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| 1 | Toripalimab plus chemotherapy as second-line treatment in previously EGFR-TKI treated patients with EGFR-mutant-advanced NSCLC:a multicenter phase-II trial显示文摘This multicenter phase-II trial aimed to investigate the efficacy,safety,and predictive biomarkers of toripalimab plus chemotherapy as second-line treatment in patients with EGFR-mutant-advanced NSCLC.Patients who failed from first-line EGFR-TKIs and did not harbor T790M mutation were enrolled.Toripalimab plus carboplatin and pemetrexed were administrated every three weeks for up to six cycles,followed by the maintenance of toripalimab and pemetrexed.The primary endpoint was objective-response rate(ORR).Integrated biomarker analysis of PD-L1 expression,tumor mutational burden(TMB),CD8+tumor-infiltrating lymphocyte(TIL)density,whole-exome,and transcriptome sequencing on tumor biopsies were also conducted.Forty patients were enrolled with an overall ORR of 50.0%and disease-control rate(DCR)of 87.5%.The median progression free survival(PFS)and overall survival were 7.0 and 23.5 months,respectively.The most common treatment-related adverse effects were leukopenia,neutropenia,anemia,ALT/AST elevation,and nausea.Biomarker analysis showed that none of PD-L1 expression,TMB level,and CD8+TIL density could serve as a predictive biomarker.Integrated analysis of whole-exome and transcriptome sequencing data revealed that patients with DSPP mutation had a decreased M2 macrophage infiltration and associated with longer PFS than those of wild type.Toripalimab plus chemotherapy showed a promising anti-tumor activity with acceptable safety profiles as the second-line setting in patients with EGFR-mutant NSCLC.DSPP mutation might serve as a potential biomarker for this combination.A phase-III trial to compare toripalimab versus placebo in combination with chemotherapy in this setting is ongoing(NCT03924050). | Tao Jiang Pingyang Wang Jie Zhang Yanqiu Zhao Jianying Zhou Yun Fan Yongqian Shu Xiaoqing Liu Helong Zhang Jianxing He Guanghui Gao Xiaoqian Mu Zhang Bao Yanjun Xu Renhua Guo Hong Wang Lin Deng Ningqiang Ma Yalei Zhang Hui Feng Sheng Yao Jiarui Wu Luonan Chen Caicun Zhou Shengxiang Ren | 2021 | Signal Transduction and Targeted Therapy2021，6，11： | 8 |
| 2 | Tailoring the mechanical anisotropy of sintered NdFeB magnets by Pr-Cu grain boundary reconstruction显示文摘Pr_(83)Cu_(17)(wt%) grain boundary reconstruction was applied to prepare sintered NdFeB magnets. The effects of addition amount and annealing on the bending strength were investigated. The results show that Pr_(83)Cu_(17) can not only effectively enhance the bending strength, but also change the mechanical anisotropy in two directions parallel and perpendicular to c-axis. The bending strength perpendicular to c-axis reaches 404 MPa in 10 wt% addition magnet, higher than 348 MPa along parallel direction. This change is attributed to the preferred distribution of boundary phases, i.e., ductile(Nd,Pr)-Fe-Cu phase along perpendicular direction to c-axis and(Nd,Pr)-Fe phase along parallel direction. Moreover, the Cu migration during 480 ℃ annealing is found to be related to this boundary phase distribution. | Minghui Tang Xiaoqian Bao Xuejiao Zhang Xing Mu Kechao Lu Jiheng Li Xuexu Gao | 2019 | Journal of Rare Earths2019，37，4： | 7 |
| 3 | Long-term,multidomain analyses to identify the breed and allelic effects in MSTN-edited pigs to overcome lameness and sustainably improve nutritional meat production显示文摘Beef and mutton production has been aided by breeding to integrate allelic diversity for myostatin(MSTN),but a lack of diversity in the MSTN germplasm has limited similar advances in pig farming.Moreover,insurmountable challenges with congenital lameness and a dearth of data about the impacts of feed conversion,reproduction,and meat quality in MSTN-edited pigs have also currently blocked progress.Here,in a largest-to-date evaluation of multiple MSTN-edited pig populations,we demonstrated a practical alternative edit-site-based solution that overcomes the major production obstacle of hindlimb weakness.We also provide long-term and multidomain datasets for multiple breeds that illustrate how MSTN-editing can sustainably increase the yields of breed-specific lean meat and the levels of desirable lipids without deleteriously affecting feed-conversion rates or litter size.Apart from establishing a new benchmark for the data scale and quality of genome-edited animal production,our study specifically illustrates how gene-editing site selection profoundly impacts the phenotypic outcomes in diverse genetic back-grounds. | Ziyao Fan Zhiguo Liu Kui Xu Tianwen Wu Jinxue Ruan Xinmin Zheng Shideng Bao Yulian Mu Tad Sonstegard Kui Li | 2022 | Science China(Life Sciences)2022，65，2： | 5 |
| 4 | Highly efficient catalytic scavenging of oxygen free radicals with graphene-encapsulated metal nanoshields显示文摘 | Junying Wang Xiaoju Cui Haobo Li Jianping Xiao Jiang Yang Xiaoyu Mu Haixia Liu Yuan-Ming Sun Xuhui Xue Changlong Liu Xiao-Dong Zhang Dehui Deng Xinhe Bao | 2018 | Nano Research2018，11，5： | 4 |
| 5 | Relationship between Lightning Activity and Tropospheric Nitrogen Dioxide and the Estimation of Lightning-produced Nitrogen Oxides over China显示文摘To better understand the relationship between lightning activity and nitrogen oxides(NOX) in the troposphere and to estimate lightning-produced NOX(LNOX) production in China more precisely, spatial and temporal distributions of vertical column densities of tropospheric nitrogen dioxide(NO_2VCDs) and lightning activity were analyzed using satellite measurements. The results showed that the spatial distribution of lightning activity is greater in the east than in the west of China, as with NO_2 VCDs. However, the seasonal and annual variation between lightning and NO_2 density show different trends in the east and west. The central Tibetan Plateau is sparsely populated without modern industry, and NO_2 VCDs across the plateau are barely affected by anthropogenic sources. The plateau is an ideal area to study LNOX. By analyzing 15 years of satellite data from that region, it was found that lightning density is in strong agreement with annual, spatial and seasonal variations of NO_2 VCDs, with a correlation coefficient of 0.79 from the linear fit. Combining Beirle's method and the linear fit equation,LNOXproduction in the Chinese interior was determined to be 0.07(0.02–0.27) Tg N yr^(-1) for 1997–2012, within the range of 0.016–0.384 Tg N yr^(-1) from previous estimates. | Fengxia GUO Xiaoyu JU Min BAO Ganyi LU Zupei LIU Yawen LI Yijun MU | 2017 | Advances in Atmospheric Sciences2017，34，2： | 4 |
| 6 | Estimation of the rational water area for controlling wind erosion in the dried-up basin of the Ebinur Lake and its effect detection显示文摘埃比纳·莱克区域被描述为“一个格林迷宫”在“ Xinjiang MapRecords:河的记录“然而,在 1910 出版了在这个区域的生态学和环境严重由于人的活动的影响被堕落了在期间最近 40 年。渴起来,有 107.4 km^2 的一个区域的湖盆在它的西北的部分形成,是没有植被,盖住 byunconsolidated 淤泥沉积物,并且在北方 Xinjiang 成为了灰尘天气的主要灰尘来源之一,并且有 4.8x10 ~ 6t 的年度数量的灰尘被大风从有 164 天的 Alataw 山脉差距从这个区域吹一年里的发生的大风。为在弄干起来的湖盆在湖区域和有效地控制的风侵蚀改进生态学的埃比纳·莱克的合理的水区域和流入在在弄干起来的湖盆分析在沉积物的小粒的作文之间的当前的生态的问题和关系以后用水平衡方程被估计并且灰尘天气,和最近的年里的生态的效果被监视。为在弄干起来的湖盆在湖区域和有效地控制的风侵蚀改进生态学的 theEbinur 湖的水区域应该至少是 800 km^2,这被考虑,并且湖应该在 7.92x10 ~ 上的再装的表面流量和地下水的年度体积 8 m^3。 | BAO Anming MU Guijin ZHANG Yi FENG Xianwei CHANG Cun YIN Xiaojun | 2006 | Chinese Science Bulletin2006，51，A01： | 4 |
| 7 | Vertical structure and seasonal variation of tidal and residual currents in the northern Huanghai Sea显示文摘Analysis of tidal current and sea level has been made based on the observations from the summer of 2006 to the winter of 2007,respectively.The result indicates that a two-layer structure of residual current exists in summer,with its upper layer going northwestward and the lower layer southeastward.In addition,some strong residuals exist in the neighboring depth of the pycnocline during the current period of astronomical tide.In winter,except some individual layersthe residual currents mostly direct to the northwest,from which we can see the fluctuation of abnormal sea-level and the appearance of associated current because of the changes of the wind field.The analysis of tidal ellipse indicates that the direction of the maximum semidiurnal component is clockwise from summer to winter,with an angle of 16-18.Moreover,in summer the semidiurnal component rotates with depth clockwise while the diurnal component counterclockwise.However,the vertical structure is almost homogeneous in winter. | SONG Jun GUO Junru QIAO Lulu MU Lin YAO Zhigang LIU Yang LI Huan BAO Xianwen SUN Xiaoyan GAO Jia | 2011 | Acta Oceanologica Sinica2011，30，5： | 4 |
| 8 | eGPS 1.0: comprehensive software for multi-omic and evolutionary analyses显示文摘It has become increasingly challenging for researchers to analyze the exponentially expanding amount of multi-omic data.Here,we describe multi-functional software named evolutionary GenotypePhenotype Systems(eGPS)that enables users to perform comprehensive multiomic and evolutionary analyses.The eGPS combines the power of cloud computing and the advantage of desktop application,has a user-friendly graphic interface and is highly interactive. | Dalang Yu Lili Dong Fangqi Yan Hailong Mu Bixia Tang Xiao Yang Tao Zeng Qing Zhou Feng Gao Zhonghuang Wang Ziqian Hao Hongen Kang Yi Zheng Hongwei Huang Yuzhang Wei Wei Pan Yaochen Xu Junwei Zhu Shilei Zhao Ciran Wang Pengyu Wang Long Dai Mushan Li Li Lan Yiwei Wang Hua Chen Yi-Xue Li Yun-Xin Fu Zhen Shao Yiming Bao Fangqing Zhao Luo-Nan Chen Guo-Qing Zhang Wenming Zhao Haipeng Li | 2019 | National Science Review2019，6，5： | 4 |
| 9 | Drift analysis of MH370 debris in the southern Indian Ocean显示文摘 | Jia GAO Lin MU Xianwen BAO Jun SONG Yang DING | 2018 | Frontiers of Earth Science2018，12，3： | 3 |
| 10 | Observation on Therapeutic Effect of Mild Moxibustion plus Acupoint Injection for Optic Atrophy显示文摘Objective:To observe the clinical effect of mild moxibustion plus acupoint injection for optic atrophy.Methods:Ninety-four patients with optic atrophy were divided into a treatment group(51 cases)and a control group(43 cases).The treatment group was treated with mild moxibustion plus acupoint injection,and the control group was treated with medications.After three courses,the change of vision was observed.Results:The total effective rate was 82.4%in the treatment group and41.9%in the control group,with a statistical difference between the two groups(P<0.05).Conclusion:Moxibustion plus acupoint injection is an effective method to treat optic atrophy. | Zhang Bao Peng Li Zhou Li-zhi Mu Jing-ping Cheng Jian-ming Huang Guo-qi | 2013 | Journal of Acupuncture and Tuina Science2013，11，2： | 2 |
| 11 | Substituent groups from aromatic dicarboxylates modulated structural diversification in the assembly of Co(Ⅱ)complexes based on the bis-pyridyl-bis-amide ligands显示文摘Four coordination polymers based on two bis-pyridyl-bis-amide ligands and three aromatic dicarboxylates with different substituent groups, namely, [Co(3-bpcb) 1.5 (NPH)(H2O)]·4H2O (1), [Co(3-bpcb)(NIPH)] (2), [Co(3-bpcb)0.5 (5-H2 AIP)]·2H2O (3), [Co(3-bpcd) 0.5 (5-H2 AIP)(H2O)]·2H2O (4) [3-bpcb = N,N′-bis(3-pyridinecarboxamide)-1,4-benzene, 3-bpcd = N,N′-bis(3- pyridine)cyclohexane-1,4-dicarboxamide, H2 NPH = 3-nitrophthalic acid, H2 NIPH = 5-nitroisophthalic acid, 5-H4 AIP = 5-aminoisophthalic acid] have been synthetized under hydrothermal conditions. Complex 1 displays a one dimensional (1D) chain based on the binuclear [Co2 (NPH)2 ] units and 3-bpcb ligands, which is extended into a three dimensional (3D) supramolecular framework through hydrogen bonding and - stacking interactions. In complex 2, the (3,5)-connected two dimensional (2D) layers are constructed from 1D Co-NIPH chains and bidentate-bridging 3-bpcb ligands. Complex 3 is a 2D double layer based on Co-5-H2 AIP 2D layers and 3-bpcb pillars. Complex 4 also displays a 2D network, which is constructed from the Co-5-H2AIP 1D double chains and 3-bpcd ligands. Finally, complexes 2-4 are extended into 3D supramolecular frameworks by hydrogen bonding or - stacking interactions. The substituent groups of dicarboxylates play an important role in the assembly and structures of the title complexes. In addition, the fluorescent properties of complexes 1-4 and the electrochemical behaviors of 3 and 4 at room temperature have been investigated. | WANG XiuLi MU Bao LIN HongYan YANG Song LIU GuoCheng TIAN AiXiang ZHANG JuWen | 2013 | Science China Chemistry2013，56，5： | 2 |
| 12 | Winter heat budget in the Huanghai Sea and the effect from Huanghai Warm Current (Yellow Sea Warm Current)显示文摘Four sources of surface heat flux (SHF) and the satellite remote sensing sea surface temperature (SST) data are combined to investigate the heat budget closure of the Huanghai Sea (HS) in winter.It is found that heat loss occurs all over the HS during winter and the area averaged heat content change decreases with a rate of-106 W/m 2.Comparing with the area averaged SHF of-150 W/m 2 from the four SHF data sets,it can be concluded that the SHF plays a dominant role in the HS heat budget during winter.In contrast,the heat advection transported by the Huanghai Warm Current (Yellow Sea Warm Current,HWC) accounted for up to 29% of the HS heat content change.Close correlation,especially in February,between the storm events and the SST increase demonstrates that the HWC behaves strongly as a wind-driven compensation current. | QIAO Lulu WANG Xiaohua WANG Yongzhi WU Dexing BAO Xianwen MU Lin | 2011 | Acta Oceanologica Sinica2011，30，5： | 2 |
| 13 | Forage biomass of 22 shrub species from Monfragüe Natural Park (SW Spain) assessed by log–log regression models显示文摘 | D. Paton J. Nu?ez D. Bao A. Mu?oz | 2002 | Journal of Arid Environments2002，，2： | 2 |
| 14 | Antibacterial effect of metallic glasses显示文摘The antibacterial effect of Fe-based,Ni-based and Cu-based metallic glasses has been studied in this research.All test metallic glasses were found to inhibit growth of Esherichia coli.The optical density value of E.coli flocculation exposed to metallic glasses,from which the number of bacteria was determined,was 65% lower than that of the match group,and 57% lower than that of the ferrite group.Moreover,the antibacterial effect was not significantly different(σ=0.05) between Cu-based,Ni-based and Fe-based metallic glasses.These results extend our understanding of the antibacterial effect of metallic antibacterial materials,and suggest new applications for metallic glasses. | LIN Bao MU Ren YANG LiFu BIAN XiuFang | 2012 | Chinese Science Bulletin2012，57，9： | 2 |
| 15 | Effect of ultrasonic treatment on the graft reaction between soy protein isolate and gum acacia and on the physicofhernical properties of conjugates显示文摘 | MU Lixia ZHAO Mourning YANG Bao | 2010 | Journal of Agricultural and Food Chemistry2010，58，7： | 1 |
| 16 | Forage biomass of 22 shrub species from Monfragae Natural Park(SW Spain)assessed by log- log regression models显示文摘 | Paton D u? ez J Bao D Mu? oz A | 2002 | Journal of Arid Enviroments2002，，52： | 1 |
| 17 | Three New Complexes Based on the Flexible Zwitterionic Dicarboxylate Ligand: Synthesis, Structures, and Properties显示文摘三新建筑群基于转变金属和两性离子的 dicarboxylate ligand 被准备了 1,1 ′-(1,4-phenylene-bis (甲又))-bis(pyridine-3-carboxylic 酸)(L) ,其公式是 {[Cd 4(L)(SO4)]·(Cl )6} n (1 ) ,[Zn (L) Cl 2] n (2 ) ,并且[公司(L) Cl 2] n (3 ) 分别地。建筑群 1-3 被元素的分析,红外光谱学, XRD,热分析和单身者描绘了水晶 X 光检查(粉末) 衍射。1 在单斜晶的空间组 C2/m 结晶,显示有三个唯一的 Cd 2+ 中心的 2-D 层结构。2 和 3 是与斜方晶的 Cmca 空间组一起的同形的结构。他们展出 1-D 之字形链,它能被连接经由氢结合相互作用(CH···O ) 产生 2-D 层。而且,电气化学的行为表明 3 用户终端设备的氧化还原作用反应是控制表面的反应。并且标题建筑群的光性质在房间温度被调查了。 | Qing Wang Bao Mu Dandan Yang Lei Lv Changxia Li Rudan Huang | 2016 | Chinese Journal of Chemistry2016，34，2： | 1 |
| 18 | Structures and Properties of Two New Three-Dimensional Inorganic-Organic Hybrid Compounds Based on Isopolymolybdate Clusters显示文摘包含不同 isopolymolybdate 单位的二新无机器官的混合材料,也就是[{ Ce ( pdca )( H 2 O )}{ Ce ( pdca )( H 2 O ) 5}]2{Mo8 O 26}·10H2 O ( 1 ),[ Cu ( phen )( H 2 O ) 2]2[Mo6 O 20]( 2 )( pdca=pyridine-2,6-dicarboxylic 酸, phen=1,10-phenanthroline )成功地在热水的条件下面被综合了,并且由元素的分析描绘了,红外系列,热 g 在化合物 1, Ce (III ) 离子被 pdca ligands 衔接形成铈器官的协作层,它是由经由 CeO 结合的共有原子价的 octamolybdate 簇的进一步的 pillared,导致 3D 的形成支柱分层的开框架的建筑学。超分子的结构由在 1D molybdate 之间的氢契约相互作用构造了的 3D 锁住的化合物 2 特征聚集了由[瞬间 6 O 20]4− polyoxoanions 和协调的水分子。它是显著的那 H 3[PMo12 O 40]·ΧH2 O 分解成 hexamolybdate 阴离子,它被 Cu (II ) 和 phen ligands 连接阳离子。而且,紫外力的系列和混合物 1-2 的荧光性质也详细被调查了。 | Jingjing Wang Xuena Yin Bao Mu Na Li Rudan Huang | 2016 | Chinese Journal of Chemistry2016，34，2： | 1 |
| 19 | Targeted core-shell nanoparticles for precise CTCF gene insert in treatment of metastatic breast cancer显示文摘Clustered regularly interspaced short palindromic repeats(CRISPR)technology emerges a remarkable potential for cure of refractory cancer like metastatic breast cancer.However,how to efficiently deliver the CRISPR system with non-viral carrier remains a major issue to be solved.Here,we report a kind of targeted core-shell nanoparticles(NPs)carrying dual plasmids(pHR-pCas9)for precise CCCTC-binding factor(CTCF)gene insert to circumvent metastatic breast cancer.The targeted core-shell NPs carrying pHR-pCas9 can accomplishγGTP-mediated cellular uptake and endosomal escape,facilitate the precise insert and stable expression of CTCF gene,inhibit the migration,metastasis,and colonization of metastatic breast cancer cells.Besides,the finding further reveals that the inhibitory mechanism of metastasis could be associated with up-regulating CTCF protein,followed by down-regulating stomatin(STOM)protein.The study offers a universal nanostrategy enabling the robust non-viral delivery of gene-editing system for treatment of severe illness. | Jialun Duan Chunjie Bao Ying Xie Haitao Guo Yixuan Liu Jianwei Li Rui Liu Peishan Li Jing Bai Yan Yan Limin Mu Xueqi Li Guiling Wang Wanliang Lu | 2022 | Bioactive Materials2022，7，5： | 1 |
| 20 | Highly stable and repeatable femtosecond soliton pulse generation from saturable absorbers based on twodimensional Cu3-xP nanocrystals显示文摘Heavily doped colloidal plasmonic nanocrystals have attracted great attention because of their lower and adjustable free carrier densities and tunable localized surface plasmonic resonance bands in the spectral range from near-infra to mid-infra wavelengths.With its plasmon-enhanced optical nonlinearity,this new family of plasmonic materials shows a huge potential for nonlinear optical applications,such as ultrafast switching,nonlinear sensing,and pulse laser generation.Cu3-xP nanocrystals were previously shown to have a strong saturable absorption at the plasmonic resonance,which enabled high-energy Q-switched fiber lasers with 6.1μs pulse duration.This work demonstrates that both high-quality mode-locked and Q-switched pulses at 1560 nm can be generated by evanescently incorporating two-dimensional(2D)Cu3-xP nanocrystals onto a D-shaped optical fiber as an effective saturable absorber.The 3 dB bandwidth of the mode-locking optical spectrum is as broad as 7.3 nm,and the corresponding pulse duration can reach 423 fs.The repetition rate of the Q-switching pulses is higher than 80 kHz.Moreover,the largest pulse energy is more than 120μJ.Note that laser characteristics are highly stable and repeatable based on the results of over 20 devices.This work may trigger further investigations on heavily doped plasmonic 2D nanocrystals as a next-generation,inexpensive,and solution-processed element for fascinating photonics and optoelectronics applications. | Haoran MU Zeke LIU Xiaozhi BAO Zhichen WAN Guanyu LIU Xiangping LI Huaiyu SHAO Guichuan XING Babar SHABBIR Lei LI Tian SUN Shaojuan LI Wanli MA Qiaoliang BAO | 2020 | Frontiers of Optoelectronics2020，13，2： | 1 |
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