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| 1 | Cryospheric Science: research framework and disciplinary system显示文摘Cryospheric changes and their impacts have received increasing concern, extending the research to include the interactions between earth spheres and the impacts of and social adaptation to cryospheric changes. As a result, Cryospheric Science is rapidly developing. However, the research framework of Cryospheric Science has not completely been set up, and the intension and extension of Cryospheric Science are unclear.Following a literature review, the research framework for Cryospheric Science and the discipline components are analysed in this paper. We consider that Cryospheric Science is an inevitable product of international research on the earth and environmental changes as well as on human sustainable development. It will not only strengthen the linkage between the cryosphere and other earth spheres by deepening traditional research areas, but will also bring more focus on the critical roles of the cryosphere in interactions between earth spheres, and will enhance the relationship between cryospheric change and climate, ecology, hydrology, surface environment and sustainable development. The disciplinary tree of Cryospheric Science is developed following the mainstream of change-impacts adaptation. The disciplines of Cryospheric Science were teased out against characteristics of traditional branches and the developing interdisciplinary branches of cryosphere elements, which will provide reference to Cryospheric Science as it systematically grows to maturity. | Dahe Qin Yongjian Ding Cunde Xiao Shichang Kang Jianwen Ren Jianping Yang Shiqiang Zhang | 2018 | National Science Review2018，5，2： | 42 |
| 2 | Preparation and Characterization of Three Monoclonal Antibodies against HIV-1 p24 Capsid Protein显示文摘HIV-1 p24 detection provides a means to aid the early diagnosis of HIV-1 infection, track the progression of disease and assess the efficacy of antiretroviral therapy. In the present study, three monoclonal antibodies (mAbs) p3JB9, p5F1 and p6F4 against HIV-1 p24 were generated. All mAbs could detect p24 of HIV-1IIIB, HIV-1Ada-M, HIV-174V mAbs p5F1 and p6F4 could detect HIV-1KM018, while p3JB9 could not. Three mAbs did not react with HIV-2ROD, HIV-2CBL-20 and SIVagmTYO-1. The recognized epitope of p5F1 was located on the Gag amino acid region DCKTILKALGPAATLEEMMTAC. The p5F1 was used to establish a modified sandwich ELISA with rabbit anti-p24 serum and showed good specificity and high sensitivity, which has been used to measure HIV-1 p24 antigen levels in research. | Guangjie Liu Jianping Wang Jianchun Xiao Zhiwei Zhao Yongtang Zheng | 2007 | Cellular & Molecular Immunology2007，4，3： | 14 |
| 3 | Prevalence and molecular characteristics of Listeria monocytogenes in cooked products and its comparison with isolates from listeriosis cases显示文摘这研究试图在 Zigong 城市里在煮的产品调查流行和 Listeria monocytogenes 的分子的特征,中国。L 的全面出现。在商店和羊肉餐馆调查了的 ready-to-eat (RTE ) 的 monocytogenes 是 16.2%(141/873 ) 。13.5% 的出现在 RTE 猪肉被观察, 6.5% 在 RTE 蔬菜,并且非常, 24.0% 在也煮了羊肉或煮了将羊杂切碎加麦片纳入羊胃中煮成的食物。Serotype 1/2b (45.4%) , 1/2a (33.3%) ,和 1/2c (14.2%) 是占优势的类型。由基于 L 的打字的 multilocus 顺序(MLST ) 比较同种细胞的建筑群(CC ) 。从从中国, CC87, CC9, CC8,和 CC3 的不同区域的 Zigong 城市和 33 个 listeriosis 案例里的煮的食物的 monocytogenes 被显示在煮的产品和 CC87 流行, CC3 是在 33 诊所来源紧张的开始的二种经常的类型。所有 CC87 污点怀有最新报导的 Listeria 致病力岛 4 (LIPI-4 ) 基因碎片 ptsA,和所有 CC3 紧张拥有了 Listeria 致病力岛 3 (LIPI-3 ) 基因碎片 llsX。这些可以增加在中国在 listeriosis 情况中属于 CC87 和 CC3 的紧张的出现并且也从 Zigong 由于煮的产品的消费加重感染的风险。ST619 (serotype 1/2b ) 怀有 llsX 和 ptsA,显示在 Zigong 的一种潜在的 hypervirulent 顺序类型。 | Hong Wang Lijuan Luo Zhengdong Zhang Jianping Deng Yan Wang Yimao Miao Ling Zhang Xi Chen Xiang Liu Songsong Sun Bo Xiao Qun Li Changyun Ye | 2018 | Frontiers of Medicine2018，12，1： | 9 |
| 4 | A discussion on the upper limit of maturity for gas generation by marine kerogens and the utmost of gas generative potential:Taking the study on the Tarim Basin as an example显示文摘The experimental data yielded by Rock-Eval pyrolysis, kerogen atomic H/C, Py-GC and gold-tube sealing thermal simulation on the marine Cambrian-Ordovician source rock from the Tarim Basin revealed that the upper limit of maturity for natural gas generation or the 'deadline of gas generation' for marine types I and II kerogens is equal to 3.0% of vitrinite reflectance (Ro); while the 'deadline of gas generation' for type III kerogens typically like coals is as high as 10% Ro. Thus, different organic matter has obviously different utmost maturities for gas generation. The mass-balance calculation by kerogen elements showed that when Ro>1.5%, the utmost amount of gas generation for the marine type II kerogen is less than 185 m3/t TOC, accounting for less than 30% of its total hydrocarbon generative potential; when Ro>2.0%, it becomes 110 m3/t TOC, less than 20% of the total hydrocarbon generative potential. The amount of the gas generative potential obtained by Rock-Eval is only around one tenth of the calculated value by the mass balance of kerogen elements at the same thermal evolutionary stage, while those by Py-GC and gold-tube sealing simulation are intervenient between the above two. The utmost of gas generative potential at the over 1.3% Ro stage is around 60―90 m3/t TOC, therefore, the amount of gas generation obtained by Rock-Eval is the minimum of gas generative potential, while that by the mass-balance calculation of kerogen elements is the maximum that the actual amount of gas generation should not exceed. | CHEN JianPing ZHAO WenZhi XIAO ZhongYao ZHANG ShuiChang DENG ChunPing SUN YongGe WANG ZhaoMing | 2007 | Chinese Science Bulletin2007，52，A01： | 8 |
| 5 | Cancer:A proteomic disease显示文摘The development of cancer is a pathological process involving multiple environmental carcinogenic factors and genetic alterations.For decades,cancer researchers have focused on genomic and transcriptomic analyses.The completion of the Human Genome Project has opened the door to the post-genome era and oncoproteomics.Proteins play a critical role in tumorigenesis and influence the differences between normal cells and malignant cells.This report proposes the concept that cancer is a proteomic disease.This concept is based on examining protein expression profiles,post-translational modifications,and protein-protein interactions in carcinogenesis using recent advances in comparative,functional and structural proteomics.This approach provides a new way of viewing carcinogenesis,presents new clues in biomarker discovery for cancer diagnosis and therapy,and reveals important scientific findings and their significance to clinical applications. | LI GuoQing XIAO ZheFeng LIU JianPing LI Cui LI Feng CHEN ZhuChu | 2011 | Science China(Life Sciences)2011，54，5： | 8 |
| 6 | Advances in research of the mid-deep South China Sea circulation显示文摘The South China Sea(SCS)is a large marginal sea connecting the Indian and Pacific oceans.Under the factors of monsoons,strait transport,and varied bathymetry,the SCS presents a three-layer structure and strong diapycnal mixing which is far greater than that in the open ocean.Theoretical analysis and observations reveal that internal tides,internal solitary waves,and strong winds are the sources of the strong mixing in the northern SCS.A major consequence of the strong mixing is an active mid-deep circulation system.This system promotes exchange of water between the SCS and adjacent oceans,and also regulates the upper layer of wind-driven circulation,making the 3 dimensional SCS circulation clearly different from that in other tropical and subtropical marginal seas.The mass transport capacity of the mid-deep circulation has a substantial impact on marine sedimentation,the biogeochemical cycle,and other processes in the SCS.This paper summarizes the recent advances in middeep sea circulation dynamics of the SCS,and discusses the opportunities and challenges in this area. | Dongxiao WANG Qiang WANG Shuqun CAI Xiaodong SHANG Shiqiu PENG Yeqiang SHU Jingen XIAO Xiaohui XIE Zhiwei ZHANG Zhiqiang LIU Jian LAN Dake CHEN Huijie XUE Guihua WANG Jianping GAN Xinong XIE Rui ZHANG Hui CHEN Qingxuan YANG | 2019 | Science China Earth Sciences2019，62，12： | 8 |
| 7 | Reduning injection for fever, rash, and ulcers in children with mild hand, foot, and mouth disease: a randomized controlled clinical study显示文摘OBJECTIVE: To assess the efficacy and safety of Reduning injection for fever, rash, and ulcers in children with mild hand, foot, and mouth disease(HFMD). METHODS: A stratified-block randomized, double-blind, parallel-controlled, and multicenter clinical trial was conducted with 360 patients in five hospitals across China: Quanzhou Children's Hospital, Shijiazhuang No. 5 Hospital, Shanghai Public Health Centre, Hunan Provincial Children's Hospital, and Kaifeng Children's Hospital. Patients were randomized into three groups with 120 in each. Group A was treated with Western Medicine, group B with Reduning injection, a Chinese herbal medicine, and group C with both Reduning injection and Western Medicine. Results were compared for treatment efficacy and safety on HFMD. The clinical outcomes were observed as follows: fever and onset time of antifebrile effect(time to bring the body temperature down ≥0.5℃ after medication); cumulative time for fever recovery(body temperature recovering to normal and lasting more than 24 h without medication); cumulative time for rash disappearance(without new rashes or ulcers appearing and the original ones fading away); and cumulative time for mouth ulcer disappearance. RESULTS: For the onset time of the antifebrile effect, there was no statistical difference between groups A and B(P>0.05) and groups B and C(P> 0.05). However, there was a statistical difference between groups A and C(P<0.05), and the effect in group C was the best. For the cumulative time for rash disappearance, there was no statistical difference between groups A and B(P>0.05). There were statistical differences between groups A and C, and groups B and C(P<0.05), and the effect in group C was the best. For the cumulative time for mouth ulcers disappearance, there were no statistical differences among the three groups(P>0.05). CONCLUSION: Reduning injection with Western Medicine for symptomatic treatment is most effective for mild HFMD. No adverse reactions were observed. | Guoliang Zhang Jie Zhao Liyun He Shiyan Yan Ziqiang Zhuo Haojie Zheng Yongping Mu Shuangjie Li Xi Zhang Jihan Huang Xiuhui Li Jianping Liu Hehe Wan Chaoyu Wei Wei Xiao | 2013 | Journal of Traditional Chinese Medicine2013，33，6： | 7 |
| 8 | Mechanism of stratospheric decadal abrupt cooling in the Early 1990s as influenced by the Pinatubo eruption显示文摘Studies have suggested that one volcanic eruption can influence seasonal to inter-annual climate variations.This study indicates that the Pinatubo eruption in 1991 may have actually induced the stratospheric decadal cooling recorded in the early 1990s.Using the NCEP/NCAR reanalysis and TOMS/SBUV satellite data,a decadal abrupt cooling of stratospheric tropical air temperature was found to have occurred in the early 1990s during a long-term descending trend.We generated the spatio-temporal structures of the decadal abrupt changes(DACs) for the stratosphere,and explored the relationship between the Pinatubo volcano eruption in 1991 and stratospheric DACs in the early 1990s.Our results suggest that the eruption of Pinatubo prompted a decadal decrease of ozone by the activation of nitrate and sulfate volcanic aerosols on ClO free radicals.The stratospheric heat absorbed by ozone decreased over a decadal time scale.As a result,decadal abrupt cooling of stratospheric tropical air temperatures occurred in the early 1990s,and may be attributed to the Pinatubo eruption.The results therefore indicate that one strong volcanic eruption can induce stratospheric decadal climate variation. | XIAO Dong LI JianPing | 2011 | Chinese Science Bulletin2011，56，8： | 7 |
| 9 | Effects of Shuanghuanglian oral liquids on patients with COVID-19:a randomized,open-label,parallel-controlled,multicenter clinical trial显示文摘We conducted a randomized,open-label,parallel-controlled,multicenter trial on the use of Shuanghuanglian(SHL),a traditional Chinese patent medicine,in treating cases of COVID-19.A total of 176 patients received SHL by three doses(56 in low dose,61 in middle dose,and 59 in high dose)in addition to standard care.The control group was composed of 59 patients who received standard therapy alone.Treatment with SHL was not associated with a difference from standard care in the time to disease recovery.Patients with 14-day SHL treatment had significantly higher rate in negative conversion of SARS-CoV-2 in nucleic acid swab tests than the patients from the control group(93.4%vs.73.9%,P=0.006).Analysis of chest computed tomography images showed that treatment with high-dose SHL significantly promoted absorption of inflammatory focus of pneumonia,which was evaluated by density reduction of inflammatory focus from baseline,at day 7(mean difference(95%CI),−46.39(−86.83 to−5.94)HU;P=0.025)and day 14(mean difference(95%CI),−74.21(−133.35 to−15.08)HU;P=0.014).No serious adverse events occurred in the SHL groups.This study illustrated that SHL in combination with standard care was safe and partially effective for the treatment of COVID-19. | Li Ni Zheng Wen Xiaowen Hu Wei Tang Haisheng Wang Ling Zhou Lujin Wu Hong Wang Chang Xu Xizhen Xu Zhichao Xiao Zongzhe Li Chene Li Yujian Liu Jialin Duan Chen Chen Dan Li Runhua Zhang Jinliang Li Yongxiang Yi Wei Huang Yanyan Chen Jianping Zhao Jianping Zuo Jianping Weng Hualiang Jiang Dao Wen Wang | 2021 | Frontiers of Medicine2021，15，5： | 7 |
| 10 | The Identification of the Cryptosporidium ubiquitum in Pre-weaned Ovines from Aba Tibetan and Qiang Autonomous Prefecture in China显示文摘Objective Cryptosporidium spp.are prevalent globally and sheep are an important zoonotic reservoir.Little data regarding the rates of Cryptosporidium infections in ovines in China are available.This study assessed the prevalence of Cryptosporidium spp.in pre‐weaned ovines from Aba Tibetan and Qiang Autonomous Prefecture in the Sichuan province of China.Methods A total of 213 fecal samples were collected from pre‐weaned ovines and were examined microscopically (following modified acid fast staining).In addition,18S rRNA genetic sequences were amplified from fecal samples by nested PCR and phylogenetically analyzed.Results The prevalence of Cryptosporidium in the collected samples was at 14.6% (31/213) and four isolates identified by PCR belonged to the Cryptosporidium cervine genotype (Cryptosporidium ubiquitum) demonstrating that this species was the primary sheep species found in sheep in China.Conclusion The present study suggested that the high incidence of Cryptosporidium in sheep poses a significant public health threat and that surveillance practices must be established to prevent zoonotic disease of humans. | SHEN YuJuan YIN JianHai YUAN ZhongYing LU WeiYuan XU YuXin XIAO LiHua CAO JianPing | 2011 | Biomedical and Environmental Sciences2011，24，3： | 5 |
| 11 | Highly efficient catalytic scavenging of oxygen free radicals with graphene-encapsulated metal nanoshields显示文摘 | Junying Wang Xiaoju Cui Haobo Li Jianping Xiao Jiang Yang Xiaoyu Mu Haixia Liu Yuan-Ming Sun Xuhui Xue Changlong Liu Xiao-Dong Zhang Dehui Deng Xinhe Bao | 2018 | Nano Research2018，11，5： | 4 |
| 12 | Zircon U-Pb Ages and Geochemistry of Permo-Carboniferous Mafic Intrusions in the Xilinhot Area, Inner Mongolia: Constraints on the Northward Subduction of the Paleo-Asian Ocean显示文摘The Central Asian Orogenic Belt(CAOB) resulted from accretion during the Paleozoic subduction of the PaleoAsian Ocean. The Xilinhot area in Inner Mongolia is located in the northern subduction zone of the central-eastern CAOB and outcropped a large number of late Paleozoic mafic intrusions. The characteristics of magma source and tectonic setting of the mafic intrusions and their response to the closure process of the Paleo-Asian Ocean are still controversial. This study presents LA-ICPMS zircon U-Pb ages and geochemical features of mafic intrusions in the Xilinhot area to constrain the northward subduction of the Paleo-Asian Ocean. The mafic intrusions consist of gabbro, hornblende gabbro, and diabase. Their intrusion times can be divided into three stages of 326-321 Ma, 276 Ma and 254 Ma by zircon U-Pb ages. The first two stages of the 326-276 Ma intrusions mostly originated from subduction-modified continental lithospheric mantle sources that underwent a variable degree partial melting(5-30%), recording the subduction of oceanic crust. The third stage of the 254 Ma mafic rocks also show arc-related features. The primary magma compositions calculated by PRIMELT2 modeling on three samples of ~326 Ma and two samples of ~254 Ma show that these mafic samples are characterized by a variable range in SiO2(47.51-51.47 wt%), Al2O3(11.46-15.55 wt%), ΣFeO(8.27-9.61 wt%), MgO(13.01-15.18 wt%) and CaO(9.13-11.67 wt%), consisting with the features between enriched mantle and lower continental crust. The source mantle melting of mafic intrusions occurred under temperatures of 1302-1351°C and pressures of 0.92-1.30 GPa. The magmatic processes occurred near the crust-mantle boundary at about 33-45 km underground. Combined with previous studies, it is concluded that Carboniferous to early Permian(~326-275 Ma) northward subduction of the Paleo-Asian oceanic crust led to the formation of the mafic magmatism in the Baolidao arc zone. The whole region had entered the collision environment at ~254 Ma, but with subduction-related environments locally. The final collision between the North China craton and the South Mongolian microcontinent may have lasted until ca. 230 Ma. | WANG Ke LI Yilong XIAO Wenjiao ZHENG Jianping Fraukje MBROUWER | 2019 | Acta Geologica Sinica(English Edition)2019，93，5： | 4 |
| 13 | Estimating abundance and density of Amur tigers along the Sino- Russian border显示文摘As an apex predator the Amur tiger(Panthera tigris altaica)could play a pivotal role in maintaining the integrity of forest ecosystems in Northeast Asia.Due to habitat loss and harvest over the past century,tigers rapidly declined in China and are now restricted to the Russian Far East and bordering habitat in nearby China.To facilitate restoration of the tiger in its historical range,reliable estimates of population size are essential to assess effectiveness of conservation interventions.Here we used camera trap data collected in Hunchun National Nature Reserve from April to June 2013 and 2014 to estimate tiger density and abundance using both maximum likelihood and Bayesian spatially explicit capture-recapture(SECR)methods.A minimum of 8 individuals were detected in both sample periods and the documentation of marking behavior and reproduction suggests the presence of a resident population.Using Bayesian SECR modeling within the 11400 km2 state space,density estimates were 0.33 and 0.40 individuals/100 km^(2) in 2013 and 2014,respectively,corresponding to an estimated abundance of 38 and 45 animals for this transboundary Sino-Russian population.In a maximum likelihood framework,we estimated densities of 0.30 and 0.24 individuals/100 km^(2) corresponding to abundances of 34 and 27,in 2013 and 2014,respectively.These density estimates are comparable to other published estimates for resident Amur tiger populations in the Russian Far East.This study reveals promising signs of tiger recovery in Northeast China,and demonstrates the importance of connectivity between the Russian and Chinese populations for recovering tigers in Northeast China. | Wenhong XIAO Limin FENG Pu MOU Dale GMIQUELLE Mark HEBBLEWHITE Joshua FGOLDBERG Hugh SROBINSON Xiaodan ZHAO Bo ZHOU Tianming WANG Jianping GE | 2016 | Integrative Zoology2016，11，4： | 4 |
| 14 | Enhancement of municipal sludge dewaterability by electrochemical pretreatment显示文摘Electrolysis is a promising technology to improve sludge dewaterability efficiently with negligible environmental impact. To intensify the electrolytic efficiency, the effect of electrolytes(NaCl, Na_2SO_4, NaNO_3, and NaClO_4) on electrolysis pretreatment of municipal sludge and its mechanisms was investigated using Ti/PbO_2 electrodes. The electrolytes,which enhanced the production of oxidative radicals, showed a significant synergetic effect in reducing the capillary suction time(CST) of sludge. NaCl was distinguished from the other electrolytes since it formed a large amount of active chlorine species, which oxidized the sludge cells to improve the sludge dewaterability. The surface morphologies as well as the soluble proteins and polysaccharides were analyzed to unravel the underlying mechanisms of sludge dewaterability. Additionally, an economic assessment showed that NaCl addition in the electrolysis pretreatment can be a suitable technique for enhancing municipal sludge dewaterability. | Ke Xiao Jianping Deng Li Zeng Tao Guo Yan Gong Bo Yang Xu Zhao Huabo Duan | 2019 | Journal of Environmental Sciences2019，31，1： | 3 |
| 15 | Ore-forming Response to Syndepositional Submarine Volcanism in Langshan-Zhaertai Mesoproterozoic SEDEX Ore Belt, Inner Mongolia, China显示文摘Ore forming process of the Dongshengmiao, Huogeqi, Tanyaokou and Jiashengpan deposits in Langshan Zhaertai Mesoproterozoic SEDEX metallogenic belt is closely related to the syndepositional volcanic activities based on the following facts: (1) The Sm Nd isochron age of the basic volcanic rocks varies from 1 491 Ma to 1 824 Ma (more than or close to the model age of the lead isotope of all sulfide minerals) in these deposits, with ε (Nd, t ) =(3.48-6.40)±0.80, whose REE composition is enriched in LREE and depleted in HREE, indicating that these volcanic rocks were derived from the mantle or lower crust. (2) The REE composition of some Pb Zn Py ores is also enriched in LREE and depleted in HREE. The chondrite normalized REE patterns are similar to those of the basic volcanic rocks. (3) In the lead isotope composition diagram of Doe and Zartman, most of sphalerite, galena, pyrite, pyrrhotite and chalcopyrite are plotted on both sides of the line for the mantle or between the lines for the mantle and lower crust. (4) Cobalt content of some pyrites is much higher than their nickel content ( w (Co)/ w (Ni)= 11.91- 12.19). (5) Some volcanic blocks and debrises have been picked out from some pyrite and pyrrhotite ores. (6) All Zn Pb Cu Fe sulfide orebodies in these deposits occur in the strata overlying the metamorphic volcanic rocks in the only second ore bearing formation. The Jiashengpan deposit lacks in syndepositional volcanic rocks in the host succession, only Pb and Zn occur without Cu, but the Dongshengmiao, Tanyaokou and Huogeqi deposits with syndepositonal volcanic rocks in the host succession contain Cu, indicating the relatively high ore forming temperatures, besides Pb and Zn. The syndepositional volcanic eruption directly supplied some ore forming metals and resulted in the secular geothermal anomaly favorable for the circulation of the submarine convective hydrothermal system, and in the precipitation of deep mineralizing fluids exhaling into the anoxide basins along the syndepositional fault system in the Langshan Zhaertai rift. | Peng Runmin Zhai Yusheng Deng Jun Xiao Rongge Wang Jianping Faculty of Earth Sciences and Mineral Resources, China University of Geosciences, Beijing 100083, China | 2000 | Journal of Earth Science2000，19，3： | 3 |
| 16 | Evolution of Specialization with Reachable Transaction Scope Based on a Simple and Symmetric Firm Resource Allocation Model显示文摘In the last decade, as an emerging transaction measure driven by computer and internet technology,e-commerce experienced explosive growth in many areas. It has greatly broken down the limitations of space and time to economic activities, thus changing the rules of business fundamentally. Significant work has been done to understand the laws of e-commerce from multiple dimensions, but the question of how e-commerce shapes firms' specialization and market structure from the perspective of spatial factors remains obscure. In this paper, we propose a simple and symmetric firm resource allocation model with a specialized-economy production function and market size constraint, to investigate how individual firms adjust resource allocation with reachable transaction scope expanded. It is shown that with the expansion of reachable transaction scope, individual firms discretely take back one unit resource from a low-investment direction and, instead, channel it to a 'specialized direction'.Meanwhile, at the macro level, an optimal division network evolves from a static self-sufficient stage to a diverse semi-specialized stage, and finally to a highly integrated completely specialized stage. Ergo, a Complex Adaptive System(CAS) based simulation framework is constructed. Designed simulation experiments are carried out and confirm to the analysis result of our proposed model. | Xiao Sun Yueting Chai Yi Liu Jianping Shen Yadong Huang | 2017 | Tsinghua Science and Technology2017，22，1： | 2 |
| 17 | Detrital Zircon U-Pb Ages and Geochemistry of the Silurian to Permian Sedimentary Rocks in Central Inner Mongolia, China: Implications for Closure of the Paleo-Asian Ocean显示文摘The Solonker suture zone has long been considered to mark the location of the final disappearance of the PaleoAsian Ocean in the eastern Central Asian Orogenic Belt(CAOB). However, the time of final suturing is still controversial with two main different proposals of late Permian to early Triassic, and late Devonian. This study reports integrated wholerock geochemistry and LA-ICP-MS zircon U-Pb ages of sedimentary rocks from the Silurian Xuniwusu Formation, the Devonian Xilingol Complex and the Permian Zhesi Formation in the Hegenshan-Xilinhot-Linxi area in central Inner Mongolia, China. The depositional environment, provenance and tectonic setting of the Silurian-Devonian and the Permian sediments are compared to constrain the tectonic evolution of the Solonker suture zone and its neighboring zones. The protoliths of the silty slates from the Xuniwusu Formation in the Baolidao zone belong to wacke and were derived from felsic igneous rocks with steady-state weathering, poor sorting and compositional immaturity. The protoliths of metasedimentary rocks from the Xilingol Complex were wackes and litharenites and were sourced from predominantly felsic igneous rocks with variable weathering conditions and moderate sorting. The Xuniwusu Formation and Xilingol Complex samples both have two groups of detrital zircon that peak at ca. 0.9-1.0 Ga and ca. 420-440 Ma, with maximum deposition ages of late Silurian and middle Devonian age, respectively. Considering the ca. 484-383 Ma volcanic arc in the Baolidao zone, the Xuxiniwu Formation represents an oceanic trench sediment and is covered by the sedimentary rocks in the Xilingol Complex that represents a continental slope sediment in front of the arc. The middle Permian Zhesi Formation metasandstones were derived from predominantly felsic igneous rocks and are texturally immature with very low degrees of rounding and sorting, indicating short transport and rapid burial. The Zhesi Formation in the Hegenshan zone has a main zircon age peak of 302 Ma and a subordinate peak of 423 Ma and was deposited in a back-arc basin with an early marine transgression during extension and a late marine regression during contraction. The formation also crops out locally in the Baolidao zone with a main zircon age peak of 467 Ma and a minor peak of 359 Ma, and suggests it formed as a marine transgression sedimentary sequence in a restricted extensional basin and followed by a marine regressive event. Two obvious zircon age peaks of 444 Ma and 280 Ma in the Solonker zone and 435 Ma and 274 Ma in Ondor Sum are retrieved from the Zhesi Formation. This suggests as a result of the gradual closure of the Paleo-Asian Ocean a narrow ocean sedimentary environment with marine regressive sedimentary sequences occupied the Solonker and Ondor Sum zones during the middle Permian. A restricted ocean is suggested by the Permian strata in the Bainaimiao zone. Early Paleozoic subduction until ca. 381 Ma and renewed subduction during ca. 310-254 Ma accompanied by the opening and closure of a back-arc basin during ca. 298-269 Ma occurred in the northern accretionary zone. In contrast, the southern accretionary zone documented early Paleozoic subduction until ca. 400 Ma and a renewed subduction during ca. 298-246 Ma. The final closure of the Paleo-Asian ocean therefore lasted at least until the early Triassic and ended with the formation of the Solonker suture zone. | LI Yilong WANG Guoqing XIAO Wenjiao ZOU Jing ZHENG Jianping Fraukje MBROUWER | 2019 | Acta Geologica Sinica(English Edition)2019，93，5： | 2 |
| 18 | Structural basis for gating mechanism of Pannexin 1 channel显示文摘Dear Editor,Pannexin 1(PANX1)plays extensive physiological roles across diverse fields of biology,including cell death,1,2 inflammation,3 cancer progression,4 and neurological disorders.5 As suggested by biochemical analysis,PANX1 forms an oligomeric channel for the facilitated diffusion of ions and large molecules across the plasma membrane upon activation.6 However,the underlying molecular gating mechanism of PANX1 and the structure of human PANX1 are still elusive.In the current study,we report the cryo-EM structures of full-length and carboxyl-terminal(CT)tail-cleaved human PANX1.Combined with single-channel electrophysiological study,we identified the key residues involved in the gating of PANX1. | Luqiu Mou Meng Ke Mengxiao Song Yuanyue Shan Qingjie Xiao Qingting Liu Jialu Li Ke Sun Lei Pu Li Guo Jia Geng Jianping Wu Dong Deng | 2020 | Cell Research2020，30，5： | 2 |
| 19 | Current management of chemotherapy-induced neutropenia in adults:key points and new challenges显示文摘Chemotherapy-induced neutropenia(CIN)is a potentially fatal and common complication in myelosuppressive chemotherapy.The timing and grade of CIN may play prognostic and predictive roles in cancer therapy.CIN is associated with older age,poor functional and nutritional status,the presence of significant comorbidities,the type of cancer,previous chemotherapy cycles,the stage of the disease,specific chemotherapy regimens,and combined therapies.There are many key points and new challenges in the management of CIN in adults including:(1)Genetic risk factors to evaluate the patient’s risk for CIN remain unclear.However,these risk factors urgently need to be identified.(2)Febrile neutropenia(FN)remains one of the most common reasons for oncological emergency.No consensus nomogram for FN risk assessment has been established.(3)Different assessment tools[e.g.,Multinational Association for Supportive Care in Cancer(MASCC),the Clinical Index of Stable Febrile Neutropenia(CISNE)score model,and other tools]have been suggested to help stratify the risk of complications in patients with FN.However,current tools have limitations.The CISNE score model is useful to support decision-making,especially for patients with stable FN.(4)There are still some challenges,including the benefits of granulocyte colony stimulating factor treatment and the optimal antibiotic regimen in emergency management of FN.In view of the current reports,our group discusses the key points,new challenges,and management of CIN. | Committee of Neoplastic Supportive-Care(CONS),China Anti-Cancer Association Committee of Clinical Chemotherapy,China Anti-Cancer Association Yi Ba Yuankai Shi Wenqi Jiang Jifeng Feng Ying Cheng Li Xiao Qingyuan Zhang Wensheng Qiu Binghe Xu Ruihua Xu Bo Shen Zhiguo Luo Xiaodong Xie Jianhua Chang Mengzhao Wang Yufu Li Yuerong Shuang Zuoxing Niu Bo Liu Jun Zhang Li Zhang Herui Yao Conghua Xie Huiqiang Huang Wangjun Liao Gongyan Chen Xiaotian Zhang Hanxiang An Yanhong Deng Ping Gong Jianping Xiong Qinghua Yao Xin An Cheng Chen Yanxia Shi Jialei Wang Xiaohua Wang Zhiqiang Wang Puyuan Xing Sheng Yang Chenfei Zhou | 2020 | Cancer Biology & Medicine2020，17，4： | 2 |
| 20 | Enhancement and mapping of tolerance to salt stress and 5-fluorocytosine in synthetic yeast strains via SCRaMbLE显示文摘Varied environmental stress can affect cell growth and activity of the cellular catalyst.Traditional path of adaptive evolution generally takes a long time to achieve a tolerance phenotype,meanwhile,it is a challenge to dissect the underlying genetic mechanism.Here,using SCRaMbLE,a genome scale tool to generate random structural variations,a total of 222 evolved yeast strains with enhanced environmental tolerances were obtained in haploid or diploid yeasts containing six synthetic chromosomes.Whole genome sequencing of the evolved strains revealed that these strains generated different structural variants.Notably,by phenotypic-genotypic analysis of the SCRaMbLEd strains,we find that a deletion of gene YFR009W(GCN20)can improve salt tolerance of Saccharomyces cerevisiae,and a deletion of gene YER056C can improve 5-flucytosine tolerance of Saccharomyces cerevisiae.This study shows applications of SCRaMbLE to accelerate phenotypic evolution for varied environmental stress and to explore relationships between structural variations and evolved phenotypes. | Jianping Kang Jieyi Li Zhou Guo Sijie Zhou Shuxin Su Wenhai Xiao Yi Wu Yingjin Yuan | 2022 | Synthetic and Systems Biotechnology2022，7，3： | 2 |
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