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| 1 | Research Progress in Occupational Health Risk Assessment Methods in China显示文摘Traditional occupational disease control and prevention has remained prevalent in China over recent decades.There are appropriately 30,000 new case reports of occupational diseases annually.Although China has already established a series of occupational disease prevention programs,occupational health risk assessment(OHRA)strategies continue to be a limitation.OHRA is a tool for controlling the health | ZHOU Li Fang TIAN Fang ZOU Hua YUAN Wei Ming HAO Mo ZHANG Mei Bian | 2017 | Biomedical and Environmental Sciences2017，30，8： | 20 |
| 2 | Progress of the key materials for organic solar cells显示文摘Organic solar cells have attracted academic and industrial interests due to the advantages like lightweight,flexibility and roll-to-roll fabrication.Nowadays,18%power conversion efficiency has been achieved in the state-of-the-art organic solar cells.The recent rapid progress in organic solar cells relies on the continuously emerging new materials and device fabrication technologies,and the deep understanding on film morphology,molecular packing and device physics.Donor and acceptor materials are the key materials for organic solar cells since they determine the device performance.The past 25 years have witnessed an odyssey in developing high-performance donors and acceptors.In this review,we focus on those star materials and milestone work,and introduce the molecular structure evolution of key materials.These key materials include homopolymer donors,D-A copolymer donors,A-D-A small molecular donors,fullerene acceptors and nonfullerene acceptors.At last,we outlook the challenges and very important directions in key materials development. | Yang Tong Zuo Xiao Xiaoyan Du Chuantian Zuo Yuelong Li Menglan Lv Yongbo Yuan Chenyi Yi Feng Hao Yong Hua Ting Lei Qianqian Lin Kuan Sun Dewei Zhao Chunhui Duan Xiangfeng Shao Wei Li Hin-Lap Yip Zhengguo Xiaol Bin Zhang Qingzhen Bian Yuanhang Cheng Shengjian Liu Ming Cheng Zhiwen Jin Shangfeng Yang Liming Ding | 2020 | Science China Chemistry2020，63，6： | 15 |
| 3 | Chronic niacin overload may be involved in the increased prevalence of obesity in US children显示文摘AIM: To investigate nicotinamide’s action on glucose metabolism, and the association between niacin consumption and obesity prevalence. METHODS: Dynamic nicotinamide’s effect on plasma hydrogen peroxide and glucose metabolism was in- vestigated using oral glucose tolerance tests with or without nicotinamide in the same five healthy subjects.Lag-regression analysis was used to examine the association between the niacin consumption and the obesity prevalence among US children using the data from the Economic Research Service of the US Department of Agriculture and from US Centers for Disease Control and Prevention, respectively. RESULTS: Compared with the control oral glucose tolerance test, the 1-h plasma hydrogen peroxide (1.4 ± 0.1 μmol/L vs 1.6 ± 0.1 μmol/L, P = 0.016) and insulin levels (247.1 ± 129.0 pmol/L vs 452.6 ± 181.8 pmol/L, P = 0.028) were signif icantly higher, and the 3-h blood glucose was signif icantly lower (5.8 ± 1.2 mmol/L vs 4.5 ± 1.1 mmol/L, P = 0.002) after coadministration of glucose and 300 mg nicotinamide. The obesity prevalence among American children increased with the increasing per capita niacin consumption, the increasing grain contribution to niacin due to niacin-fortification, and the increasing niacin-fortified ready-to-eat cereal consumption, with a 10-year lag. The regression analyses showed that the obesity prevalence in the US children of all age groups was determined by niacin consumption (R2 = 0.814, 0.961 and 0.94 for 2-5 years, 6-11 years and 12-19 years age groups, respectively). CONCLUSION: The appetite-stimulating effect of nicotinamide appears to involve oxidative stress. Excess niacin consumption may be a major factor in the increased obesity prevalence in US children. | Li, Da Sun, Wu-Ping Zhou, Yi-Ming Liu, Qi-Gui Zhou, Shi-Sheng Luo, Ning Bian, Fu-Ning Zhao, Zhi-Gang Guo, Ming | 2010 | World Journal of Gastroenterology2010，16，19： | 10 |
| 4 | Nicotinamide overload may play a role in the development of type 2 diabetes显示文摘AIM: To investigate whether nicotinamide overload plays a role in type 2 diabetes. METHODS: Nicotinamide metabolic patterns of 14diabetic and 14 non-diabetic subjects were compared using HPLC. Cumulative effects of nicotinamide and N1-methylnicotinamide on glucose metabolism, plasma H2O2 levels and tissue nicotinamide adenine dinucleotide (NAD) contents of adult Sprague-Dawley rats were observed. The role of human sweat glands and rat skin in nicotinamide metabolism was investigated using sauna and burn injury, respectively. RESULTS: Diabetic subjects had significantly higher plasma N 1-methylnicotinamide levels 5 h after a 100-mg nicotinamide load than the non-diabetic subjects (0.89 ± 0.13 μmol/L vs 0.6 ± 0.13 μmol/L, P < 0.001). Cumulative doses of nicotinamide (2 g/kg) significantly increased rat plasma N 1-methy lnico-tinamide concentrations associated with severe insulin resistance, which was mimicked by N1-methy-lnicotinamide. Moreover, cumulative exposure to N1-methylnicotinamide (2 g/kg) markedly reduced rat muscle and liver NAD contents and erythrocyte NAD/NADH ratio, and increased plasma H2O2 levels. Decrease in NAD/NADH ratio and increase in H2O2 generation were also observed in human erythrocytes after exposure to N1-methylnicotinamide in vitro. Sweating eliminated excessive nicotinamide (5.3-fold increase in sweat nicotinamide concentration 1 h after a 100-mg nicotinamide load). Skin damage or aldehyde oxidase inhibition with tamoxifen or olanzapine, both being notorious for impairing glucose tolerance, delayed N1-methylnicotinamide clearance. CONCLUSION: These f indings suggest that nicotinamide overload, which induced an increase in plasma N 1-methylnicotinamide, associated with oxidative stress and insulin resistance, plays a role in type 2 diabetes. | Shi-Sheng Zhou Da Li Wu-Ping Sun Ming Guo Yong-Zhi Lun Yi-Ming Zhou Fu-Cheng Xiao Li-Xin Jing Shen-Xia Sun Li-Bin Zhang Ning Luo Fu-Ning Bian Wei Zou Lai-Bin Dong Zhi-Gang Zhao Sheng-Fan Li Xiao-Jie Gong Zeng-Guo Yu Chang-Bin Sun Cong-Long Zheng Dong-Ju Jiang Zheng-Ning Li | 2009 | World Journal of Gastroenterology2009，15，45： | 8 |
| 5 | A specific objective supplemental factor in evaluating acute mountain sickness: ΔHR in combination with SaO_2显示文摘Background: So far, there have been no measurements confirmed useful in diagnosing acute mountain sickness(AMS). The aim of this study was to determine the role of heart rate(HR) difference(ΔHR) and oxygen saturation(Sa O2) as objective risk factors in aiding the diagnosis of AMS.Methods: A total of 1,019 participants were assigned to either the acute exposure group(AEG): from 500 m to 3,700 m by flight within 2.5 hours(n=752); or the pre-acclimatization group(PAG): ascended to 4,400 m from 3,650 m within three hours by car after adapting 33 days at 3,650m(n=267). The questionnaires or measurements of resting Sa O2 and HR were completed between 18 and 24 hours before departure and after arrival.Results: Incidence of AMS was 61.3%(461) in AEG, with 46.1%(347) mild cases and 15.2%(114) severe cases. In PAG, the incidence was 38.9%(104), with 30.7%(82) mild cases and 8.2%(22) severe cases. The AMS subjects showed a significant increase in HR and a decrease in Sa O2 levels compared with the non-AMS subjects in both groups. ΔHR and post-exposure Sa O2 were significantly correlated with the Lake Louise Score(LLS) in both groups. Stepwise logistic regression analysis revealed the ΔHR >25 and Sa O2 <88% in AEG as well as ΔHR >15 and Sa O2 <86% in PAG to be independent risk factors of AMS. Combining these two measurements could specifically indicate participants with AMS, which showed a positive predictive value of 89% and specificity of 97% in AEG as well as 85% and 98% in PAG.Conclusion:ΔHR or Sa O2, as objective measurements, correlate with AMS. Combination of these two measurements may be useful as an additional specific and objective factor to further confirm the diagnosis of AMS. | Ming Li Ji-Hang Zhang Guo-Xi Zhao Shi-Zhu Bian Xu-Bin Gao Xi Liu Jie Yu Jun-Qing Dong Guo-Zhu Chen Hong Wang Lan Huang | 2015 | Military Medical Research2015，3，3： | 6 |
| 6 | MicroRNA-27a-mediated repression of cysteine-rich secretory protein 2 translation in asthenoteratozoospermic patients显示文摘充满半胱氨酸的能分泌的蛋白质(CRISP2 ) 2 是在在 modulating 精子 flagellar 活动性, acrosome 反应,和配偶子熔化起作用的精子的重要蛋白质。精子缺乏 CRISP2 展览低精子活动性和反常形态学。然而,在 asthenoteratozoospermia (ATZ ) 位于 CRISP2 的减小下面的分子的机制仍然保持未知。在这研究, CRISP2 蛋白质而非它的 mRNA 的低表示作为与 normozoospermic 男性相比从 ATZ 病人在呼喊的精子被观察。随后,生物信息的预言,酶记者试金,和 microRNA-27a (miR-27a ) transfection 实验表明 miR-27a 明确地由绑定指向 CRISP2 到它的 3 untranslated 区域(3-UTR ) , posttranscriptionally 压制 CRISP2 表示。进一步的证据被高 miR-27a 表示的临床的观察从在 miR-27a 表示和 CRISP2 蛋白质表示之间的 ATZ 病人和否定关联在呼喊的精子提供。最后,回顾的后续研究支持了那两高 miR-27a 表情和低 CRISP2 蛋白质表示与低进步精子活动性,反常形态学,和不孕被联系。这研究在 ATZ 表明为减少的 CRISP2 表示负责的新奇机制,它可以为对待男不孕,或为男避孕提供一个潜在的治疗学的目标。 | Jun-Hao Zhou Qi-Zhao Zhou Jian-Kun Yang Xiao-Ming Lyu Jun Bian Wen-Bin Guo Zi-Jian Chen Ming Xia Hui Xia Tao Qi Xin Li Cun-Dong Liu | 2017 | Asian Journal of Andrology2017，19，5： | 4 |
| 7 | PECS: Towards Personalized Edge Caching for Future Service-Centric Networks显示文摘Mobile operators face the challenge of how to best design a service-centric network that can effectively process the rapidly increasing number of bandwidth-intensive user requests while providing a higher quality of experience(QoE). Existing content distribution networks(CDN) and mobile content distribution networks(mCDN) have both latency and throughput limitations due to being multiple network hops away from end-users. Here, we first propose a new Personalized Edge Caching System(PECS) architecture that employs big data analytics and mobile edge caching to provide personalized service access at the edge of the mobile network. Based on the proposed system architecture, the edge caching strategy based on user behavior and trajectory is analyzed. Employing our proposed PECS strategies, we use data mining algorithms to analyze the personalized trajectory and service usage patterns. Our findings provide guidance on how key technologies of PECS can be employed for current and future networks. Finally, we highlight the challenges associated with realizing such a system in 5G and beyond. | Ming Yan Wenwen Li Chien Aun Chan Sen Bian Chih-Lin I André F. Gygax | 2019 | China Communications2019，16，8： | 3 |
| 8 | Interleukin-34 deficiency aggravates development of colitis and colitis-associated cancer in mice显示文摘BACKGROUND Although expression of interleukin(IL)-34 is upregulated in active ulcerative colitis(UC),the molecular function and underlying mechanism are largely unclear.AIM To investigate the function of IL-34 in acute colitis,in a wound healing model and in colitis-associated cancer in IL-34-deficient mice.METHODS Colitis was induced by administration of dextran sodium sulfate(DSS),and carcinogenesis was induced by azoxymethane(AOM).Whether the impact of IL-34 on colitis was dependent on macrophages was validated by depletion of macrophages in a murine model.The association between IL-34 expression and epithelial proliferation was studied in patients with active UC.RESULTS IL-34 deficiency aggravated murine colitis in acute colitis and in wound healing phase.The effect of IL-34 on experimental colitis was not dependent on macrophage differentiation and polarization.IL-34-deficient mice developed more tumors than wild-type mice following administration of AOM and DSS.No significant difference was shown in degree of cellular differentiation in tumors between wild-type and IL-34-deficient mice.IL-34 was dramatically increased in the active UC patients as previously reported.More importantly,expression of IL-34 was positively correlated with epithelial cell proliferation in patients with UC.CONCLUSION IL-34 deficiency exacerbates colonic inflammation and accelerates colitis-associated carcinogenesis in mice.It might be served as a potential therapeutic target in UC. | Zhao-Xiu Liu Wei-Jie Chen Yang Wang Bing-Qian Chen Yi-Cun Liu Tiao-Chun Cheng Lei-Lei Luo Lin Chen Lin-Ling Ju Yuan Liu Ming Li Nan Feng Jian-Guo Shao Zhao-Lian Bian | 2022 | World Journal of Gastroenterology2022，28，47： | 3 |
| 9 | Enrichment factors of movable hydrocarbons in lacustrine shale oil and exploration potential of shale oil in Gulong Sag,Songliao Basin,NE China显示文摘The geological characteristics and production practices of the major middle-and high-maturity shale oil exploration areas in China are analyzed.Combined with laboratory results,it is clear that three essential conditions,i.e.economic initial production,commercial cumulative oil production of single well,and large-scale recoverable reserves confirmed by the testing production,determine whether the continental shale oil can be put into large-scale commercial development.The quantity and quality of movable hydrocarbons are confirmed to be crucial to economic development of shale oil,and focuses in evaluation of shale oil enrichment area/interval.The evaluation indexes of movable hydrocarbon enrichment include:(1)the material basis for forming retained hydrocarbon,including TOC>2%(preferentially 3%-4%),and typeⅠ-Ⅱkerogens;(2)the mobility of retained hydrocarbon,which is closely related to the hydrocarbon composition and flow behaviors of light/heavy components,and can be evaluated from the perspectives of thermal maturity(Ro),gas-oil ratio(GOR),crude oil density,quality of hydrocarbon components,preservation conditions;and(3)the reservoir characteristics associated with the engineering reconstruction,including the main pore throat distribution zone,reservoir physical properties(including fractures),lamellation feature and diagenetic stage,etc.Accordingly,13 evaluation indexes in three categories and their reference values are established.The evaluation indicates that the light shale oil zones in the Gulong Sag of Songliao Basin have the most favorable enrichment conditions of movable hydrocarbons,followed by light oil and black oil zones,containing 20.8×10^(8) t light oil resources in reservoirs with R_(0)>1.2%,pressure coefficient greater than 1.4,effective porosity greater than 6%,crude oil density less than 0.82 g/cm^(3),and GOR>100 m/m^(3).The shale oil in the Gulong Sag can be explored and developed separately by the categories(resource sweet spot,engineering sweet spot,and tight oil sweet spot)depending on shale oil flowability.The Gulong Sag is the most promising area to achieve large-scale breakthrough and production of continental shale oil in China. | ZHAO Wenzhi BIAN Congsheng LI Yongxin ZHANG Jinyou HE Kun LIU Wei ZHANG Bin LEI Zhengdong LIU Chang ZHANG Jingya GUAN Ming LIU Shijul | 2023 | Petroleum Exploration and Development2023，50，3： | 2 |
| 10 | Predicting the degradation behavior of magnesium alloys with a diffusion-based theoretical model and in vitro corrosion testing显示文摘Magnesium alloys have shown great potential for their use in the medical device field, due to the promising biodegradability. However, it remains a challenge to characterize the degradation behavior of the Mg alloys in a quantitative manner. As such, controlling the degradation rate of the Mg alloys as per our needs is still hard, which greatly limits the practical application of the Mg alloys as a degradable biomaterial.This paper discussed a numerical model developed based on the diffusion theory, which can capture the experimental degradation behavior of the Mg alloys precisely. The numerical model is then implemented into a finite element scheme, where the model is calibrated with the data from our previous studies on the corrosion of the as-cast Mg-1 Ca and the as-rolled Mg-3 Ge binary alloys. The degradation behavior of a pin implant is predicted using the calibrated model to demonstrate the model’s capability. A standard flow is provided in a practical framework for obtaining the degradation behavior of any biomedical Mg alloys. This methodology was further verified via the comparison with enormous available experimental results. Lastly, the material parameters defined in this model were provided as a new kind of material property. | Zhenquan Shen Ming Zhao Dong Bian Danni Shen Xiaochen Zhou Jianing Liu Yang Liu Hui Guo Yufeng Zheng | 2019 | Journal of Materials Science & Technology2019，35，7： | 2 |
| 11 | Global occurrence,bioaccumulation factors and toxic effects of polychlorinated biphenyls in tuna:A review显示文摘Polychlorinated biphenyls(PCBs)tend to accumulate in adipose tissue and induce toxicity due to their high lipophilicity and persistence.Tuna play an important role in the ocean food web and human diet.PCBs can damage the growth of tuna directly and have some adverse effects on human indirectly.This review aims to provide geographic variations,bioaccumulation factors and the toxic effects of PCBs in tuna.PCB levels found were varied significantly among the different regions and it showed a trend of offshore greater than pelagic,with the northern hemisphere higher than the southern hemisphere.The highest PCB concentration of tuna was in FAO area 37.Nearly all of the specimens presented similar domain configuration,while their concentrations varied significantly.PCB congeners and concentrations in tuna were affected by a vast of factors,such as geographical distribution,tissue types,trophic level and growth stage,gender,tuna species and physical and chemical properties of PCBs.They can damage reproductive,neurologic and development systems.This review gives a systematic insight into PCBs in tuna and highlights the more attention should be paid to the long-term changes of PCBs in tuna and oceans.There is also a need to strengthen the assessment of PCB impacts on tuna ecology. | Jingqian Xie Zhihe Bian Tian Lin Ling Tao Qiang Wu Ming Chu | 2020 | Emerging Contaminants2020，6，1： | 2 |
| 12 | Numerical analysis of heat transfer enhancement on steam condensation in the presence of air outside the tube显示文摘In loss-of-coolant accidents,a passive containment heat removal system protects the integrity of the containment by condensing steam.As a large amount of air exists in the containment,the steam condensation heat transfer can be significantly reduced.Based on previous research,traditional methods for enhancing pure steam condensation may not be applicable to steam–air condensation.In the present study,new methods of enhancing condensation heat transfer were adopted and several potentially enhanced heat transfer tubes,including corrugated tubes,spiral fin tubes,and ring fin tubes were designed.STAR-CCM+was used to determine the effect of enhanced heat transfer tubes on the steam condensation heat transfer.According to the calculations,the gas pressure ranged from 0.2 to 1.6 MPa,and air mass fraction ranged from 0.1 to 0.9.The effective perturbation of the high-concentration air layer was identified as the key factor for enhancing steam–air condensation heat transfer.Further,the designed corrugated tube performed well at atmospheric pressure,with a maximum enhancement of 27.4%,and performed poorly at high pressures.In the design of spiral fin tubes,special attention should be paid to the locations that may accumulate high-concentration air.Nonetheless,the ring-fin tubes generally displayed good performance under all conditions of interest,with a maximum enhancement of 24.2%. | Wen-Tao Li Xian-Ke Meng Hao-Zhi Bian Ming Ding | 2022 | Nuclear Science and Techniques2022，33，8： | 2 |
| 13 | Benefit of everolimus in treatment of an intrahepatic cholangiocarcinoma patient with a PIK3CA mutation显示文摘Intrahepatic cholangiocarcinoma(ICC) is a relatively rare form of liver cancer with a poor prognosis. The therapeutic options for patients with advanced ICC are limited and usually ineffective. There is currently no approved targeted therapy for ICC, although accumulating evidence supports inhibition of the PI3K/Akt/m TOR signaling pathway as a promising therapeutic strategy in the treatment of ICC. Here, we report a patient with stage IV ICC harboring a PIK3 CA mutation who responded well to the m TOR inhibitor everolimus. Computed tomography and magnetic resonance imaging demonstrated shrinkage of the tumor and maintenance of a partial response for 6.5 mo after everolimus treatment as the best response. To the best of our knowledge, this is the first clinical case report in the literature of clinical benefit from everolimus treatment in an ICC patient with PIK3 CA mutation. | Ji-Lai Bian Mei-Mei Wang En-Juan Tong Jing Sun Ming Li Zhi-Bo Miao Yan-Lin Li Bai-Hong Zhu Jia-Jia Xu | 2017 | World Journal of Gastroenterology2017，23，23： | 2 |
| 14 | Positive corona inception voltages and corona currents for air at various pressures and humidities显示文摘 | BIAN Xing ming HUI Jian-feng CHEN Yong | 2010 | IEEE Transactions on Dielectrics and Electrical Insulation2010，17，1： | 1 |
| 15 | Application of the Structural Topological Optimization in the Column Stability Design显示文摘 | Bian Bing Chuan Peng Guan Ming Sui Yun Kang | 2010 | Applied Mechanics and Materials2010，，37： | 1 |
| 16 | Hydrogen sulfide protects MC3T3-E1 osteoblastic cells against H 2 O 2 -induced oxidative damage—implications for the treatment of osteoporosis显示文摘 | Zhong-Shi Xu Xin-Yu Wang De-Ming Xiao Li-Fang Hu Ming Lu Zhi-Yuan Wu Jin-Song Bian | 2011 | Free Radical Biology and Medicine2011，，10： | 1 |
| 17 | Flame retardancy of hollow glass microsphere/rigid polyurethane foams in the presence of expandable graphite显示文摘 | BIAN Xiang-cheng TANG Jian-hua LI Zhong ming | 2008 | Journal of Applied Polymer Science2008，109，： | 1 |
| 18 | No Relationship between Maternal Iron Status and Postpartum Depression in Two Samples in China显示文摘 | Rinat Armony-Sivan Jie Shao Ming Li Gengli Zhao Zhengyan Zhao Guobing Xu Min Zhou Jianying Zhan Yang Bian Chai Ji Xing Li Yaping Jiang Zhixiang Zhang Blair J. Richards Twila Tardif Betsy Lozoff Laura Murray-Kolb | 2012 | Journal of Pregnancy2012，，： | 1 |
| 19 | Alpha Klotho and phosphate homeostasis显示文摘 | Ao Bian Changying Xing Ming Chang Hu | 2014 | J Endocrinol invest2014，37，11： | 1 |
| 20 | Frequency and predictors of spontaneous hemorrhagic transformation in ischemic stroke and its association with prognosis显示文摘 | Song Tan Deren Wang Ming Liu Shihong Zhang Bo Wu Bian Liu | 2014 | Journal of Neurology2014，，5： | 1 |
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