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| 1 | 人为气溶胶排放导致最近80年东亚夏季风在过去四个世纪以来空前减弱显示文摘亚洲夏季风(Asian Summer Monsoon,ASM)对亚洲数十亿人口的生存、亚洲生态系统和生物多样性的分布、以及农业生产(粮食安全)和工业活动影响严重。因此了解ASM过去时空变化及其动力学过程对陆地生态系统、水资源、森林和景观研究至关重要。近几十年,器测记录显示以降水量为代表的ASM强度一直在减弱,但这一减弱趋势的起始时间和动力学过程尚不清楚。为此,第一次集成了ASM西部-中部边缘带10个对降水敏感的树木年轮宽度年表,重建了公元1566年以来反映ASM强度变化的降水序列。重建结果不仅捕捉到了ASM过去4个世纪以来强弱变化历史,也反映出历史上蝗灾与弱季风的关联。特别是发现了最近80年具有过去448年中前所未有的、最为强烈的、显著且持续时间最长的ASM强度减弱趋势。这一减弱趋势与在温室效应影响下ASM本该增强的预期大相庭径。耦合气候模型实验表明,北半球人为硫酸盐气溶胶排放的逐渐增加,对ASM减弱起了决定性作用。 | 刘禹 蔡文炬 孙长峰 宋慧明 Kim MCobb 李建平 Steven WLeavitt 吴立新 蔡秋芳 刘若时 Benjamin Ng Paolo Cherubini Ulf Büntgen 宋怡 王国建 雷莺 晏利斌 李强 马永永 方丛羲 孙军艳 李旭祥 Deliang Chen Hans WLinderholm | 2019 | 地球环境学报2019，10，6： | 7 |
| 2 | Size-Dependent Joule Heating of Gold Nanoparticles Using Capacitively Coupled Radiofrequency Fields显示文摘Capacitively coupled shortwave radiofrequency fields(13.56 MHz)resistively heat low concentrations(~1 ppm)of gold nanoparticles with a thermal power dissipation of~380 kW/g of gold.Smaller diameter gold nanoparticles(<50 nm)heat at nearly twice the rate of larger diameter gold nanoparticles(≥50 nm),which is attributed to the higher resistivity of smaller gold nanostructures.A Joule heating model has been developed to explain this phenomenon and provides critical insights into the rational design and engineering of nanoscale materials for noninvasive thermal therapy of cancer. | Christine H.Moran Sean M.Wainerdi Tonya K.Cherukuri Carter Kittrell Benjamin J.Wiley Nolan W.Nicholas Steven A.Curley John S.Kanzius Paul Cherukuri | 2009 | Nano Research2009，2，5： | 4 |
| 3 | Disentangling multiple scattering with deep learning:application to strain mapping from electron diffraction patterns显示文摘A fast,robust pipeline for strain mapping of crystalline materials is important for many technological applications.Scanning electron nanodiffraction allows us to calculate strain maps with high accuracy and spatial resolutions,but this technique is limited when the electron beam undergoes multiple scattering.Deep-learning methods have the potential to invert these complex signals,but require a large number of training examples.We implement a Fourier space,complex-valued deep-neural network,FCU-Net,to invert highly nonlinear electron diffraction patterns into the corresponding quantitative structure factor images.FCU-Net was trained using over 200,000 unique simulated dynamical diffraction patterns from different combinations of crystal structures,orientations,thicknesses,and microscope parameters,which are augmented with experimental artifacts.We evaluated FCU-Net against simulated and experimental datasets,where it substantially outperforms conventional analysis methods.Our code,models,and training library are open-source and may be adapted to different diffraction measurement problems. | Joydeep Munshi Alexander Rakowski Benjamin H.Savitzky Steven E.Zeltmann Jim Ciston Matthew Henderson Shreyas Cholia Andrew M.Minor Maria K.Y.Chan Colin Ophus | 2022 | npj Computational Materials2022，，1： | 2 |
| 4 | Surgical Management of Early-Stage Hepatocellular Carcinoma: Resection or Transplantation?显示文摘 | Emily C. Bellavance Kimberly M. Lumpkins Gilles Mentha Hugo P. Marques Lorenzo Capussotti Carlo Pulitano Pietro Majno Paulo Mira Laura Rubbia-Brandt Alessandro Ferrero Luca Aldrighetti Steven Cunningham Nadia Russolillo Benjamin Philosophe Eduardo Barroso | 2008 | Journal of Gastrointestinal Surgery2008，，10： | 2 |
| 5 | A Laboratory Model to Evaluate Cutout Resistance of Implants for Pertrochanteric Fracture Fixation显示文摘 | Mark B. Sommers Christoph Roth H. Hall Benjamin C. C. Kam Larry W. Ehmke James C. Krieg Steven M. Madey Michael Bottlang | 2004 | Journal of Orthopaedic Trauma2004，，6： | 2 |
| 6 | Macrophage-specific inhibition of the histone demethylase JMJD3 decreases STING and pathologic inflammation in diabetic wound repair显示文摘Macrophage plasticity is critical for normal tissue repair following injury.In pathologic states such as diabetes,macrophage plasticity is impaired,and macrophages remain in a persistent proinflammatory state;however,the reasons for this are unknown.Here,using single-cell RNA sequencing of human diabetic wounds,we identified increased JMJD3 in diabetic wound macrophages,resulting in increased inflammatory gene expression.Mechanistically,we report that in wound healing,JMJD3 directs early macrophage-mediated inflammation via JAK1,3/STAT3 signaling.However,in the diabetic state,we found that IL-6,a cytokine increased in diabetic wound tissue at later time points post-injury,regulates JMJD3 expression in diabetic wound macrophages via the JAK1,3/STAT3 pathway and that this late increase in JMJD3 induces NFκB-mediated inflammatory gene transcription in wound macrophages via an H3K27me3 mechanism.Interestingly,RNA sequencing of wound macrophages isolated from mice with JMJD3-deficient myeloid cells(Jmjd3f/fLyz2Cre+)identified that the STING gene(Tmem173)is regulated by JMJD3 in wound macrophages.STING limits inflammatory cytokine production by wound macrophages during healing.However,in diabetic mice,its role changes to limit wound repair and enhance inflammation.This finding is important since STING is associated with chronic inflammation,and we found STING to be elevated in human and murine diabetic wound macrophages at late time points.Finally,we demonstrate that macrophage-specific,nanoparticle inhibition of JMJD3 in diabetic wounds significantly improves diabetic wound repair by decreasing inflammatory cytokines and STING.Taken together,this work highlights the central role of JMJD3 in tissue repair and identifies cell-specific targeting as a viable therapeutic strategy for nonhealing diabetic wounds. | Christopher O.Audu William J.Melvin Amrita D.Joshi Sonya J.Wolf Jadie Y.Moon Frank M.Davis Emily C.Barrett Kevin D.Mangum Hongping Deng Xianying Xing Rachel Wasikowski Lam C.Tsoi Sriganesh B.Sharma Tyler M.Bauer James Shadiow Matthew A.Corriere Andrea TObi Steven LKunkel Benjamin Levi Bethany BMoore Johann EGudjonsson Andrew MSmith Katherine A.Gallagher | 2022 | Cellular & Molecular Immunology2022，19，11： | 2 |
| 7 | Endothelin-1 activation in pediatric patients undergoing surgical coarctation of the aorta repair显示文摘AIM To determine endothelin-1(ET-1)concentration before and after surgical coarctectomy and evaluate its association with left ventricular geometric change.METHODSA prospective,cohort study of 24 patients aged 2 d to 10years with coarctation of the aorta undergoing surgical repair.A sub-cohort of patients with age<1 mo was classified as'neonates'.Echocardiograms were performed just prior to surgery and in the immediate post-op period to assess left ventricle mass index and relative wall thickness(RWT).Plasma ET-1 levels were assessed at both time points.Association between ET-1 levels and ventricular remodeling was assessed.RESULTSPatients<1 year demonstrated higher pre-op ET-1 than post-op(2.8 pg/m L vs 1.9 pg/m L,P=0.02).Conversely,patients>1 year had no change in ET-1 concentration before and after surgery(1.1 vs 1.4,NS).Pre-op,patients<1 year demonstrated significantly higher ET-1 than older children(2.8 vs 1.1,P=0.001).Post-op there was no difference between the age groups(1.9 vs 1.4,NS).Neither RWT nor left ventricle mass index(LVMI)varied from pre-op to post-op.The subset of neonates showed a strong positive correlation between pre-op ET-1 and RWT(r=0.92,P=0.001).Patients with ET-1>2 pg/m L preop demonstrated higher LVMI(65.7 g/m^(2.7) vs 38.5 g/m^(2.7),P=0.004)and a trend towards higher RWT(45%vs39%,P=0.07)prior to repair than those with lower ET-1concentration.CONCLUSIONET-1 concentration is significantly variable in the perioperative period surrounding coarctectomy.Older children and infants have different responses to surgical repair suggesting different mechanisms of activation. | Benjamin Steven Frank Tracy T Urban Suhong Tong Courtney Cassidy Max B Mitchell Christopher S Nichols Jesse A Davidson | 2017 | World Journal of Cardiology2017，9，12： | 2 |
| 8 | Compression anastomosis: history and clinical considerations显示文摘 | Orit Kaidar-Person Raul J. Rosenthal Steven D. Wexner Samuel Szomstein Benjamin Person | 2008 | The American Journal of Surgery2008，，6： | 2 |
| 9 | Nephrectomy Induced Chronic Renal Insufficiency is Associated With Increased Risk of Cardiovascular Death and Death From Any Cause in Patients With Localized cT1b Renal Masses显示文摘 | Christopher J. Weight Benjamin T. Larson Amr F. Fergany Tianming Gao Brian R. Lane Steven C. Campbell Jihad H. Kaouk Eric A. Klein Andrew C. Novick | 2010 | The Journal of Urology2010，，： | 2 |
| 10 | Partial Nephrectomy Is Associated with Improved Overall Survival Compared to Radical Nephrectomy in Patients with Unanticipated Benign Renal Tumours 显示文摘 | Christopher J. Weight Gregory Lieser Benjamin T. Larson Tianming Gao Brian R. Lane Steven C. Campbell Inderbir S. Gill Andrew C. Novick Amr F. Fergany | 2010 | European Urology2010，，2： | 1 |
| 11 | Acceleration of the discrete element method (DEM) on a reconfigurable co-processor 显示文摘 | BENJAMIN C S STEVEN F Q ANDREW H C C | 2004 | Computers and Structures2004，82，2021： | 1 |
| 12 | Genetic Alterations Associated With Progression From Pancreatic Intraepithelial Neoplasia to Invasive Pancreatic Tumor显示文摘 | Stephen J. Murphy Steven N. Hart Joema Felipe Lima Benjamin R. Kipp Mitchell Klebig Jennifer L. Winters Csilla Szabo Lizhi Zhang Bruce W. Eckloff Gloria M. Petersen Steven E. Scherer Richard A. Gibbs Robert R. McWilliams George Vasmatzis Fergus J. Couch | 2013 | Gastroenterology2013，，5： | 1 |
| 13 | Heart rate and behavior are regulated independently of corticosterone following diverse acute stressors显示文摘 | Benjamin C Nephew Steven A Kahn L Michael Romero | 2003 | General and Comparative Endocrinology2003，133，2： | 1 |
| 14 | Fatigue Risk Management in the Workplace显示文摘 | Steven E. Lerman Evamaria Eskin David J. Flower Eugenia C. George Benjamin Gerson Natalie Hartenbaum Steven R. Hursh Martin Moore-Ede | 2012 | Journal of Occupational and Environmental Medicine2012，，2： | 1 |
| 15 | Do medical students respond empathetically to a virtual patient?显示文摘 | Adeline M. Deladisma Marc Cohen Amy Stevens Peggy Wagner Benjamin Lok Thomas Bernard Christopher Oxendine Lori Schumacher Kyle Johnsen Robert Dickerson Andrew Raij Rebecca Wells Margaret Duerson J. Garrett Harper D. Scott Lind | 2007 | The American Journal of Surgery2007，，6： | 1 |
| 16 | Paclitaxel Stent Coating Inhibits Neointimal Hyperplasia at 4 Weeks in a Porcine Model of Coronary Restenosis显示文摘 | Alan W. Heldman Linda Cheng G. Mark Jenkins Phillip F. Heller Dong-Woon Kim Melvin Ware Cynthia Nater Ralph H. Hruban Banafsheh Rezai Benjamin S. Abella Katherine E. Bunge James L. Kinsella Steven J. Sollott Edward G. Lakatta Jeffrey A. Brinker William L. | 2001 | Circulation: Journal of the American Heart Association2001，，： | 1 |
| 17 | Postoperative day 1 serum human chorionic gonadotropin level as a predictor of persistent ectopic pregnancy after conservative surgical management显示文摘 | Steven D. Spandorfer Stephen W. Sawin Ivor Benjamin Kurt T. Barnhart | 1997 | Fertility and Sterility1997，，3： | 1 |
| 18 | The role of the circadian system in fractal neurophysiological control显示文摘 | Benjamin R. Pittman‐Polletta Frank A. J. L. Scheer Matthew P. Butler Steven A. Shea Kun Hu | 2013 | Biol Rev2013，，4： | 1 |
| 19 | Empirical study to investigate the range of force feedback necessary for best operator performance in a haptic controlled excavator interface 显示文摘 | Osafo-Yeboah Benjamin Jiang Steven Delpish Ritson | 2013 | International Journal of Industrial Ergonomics2013，43，3： | 1 |
| 20 | Circulating Tumor Cells in Colorectal Cancer: Past, Present, and Future Challenges显示文摘 | Benjamin P. Negin Steven J. Cohen | 2010 | Current Treatment Options in Oncology2010，，： | 1 |
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