under unmagnified NBI observation,and an intrapapillary capillary loop(IPCL) classification was made.A total of 93 consecutive pharyngeal lesions were diagnosed as IPCL type Ⅳ and were suspected to represent dysplasia.Sixty-two lesions of approximately 1 mm in diameter were biopsied in the clinic,and 17 lesions with larger diameters were resected by endoscopic submucosal dissection(ESD) at the Hiroshima University Hospital.In addition to the histological diagnoses,the lesion diameters were microscopically measured in 45 of the 62 biopsies.Thirtyfour of the 62 biopsied patients received endoscopic follow up.RESULTS:Minute pharyngeal lesions were diagnosed in 93 of approximately 3000 patients receiving magnified NBI examinations at the clinic.Of the 93 patients with IPCL type Ⅳ lesions,80 were men,and 13 were women.Fifty-six were drinkers,and 57 were smokers.Two had esophageal cancer.Twenty-one lesions were located on the posterior hypopharyngeal wall,and 72 lesions were located on the posterior oropharyngeal wall.All 93 lesions were flat and showed similar findings in the magnified and unmagnified NBI examinations.Although almost all of the IPCL type Ⅳ lesions showed faint redness when examined under white light,it was difficult to diagnose the lesions using only this technique because the contrast was weaker than that achieved in the NBI examinations.Of the 93 lesions,only 3 had diameters greater than 2.1 mm.Sixty-two lesions of approximately 1 mm were biopsied in the clinic,whereas 17 larger lesions were treated by ESD at the Hiroshima University Hospital.Of the 79 pharyngeal lesions that were biopsied or resected by ESD,5 were histologically diagnosed as high-grade dysplasia,39 were diagnosed as low-grade dysplasia,and 39 were determined to be non-dysplastic lesions.There were no cancerous lesions.Histologically,abnormal cell size variations and increased nuclear size were observed in all of the high-grade dysplasia lesions,while the incidence of these findings in the low-grade dysplasia lesions was low.Of the 62 biopsied lesions,45 were microscopically measurable.The measured diameters ranged from 0.1 to 2.0 mm.The dysplasia ratios increased with the diameters.A follow-up endoscopic examination of the 34 biopsied patients found the rate of complete resection by biopsy to be 79%.The largest lesion in which complete resection was expected was a low-grade dysplasia of 1.9 mm in diameter.CONCLUSION:Minute pharyngeal lesions suspected to be dysplasia that are identified by NBI magnifying endoscopy should be biopsied to determine the diagnosis and further treatment. | Takashi Kumamoto Kazuhiro Sentani Shiro Oka Shinji Tanaka Wataru Yasui | 2012 | World Journal of Gastroenterology2012，18，44： | 1 |
| 16 | Colorectal neuroendocrine carcinoma: A case report and review of the literature显示文摘BACKGROUND Colorectal neuroendocrine carcinoma (NEC) is a rare tumor that demonstrates aggressive growth pattern with ingrowth into the tract, metastasis to the other organs, and invasion to the surrounding organs;these clinical characteristics result in poor prognosis. Surgical resection appears as an effective approach;however, because it is difficult to accurately diagnose NEC during the early stage and owing to its aggressive growth pattern, development of a reliable standard chemotherapy regimen and management strategies are essential. CASE SUMMARY Here, we report the case of patient with NEC showing an aggressive growth pattern that resulted in the rupture of the tumor to the outside the colon after stenting of the internal colonic stenosis. In addition, the tumor invaded into the duodenum, thereby causing duodenal stenosis that required an additional stent in the duodenum. This aggressive growth pattern is one of the main features of the NEC that is different from adenocarcinoma. To clarify the clinical characteristics, we reviewed 60 recently reported cases, including data on tumor location, size, treatment, and prognosis. CONCLUSION We consider that the information presented here is of great significance for the diagnosis, treatment, and management of symptoms of the patients with NEC. | Tomoaki Yoshida Kenya Kamimura Kazunori Hosaka Koji Doumori Hiromitsu Oka Akito Sato Yasuo Fukuhara Shoji Watanabe Tomomi Sato Akira Yoshikawa Takashi Tomidokoro Shuji Terai | 2019 | World Journal of Clinical Cases2019，7，14： | 1 |
| 17 | Prostate cancer: a comparative study of 11C-choline PET and MR imaging combined with proton MR spectroscopy显示文摘 | Takako Yamaguchi Jin Lee Hiroji Uemura Takeshi Sasaki Nobukazu Takahashi Takashi Oka Kazuya Shizukuishi Hisashi Endou Yoshinobu Kubota Tomio Inoue | 2005 | European Journal of Nuclear Medicine and Molecular Imaging2005，，7： | 1 |
| 18 | Hepatic maturation in differentiating embryonic stem cells in vitro显示文摘 | Takashi Hamazaki Yasuhiko Iiboshi Masahiro Oka Philip J. Papst Amy M. Meacham Leonard I. Zon Naohiro Terada | 2001 | FEBS Letters2001，，1： | 1 |
| 19 | Physical activity and immune senescence in men显示文摘 | SHOJI SHINKAI HIDEAKI KOHNO KEI KIMURA TAKASHI KOMURA HIDENORI ASAI REIKO INAI KEIZO OKA YOSHIKA KUROKAWA ROY J. SHEPHARD | 1995 | Medicine & Science in Sports & Exercise1995，，11： | 1 |
| 20 | Development of an artificial articular cartilage 显示文摘 | Takashi Noguchi Masanori Oka Praveen Kumar Ken Ikeu chi | 1990 | Clinical Materials1990，6，4： | 1 |
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