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| 1 | Comparison of surgical indications for hysterectomy by age and approach in 4653 Chinese women显示文摘约 100 万子宫切除每年在中国被执行。然而,关于指示的国家数据和为子宫切除的外科的途径正在缺乏。这研究的目的是在中国女人为子宫切除在不同年龄组和不同外科的途径的相对优点为子宫切除检验外科的指示。从从 2004 ~ 2009 在 Tongji 医院里执行的子宫切除的 4653 个盒子的临床的数据被分析。子宫切除最通常 4049 年在女人之中被执行(2299;49.4%) 。总的来说, colporrhagia 和腹的疼痛是为子宫切除的二个很普通的指示。由年龄组的最普通的指示如下:恶意的卵巢的瘤, 70 年。恶意的原因论的比例也到年龄变化了,在女人是最高的变老 P < 0.05 ) 。两个都,流血和输血体积的数量要求了在阴道途径是更小的,没有其它之间的重要差别。使用的外科的途径也与外科的范围有关。外科的指示和双边的 oophorectomy 的率到年龄变化了。以两个都操作时间和流血和要求的输血体积的数量,阴道途径比所有另外的外科的途径优异。 | Jingjing Jiang Ting Ding Aiyue Luo Yunping Lu Ding Ma Shixuan Wang | 2014 | Frontiers of Medicine2014，8，4： | 2 |
| 2 | Effect of tumor suppressor gene PTEN on the resistance to cisplatin in human ovarian cancer cell lines and related mechanisms显示文摘 | HuiJuan Wu Yang Cao Danhui Weng Hui Xing Xiaohong Song Jianfeng Zhou Gang Xu Yunping Lu Shixuan Wang Ding Ma | 2008 | Cancer Letters2008，，2： | 1 |
| 3 | Expression of pin1 and ki67 in cervical cancer and their significance显示文摘 | Li Hongyu Shen Hongling Xu Qian Deng Dongrui Wang Shixuan Lu Yunping Ma Ding | 2006 | Journal of Huazhong University of Science and Technology [Medical Sciences]2006，，： | 1 |
| 4 | Reversal of multidrug resistance and inhibition of phosphorylation of AKT in human ovarian cancer cell line by wild-type PTEN gene显示文摘 | Huijuan Wu Danhui Weng Hui Xing Yunping Lu Ding Ma | 2008 | Journal of Huazhong University of Science and Technology2008，，6： | 1 |
| 5 | A broadly neutralizing antibody against SARS-CoV-2 Omicron variant infection exhibiting a novel trimer dimer conformation in spike protein binding显示文摘Dear Editor,The constant evolution of SARS-CoV-2 has resulted in the emergence of circulating variants during the COVID-19 pandemic.Recently,a newly emerged B.1.1.529(Omicron)variant raised global concern.Compared with the original SARS-CoV-2 strain and other variants of concern(VOCs),the Omicron variant has more than 30 mutations on its spike(S)protein,of which 16 mutations are located in the receptor-binding domain(RBD). | Yingdan Wang Wuqiang Zhan Jiangyan Liu Yanqun Wang Xiang Zhang Meng Zhang Lin Han Yunping Ma Lu Lu Yumei Wen Zhenguo Chen Jincun Zhao Fan Wu Lei Sun Jinghe Huang | 2022 | Cell Research2022，32，9： | 1 |
| 6 | Production and verification of human papillomavirus type 18 vaccinein vitro显示文摘 | Shujie Liao Shixuan Wang Ling Xu Dongrui Deng Qian Xu Wei Wang Tao Zhu Xiangyang Bai Jianfeng Zhou Gang Xu Yunping Lu Li Meng Ding Ma | 2008 | Oncology Reports2008，，1： | 1 |
| 7 | A Novel Retrograde AAV Variant for Functional Manipulation of Cortical Projection Neurons in Mice and Monkeys显示文摘Retrograde adeno-associated viruses(AAVs)are capable of infecting the axons of projection neurons and serve as a powerful tool for the anatomical and functional characterization of neural networks.However,few retro-grade AAV capsids have been shown to offer access to cor-tical projection neurons across different species and enable the manipulation of neural function in non-human primates(NHPs).Here,we report the development of a novel retro-grade AAV capsid,AAV-DJ8R,which efficiently labeled cortical projection neurons after local administration into the striatum of mice and macaques.In addition,intrastriatally injected AAV-DJ8R mediated opsin expression in the mouse motor cortex and induced robust behavioral alterations.Moreover,AAV-DJ8R markedly increased motor cortical neuron firing upon optogenetic light stimulation after viral delivery into the macaque putamen.These data demonstrate the usefulness of AAV-DJ8R as an efficient retrograde tracer for cortical projection neurons in rodents and NHPs and indicate its suitability for use in conducting functional interrogations. | Yefei Chen Jingyi Wang Jing Liu Jianbang Lin Yunping Lin Jinyao Nie Qi Yue Chunshan Deng Xiaofei Qi Yuantao Li Ji Dai Zhonghua Lu | 2024 | Neuroscience Bulletin2024，40，1： | 0 |
| 8 | Fluorination-mitigated high-current degradation of amorphous InGaZnO thin-film transistors显示文摘As growing applications demand higher driving currents of oxide semiconductor thin-film transistors(TFTs),severe instabilities and even hard breakdown under high-current stress(HCS)become critical challenges.In this work,the triggering voltage of HCS-induced self-heating(SH)degradation is defined in the output characteristics of amorphous indium-galliumzinc oxide(a-IGZO)TFTs,and used to quantitatively evaluate the thermal generation process of channel donor defects.The fluorinated a-IGZO(a-IGZO:F)was adopted to effectively retard the triggering of the self-heating(SH)effect,and was supposed to originate from the less population of initial deep-state defects and a slower rate of thermal defect transition in a-IGZO:F.The proposed scheme noticeably enhances the high-current applications of oxide TFTs. | Yanxin Wang Jiye Li Fayang Liu Dongxiang Luo Yunping Wang Shengdong Zhang Lei Lu | 2023 | Journal of Semiconductors2023，44，9： | 0 |
| 9 | A Dynamically Reconfigurable Accelerator Design Using a Sparse-Winograd Decomposition Algorithm for CNNs显示文摘Convolutional Neural Networks(CNNs)are widely used in many fields.Due to their high throughput and high level of computing characteristics,however,an increasing number of researchers are focusing on how to improve the computational efficiency,hardware utilization,or flexibility of CNN hardware accelerators.Accordingly,this paper proposes a dynamically reconfigurable accelerator architecture that implements a Sparse-Winograd F(2×2.3×3)-based high-parallelism hardware architecture.This approach not only eliminates the pre-calculation complexity associated with the Winograd algorithm,thereby reducing the difficulty of hardware implementation,but also greatly improves the flexibility of the hardware;as a result,the accelerator can realize the calculation of Conventional Convolution,Grouped Convolution(GCONV)or Depthwise Separable Convolution(DSC)using the same hardware architecture.Our experimental results show that the accelerator achieves a 3x–4.14x speedup compared with the designs that do not use the acceleration algorithm on VGG-16 and MobileNet V1.Moreover,compared with previous designs using the traditional Winograd algorithm,the accelerator design achieves 1.4x–1.8x speedup.At the same time,the efficiency of the multiplier improves by up to 142%. | Yunping Zhao Jianzhuang Lu Xiaowen Chen | 2021 | Computers, Materials & Continua2021，，1： | 0 |
| 10 | A broadly neutralizing antibody inhibits SARS-CoV-2 variants through a novel mechanism of disrupting spike trimer integrity显示文摘Dear Editor,Since the start of the COVID-19 pandemic,thousands of neutralizing antibodies(NAbs)targeting different epitopes of the spike protein have been identifed and characterized.1-3 However,the emergence of the Omicron variant and its subvariants has raised global concern due to their resistance to most reported monoclonal antibodies and dramatically decreases the immune effcacy of current Vaccines.4sA newly emerging,subvariant XBB.1.16 that is rapidly disseminating on a global scale has been associated with a previously unreported symptom of red or pink eye.Compared to XBB.1.5,XBB.1.16 harbors two additional mutations,E180V and K478R,which are hypothesized to confer enhanced transmissibility and antigenic escape.? | Yunping Ma Qiyu Mao Yingdan Wang Zhaoyong Zhang Jiali Chen Aihua Hao Palizhati Rehati Yanqun Wang Yumei Wen Lu Lu Zhenguo Chen Jincun Zhao Fan Wu Lei Sun Jinghe Huang | 2023 | Cell Research2023，33，12： | 0 |
| 11 | PTEN coding product:a new marker for tumorigenesis and progession of endometrial carcinoma显示文摘Objective:To investigate the expression of PTEN in carcinogenesis and development of endometrial carcinoma.Methods:The expression of PTEN was detected by reverse transcription-polymerase chain reaction(RT-PCR)methods from 24 cases with endometrial carcinoma,10 cases with endometrial atypical hyperplasia,10 cases with endometrial hyperplasia and 10 cases with normal endometrium and by SP immunohistochemical methods from 73 cases with endometrial carcinoma,25 cases with endometrial atypical hyperplasia,71 cases with endometrial hyperplasia and 31 cases with normal endometrium.Results:PTEN expression of both RNA and protein in patients with endometrial carcinoma and endometrial atypical hyperplasia was significantly lower than that of patients with endometrial hyperplasia and normal endometrium.mRNA relative value was 0.35±0.13,0.46±0.11,2.32±0.32,2.45±0.51,respectively.Loss of PTEN expression rates were 66.67%(38/57),76.00%(19/25),5.63%(4/71),0(0/31),repectively.The results were also compared with clinical parameters.Loss of PTEN expression in patients with endometrial carcinoma was significantly related to histological classification(P<0.0001)and differentiation(P<0.05).It was not related to depth of myometrium invasion and clinical stage(P>0.05).Conclusion:Loss of PTEN expression is an early event in endometrial tumorigenesis.Detection of PTEN protein may be a diagnostic biomarker for endometrial precancers and adenocarcinoma. | Gao Qinglei Li Jing Xing Hui Lu Yunping Zhou Jianfeng Ma Ding | 2008 | 现代妇产科进展2008，17，10： | 0 |
| 12 | Trade-Off between Efficiency and Effectiveness: A Late Fusion Multi-View Clustering Algorithm显示文摘Late fusion multi-view clustering(LFMVC)algorithms aim to integrate the base partition of each single view into a consensus partition.Base partitions can be obtained by performing kernel k-means clustering on all views.This type of method is not only computationally efficient,but also more accurate than multiple kernel k-means,and is thus widely used in the multi-view clustering context.LFMVC improves computational efficiency to the extent that the computational complexity of each iteration is reduced from Oen3T to OenT(where n is the number of samples).However,LFMVC also limits the search space of the optimal solution,meaning that the clustering results obtained are not ideal.Accordingly,in order to obtain more information from each base partition and thus improve the clustering performance,we propose a new late fusion multi-view clustering algorithm with a computational complexity of Oen2T.Experiments on several commonly used datasets demonstrate that the proposed algorithm can reach quickly convergence.Moreover,compared with other late fusion algorithms with computational complexity of OenT,the actual time consumption of the proposed algorithm does not significantly increase.At the same time,comparisons with several other state-of-the-art algorithms reveal that the proposed algorithm also obtains the best clustering performance. | Yunping Zhao Weixuan Liang Jianzhuang Lu Xiaowen Chen Nijiwa Kong | 2021 | Computers, Materials & Continua2021，，3： | 0 |
| 13 | Expression of recombinant human butyrylcholinesterase in the milk of transgenic mice显示文摘Butyrylcholinesterase(BCHE)is a natural bioscavenger that protects humans against organophosphate toxicity.Due to the limited yield of human BCHE(hBCHE)when purifying from human plasma,it is necessary to find an alternative method to produce this protein.One potential method is to produce transgenic livestock that make modified milk containing high concentration of hBCHE.In this study,we cloned the hBCHEgene into a human lactoferrin(hLF)bacterial artificial chromosome(BAC)construct to make a hLFhBCHE BAC construct.Subsequently,we injected the BAC construct into pronuclei of mouse fertilized embryos and generated transgenic mice.Expression analysis showed that recombinant hBCHE(rhBCHE)was expressed efficiently in the mammary gland of the transgenic mice and the concentration of rhBCHE in the milk of individual mice ranged from 7612 to 15928 mg·L^(–1).Protein function tests showed that rhBCHE has the same enzymatic activity as the native hBCHE.Our results pave the way for making transgenic livestock to produce large quantities of rhBCHE. | Dan LU Shengzhe SHANG Shen LIU Ying WU Fangfang WU Tan TAN Qiuyan LI Yunping DAI Xiaoxiang HU Yaofeng ZHAO Ning LI | 2014 | Frontiers of Agricultural Science and Engineering2014，1，3： | 0 |
| 14 | Development of Si(Li) Detector and Its Applications显示文摘DevelopmentofSi(Li)DetectorandItsApplications￥TanJilian;JinGenming;ZhangJinxia;LuZiwei;BaoZhiqin;Pengxingping;LiCunfan;XuYunp... | Tan Jilian Jin Genming Zhang Jinxia Lu Ziwei Bao Zhiqin Peng xingping Li Cunfan Xu Yunping and Feng Ying | 1996 | IMP & HIRFL Annual Report1996，，1： | 0 |
| 15 | Development and Improvement of Total Depleted An-Si Surface Barrier Detector Series and its Application in Heavy ion Physics显示文摘DevelopmentandImprovementofTotalDepletedAn-SiSurfaceBarrierDetectorSeriesanditsApplicationinHeavyionPhysics￥TanJilan;LiCunfan... | Tan Jilan Li Cunfan Jin Geming Bao Zhiqin Xun Yunping Zhao Rongpu Lu Ziwei and Zhang Jinxia | 1996 | IMP & HIRFL Annual Report1996，，1： | 0 |
| 16 | Expression and bioinformatic analysis of lymphoma-associated novel gene KIAA0372显示文摘The purpose of this study was to explore the differentially expressed genes in lymph-node cells(LNC)of lymphomas and reactive lymph node hyperplasia,and to perform an initial bioinformatic analysis on a novel gene,KIAA0372,which is highly expressed in the LNC of lymphomas.mRNA extracted from LNC of lymphomas and reactive lymph node hyperplasia were respectively marked with biotin and hybridized with Gene Expression Chips,resulting in differentially expressed genes.Initial bioinformatic analysis was then performed on a novel gene named KIAA0372,whose function has not yet been explored.Its structure and genomic location,its product’s physical and chemical properties,subcellular localization and functional domains,were also predicted.Further,a systematic evolution analysis was performed on similar proteins from among several species.Using Gene Expression Chips,many differentially expressed genes were uncovered.Efficient bioinformatic analysis has fundamentally determined that KIAA0372 is an extracellular protein which may be involved in TGF-b signaling.Microarray is an efficient and high throughput strategy for detection of differentially expressed genes.And KIAA0372 is thought to be a potential target for tumor research using bioinformatic analysis. | BAI Xiangyang TANG Duozhuang ZHU Tao SUN Lishi YAN Lingling LU Yunping ZHOU Jianfeng MA Ding | 2007 | Frontiers of Medicine2007，1，1： | 0 |
| 17 | Investigation of gene therapy of adenovirus in immune suppression显示文摘The aim of this paper is to investigate the safety of reconstructed adenovirus in immunosuppressive ther-apeutics and to explore the role of ciclosporin A in ant-agonizing the elimination of the vector.Several rats were given retroperitoneal injection of purified ADV-TK in order to obtain models.After 14 days’treatment of ciclos-porin A,samples of different periods were obtained,then stained with hematoxylin-eosin(HE)to detect inflam-mation reactions.Immunohistochemistry was used to examine the expression of adenovirus in organs.The results are as follows:(1)In HE stained sections of the organs,some transitory and reversible inflammation was detected.(2)In immunohistochemistry assay,recon-structed adenovirus decreased gradually as time went by in the control group,while it did not happen in the experi-mental group in which the adenovirus showed a relative increase compared with their counterparts(P,0.05).(3)The distributions of adenovirus in the liver,spleen and lung were higher than those in the other organs detected.Reconstructed adenovirus as a vector is definitely safe in immunosuppressive therapeutics,and ciclosporin A,to some extent,is able to consequently inhibit the immune response of the rats and prolong the existing period of adenovirus. | Xi XIA Beibei WANG Li CAO Gang CHEN Peng WU Yunping LU Jianfeng ZHOU Ding MA | 2008 | Frontiers of Medicine2008，2，4： | 0 |
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