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| 1 | Chemotherapy-induced intestinal inflammatory responses are mediated by exosome secretion of double-strand DNA via AIM2 inflammasome activation显示文摘化疗经常被知道导致严重的胃肠的道毒性,但是内在的机制仍然保持不清楚。这研究作为一个代表性的代理人认为广泛地应用的细胞毒素的代理人是 irinotecan (CPT-11 ) 并且证明治疗从说明混合物的限制剂量的肠的毒性的肠导致双海滨 DNA 的巨大的版本。明确地,通过 exosome 分泌物释放的 self-DNA 进入天生的有免疫力的房间的 cytosol 并且激活 AIM2 (在黑瘤 2 不在) inflammasome。这导致成熟 IL-1 和 IL-18 分泌物并且导致肠的 mucositis 和迟了发作的腹泻。有趣地,在 AIM2 缺乏的老鼠或由象镇静药那样的一个药理学禁止者,没有影响 CPT-11 的 anticancer 功效, AIM2 发信号的废除显著地减少导致药的腹泻的发生。这些调查结果提供化疗怎么触发引起肠的毒性的天生的有免疫力的回答的机械学的卓见,并且揭示维持反瘤效果,但是围绕联系不利煽动性的反应的新化疗政体。 | Lian, Qiaoshi Xu, Jun Yan, Shanshan Huang, Min Ding, Honghua Sun, Xiaoyu Bi, Aiwei Ding, Jian Sun, Bing Geng, Meiyu | 2017 | Cell Research2017，27，6： | 18 |
| 2 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 3 | A Review of Comminution Age Method and Its Potential Application in the East China Sea to Constrain the Time Scale of Sediment Source-to-Sink Process显示文摘The East China Sea(ECS) is a river-dominated epicontinental sea, linking the Asian continent to the northwestern Pacific via the large rivers originating from Tibetan Plateau. The relevant huge influx of riverine detritus has developed unique sedimentary systems in the ECS during the Quaternary, offering ideal terrestrial archives for reconstructing Quaternary paleoenvironmental changes and studying land-sea interactions. Overall, two characteristic river systems dominate the sedimentary systems and sediment source to sink transport patterns in the ECS, represented by the Changjiang(Yangtze River) and Huanghe(Yellow River) for the large river system and Taiwan rivers for the small river system. Given this, the sediments derived from both river systems bear distinct features in terms of parent rock lithology, provenance weathering and sediment transport. Previous studies mostly focus on either the ‘source' discrimination or the ‘sink' records of the sedimentary system in the ECS, while the source to sink process linking the land and sea, in particular its time scale, has been poorly understood. Here we introduce a newly-developed dating technique, the ‘comminution age' method, which offers a quantitative constraint on the time scale of sediment transfer from its ultimate source to the final depositional sink. This novel method is of great significance for improving our understanding on the earth surface processes including tectonic-climate driven weathering, and sediment recycling in relation to landscape evolution and marine environmental changes. The application of comminution age method in the ECS will provide important constraints on sediment source-to-sink process and more evidences for the construction of late Quaternary paleoenvironmental changes under these unique sedimentary systems. | LI Chao YANG Shouye LIAN Ergang BI Lei ZHANG Zhaofeng | 2015 | Journal of Ocean University of China2015，14，3： | 4 |
| 4 | Strain-hardening and warm deformation behaviors of extruded Mg-Sn-Yb alloy sheet显示文摘Strain-hardening and warm deformation behaviors of extruded Mg-2Sn-0.5Yb alloy(at.%)sheet were investigated in uniaxial tensile test at temperatures of 25-250 ℃ and strain rates of 1×10^(−3) s^(−1)-0.1 s^(−1).The data fit with the Kocks-Mecking type plots were used to show different stages of strain hardening.Besides III-stage and IV-stage,the absence of the II-stage strain hardening at room temperature should be related to the sufficient dynamic recrystallization during extrusion.The decrease of strain hardening ability of the alloy after yielding was attributed to the reduction of dislocation density with increasing testing temperature.Strain rate sensitivity(SRS)was significantly enhanced with increasing temperature,and the corresponding m-value was calculated as 0.07-0.12,which indicated that the deformation mechanism was dominated by the climb-controlled dislocation creep at 200 ℃.Furthermore,the grain boundary sliding(GBS)was activated at 250 ℃,which contributed to the higher SRS.The activation energy was calculated as 213.67 kJ mol^(−1),which was higher than that of lattice diffusion or grain boundary self-diffusion.In addition,the alloy exhibited a quasi superplasticity at 250 ℃ with a strain rate of 1×10^(−3) s^(−1),which was mainly related to the fine microstructure and the presence of the Mg2Sn and Mg2(Sn,Yb)particles. | Jing Jiang Guangli Bi Guoyong Wang Qing Jiang Jianshe Lian Zhonghao Jiang | 2014 | Journal of Magnesium and Alloys2014，2，2： | 3 |
| 5 | Double-peak ageing behavior of Mg–2Dy–0.5Zn alloy显示文摘 | Guangli Bi Daqing Fang Lei Zhao Qingxin Zhang Jianshe Lian Qing Jiang Zhonghao Jiang | 2011 | Journal of Alloys and Compounds2011，，32： | 2 |
| 6 | Effect of 1,25-Dihydroxyvitamin D_3 on Regulatory T Cells in Ovariectomized Mice显示文摘Objective To investigate the correlation between regulatory T(Treg) cells and postmenopausal osteoporosis and the antiosteoporotic effect of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] in relation to Treg cells. Methods Fifty female BALB/c mice were randomly divided into five groups: the basal control(BAS), Sham, ovariectomy(OVX), OVX+diethylstilbestrol(OVX+DES), and OVX+1,25(OH)2D3. Tibias were harvested and processed with decalcification for quantitative bone histomorphometry. Femurs were stained by immunohistochemistry to detect Foxp3 protein expression. Spleens were used to detect Treg and Foxp3 gene expression by flow cytometry and quantitative RT-PCR, respectively. Results In comparison with the Sham group, a significant decrease was found in the OVX group in such indices as trabecular bone volume/total tissue area(BV/TV), trabecular number(Tb.N) and trabecular thickness(Tb.Th). 1,25(OH)2D3 and DES partly prevented the decrease in BV/TV, Tb.N, Tb.Th in OVX mice. Treg cell number, Foxp3 mRNA expression in spleen and Foxp3 protein expression in femur significantly decreased in the OVX-treated group compared with those in the sham group. 1,25(OH)2D3 and DES significantly increased Treg cell number and Foxp3 expression. Treg cells and Foxp3 gene expression were related to bone histomorphometric parameters. Conclusion The decrease in Treg cell numbers is relevant to the postmenopausal osteoporosis. The antiosteoporosis of 1,25(OH)2D3 is related to regulatory T cells. | LIU Jun Chen ZHOU Chen Hui ZHANG Xue CHEN Yan XU Bi Lian CUI Liao XU Dao Hua | 2014 | Biomedical and Environmental Sciences2014，27，10： | 2 |
| 7 | Microstructures and mechanical properties of extruded Mg-2Sn-xYb(x=0,0.1,0.5 at.%)sheets显示文摘Microstructures and mechanical properties of extruded Mg-2Sn-xYb(x=0,0.1,0.5 at.%)sheets were investigated.The grain size of as-cast Mg-2Sn alloy is significantly reduced with increasing Yb concentration.In addition toα-Mg and Mg_(2)Sn phase,some fine Mg_(2)(Sn,Yb)particles are observed in as-cast Mg-2Sn-0.5Yb alloy,but these fine particles are not observed in as-cast Mg-2Sn-0.1Yb alloy due to a high solubility of Yb in Mg matrix.Tensile tests demonstrated that extruded Mg-2Sn-0.5Yb sheet exhibited the highest tensile strength and available elongation to failure at room temperature,while extruded Mg-2Sn-0.1Yb alloy exhibited the highest tensile properties at 100°C and 200°C.The difference in the tensile properties of extruded sheets mainly arises from the different strengthening roles of grain refinement,solid solution strengthening and precipitation strengthening of particles. | Jing Jiang Guangli Bi Jiaan Liu ChunChun Ye Jianshe Lian Zhonghao Jiang | 2014 | Journal of Magnesium and Alloys2014，2，3： | 2 |
| 8 | Separation theory of the incident and scattered sound fields in spherical coordinate显示文摘By the spherical wave spectrum transform,the sound pressures on the two spherical surfaces surrounding the scattering objects with arbitrarily-shaped sur-faces are decomposed into spherical wave components that propagate in a known manner,the relationships between the spherical wave components of the same order on the two spherical surfaces are established by the wave field extrapolation theorem,and the formula of the separation theory in the spherical coordinate is established in the wave-number domain. After separating the scattered pressure,the total scattered field can be obtained by holographic reconstruction and predic-tion. In order to overcome the instability of acoustic inverse problem,a new wave-number domain filter technique is proposed. It is proved that,as long as the two holographic spherical surfaces are taken to be close enough,the singularity of the separation formula can be avoided. The results of numerical simulation dem-onstrate the feasibility and validity of the separation theory. | LI WeiBing LIAN MeiZhuan BI ChuanXing CHEN Jian CHEN XinZhao | 2007 | Science China(Technological Sciences)2007，50，3： | 2 |
| 9 | Mechanisms of lumbroki-nase in protection of cerebral ischemia显示文摘 | Hong Ruiji Lian Wang Hui Bi | 2008 | Eur J Pharmacology2008，590，13： | 1 |
| 10 | Optical Imaging of Surface-Immobilized Oligonucleotide Probes on DNA Microarrays Using Liquid Crystals显示文摘 | Siok Lian Lai Shisheng Huang Xinyan Bi | 2009 | Langmuir2009，25，1： | 1 |
| 11 | An elevated temperature Mg-Dy-Zn alloy with long period stacking ordered phase by extrusion 显示文摘 | BI G L FANG D Q ZHAO L LIAN J S JIANG Q JIANG Z H | 2011 | Materials Science and Engineering A2011，528，： | 1 |
| 12 | Mechanisms of lumbrokinase in protection of cerebral ischemia显示文摘 | Hongrui Ji Lian Wang Hui Bi Lihua Sun Benzhi Cai Yuping Wang Jinlong Zhao Zhimin Du | 2008 | European Journal of Pharmacology2008，，1： | 1 |
| 13 | Direct deter- mination of aluminum in drinking and natural waters as 8-hydroxyquinoline chelate by RP HPLC显示文摘 | Lian Hong-zhen Bi Shu-ping Chen Yi-jun | 2001 | Journal of Liq uid Chromatography Related Technologies2001，24，21： | 1 |
| 14 | Morin applied in speciation of aluminum in natural waters and biological samples by reversed-phase high-performance liquid chromatography with fluorescence detection显示文摘 | LIAN H Z KANG Y F BI S P | 2003 | Analytical Bioanalytical Chemistry2003，376，： | 1 |
| 15 | An elevated temperature Mg–Dy–Zn alloy with long period stacking ordered phase by extrusion显示文摘 | Guangli Bi Daqing Fang Lei Zhao Jianshe Lian Qing Jiang Zhonghao Jiang | 2011 | Materials Science & Engineering A2011，，10： | 1 |
| 16 | Spatial Distribution Pattern of the Steppe Toad-headed Lizard(Phrynocephalus frontalis) and Its Influencing Factors显示文摘Spatial distribution patterns are associated with life history and behavioral adaptations of animals. For studying the spatial distribution pattern of the steppe toad-headed lizard(Phrynocephalus frontalis) and its influencing factors,we conducted experiments in Hunshandake Sandy Land in Inner Mongolia,China in July 2009. By calculating the clustered indices,we found that the lizard was aggregately distributed when the sampling quadrat was smaller than 10 m × 10 m,and uniformly distributed when it was greater than 10 m × 10 m. The Nearest Neighbor Rule showed a clustering distribution pattern for P. frontalis and the distribution pattern was quadrat-sampling dependent. Furthermore,the cluster was determined by environmental factors when the sampling quadrat was smaller than 20 m × 20 m,but it was determined by both environmental factors and characteristics of the lizard when it was larger than 20 m × 20 m. Our results suggested that the steppe toad-headed lizards tended to aggregate into suitable habitat patches in desert areas. Additionally,we discussed that the lizard aggregation could be potentially used as an indictor of movement of sand dunes. | Xue LIAN Zhigang JIANG Xiaoge PING Songhua TANG Junhuai BI Chunwang LI | 2012 | Asian Herpetological Research2012，3，1： | 1 |
| 17 | The phased chromosome-scale genome of yellowhorn sheds light on the mechanism of petal color change显示文摘Yellowhorn(Xanthoceras sorbifolium), especially its varieties, is the red petal yellowhorn(X. sorbifolium var. purpurea), an important tree species with great ornamental value, and its flower petals change color throughout the flowering period. In this study, we mainly focused on the mechanism of the petal color change with transcriptomics and metabolomics data. A phased chromosome-scale assembly of the red petal yellowhorn genome was generated using the PacBio high-fidelity reads, Illumina short reads, and Phase genomics Proximo Hi-C data. The final de novo assembly yielded 533.67 Mb with a contig N50 of 5.42 Mb, and 27 501 protein-coding genes were predicted. Notably, an alternate haplotig assembly was also obtained. Furthermore, a variation database for the alleles within the genome was constructed. Subsequently, the expression pattern of flower pigmentation-related genes and allelic expression imbalance events were investigated. Apart from 6 genes involved in the anthocyanin biosynthesis pathway regulated by the activation of 15 MYB-bHLH-WD40s, the increased expression of senescencerelated gene 1(SRG1) and 2-oxoglutarate-dependent dioxygenase(DIOX5) might also result in decreasing content of lutein and increasing abundance of(E/Z)-phytoene, cyanidin-3-O-rutinoside, and cyanidin-3-O-sambubioside. These changes in genes and metabolites were most likely related to the petal color change in red petal yellowhorn. This phased chromosome-scale genome assembly provides more accurate genomic information for future molecular breeding and facilitates allele function studies of the red petal yellowhorn. | Quanxin Bi Mengke Wang Jiang Li Jinmin Lian Yongchao Niu Yifan Cui Xiaojuan Liu Haiyan Yu Libing Wang | 2023 | Horticultural Plant Journal2023，9，6： | 0 |
| 18 | A 5′tRNA-Ala-derived small RNA regulates anti-fungal defense in plants显示文摘Apart from their primordial role in protein synthesis,t RNAs can be cleaved to produce t RNA-derived small RNAs(ts RNAs).The biological functions of ts RNAs in plants remain largely unknown.In this study,we developed Rtc B ligation-based small RNA(s RNA)sequencing,a method that captures and distinguishes between 3′-2′,3′-cyclic-phosphate(c P)/phosphate(P)-terminated s RNAs and 3′-OH-terminated s RNAs,and profiled 5′ts RNAs and 5′t RNA halves in Arabidopsis thaliana.We found that Arabidopsis 5′ts RNAs and 5′t RNA halves predominantly contain a c P at the 3′end and require S-like RNase 1(RNS1)and RNS3 for their production.One of the most abundant 5′ts RNAs,5′ts R-Ala,by associating with AGO1,negatively regulates Cytochrome P45071 A13(CYP71 A13)expression and camalexin biosynthesis to repress anti-fungal defense.Interestingly,5′ts R-Ala is downregulated upon fungal infection.Our study provides a global view of 5′ts RNAs and 5′t RNA halves in Arabidopsis and unravels an important role of a 5′ts RNA in regulating anti-fungal defense. | Hanqing Gu Bi Lian Yuxiang Yuan Ci Kong Yan Li Chang Liu Yijun Qi | 2022 | Science China(Life Sciences)2022，65，1： | 0 |
| 19 | 不依赖于Dicer的新型siRNA介导拟南芥DNA甲基化显示文摘DNA甲基化在转座子沉默和基因表达调控等方面有重要作用。普遍认为,在植物中,从头建立DNA甲基化由一类Dicer-like3(DCL3)加工生成的长siRNA所介导。 | Ruiqiang Ye Zulong Chen Bi Lian M.Jordan Rowley Ning Xia Jijie Chai Yan Li Xin-Jian He Andrzej T.Wierzbicki 戚益军 | 2017 | 科学新闻2017，19，4： | 0 |
| 20 | Diet, Food Intake of Phrynocephalus frontalis (Agamidae) and Its Potential Role in Desert Habitat显示文摘We examined the dietary diversity and food intake of Phrynocephalus frontalis, compared the difference of insect diversity in the natural habitats with different lizard densities, and discussed the potential role of this lizard in the desert ecosystem. The results show that:(1) arthropodans of the orders Coleoptera, Hymenoptera and Hemiptera were major dietary components of P. frontalis;(2) coleoptera larvae always formed the predominant component of lizard diets;(3) dietary diversities of P. frontalis were not significantly different between summer and autumn or between the two sexes;(4) the similarity in trophic niches between seasons was 0.756, whereas the similarity in trophic niches between sexes was 0.994;(5) stomach content weight of lizards varied significantly among different seasons, but there was no significant difference in stomach content weight between sexes;(6) insect diversity differed significantly among the groups of the habitat with different degrees of lizard density, and the habitat with moderate lizards density had the highest insect diversity. We infer that P. frontalis prey mainly on insects and change their diet and food intake with season; males and females consumed similar preys in types and weights. As an important predator, P. frontalis could affect the insect community in the arid ecosystem of Hunshandak Desert on the Mongolian Plateau. | Chunwang LI Xue LIAN Songhua TANG Junhuai BI Zhigang JIANG | 2013 | Asian Herpetological Research2013，4，4： | 0 |
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