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| 1 | Development of a rapid and sensitivity magnetic chemiluminescence immunoassay for DNA methyltransferase 1 in human serum显示文摘DNA methyltransferase 1(DNMT1)is a useful biomarker for lung cancer in early clinical diagnosis.A rapid magnetic chemiluminescence immunoassay(MCLIA)for DNMT1 in human serum has been developed.Horseradish peroxidase(HRP)-second-Ab was used to labeled polyclonal antibodies of anti-DNMT1.DNMT1 in sample integrates with specific immunomagnetic beads and can constitute a supersandwiched immunoreaction.In magnetic field,nonspecific materials can be separated.After luminescent substrate luminol-H2O2-BIP was added,the relative light unit(RLU)of HRP was detected and was discovered to be directly proportional to the content of DNMT1 in sample.The correlative variables involved in the MCLIA value were optimized and the methodological evaluation was carried out.After optimization,in the range of0.5–128 ng/mL,the linear regression equation was y=0.5014 x+1.769(x was logCDNMT1,y was relative luminescence units(RLU)/RLU0),and the limit of detection was 0.01 ng/mL.The RSD of intra-and interassays were 15.8%–16.9%and 14.3%–18.1%,respectively.The recovery was from 70.0%to 106.2%.Furthermore,paralleled with purchasable enzyme-linked immunosorbent assay(ELISA)kits,MCLEIA had lower detection limit,wider linear range and shorter detection time.Therefore,the MCLEIA established in this study could be used for the sensitive detection of DNMT1 in serum sample. | Sitian He Leiliang He Beibei Liu Songcheng Yu Li'e Liu Yongmei Tian Jia Wang Lihua Ding Yilin Wang Lingbo Qu Fei Yu Yongjun Wu | 2019 | Chinese Chemical Letters2019，30，5： | 4 |
| 2 | Synthesis and Herbicidal Activity of N-(2,2-Dimethyl-7-alkoxy- 2,3-dihydrobenzofuran-5-yl)-2-(4-arylxoyphenoxy)propionamides显示文摘 | LIN Ding XIAO Mengwu YANG Zihui LI Beibei HU Aixi YE Jiao | 2017 | Chemical Research in Chinese Universities2017，33，1： | 3 |
| 3 | Surface Oxygen Injection in Tin Disulfide Nanosheets for Efficient CO_(2) Electroreduction to Formate and Syngas显示文摘Surface chemistry modification represents a promising strategy to tailor the adsorption and activation of reaction intermediates for enhancing activity.Herein,we designed a surface oxygen-injection strategy to tune the electronic structure of SnS_(2) nanosheets,which showed effectively enhanced electrocatalytic activity and selectivity of CO_(2) reduction to formate and syngas(CO and H_(2)).The oxygen-injection SnS_(2) nanosheets exhibit a remarkable Faradaic efficiency of 91.6%for carbonaceous products with a current density of 24.1 mA cm^(−2) at−0.9 V vs RHE,including 83.2%for formate production and 16.5%for syngas with the CO/H_(2) ratio of 1:1.By operando X-ray absorption spectroscopy,we unravel the in situ surface oxygen doping into the matrix during reaction,thereby optimizing the Sn local electronic states.Operando synchrotron radiation infrared spectroscopy along with theoretical calculations further reveals that the surface oxygen doping facilitated the CO_(2) activation and enhanced the affinity for HCOO*species.This result demonstrates the potential strategy of surface oxygen injection for the rational design of advanced catalysts for CO_(2) electroreduction. | Tao Chen Tong Liu Tao Ding Beibei Pang Lan Wang Xiaokang Liu Xinyi Shen Sicong Wang Dan Wu Dong Liu Linlin Cao Qiquan Luo Wei Zhang Wenkun Zhu Tao Yao | 2021 | Nano-Micro Letters2021，13，11： | 3 |
| 4 | Light weight, mechanically strong and biocompatible α-chitin aerogels from different aqueous alkali hydroxide/urea solutions显示文摘Light weight and mechanically strong α-chitin aerogels were fabricated using the sol-gel/self-assembly method from α-chitin in different aqueous alkali hydroxide(KOH, Na OH and Li OH)/urea solutions. All of the α-chitin solutions exhibited temperature-induced rapid gelation behavior. 13 C nuclear magnetic resonance(NMR) spectra revealed that the aqueous alkali hydroxide/urea solutions are non-derivatizing solvents for α-chitin. Fourier transform infrared(FT-IR), X-ray diffraction(XRD) and cross-polarization magic angle spinning(CP/MAS) 13 C NMR confirmed that α-chitin has a stable aggregate structure after undergoing dissolution and regeneration. Subsequently, nanostructured α-chitin aerogels were fabricated by regeneration from the chitin solutions in ethanol and then freeze-drying from t-Bu OH. These α-chitin aerogels exhibited high porosity(87% to 94%), low density(0.09 to 0.19 g/cm^3), high specific surface area(419 to 535 m^2/g) and large pore volume(2.7 to 3.8 cm^3/g). Moreover, the α-chitin aerogels exhibited good mechanical properties under compression and tension models. In vitro studies showed that m BMSCs cultured on chitin hydrogels have good biocompatibility. These nanostructured α-chitin aerogels may be useful for various applications, such as catalyst supports, carbon aerogel precursors and biomedical materials. | Beibei Ding Dan Zhao Jianhui Song Huichang Gao Duoduo Xu Min Xu Xiaodong Cao Lina Zhang Jie Cai | 2016 | Science China Chemistry2016，59，11： | 2 |
| 5 | Ultrathin Ti_(3)C_(2) nanowires derived from multi-layered bulks for high-performance hydrogen evolution reaction显示文摘One-dimensional ultrathin nanowires(NWs)offer a great deal of promising properties for electrochemical energy storage and conversion due to their nanoscale confinement effect and high surface-to-volume ratios.It is highly desirable to precisely design and synthesize ultrathin Ti_(3)C_(2)NWs in the aspect of size,crystalline structure and composition.Here,we report a simple alkalization strategy to design the ultrathin Ti_(3)C_(2)NWs for hydrogen evolution reaction(HER)by modulating the surface-active sites.The design principle can well improve the amount of the defect sites and ion accessibility to increase the interactions between Ti_(3)C_(2)NWs and H^(*).The optimized Ti_(3)C_(2)NWs achieve an overpotential of 476 mV at the current density of 10 mA/cm^(2)and a Tafel slope of 129 mV/dec for HER catalysis,which are superior to that of Ti_(3)C_(2)nanosheets and m-Ti_(3)C_(2).It paves an avenue for the rational transformation of MXene bulks to one-dimensional NWs catalysts for HER. | Weiwei Zhao Beibei Jin Longlu Wang Chengbo Ding Mengyue Jiang Tiantian Chen Shuaihang Bi Shujuan Liu Qiang Zhao | 2022 | Chinese Chemical Letters2022，33，1： | 2 |
| 6 | Motivating Ru-bri site of RuO_(2)by boron doping toward high performance acidic and neutral oxygen evolution显示文摘The electrocatalysis of oxygen evolution reaction(OER)plays a key role in clean energy storage and transfer.Nonetheless,the sluggish kinetics and poor durability under acidic and neutral conditions severely hinder practical applications such as electrolyzer compatible with the powerful proton exchange membrane and biohybrid fuel production.Here,we report a borondoped ruthenium dioxide electrocatalyst(B-RuO_(2))fabricated by a facile boric acid assisted strategy which demonstrates excellent acidic and neutral OER performances.Density functional theory calculations and advanced characterizations reveal that the boron species form an anomalous B–O covalent bonding with the oxygen atoms of RuO_(2)and expose the fully coordinately bridge ruthenium site(Ru-bri site),which seems like a switch that turns on the inactive Ru-bri site into OER-active,resulting in more exposed active sites,modified electronic structure,and optimized binding energy of intermediates.Thus,the B-RuO_(2)exhibits an ultralow overpotential of 200 mV at 10 mA/cm^(2)and maintains excellent stability compared to commercial RuO_(2)in 0.5 M sulfuric acid.Moreover,the superior performance is as well displayed in neutral electrolyte,surpassing most previously reported catalysts. | Chongjing Liu Beibei Sheng Quan Zhou Dengfeng Cao Honghe Ding Shuangming Chen Pengjun Zhang Yujian Xia Xiaojun Wu Li Song | 2022 | Nano Research2022，15，8： | 1 |
| 7 | Development of three-layer intermediate temperature solid oxide fuel cells with direct stainless steel based anodes显示文摘 | Liu Zhangbo Liu Beibei Ding Dong | | 0，，： | 1 |
| 8 | A genome-wide comparison of genes responsive to autopolyploidy inIsatis indigotica usingArabidopsis thaliana Affymetrix genechips显示文摘 | Beibei Lu Xinzhu Pan Lei Zhang Beibei Huang Lianna Sun Bin Li Bo Yi Shuiqing Zheng Xiaojing Yu Ruxian Ding Wansheng Chen | 2006 | Plant Molecular Biology Reporter2006，，2： | 1 |
| 9 | Electrical prop-erties of samaria-doped ceria electrolytes from highly active powders显示文摘 | Ding Dong Liu Beibei Gong Mingyang | | 0，，15： | 1 |
| 10 | Effect of impregnation phases on the performance of Ni-based anodes for low temperature solid oxide fuel cells 显示文摘 | LIU Zhangbo DING Dong LIU Beibei | 2011 | Journal of Power Sources2011，196，20： | 1 |
| 11 | Facile preparation of robust and biocompatible chitin aerogels显示文摘 | Ding Beibei Cai Jie Huang Junchao | 2012 | Mater Chem2012，22，12： | 1 |
| 12 | A genome-wide comparison of genes responsive to autopolyploidy inIsatis indigotica usingArabidopsis thaliana Affymetrix genechips显示文摘 | Beibei Lu Xinzhu Pan Lei Zhang Beibei Huang Lianna Sun Bin Li Bo Yi Shuiqing Zheng Xiaojing Yu Ruxian Ding Wansheng Chen | 2006 | Plant Molecular Biology Reporter2006，，2： | 1 |
| 13 | The facile synthesis of hierarchical NiCoO 2 nanotubes comprised ultrathin nanosheets for supercapacitors显示文摘 | Xin Xu Han Zhou Shujiang Ding Jun Li Beibei Li Demei Yu | 2014 | Journal of Power Sources2014，，： | 1 |
| 14 | NPC1-regulated dynamic of clathrin-coated pits is essential for viral entry显示文摘Viruses utilize cellular lipids and manipulate host lipid metabolism to ensure their replication and spread.Therefore,the identification of lipids and metabolic pathways that are suitable targets for antiviral development is crucial.Using a library of compounds targeting host lipid metabolic factors and testing them for their ability to block pseudorabies virus(PRV)and vesicular stomatitis virus(VSV)infection,we found that U18666A,a specific inhibitor of Niemann-Pick C1(NPC1),is highly potent in suppressing the entry of diverse viruses including pseudotyped severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).NPC1 deficiency markedly attenuates viral growth by decreasing cholesterol abundance in the plasma mem-brane,thereby inhibiting the dynamics of clathrin-coated pits(CCPs),which are indispensable for clathrin-mediated endocytosis.Significantly,exogenous cholesterol can complement the dynamics of CCPs,leading to efficient viral entry and infectivity.Administration of U18666A improves the survival and pathology of PRV-and influenza A virus-infected mice.Thus,our studies demonstrate a unique mechanism by which NPC1 inhibition achieves broad antiviral activity,indicating a potential new therapeutic strategy against SARS-CoV-2,as well as other emerging viruses. | Guoli Li Bingqian Su Pengfei Fu Yilin Bai Guangxu Ding Dahua Li Jiang Wang Guoyu Yang Beibei Chu | 2022 | Science China(Life Sciences)2022，65，2： | 1 |
| 15 | Analysis of genetic variability and population structure of the endemic medicinal Limonium sinense using molecular markers显示文摘 | Ge Ding Daizhen Zhang Yanqiu Yu Lingling Zhao Beibei Zhang | 2013 | Gene2013，，2： | 1 |
| 16 | Intercellular transfer of activated STING triggered by RAB22A-mediated non-canonical autophagy promotes antitumor immunity显示文摘STING,an endoplasmic reticulum(ER)transmembrane protein,mediates innate immune activation upon cGAMP stimulation and is degraded through autophagy.Here,we report that activated STING could be transferred between cells to promote antitumor immunity,a process triggered by RAB22A-mediated non-canonical autophagy.Mechanistically,RAB22A engages PI4K2A to generate PI4P that recruits the Atg12–Atg5–Atg16L1 complex,inducing the formation of ER-derived RAB22A-mediated non-canonical autophagosome,in which STING activated by agonists or chemoradiotherapy is packaged.This RAB22A-induced autophagosome fuses with RAB22A-positive early endosome,generating a new organelle that we name Rafeesome(RAB22A-mediated non-canonical autophagosome fused with early endosome).Meanwhile,RAB22A inactivates RAB7 to suppress the fusion of Rafeesome with lysosome,thereby enabling the secretion of the inner vesicle of the autophagosome bearing activated STING as a new type of extracellular vesicle that we define as R-EV(RAB22A-induced extracellular vesicle).Activated STING-containing R-EVs induce IFNβrelease from recipient cells to the tumor microenvironment,promoting antitumor immunity.Consistently,RAB22A enhances the antitumor effect of the STING agonist diABZI in mice,and a high RAB22A level predicts good survival in nasopharyngeal cancer patients treated with chemoradiotherapy.Our findings reveal that Rafeesome regulates the intercellular transfer of activated STING to trigger and spread antitumor immunity,and that the inner vesicle of non-canonical autophagosome originated from ER is secreted as R-EV,providing a new perspective for understanding the intercellular communication of organelle membrane proteins. | Ying Gao Xueping Zheng Boyang Chang Yujie Lin Xiaodan Huang Wen Wang Shirong Ding Weixiang Zhan Shang Wang Beibei Xiao Lanqing Huo Youhui Yu Yilin Chen Run Gong Yuanzhong Wu Ruhua Zhang Li Zhong Xin Wang Qiuyan Chen Song Gao Zhengfan Jiang Denghui Wei Tiebang Kang | 2022 | Cell Research2022，32，12： | 1 |
| 17 | A Kaposi’s sarcoma-associated herpes virus-encoded microRNA contributes to dilated cardiomyopathy显示文摘Dilated cardiomyopathy(DCM)is the leading cause of heart transplantation.By microRNA(miRNA)array,a Kaposi’s sarcoma-associated herpes virus(KSHV)-encoded miRNA,kshv-miR-K12-1-5p,was detected in patients with DCM.The KSHV DNA load and kshv-miR-K12-1-5p level in plasma from 696 patients with DCM were measured and these patients were followed-up. | Yanru Zhao Huaping Li Hengzhi Du Zhongwei Yin Mengying He Jiahui Fan Xiang Nie Yang Sun Huiying Hou Beibei Dai Xudong Zhang Yuanyuan Cai Kunying Jin Nan Ding Zheng Wen Jiang Chang Chen Chen Dao Wen Wang | 2023 | Signal Transduction and Targeted Therapy2023，8，7： | 1 |
| 18 | Multifunctional cellular carbon foams derived from chitosan toward self-cleaning, thermal insulation, and highly efficient microwave absorption properties显示文摘To adapt the practical demand,designing and constructing the multifunctional microwave absorbers(MAs)is the key future direction of research and development.However,effective integrating the multiple functions into a single material remains a huge challenge.Herein,cellular carbon foams(CCFs)with different porous structures were elaborately designed and fabricated in high efficiency through a facile continuous freeze-drying and carbonization processes using a sustainable biomass chitosan as the precursor.The obtained results revealed that the thermal treated temperature and g-C_(3)N_(4) amount played a great impact on the carbonization degrees,pore sizes,and morphologies of CCFs,which led to their tunable electromagnetic(EM)parameters,improved conduction loss,and polarization loss abilities.Owing to the special cellular structure,the designed CCFs samples simultaneously displayed the strong absorption capabilities,broad absorption bandwidths,and thin matching thicknesses.Meanwhile,the as-prepared CCFs exhibited the strong hydrophobicity and good thermal insulation,endowing its attractive functions of self-cleaning and thermal insulation.Therefore,our findings not only presented a facile approach to produce different porous structures of CCFs,but also provided an effective strategy to develop multifunctional high-performance MAs on basis of three-dimensional CCFs. | Beibei Zhan Yanling Hao Xiaosi Qi Yunpeng Qu Junfei Ding Jing-liang Yang Xiu Gong Yanli Chen Qiong Peng Wei Zhong | 2024 | Nano Research2024，17，3： | 0 |
| 19 | Investigation of gene therapy of adenovirus in immune suppression显示文摘The aim of this paper is to investigate the safety of reconstructed adenovirus in immunosuppressive ther-apeutics and to explore the role of ciclosporin A in ant-agonizing the elimination of the vector.Several rats were given retroperitoneal injection of purified ADV-TK in order to obtain models.After 14 days’treatment of ciclos-porin A,samples of different periods were obtained,then stained with hematoxylin-eosin(HE)to detect inflam-mation reactions.Immunohistochemistry was used to examine the expression of adenovirus in organs.The results are as follows:(1)In HE stained sections of the organs,some transitory and reversible inflammation was detected.(2)In immunohistochemistry assay,recon-structed adenovirus decreased gradually as time went by in the control group,while it did not happen in the experi-mental group in which the adenovirus showed a relative increase compared with their counterparts(P,0.05).(3)The distributions of adenovirus in the liver,spleen and lung were higher than those in the other organs detected.Reconstructed adenovirus as a vector is definitely safe in immunosuppressive therapeutics,and ciclosporin A,to some extent,is able to consequently inhibit the immune response of the rats and prolong the existing period of adenovirus. | Xi XIA Beibei WANG Li CAO Gang CHEN Peng WU Yunping LU Jianfeng ZHOU Ding MA | 2008 | Frontiers of Medicine2008，2，4： | 0 |
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