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| 1 | Influence of N on precipitation behavior,associated corrosion and mechanical properties of super austenitic stainless steel S32654显示文摘The influence of N on the precipitation behavior,associated corrosion,and mechanical properties of S32654 were investigated by microstructural,electrochemical,and mechanical analyses.Increasing the N content results in several alterations:(1) grain refinement,which promotes intergranular precipitation;(2) a linear increase in the driving force for Cr2 N and Mo activity,which accelerates the precipitation of intergranular Cr2 N and π phase,respectively;(3) a linear decrease in the driving force for σ phase and Cr activity,which suppresses the formation of intragranular σ phase.The total amount of precipitates first decreased and then increased with the N content increasing.Furthermore,the intergranular corrosion susceptibility depended substantially on the total amount of precipitates and also first exhibited a decreasing and then an increasing trend as the N content increased.In addition,aging precipitation caused a considerable decrement in the ultimate tensile strength(UTS) and a remarkable increment in the yield strength(YS).Both the UTS and YS always increased with N content increasing throughout the solution and aging process.Whereas the elongation was considerably sensitive to the aging treatment,it exhibited marginal variation with the N content increasing. | Shucai Zhang Huabing Li Zhouhua Jiang Zhixing Li Jingxi Wu Binbin Zhang Fei Duan Hao Feng Hongchun Zhu | 2020 | Journal of Materials Science & Technology2020，42，7： | 10 |
| 2 | Pollution characteristics and ecological risk of polycyclic aromatic hydrocarbons (PAHs) in surface sediments of the southern part of the Haihe River system in China显示文摘The southern part of the Haihe River system, the largest river system in the Haihe River Basin, is important to maintain a healthy ecosystem and safe drinking water as well as for the economic development of China. To assess the effect of rapid industrialization and urbanization on the pattern of polycyclic aromatic hydrocarbon (PAH) contamination, the PAH pollution characteristics of the southern part of the Haihe River system was investigated. Sixteen PAHs in surface sediments samples collected from 24 sites covering the southern part of the Haihe River system from the upstream to the estuaries were detected and analyzed. The total PAH concentration ranged from 258.77 to 11296.66 ng/g dry weight. On average, 2-, 3-, 4-, 5and 6-ring PAHs comprised 25.32%, 27.22%, 22.62%, 14.89% and 9.96% of the total PAHs, respectively. Sites with high concentrations were concentrated in the Fuhe River, Fuyang River and Wei River, which are located near cities. A risk quotient (RQ) was used to assess the ecological risk of PAHs. The mean values of the RQ(MPCs) of individual PAHs were lower than 1.00, except for those of naphthalene (2.00) and pyrene (1.67). The RQPAHs calculated for the samples indicated that the Xidayang reservoir and the estuary of the Ziya River were determined to be at a low risk level, while Baoding City, Handan City and Aixinzhuang were determined to be at a high risk level. | LIU Feng LIU JingLing CHEN QiuYing WANG BinBin CAO ZhiGuo | 2013 | Chinese Science Bulletin2013，58，27： | 9 |
| 3 | Effect of nitrogen on corrosion behaviour of a novel high nitrogen medium-entropy alloy CrCoNiN manufactured by pressurized metallurgy显示文摘A novel high nitrogen medium-entropy alloy CrCoNiN, which had higher strength and slightly lower ductility than CrCoNi alloy, was successfully manufactured by pressurized metallurgy. The microstructure and corrosion behaviour were investigated by microscopic, electrochemical and spectroscopic methods.The results indicated that nitrogen existed in the form of Cr_2N precipitates and uniformly distributed N atoms, and nitrogen alloying significantly refined the grain size. Besides, nitrogen enriched on the outmost surface of passive film and metal/film interface as ammonia(NH-_3 and NH_4^+) and CrN, respectively. The significant improvement of corrosion resistance of CrCoNiN was attributed to the lower metastable pitting susceptibility together with thicker, less defective and more compact passive film. | Hao Feng Huabing Li Xiaolei Wu Zhouhua Jiang Si Zhao Tao Zhang Dake Xu Shucai Zhang Hongchun Zhu Binbin Zhang Muxin Yang | 2018 | Journal of Materials Science & Technology2018，34，10： | 8 |
| 4 | MicroRNA-638 inhibits cell proliferation by targeting phospholipase D1 in human gastric carcinoma显示文摘MicroRNAs (miRNAs ) 是经常是玩的小非编码的 RNA 的一种类型在 carcinogenesis 的重要角色,而是 miRNAs 的 carcinogenic 机制仍然是不清楚的。这研究将在癌(GC ) 调查功能和 miR-638 的机制。在 GC 和 miR-638 的 DNA 拷贝数字的 miR-638 的表示被即时 PCR 检测。房间增长上的 miR-638 的效果被数 kit-8 试金测量。不同试金,包括生物信息学算法(TargetScan 并且人权保护) ,酶报告试金并且西方的弄污,被用来在 GC 识别 miR-638 的目标基因。在临床的 CRC 纸巾的 miR-638 目标基因的表示被 immunohistochemical 试金也验证。从这研究,我们发现 miR-638 与相应 noncancerous 纸巾(NCT ) 相比是在 GC 纸巾的 downregulated,并且 miR-638 的 DNA 拷贝数字比 NCT 在 GC 是更低的,它可以在 GC 导致 miR-638 的相应 downregulation。miR-638 的宫外的表示在 vitro 禁止了 GC 细胞生长。随后,我们鉴别 PLD1 是在 GC,和 silencing PLD1 表示 phenocopied 的 miR-638 的目标基因 GC 房间增长上的 miR-638 的禁止的效果。而且,我们观察到 PLD1 是在在预言的 GC 的 PLD1 的 GC 纸巾,和高表示的 overexpressed 差的全面幸存。在摘要,我们表明 miR-638 通过禁止 PLD1 在 GC 作为肿瘤 suppressor 工作。 | Jiwei Zhang Zehua Bian Jialiang Zhou Mingxu Song Zhihui Liu Yuyang Feng Li Zhe Binbin Zhang Yuan Yin Zhaohui Huang | 2015 | Protein & Cell2015，6，9： | 8 |
| 5 | Ce-modified AlZr pillared clays supported-transition metals for catalytic combustion of chlorobenzene显示文摘In this article, we provided a one-step hydrothermal method to prepare composite AlZr pillaring agents,and synthesized AlZr-pillared clays(AlZr-PILC) via ion exchange. Compared with conventional methods,our method successfully shortened synthetic routes and greatly reduced consumption of the materials.Then, AlZr-PILC-supported manganese and cerium oxide catalysts were obtained by impregnation method. The compositions and properties of these catalysts were characterized by some technical means.The energy dispersive X-ray spectroscopy clearly shows the existence of Mn, Ce, and O, which indicates the successful loading of the active components on the surface of AlZr-PILC. Meanwhile, the results of Xray diffraction(XRD) and N_2 adsorption experiments demonstrate that the synthesized AlZr-PILC outperforms the raw clays(Na-mmt) and mononuclear AI-PILC in the catalytic combustion of chlorobenzene. XRD and high-re solution transmission electron microscopy also proves that the high activity of them is related to the high dispersion of the oxides and the exposure of more active sites. H_2-temperature-programmed reduction shows that cerium can promote the redox cycles of the manganese system through the strong interactions between MnO_2, CeO_2 and AlZr-PILC. In particular, MnCe(9:1)/AlZr-PILC shows the best catalytic activity in the catalytic combustion of chlorobenzene. | Binbin Feng Yingxi Wei Yingnan Qiu Shufeng Zuo Na Ye | 2018 | Journal of Rare Earths2018，36，11： | 4 |
| 6 | Cold Stress-induced Glucosyltransferase CsUGT78A15 is Involved in the Formation of Eugenol Glucoside in Camellia sinensis显示文摘Eugenol is a natural phenolic compound known for its health-promoting properties and its ability to add a floral scent to tea plants.Plant eugenol glycosides have been identified and shown to make important contributions to fruit floral quality.However,the details of their biosynthesis and metabolism in tea plants are still unknown.Here,eugenol glucoside was unambiguously identified as a native metabolite in the tea plant,and its biosynthesis was shown to be induced by low temperature treatment.Through the analysis of UGTs induced by low temperature,the glycosyltransferase CsUGT78A15 was identified in tea,and its encoded protein was shown to catalyze the glucosylation of eugenol.Vmax/Km ratios showed that eugenol was the most suitable substrate for CsUGT78A15.Sugar donor preference analysis showed that CsUGT78A15 had a higher selectivity for glucose,followed by galactose and glucuronic acid.The expression of CsUGT78A15was correlatedwith the accumulation of eugenol glucoside in different tissues and genotypes of tea.Down-regulation of CsUGT78A15 led to a decreased eugenol glucoside content under cold stress,indicating that CsUGT78A15 plays an important role in the biosynthesis of eugenol glucoside under cold stress.The identification of eugenol glucoside in the tea plant and the discovery of a cold stress-induced eugenol glucosyltransferase in tea provide the foundation for the improvement of tea flavor under cold stress and the biotechnological production of eugenol glucoside. | Mingyue Zhao Binbin Cai Jieyang Jin Na Zhang Tingting Jing Jingming Wang Yuting Pan Zixiang Zhou Yifan Zhao Yingying Feng Feng Yu Mengting Zhang Yating Li Zhonghua Liu Chuankui Song | 2020 | Horticultural Plant Journal2020，6，6： | 4 |
| 7 | Imposing Active Sources during High-Frequency Passive Surface-Wave Measurement显示文摘 | Feng Cheng Jianghai Xia Chao Shen Yue Hu Zongbo Xu Binbin Mi | 2018 | Engineering2018，4，5： | 3 |
| 8 | Prediction of radiosensitivity in primary central nervous system germ cell tumors using dynamic contrast-enhanced magnetic resonance imaging显示文摘Objective: To evaluate the feasibility of dynamic contrast-enhanced magnetic resonance imaging(DCEMRI) for predicting tumor response to radiotherapy in patients with suspected primary central nervous system(CNS) germ cell tumors(GCTs).Methods: DCE-MRI parameters of 35 patients with suspected primary CNS GCTs were obtained prior to diagnostic radiation, using the Tofts and Kermode model. Radiosensitivity was determined in tumors diagnosed 2 weeks after radiation by observing changes in tumor size and markers as a response to MRI. Taking radiosensitivity as the gold standard, the cut-off value of DCE-MRI parameters was measured by receiver operating characteristic(ROC) curve. Diagnostic accuracy of DCE-MRI parameters for predicting radiosensitivity was evaluated by ROC curve.Results: A significant elevation in transfer constant(Ktrans) and extravascular extracellular space(Ve)(P=0.000), as well as a significant reduction in rate constant(Kep)(P=0.000) was observed in tumors. Ktrans, relative Ktrans, and relative Kep of the responsive group were significantly higher than non-responsive groups. No significant difference was found in Kep, Ve, and relative Ve between the two groups. Relative Ktrans showed the best diagnostic value in predicting radiosensitivity with a sensitivity of 100%, specificity of 91.7%, positive predictive value(PPV) of 95.8%, and negative predictive value(NPV) of 100%.Conclusions: Relative Ktrans appeared promising in predicting tumor response to radiation therapy(RT). It is implied that DCE-MRI pre-treatment is a requisite step in diagnostic procedures and a novel and reliable approach to guide clinical choice of RT. | Chenlu Feng Peiyi Gao Xiaoguang Qiu Tianyi Qian Yan Lin Jian Zhou Binbin Sui | 2015 | Chinese Journal of Cancer Research2015，27，3： | 3 |
| 9 | Refinement mechanism of cerium addition on solidification structure and sigma phase of super austenitic stainless steel S32654显示文摘The influence of Ce addition on the solidification structure and σphase of super austenitic stainless steel S32654 was systematically investigated via microstructural characterization and thermodynamic calcula- tion. The results indicate that a small addition of Ce could modify MgO and MnS into Ce-bearing inclu- sions Ce_(2)O_(3)and Ce_(2)O_(2)S. Ce addition led to noticeable refinement of both the dendrite structure and σphase. The refinement mechanism could be attributed to the combined actions of effective Ce-bearing inclusions and solute Ce. Effective Ce-bearing inclusions could serve as heterogeneous nucleation cores of austenite as well as σphase, which provided a favorable prerequisite for their refinement. Solute Ce significantly enhanced the undercooling degree of the system, further promoting dendrite structure re- finement. Meanwhile, solute Ce improved the eutectic precipitation conditions of σphase and further promoted its nucleation, while the dendrite refinement limited its growth space. Finally, more fine and dispersed σphase particles formed in S32654 with Ce addition. The refinement of dendrite structure and σ phase will reduce the temperature and time required for high-temperature homogenization, which is beneficial to the hot working of this steel. | Shucai Zhang Jiangtao Yu Huabing Li Zhouhua Jiang Yifeng Geng Hao Feng Binbin Zhang Hongchun Zhu | 2022 | Journal of Materials Science & Technology2022，，7： | 3 |
| 10 | Family-level diversity of extracellular proteases of sedimentary bacteria from the South China Sea显示文摘Protease-producing bacteria and their extracellular proteases are key players in degrading organic nitrogen to drive marine nitrogen cycling and yet knowledge on both of them is still very limited. This study screened protease-producing bacteria from the South China Sea sediments and analyzed the diversity of their extracellular proteases at the family level through N-terminal amino acid sequencing. Results of the 16 S rRNA gene sequence analysis showed that all screened protease-producing bacteria belonged to the class Gammaproteobacteria and most of them were affiliated with different genera within the orders Alteromonadales and Vibrionales. The Nterminal amino acid sequence analysis for fourteen extracellular proteases from fourteen screened bacterial strains revealed that all these proteases belonged to the M4 family of metalloproteases or the S8 family of serine proteases. This study presents new details on taxa of marine sedimentary protease-producing bacteria and types of their extracellular proteases, which will help to comprehensively understand the process and mechanism of the microbial enzymatic degradation of marine sedimentary organic nitrogen. | Jinyu Yang Yangyang Feng Xiulan Chen Binbin Xie Yuzhong Zhang Mei Shi Xiying Zhang | 2019 | Acta Oceanologica Sinica2019，38，12： | 3 |
| 11 | One-step synthesis of dimethyl ether from syngas on ordered mesoporous copper incorporated alumina显示文摘Ordered mesoporous copper incorporated Al_2O_3(Cu/Al_2O_3) with high Cu dispersion were prepared by a facile solution combustion synthesis method using aluminum nitrate and copper nitrate as oxidants and urea as fuel. It is a facile and green route to synthesize catalysts for dimethyl ether directly from syngas. Cu/Al_2O_3 catalysts were characterized by XRD, N_2 adsorption–desorption, SEM-EDS, and H_2-TPR.The results indicate that the catalysts obtain an ordered mesoporous structure and copper is homogenously dispersed. The mesoporous Cu/Al_2O_3 catalysts were utilized as bifunctional catalysts in syngas to dimethyl ether reaction(STD). The copper content affects the catalytic performance in STD reaction. The CO conversion and DME selectivity of Cu/Al_2O_3 with 15% copper molar ratio achieve 52.9% and 66.1%,respectively. Moreover, the mesoporous Cu/Al_2O_3 catalysts show excellent stability in STD reaction. | Yan Wang Yuexian Chen Feng Yu Dahai Pan Binbin Fan Jinghong Ma Ruifeng Li | 2016 | Journal of Energy Chemistry2016，25，5： | 3 |
| 12 | Research progress in rehabilitation treatment of stroke patients A bibliometric analysis显示文摘BACKGROUND: Stroke presents as a transient or chronic brain dysfunction and is associated with high morbidity and high mortality. The doctors and scientists would like to argue how to enhance the validity of the rehabilitation treatment and how to further improve the level of treatment on stroke. OBJECTIVE: The aim of this study was to quantitatively analyze the current worldwide progress in research on stroke rehabilitation treatment based on Web of Science database and ClinicalTrial.gov in the past 10 years. METHODS: We conducted a quantitative analysis of clinical trial articles regarding stroke rehabilitation published in English from 2003 to 2013 and indexed in the National Institutes of Health Clinical Trials registry and Web of Science databases. Data were downloaded on March 15, 2013. RESULTS: (1) From 2003 to 2013, 2 654 clinical trials investigating stroke were indexed in ClinicalTrials.gov. There were only 58 clinical trials registered in 2003, and there was a marked increase from 2005. A total of 605 clinical trials on the rehabilitation of stroke were conducted in the past 10 years. (2) The analysis showed that most of the trials in the field were registered by North American institutions. With respect to the Asian countries, China and Taiwan Region of China also published a reasonable proportion of the trials, but comparatively speaking, the number of trials is really rare. Most of the interventions were drugs, followed by the devices, and behavioral interventions were ranked third. (3) In the past 10 years, there were 4 052 studies on stroke indexed by Web of Science database. CONCLUSION: From perspective of research progress, we found that the number of clinical trials and papers on stroke rehabilitation has increased significantly in the past 10 years, between them a remarkable positive correlation exists. | Xiaodong Feng Chengmei Liu Qingchuan Guo Yanjie Bai Yafeng Ren Binbin Ren Junmin Bai Lidian Chen | 2013 | Neural Regeneration Research2013，8，15： | 3 |
| 13 | A double integral method for quantitative evaluation of influence on thin-walled casing response caused by bearing uncertainties显示文摘Bearings in a gas turbine engine are the key connecting components transmitting force and motion between rotors and thin-walled flexible casing.The bearing stiffness and damping of squeeze film damper(SFD)nearby bearings are easily affected by many factors,such as assembly process,load condition and temperature variation,resulting in uncertainties.The uncertainties may influence the response of the measuring point on the casing.Hence,it is difficult to carry out the fault diagnosis,whole machine balancing and other related works.In this paper,a double integral quantitative evaluation method is proposed to simultaneously analyze the influence of two uncertain dynamic coefficients on the response amplitude and phase of casing measuring points.Meanwhile,the coupling influence of stiffness and damping accompanied by dramatic changes with rotational speeds are essentially discussed.As an example,a typical engine bearing-casing system with complex dynamic characteristics is analyzed.The impact of uncertain dynamic coefficients on the unbalance response is quantitatively evaluated. | Binbin GENG Yanfei ZUO Zhinong JIANG Kun FENG Chen WANG Jie WANG | 2020 | Chinese Journal of Aeronautics2020，33，9： | 2 |
| 14 | 中国家族性胃癌的研究(英文)显示文摘Objective:The aim of the study was to investigate the influence of gastric cancer family history in the gastric cancer (GC) patients. Methods: Gastric cancer family histories within second degree relatives and clinicopathological features were obtained for 497 patients. Results:Of the 497 probands,235 probands were incorporated into familial gastric cancer (FGC) group (there were at least two GC members in the family); 262 probands were included in the non-FGC group (relatives only affected with non-GCs). Of 614 tumors in relatives,GC was the most frequent,followed by lung cancer,esophageal cancer,hepatocellular cancer,colorectal cancer,urogenital cancer,breast cancer,and pancreatic cancer. Most affected members aggregated within first-degree relatives. The ratio of males to females in affected first-degree relatives was usually higher in male probands. Paternal history of GC was a strong risk for GC in males,while risk of GC by maternal history of GCs was increased in females. Difference in tumor histological types between the two groups was derived from an excess of diffuse GC in non-FGC male probands. The lower site was the most frequent tumor location in all subgroups. Conclusion:Distribution of associated non-GCs in a family history of GC may vary with geographic areas. GC may have different genetic and/or environmental etiology in different families,and a certain subtype may be inherited in a male-influenced fashion. | Binbin Wang Zhijuan Li Caigang Liu Huimian Xu Feng Jin Ping Lu | 2010 | The Chinese-German Journal of Clinical Oncology2010，9，6： | 2 |
| 15 | The C_(6)D_(6)detector system on the Back-n beam line of CSNS显示文摘Introduction The neutron capture cross sections are very important in the field of nuclear device design and basic physics research.Hydrogen-free liquid scintillator such as C_(6)D_(6)detectors are widely used in the neutron capture cross-sectional measurements for the low neutron sensitivity and fast time response.The Back-n white neutron source at China Spallation Neutron Source is the first spallation white neutron source in China,and it is suitable for neutron capture cross-sectional measurement.Materials and methods A C_(6)D_(6)detector system was built in the Back-n experimental station.The pulse height weighting technique was used to determine the system’s detection efficiency.The response to gamma rays of the C_(6)D_(6)detector was measured,and the energy resolution function was determined.Monte Carlo simulation with Geant4 code was carried out to get the weighting function of this C_(6)D_(6)detector system.Additionally,the systematic uncertainty of the weighting function was also determined.Conclusion According to the experimental and simulation results,this C_(6)D_(6)detector system can be used to measure neutron capture cross section. | Jie Ren Xichao Ruan Jie Bao Guangyuan Luan Wei Jiang Qi An Huaiyong Bai Ping Cao Qiping Chen Yonghao Chen Pinjing Cheng Zengqi Cui Ruirui Fan Changqing Feng Minhao Gu Fengqin Guo Changcai Han Zijie Han Guozhu He Yongcheng He Yuefeng He Hanxiong Huang Weiling Huang Xiru Huang Xiaolu Ji Xuyang Ji Haoyu Jiang Hantao Jing Ling Kang Mingtao Kang Bo Li Lun Li Qiang Li Xiao Li Yang Li Yang Li Rong Liu Shubin Liu Xingyan Liu Yinglin Ma Changjun Ning Binbin Qi Zhaohui Song Hong Sun Xiaoyang Sun Zhijia Sun Zhixin Tan Hongqing Tang Jingyu Tang Pengcheng Wang Qi Wang Taofeng Wang Yanfeng Wang Zhaohui Wang Zheng Wang Jie Wen Zhongwei Wen Qingbiao Wu Xiaoguang Wu Xuan Wu Likun Xie Yiwei Yang Han Yi Li Yu Tao Yu Yongji Yu Guohui Zhang Jing Zhang Linhao Zhang Liying Zhang Qingmin Zhang Qiwei Zhang Xianpeng Zhang Yuliang Zhang Zhiyong Zhang Yingtan Zhao Liang Zhou Zuying Zhou Danyang Zhu Kejun Zhu Peng Zhu | 2019 | Radiation Detection Technology and Methods2019，3，3： | 1 |
| 16 | Asymmetric interfaces and high-TC ferromagnetic phase in La_(0.67)Ca_(0.33)MnO_(3)/SrRuO_(3)superlattices显示文摘Interfacial magnetism in functional oxide heterostructures not only exhibits intriguing physical phenomena but also implies great potential for device applications.In these systems,interfacial structural and electronic reconstructions are essential for improving the stability and tunability of the magnetic properties.In this work,we constructed ultra-thinLa_(0.67)Ca_(0.33)MnO_(3)/SrRuO_(3)(SRO)layers into superlattices,which exhibited a robust ferromagnetic phase.The high Curie temperature(TC)reaches 291 K,more than 30 K higher than that of bulk LCMO.We found that the LCMO/SRO superlattices consisted of atomically-sharp and asymmetric heterointerfaces.Such a unique interface structure can trigger a sizable charge transfer as well as a ferroelectric-like polar distortion.These two interfacial effects cooperatively stabilized the high-T_(C)ferromagnetic phase.Our results could pave a promising approach towards effective control of interfacial magnetism and new designs of oxide-based spintronic devices. | Lili Qu Da Lan Liang Si Chao Ma Shasha Wang Liqiang Xu Kexuan Zhang Feng Jin Zixun Zhang Enda Hua Binbin Chen Guanyin Gao Feng Chen Haifeng Du Karsten Held Lingfei Wang Wenbin Wu | 2021 | Nano Research2021，14，10： | 1 |
| 17 | A novel 5-DOF fully parallel kinematic machine tool显示文摘 | Feng Gao Binbin Peng Hui Zhaoin Li | 2006 | The International Journal of Advanced Manufacturing Technology2006，31，12： | 1 |
| 18 | A novel 5-DOF fully parallel kinematic machine tool显示文摘 | GAO Feng PENG Binbin ZHAO Hui | 2006 | International Journal of Advanced Manufacturing Technology2006，31，： | 1 |
| 19 | Lewis acid-catalyzed in situ transesterification/esterification of microalgae in supercritical ethanol显示文摘 | Binbin Jin Peigao Duan Yuping Xu Bing Wang Feng Wang Lei Zhang | 2014 | Bioresource Technology2014，，： | 1 |
| 20 | New Gene Variants Associated with the Risk of Chronic HBV Infection显示文摘Some patients with chronic hepatitis B virus(HBV)infection failed to clear HBV,even persistently continue to produce antibodies to HBV.Here we performed a two stage genome wide association study in a cohort of Chinese patients designed to discover single nucleotide variants that associate with HBV infection and clearance of HBV.The first stage involved genome wide exome sequencing of 101 cases(HBsAg plus anti-HBs positive)compared with 102 control patients(antiHBs positive,HBsAg negative).Over 80%of individual sequences displayed 209 sequence coverage.Adapters,uncertain bases[10%or low-quality base calls([50%)were filtered and compared to the human reference genome hg19.In the second stage,579 chronic HBV infected cases and 439 HBV clearance controls were sequenced with selected genes from the first stage.Although there were no significant associated gene variants in the first stage,two significant gene associations were discovered when the two stages were assessed in a combined analysis.One association showed rs506121-“T”allele[within the dedicator of cytokinesis 8(DOCK8)gene]was higher in chronic HBV infection group than that in clearance group(P=0.002,OR=0.77,95%CI[0.65,0.91]).The second association involved rs2071676—A allele within the Carbonic anhydrase(CA9)gene that was significantly elevated in chronic HBV infection group compared to the clearance group(P=0.0003,OR=1.35,95%CI[1.15,1.58]).Upon replication these gene associations would suggest the influence of DOCK8 and CA9 as potential risk genetic factors in the persistence of HBV infection. | Mengjie Fan Jing Wang Sa Wang Tengyan Li Hong Pan Hankui Liu Huifang Xu Daria V.Zhernakova Stephen J.O’Brien Zhenru Feng Le Chang Erhei Dai Jianhua Lu Hongli Xi Yanyan Yu Jianguo Zhang Binbin Wang Zheng Zeng | 2020 | Virologica Sinica2020，35，4： | 1 |
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