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| 1 | Are there new approaches for diagnosis, therapy guidance and outcome prediction of sepsis?显示文摘Beside many efforts to improve outcome, sepsis is still one of the most frequent causes of death in critically ill patients. It is the most common condition with high mortality in intensive care units. The complexity of the septic syndrome comprises immunological aspects- i.e.,sepsis induced immunosuppression- but is not restricted to this fact in modern concepts. So far, exact mechanisms and variables determining outcome and mortality stay unclear. Since there is no typical risk profile, early diagnosis and risk stratification remain difficult, which hinders rapid and effective treatment initiation. Due to the heterogeneous nature of sepsis, potential therapy options should be adapted to the individual. Biomarkers like C-reactive protein and procalcitonin are routinely used as complementary tools in clinical decision-making. Beyond the acute phase proteins, a wide bunch of promising substances and non-laboratory tools with potential diagnostic and prognostic value is under intensive investigation. So far, clinical decision just based on biomarker assessment is not yet feasible. However, biomarkers should be considered as a complementary approach. | Dubravka Kojic Benedikt H Siegler Florian Uhle Christoph Lichtenstern Peter P Nawroth Markus A Weigand Stefan Hofer Thorsten Brenner | 2015 | World Journal of Experimental Medicine2015，5，2： | 14 |
| 2 | Particle-Image Velocimetry and Force Measurements of Leading-Edge Serrations on Owl-Based Wing Models显示文摘 | Andrea Winzen Benedikt Roidl Stephan Klan Michael Klaas Wolfgang Schroder | 2014 | Journal of Bionic Engineering2014，11，3： | 8 |
| 3 | Gut-liver axis signaling in portal hypertension显示文摘Portal hypertension(PHT)in advanced chronic liver disease(ACLD)results from increased intrahepatic resistance caused by pathologic changes of liver tissue composition(structural component)and intrahepatic vasoconstriction(functional component).PHT is an important driver of hepatic decompensation such as development of ascites or variceal bleeding.Dysbiosis and an impaired intestinal barrier in ACLD facilitate translocation of bacteria and pathogen-associated molecular patterns(PAMPs)that promote disease progression via immune system activation with subsequent induction of proinflammatory and profibrogenic pathways.Congestive portal venous blood flow represents a critical pathophysiological mechanism linking PHT to increased intestinal permeability:The intestinal barrier function is affected by impaired microcirculation,neoangiogenesis,and abnormal vascular and mucosal permeability.The close bidirectional relationship between the gut and the liver has been termed“gut-liver axis”.Treatment strategies targeting the gut-liver axis by modulation of microbiota composition and function,intestinal barrier integrity,as well as amelioration of liver fibrosis and PHT are supposed to exert beneficial effects.The activation of the farnesoid X receptor in the liver and the gut was associated with beneficial effects in animal experiments,however,further studies regarding efficacy and safety of pharmacological FXR modulation in patients with ACLD are needed.In this review,we summarize the clinical impact of PHT on the course of liver disease,discuss the underlying pathophysiological link of PHT to gut-liver axis signaling,and provide insight into molecular mechanisms that may represent novel therapeutic targets. | Benedikt Simbrunner Mattias Mandorfer Michael Trauner Thomas Reiberger | 2019 | World Journal of Gastroenterology2019，25，39： | 6 |
| 4 | Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma显示文摘 | Andrew D. Rhim Paul E. Oberstein Dafydd H. Thomas Emily T. Mirek Carmine F. Palermo Stephen A. Sastra Erin N. Dekleva Tyler Saunders Claudia P. Becerra Ian W. Tattersall C. Benedikt Westphalen Jan Kitajewski Maite G. Fernandez-Barrena Martin E. Fernandez- | 2014 | Cancer Cell2014，，： | 5 |
| 5 | 日本鳗鲡仔鱼摄食机理及其营养策略显示文摘Leptocephalus larvae are the unique stage of larval development in all groups of fishes from the superorder Elopomorpha (Anguilliformes, Elopiformes and Notacanthiformes). To explain the leptocephalus strategy of larval development, various attempts have been made on the morphology, physiology and biochemistry of leptocephalus larvae. However, the feeding mechanism of leptocephalus larvae is still unknown. The Japanese eel (Anguilla japonica) larvae were found to have well developed scotopic vision, mechanoreception and chemoreception. Both early and leptocephalus larvae of Japanese eel actively ingested a kind of paste food by first touching the food with their snout and then tearing off a big mouthful of the paste with their sharp teeth. Chemoreception was shown to be critical to elicit the feeding response. Feeding by Sflex posture from a distance might be of some significance for the early larvae to catch movable food. It is proposed that that the natural food of Japanese eel larvae would be relatively large, rather soft, inactive and negatively phototactic. The developmental mode of sensory system and behavior of Japanese eel larvae seems to be similar to some deep sea fishes but contrast with most marine teleost fishes. | 梁旭方 谢骏 王秋荣 Benedikte H Pedersen | 2002 | 水产学报2002，26，6： | 4 |
| 6 | The Plastid-Localized NAD-Dependent Malate Dehydrogenase Is Crucial for Energy Homeostasis in Developing Arabidopsis thaliana Seeds显示文摘当光合作用不在时, ATP 被 ATP/ADP transporters 进口进叶绿体和非绿的质体或在 glycolysis 期间形成了,要求 NAD+ 的连续新生的后者,由 NADMDH 的 plastidial isoform 供应了。在在 Arabidopsis 的 plNADMDH 基因为 T-DNA 插入异种屏蔽期间,仅仅异质接合的植物能被孤立,同型结合的猛烈异种仅仅在互补以后成长了。这些异质接合的植物显示出其他的改革 NAD+ 酶的更高的抄本层次, NADHGOGAT,并且,显著地,当铵是唯一的 N 来源时,改进了生长。在 situ,杂交并且 GUS 组织化学的染色表明 plNADMDH 特别地充满男、女的配偶体。猛烈 plNADMDH 花粉展览在 vitro 损害了试管生长,它能被增加 NADHGOGAT 的底层克服。在 vivo,猛烈花粉能使肥沃卵房间。异质接合的植物包含的 selfed 的年轻 siliques 相应于 wild-type/heterozygous (绿色) 和同型结合的猛烈异种(白色) 在的绿、白的种子一(1:2 ): 1 比率。同型结合的猛烈种子的胚胎仅仅到达了球状的阶段,绿,并且发展了到微小的起皱的种子。有在本国的倡导者下面的基因的互补救了作为野类型开发的这个缺点,和所有种子。这建议在 plNADMDH 异种的一个堵住的主要生理的过程停止胚胎和内乳开发,因此避免在损害后代吸收投资。 | Jennifer Selinski Nicolas Konig Benedikt Wellmeyer Guy T. Hanke Vera Linke H. Ekkehard Neuhaus Renate Scheibe | 2014 | Molecular Plant2014，7，1： | 4 |
| 7 | Statistically Extrapolated Nowcasting of Summertime Precipitation over the Eastern Alps显示文摘This paper presents a new multiple linear regression(MLR) approach to updating the hourly, extrapolated precipitation forecasts generated by the INCA(Integrated Nowcasting through Comprehensive Analysis) system for the Eastern Alps.The generalized form of the model approximates the updated precipitation forecast as a linear response to combinations of predictors selected through a backward elimination algorithm from a pool of predictors. The predictors comprise the raw output of the extrapolated precipitation forecast, the latest radar observations, the convective analysis, and the precipitation analysis. For every MLR model, bias and distribution correction procedures are designed to further correct the systematic regression errors. Applications of the MLR models to a verification dataset containing two months of qualified samples,and to one-month gridded data, are performed and evaluated. Generally, MLR yields slight, but definite, improvements in the intensity accuracy of forecasts during the late evening to morning period, and significantly improves the forecasts for large thresholds. The structure–amplitude–location scores, used to evaluate the performance of the MLR approach,based on its simulation of morphological features, indicate that MLR typically reduces the overestimation of amplitudes and generates similar horizontal structures in precipitation patterns and slightly degraded location forecasts, when compared with the extrapolated nowcasting. | Min CHEN Benedikt BICA Lukas TCHLER Alexander KANN Yong WANG | 2017 | Advances in Atmospheric Sciences2017，34，7： | 3 |
| 8 | Towards a versatile point-of-care systemcombining femtosecond laser generatedmicrofluidic channels and direct laserwritten microneedle arrays显示文摘Microneedle-based microfluidic systems have a great potential to become well-accepted medical devices for simple,accurate,and painless drug delivery and lab-on-a-chip diagnostics.In this work,we report on a novel hybrid approach combining femtosecond direct laser written microneedles with femtosecond laser generated microfluidic channels providing an important step towards versatile medical point-of-care systems.Hollow microneedle arrays are fabricated by a laser system designed for two-photon polymerization applications.Compression tests of two different types of truncated cone-shaped microneedle arrays prepared from OrmoComp^(■)give information about the microneedle mechanical strength,and the results are compared to skin insertion forces.Three-dimensional microchannels are directly created inside PMMA bulk material by an ultrashort pulse laser system with vertical channels having adjustable cross-sectional areas,which allow attaching of microneedles to the microfluidic system.A comprehensive parameter study varying pulse duration and repetition rate is performed on two-photon polymerization to identify an optimal laser power range for fabricating microneedles using the same pulse duration and repetition rate as for microchannels.This addresses the advantage of a single laser system process that overcomes complex fabrication methods.A proof of concept flow test with a rhodamine B dye solution in distilled water demonstrates that the combination of microneedles and microchannels qualifies for microfluidic injection and extraction applications. | Anika Trautmann Gian-Luca Roth Benedikt Nujiqi Thomas Walther Ralf Hellmann | 2019 | Microsystems & Nanoengineering2019，5，1： | 3 |
| 9 | Interventional treatment of the left subclavian in 2 patients with coronary steal syndrome显示文摘In patients with history of coronary artery disease angina pectoris is usually attributed to the progression of atherosclerotic lesions. However,in patients with previous coronary artery bypass graft operation(CABG) using internal mammary artery grafts,great vessel disease should also be considered. Herein we present two patients with history of CABG whose symptoms were suspicious for coronary ischemia. During cardiac catheterization reverse blood flow was observed from the left artery disease to the left internal mammary artery(LIMA) graft in both cases. After angioplasty and stent implantation of the left subclavian artery antegrade flow was restored in the LIMA grafts and both patients had complete resolution of symptoms. | Julia Heid Britta Vogel Arnt Kristen Wanda Kloos Benedikt Kohler Hugo A Katus Grigorios Korosoglou | 2017 | World Journal of Cardiology2017，9，1： | 3 |
| 10 | Two-photon lithography for 3D magnetic nanostructure fabrication显示文摘铁磁性的材料作为在数据存储设备记录媒介许多十年被利用了。到一架二维的飞机的材料的监禁是在完成超离频的记录的一个重要瓶颈密度,和这导致了提议三维(3D ) 利用领域的跑道记忆沿着 nanowires 围繁殖。然而,复杂几何学的磁性的 nanostructures 高度容易正在质问并且不是的 3D 的制造与标准平版印刷术技术完成了。这里,我们表明一条新途径构造 3D 用二光子的平版印刷术和电气化学的免职的联合的复杂几何学的磁性的 nanostructures。磁性被发现是亲密地,与结构,和磁性的成像的 3D 几何学有关,实验提供领域墙在 3D nanostructured 连接卡住的证据。 | Gwilym Williams Matthew Hunt Benedikt Boehm Andrew May Michael Taverne Daniel Ho Sean Giblin Dan Read John Rarity Rolf Allenspach Sam Ladak | 2018 | Nano Research2018，11，2： | 3 |
| 11 | Advances in radiotherapy and targeted therapies for rectal cancer显示文摘The last decade witnessed a significant progress in understanding the biology and immunology of colorectal cancer alongside with the technical innovations in radiotherapy.The stepwise implementation of intensitymodulated and image-guided radiation therapy by means of megavolt computed tomography and helical tomotherapy enabled us to anatomically sculpt dose delivery,reducing treatment related toxicity.In addition,the administration of a simultaneous integrated boost offers excellent local control rates.The novel challenge is the development of treatment strategies for medically inoperable patient and organ preserving approaches.However,distant control remains unsatisfactory and indicates an urgent need for biomarkers that predict the risk of tumor spread.The expected benefit of target?ed therapies that exploit the tumor genome alone is so far hindered by high cost techniques and pharmaceuticals,hence hardly justifying rather modest improvements in patient outcomes.On the other hand,the immune landscape of colorectal cancer is now better clarified with regard to the immunosuppressive network that promotes immune escape.Both N2 neutrophils and myeloid-derived suppressor cells(MDSC)emerge as useful clinical biomarkers of poor prognosis,while the growing list of anti-MDSC agents shows promising ability to boost antitumor T-cell immunity in preclinical settings.Therefore,integration of genetic and immune biomarkers is the next logical step towards effective targeted therapies in the context of personalized cancer treatment. | Alexandra Sermeus Wim Leonard Benedikt Engels Mark De Ridder | 2014 | World Journal of Gastroenterology2014，20，1： | 3 |
| 12 | 不同天气背景下京津冀降水临近外推预报显示文摘基于2019—2020年京津冀地区不同天气系统影响下的降水过程,采用交叉相关法和光流法对快速更新多尺度分析和预报综合集成系统(Rapid-refresh Multi-Scale Analysis and Prediction System-Integration,RMAPS_IN)的降水分析产品进行0~2 h临近外推预报的批量试验。结果表明:由交叉相关法和光流法计算的两种外推矢量在大小和方向上存在一定差异,直接差异与影响降水的天气系统位置有明显的对应关系,而方向差异受地理位置的影响更明显,台风类降水呈弧形带状分布,低槽冷锋类、低涡类、气旋类、暖切变线类等几类降水均呈西北大东南小的特点;预报效果方面,总体上交叉相关法优于光流法,尤其是预报时效超过30 min以后,各种降水类型的批量检验结果显示交叉相关法的预报评分优于光流法,且预报时效越长、优势越明显,但预报时效为10 min时,光流法在低涡类、台风类、暖切变线类的空报率上优于交叉相关法。此外,基于外推的临近预报方法对京津冀地区台风类降水的预报效果最好,其次为暖切变线类、低涡类、低槽冷锋类、气旋类。 | 王玉虹 Bica Benedikt | 2022 | 应用气象学报2022，33，3： | 3 |
| 13 | First determination of the highly genotoxic fungal contaminant altertoxin II in a naturally infested apple sample显示文摘Altertoxin II is an epoxide-holding perylene quinone and secondary metabolite produced by Alternaria molds.Its genotoxic potential and the high concentrations determined in laboratory fungal cultures resulted in an increased scientific interest in this emerging contaminant.However,no natural occurrence in food has been reported to date to the best of our knowledge.Here,we unambiguously identified altertoxin II in a naturally infected,unprocessed apple.Applying a validated LC-MS/MS method,fruit peel spots(approx.1 mm in diameter),typically associated with Alternaria infestation,were tested for 17 mycotoxins produced by this genus.Negligible concentrations of tentoxin were determined 24 h after harvest,and the dibenzopyrones alternariol,alternariol monomethyl ether(AME)and AME-3-sulfate after six months of storage.Overall,these contamination patterns can be considered unlikely to be of toxicological concern for consumers.However,an inconspicuous peel lesion(0.5×1 cm)separately sampled from a stored apple,exhibited considerably high concentrations of 14 Alternaria toxins,including dibenzopyrones,their barely studied modified forms(glucosides and sulfates),as well as genotoxic perylene quinones including altertoxin II.Considering the toxicological potential of this compound,contaminations in such infected fruit parts should not be underestimated,e.g.in the case of exposure through the consumption of fresh smoothies or fruit juices. | Hannes Puntscher Doris Marko Benedikt Warth | 2020 | Emerging Contaminants2020，6，1： | 2 |
| 14 | A comprehensive analysis of the Bencao(herbal)small RNA Atlas reveals novel RNA therapeutics for treating human diseases显示文摘Cross-kingdom herbal mi RNA was first reported in 2012.Using a modified herbal extraction protocol,we obtained 73,677,287sequences by RNA-seq from 245 traditional Chinese Medicine(TCM),of which 20,758,257 were unique sequences.We constructed a Bencao(herbal)small RNA(s RNA)Atlas(http://gffzz4a3adbfa122d4a47hwf66w990b5506fcu.ffgz.tsg.suse.edu.cn),annotated the sequences by sequence-based clustering,and created a nomenclature system for Bencao s RNAs.The profiles of 21,757 mi RNAs in the Atlas were highly consistent with those of plant mi RNAs in mi RBase.Using software tools,our results demonstrated that all human genes might be regulated by s RNAs from the Bencao s RNA Atlas,part of the predicted human target genes were experimentally validated,suggesting that Bencao s RNAs might be one of the main bioactive components of herbal medicines.We established roadmaps for oligonucleotide drugs development and optimization of TCM prescriptions.Moreover,the decoctosome,a lipo-nano particle consisting of 0.5%–2.5%of the decoction,demonstrated potent medical effects.We propose a Bencao(herbal)Index,including small-molecule compounds(SM),protein peptides(P),nucleic acid(N),non-nucleic and non-proteinogenic large-molecule compounds(LM)and elements from Mendeleev's periodic table(E),to quantitatively measure the medical effects of botanic medicine.The Bencao s RNA Atlas is a resource for developing gene-targeting oligonucleotide drugs and optimizing botanical medicine,and may provide potential remedies for the theory and practice of one medicine. | Yinghao Cao Yexuan Lin Na Sun Xinyi Du Yixin Dong Song Mei Xingyu Deng Xiaobei Li Shaoting Guo Kegong Tang Jiaqi Liu Xiangyu Qiao Dandan Zhao Yuhao Qin Cong Zhang Tianyi Xin Xiaohu Shi Congzhao Zhou Tao Dong De-an Guo Benedikt MKessler Dong Xu Jingyuan Song Fengming Huang Xiaoyue Wang Chengyu Jiang | 2023 | Science China(Life Sciences)2023，66，10： | 2 |
| 15 | Progastrin Stimulates Colonic Cell Proliferation via CCKBR- and β-Arrestin–Dependent Suppression of BMP2显示文摘 | Guangchun Jin C. Benedikt Westphalen Yoku Hayakawa Daniel L. Worthley Samuel Asfaha Xiangdong Yang Xiaowei Chen Yiling Si Hongshan Wang Yagnesh Tailor Richard A. Friedman Timothy C. Wang | 2013 | Gastroenterology2013，，： | 2 |
| 16 | From herbal small RNAs to one medicine显示文摘In this special topic 'Herbal small RNAs, novel precision medicine from Mother Nature', we present four original articles that study the entry of small RNAs derived from herbs used in traditional Chinese medicine into mammalian cells and their function within human and mouse cells, and one review paper focusing on current trends in herb genomics (Du et al., 2017;Huang et al., 2018;Zhang et al., 2018;Li et al., 2019;Xin et al., 2018). | Chao Ji Skirmantas Kriaucionis Benedikt M.Kessler Chengyu Jiang | 2019 | Science China(Life Sciences)2019，62，3： | 2 |
| 17 | Earth orientation parameters from VLBI determined with a Kalman filter显示文摘This paper introduces the reader to our Kalman filter developed for geodetic VLBI(very long baseline interferometry) data analysis. The focus lies on the EOP(Earth Orientation Parameter) determination based on the Continuous VLBI Campaign 2014(CONT14) data, but also earlier CONT campaigns are analyzed. For validation and comparison purposes we use EOP determined with the classical LSM(least squares method) estimated from the same VLBI data set as the Kalman solution with a daily resolution. To gain higher resolved EOP from LSM we run solutions which yield hourly estimates for polar motion and dUTl = Universal Time(UT1)-Coordinated Universal Time(UTC). As an external validation data set we use a GPS(Global Positioning System) solution providing hourly polar motion results.Further, we describe our approach for determining the noise driving the Kalman filter. It has to be chosen carefully, since it can lead to a significant degradation of the results. We illustrate this issue in context with the de-correlation of polar motion and nutation.Finally, we find that the agreement with respect to GPS can be improved by up to 50% using our filter compared to the LSM approach, reaching a similar precision than the GPS solution. Especially the power of erroneous high-frequency signals can be reduced dramatically, opening up new possibilities for highfrequency EOP studies and investigations of the models involved in VLBI data analysis.We prove that the Kalman filter is more than on par with the classical least squares method and that it is a valuable alternative, especially on the advent of the VLBI2010 Global Observing System and within the GGOS frame work. | Maria Karbon Benedikt Soja Tobias Nilsson Zhiguo Deng Robert Heinkelmann Harald Schuh | 2017 | Geodesy and Geodynamics2017，8，6： | 2 |
| 18 | Fibrin gel as a three dimensional matrix in cardiovascular tissue engineering显示文摘 | Ye Q Benedikt P | 2000 | Eur J Cardiothorac Surg2000，17，3： | 1 |
| 19 | Determination of multi-mycotoxin occurrence in cereals,muts and their products in Cameroon by liquid chromatography tandem mass spectrometry(LC-MS/MS)显示文摘 | Wilfred A A Benedikt W Michael S | 2013 | Food Control2013，31，2： | 1 |
| 20 | Preoperative Helical Tomotherapy and Megavoltage Computed Tomography for Rectal Cancer: Impact on the Irradiated Volume of Small Bowel显示文摘 | Benedikt Engels Mark De Ridder Koen Tournel Alexandra Sermeus Peter De Coninck Dirk Verellen Guy A. Storme | 2009 | International Journal of Radiation Oncology, Biology, Physics2009，，5： | 1 |
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