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| 1 | Capecitabine and irinotecan with and without bevacizumab for advanced colorectal cancer patients显示文摘AIM:To investigate the efficacy and safety of capecitabine plus irinotecan±bevacizumab in advanced or metastatic colorectal cancer patients. METHODS:Forty six patients with previously untreated,locally-advanced or metastatic colorectal cancer(mCRC) were recruited between 2001-2006 in a prospective open-label phaseⅡtrial,in German community-based outpatient clinics.Patients received a standard capecitabine plus irinotecan(CAPIRI) or CAPIRI plus bevacizumab(CAPIRI-BEV) regimen every 3 wk. Dose reductions were mandatory from the first cycle in cases of>grade 2 toxicity.The treatment choice of bevacizumab was at the discretion of the physician.Theprimary endpoints were response and toxicity and secondary endpoints included progression-free survival and overall survival. RESULTS:In the CAPIRI group vs the CAPRI-Bev group there were more female than male patients(47% vs 24%) ,and more patients had colon as the primary tumor site(58.8%vs 48.2%) with fewer patients having sigmoid colon as primary tumor site(5.9%vs 20.7%) .Grade 3/4 toxicity was higher with CAPIRI than CAPIRI-Bev:82%vs 58.6%.Partial response rates were 29.4%and 34.5%,and tumor control rates were 70.6%and 75.9%,respectively.No complete responses were observed.The median progression-free survival was 11.4 mo and 12.8 mo for CAPIRI and CAPIRI-Bev,respectively.The median overall survival for CAPIRI was 15 mo(458 d) and for CAPIRI-Bev 24 mo(733 d) .These differences were not statistically different.In the CAPIRI-Bev,group,two patients underwent a full secondary tumor resection after treatment,whereas in the CAPIRI group no cases underwent this procedure. CONCLUSION:Both regimens were well tolerated and offered effective tumor growth control in this outpatient setting.Severe gastrointestinal toxicities and thromboembolic events were rare and if observed were never fatal. | Markus Moehler Martin F Sprinzl Murad Abdelfattah Carl C Schimanski Bernd Adami Werner Godderz Klaus Majer Dimitri Flieger Andreas Teufel Juergen Siebler Thomas Hoehler Peter R Galle Stephan Kanzler | 2009 | World Journal of Gastroenterology2009，15，4： | 10 |
| 2 | Quantification of Obstructive and Nonobstructive Coronary Lesions by 64-Slice Computed Tomography显示文摘 | Alexander W. Leber Andreas Knez Franz von Ziegler Alexander Becker Konstantin Nikolaou Stephan Paul Bernd Wintersperger Maximilian Reiser Christoph R. Becker Gerhard Steinbeck Peter Boekstegers | 2005 | Journal of the American College of Cardiology2005，，1： | 4 |
| 3 | Contrast-enhanced coronary artery visualization by dual-source computed tomography—Initial experience显示文摘 | Stephan Achenbach Dieter Ropers Axel Kuettner Thomas Flohr Bernd Ohnesorge Herbert Bruder Heike Theessen Meri Karakaya Werner G. Daniel Werner Bautz Willi A. Kalender Katharina Anders | 2005 | European Journal of Radiology2005，，3： | 3 |
| 4 | Quantification of Obstructive and Nonobstructive Coronary Lesions by 64-Slice Computed Tomography显示文摘 | Alexander W. Leber Andreas Knez Franz von Ziegler Alexander Becker Konstantin Nikolaou Stephan Paul Bernd Wintersperger Maximilian Reiser Christoph R. Becker Gerhard Steinbeck Peter Boekstegers | 2005 | Journal of the American College of Cardiology2005，，1： | 2 |
| 5 | Detection of Coronary Artery Stenoses With Thin-Slice Multi-Detector Row Spiral Computed Tomography and Multiplanar Reconstruction显示文摘 | Dieter Ropers Ulrich Baum Karsten Pohle Katharina Anders Stefan Ulzheimer Bernd Ohnesorge Christian Schlundt Werner Bautz Werner G. Daniel Stephan Achenbach | 2003 | Circulation: Journal of the American Heart Association2003，，5： | 2 |
| 6 | Cognitive dysfunction in schizophrenia: comparison of treatment with atypical antipsychotic agents and conventional neuroleptic drugs显示文摘 | Bernd Gallhofer Ulrike Bauer Steffanie Lis Stephan Krieger Harald Gruppe | 1996 | European Neuropsychopharmacology1996，，： | 1 |
| 7 | Intraspecific polymorphisms of Eimeria species due to resistance against anticoccidial drugs显示文摘 | Bernd Stephan Axel Haberkorn | 1996 | Parasitology Research1996，82，8： | 1 |
| 8 | Oral budesonide therapy improves quality of life in patients with collagenous colitis显示文摘 | Ahmed Madisch Peter Heymer Claudia Voss Bernd Wigginghaus Elke B?stlein Ekkehard Bayerd?rffer Eberhard Meier Wolfgang Schimming Birgit Bethke Manfred Stolte Stephan Miehlke | 2005 | International Journal of Colorectal Disease2005，，4： | 1 |
| 9 | Hedge fund return sensitivity to global liquidity显示文摘 | Stephan Kessler Bernd Scherer | 2010 | Journal of Financial Markets2010，，2： | 1 |
| 10 | SPECT/CT*显示文摘 | Buck Andreas K Nekolla Stephan Ziegler Sibylle Beer Ambros Krause Bernd J Herrmann Ken Scheidhauer Klemens Wester Hans-Juergen Rummeny Ernst J Schwaiger Markus Drzezga Alexander | 2008 | The Journal of Nuclear Medicine2008，，： | 1 |
| 11 | Boswellia serrata extract for the treatment of collagenous colitis. A double-blind, randomized, placebo-controlled, multicenter trial显示文摘 | Ahmed Madisch Stephan Miehlke Otto Eichele Jenny Mrwa Birgit Bethke Eberhard Kuhlisch Elke B?stlein Georg Wilhelms Andrea Morgner Bernd Wigginghaus Manfred Stolte | 2007 | International Journal of Colorectal Disease2007，，12： | 1 |
| 12 | Endothelial Dysfunction Is Detectable in Young Normotensive First-Degree Relatives of Subjects With Type 2 Diabetes in Association With Insulin Resistance显示文摘 | Bernd M. Balletshofer Kilian Rittig Markus D. Enderle Anette Volk Elke Maerker Stephan Jacob Stephan Matthaei Kristian Rett Hans U. H?ring | 2000 | Circulation: Journal of the American Heart Association2000，，15： | 1 |
| 13 | Common mutations of β-catenin in adamantinomatous craniopharyngiomas but not in other tumours originating from the sellar region显示文摘 | Rolf Buslei Michael Nolde Bernd Hofmann Stephan Meissner Ilker Y. Eyupoglu Florian Siebzehnrübl Eric Hahnen Jürgen Kreutzer Rudolf Fahlbusch | 2005 | Acta Neuropathologica2005，，： | 1 |
| 14 | Detection of Coronary Artery Stenoses With Thin-Slice Multi-Detector Row Spiral Computed Tomography and Multiplanar Reconstruction显示文摘 | Dieter Ropers Ulrich Baum Karsten Pohle Katharina Anders Stefan Ulzheimer Bernd Ohnesorge Christian Schlundt Werner Bautz Werner G. Daniel Stephan Achenbach | 2003 | Circulation: Journal of the American Heart Association2003，，5： | 1 |
| 15 | Patienten mit Diabetes mellitus: psychosoziale Belastung und Inanspruchnahme von psychosozialen Angeboten Eine multizentrische Studie显示文摘 | Stephan Herpertz Bernd Johann Kerstin Lichtblau Margareta Stadtb?umer Margit Kocnar Renate Kr?mer-Paust Rainer Paust Horst Heinemann Wolfgang Senf | 2000 | Medizinische Klinik2000，，7： | 1 |
| 16 | PTEN loss defines a PI3K/AKT pathway-dependent germinal center subtype of diffuse large B-cell lymphoma显示文摘 | Matthias Pfeifer Michael Grau Dido Lenze S?ren-Sebastian Wenzel Annette Wolf Brigitte Wollert-Wulf Kerstin Dietze Hendrik Nogai Benjamin Storek Hannelore Madle Bernd D?rken Martin Janz Stephan Dirnhofer Peter Lenz Michael Hummel Alexandar Tzankov Georg Le | 2013 | Proceedings of the National Academy of Sciences2013，，30： | 1 |
| 17 | Dual Source CT Coronary Angiography in Severely Obese Patients: Trading Off Temporal Resolution and Image Noise显示文摘 | Sebastian Leschka Bjoern Stinn Florian Schmid Bernd Schultes Martin Thurnheer Stephan Baumueller Paul Stolzmann Hans Scheffel Thomas G. Flohr Simon Wildermuth Hatem Alkadhi | 2009 | Investigative Radiology2009，，11： | 1 |
| 18 | Boswellia serrata extract for the treatment of collagenous colitis. A double-blind, randomized, placebo-controlled, multicenter trial显示文摘 | Ahmed Madisch Stephan Miehlke Otto Eichele Jenny Mrwa Birgit Bethke Eberhard Kuhlisch Elke B?stlein Georg Wilhelms Andrea Morgner Bernd Wigginghaus Manfred Stolte | 2007 | International Journal of Colorectal Disease2007，，12： | 1 |
| 19 | IL-4/IL-13 pathway genetics strongly influence serum IgE levels and childhood asthma显示文摘 | Michael Kabesch Michaela Schedel David Carr Bernd Woitsch Christian Fritzsch Stephan K. Weiland Erika von Mutius | 2006 | The Journal of Allergy and Clinical Immunology2006，，2： | 1 |
| 20 | An end-member algorithm for deciphering modern detrital processes from lake sediments of Lake Donggi Cona, NE Tibetan Plateau, China显示文摘 | Elisabeth Dietze Kai Hartmann Bernhard Diekmann Janneke IJmker Frank Lehmkuhl Stephan Opitz Georg Stauch Bernd Wünnemann Andreas Borchers | 2011 | Sedimentary Geology2011，，： | 1 |
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