|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Gastrodin prevents steroid-induced osteonecrosis of the femoral head in rats by anti-apoptosis显示文摘 | Zheng Huifeng Yang Erping Peng Hao Li Jianping Chen Sen Zhou Jianlin Fang Hongsong Qiu Bo Wang Zhe | 2014 | Chinese Medical Journal2014，，22： | 17 |
| 2 | A robust and efficient structural reliability method combining radial-based importance sampling and Kriging显示文摘Simulation based structural reliability analysis suffers from a heavy computational burden, as each sample needs to be evaluated on the performance function, where structural analysis is performed. To alleviate the computational burden, related research focuses mainly on reduction of samples and application of surrogate model, which substitutes the performance function. However,the reduction of samples is achieved commonly at the expense of loss of robustness, and the construction of surrogate model is computationally expensive. In view of this, this paper presents a robust and efficient method in the same direction. The present method uses radial-based importance sampling (RBIS) to reduce samples without loss of robustness. Importantly, Kriging is fully used to efficiently implement RBIS. It not only serves as a surrogate to classify samples as we all know, but also guides the procedure to determine the optimal radius, with which RBIS would reduce samples to the highest degree. When used as a surrogate, Kriging is established through active learning, where the previously evaluated points to determine the optimal radius are reused. The robustness and efficiency of the present method are validated by five representative examples, where the present method is compared mainly with two fundamental reliability methods based on active learning Kriging. | XIONG Bo TAN HuiFeng | 2018 | Science China(Technological Sciences)2018，61，5： | 5 |
| 3 | The origin of Mosuo people as revealed by mtDNA and Y chromosome variation显示文摘The Mosuo, living in the Lugu Lake area in northwest Yunnan Province, China, is the only matriarchal population in China. The Mosuo was officially identified as Naxi nationality although its relationship with Naxi remains controversial. We studied the genetic relationship between the Mosuo and five other ethnic groups currently residing in northwest Yunnan, i.e. Naxi, Tibetan, Bai, Yi and Pumi, by typing the genetic variations in mtDNA HVS1 and 21 Y chromosome markers (13 SNPs & 8 STR markers). We showed that the maternal lineages of the Mosuo bear the strongest resemblance with those found in Naxi while its paternal lineages are more similar to those that are prevalent in Yunnan Tibetan. The marked difference between paternal and maternal lineages may be attributable to the genetic history, matriarchal structure, and visiting marriage. | WEN Bo, SHI Hong, REN Ling, XI Huifeng, LI Kaiyuan, ZHANG Wenyi, SU Bing, SI Shiheng, JIN Li & XIAO ChunjieJoined Laboratory of Human Population Genetics of Yunnan University and Fudan University, Kunming 650091, China Key Laboratory of Bioresources Conservation and Utilization & Human Genetics Center of Yunnan University, Kunming 650091, China National Key Laboratory of Genetic Engineering & Center for Anthropological Studies, School of Life Sciences, Fudan University, Shanghai 200433, China Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650031, China Center for Genome Information, Department of Environmental Health, University of Cincinnati, Cincinnati 45267, USA The Central Hospital of Ninglang County, Ninglang 674300, China | 2004 | Science China(Life Sciences)2004，47，1： | 3 |
| 4 | NUPR1 promotes the proliferation and metastasis of oral squamous cell carcinoma cells by activating TFE3-dependent autophagy显示文摘Oral squamous cell carcinoma(OSCC)is the most common type of oral malignancy,and metastasis accounts for the poor prognosis of OSCC.Autophagy is considered to facilitate OSCC development by mitigating various cellular stresses;nevertheless,the mechanisms of autophagy in OSCC cell proliferation and metastasis remain unknown.In our study,high-sensitivity label-free quantitative proteomics analysis revealed nuclear protein 1(NUPR1)as the most significantly upregulated protein in formalin-fixed paraffin-embedded tumour samples derived from OSCC patients with or without lymphatic metastasis. | Tengfei Fan Xiaoning Wang Sheng Zhang Ping Deng Yi Jiang Yidan Liang Sheng Jie Qing Wang Chuwen Li Guocai Tian Zhen Zhang Zhenhu Ren Bo Li Yanrong Chen Zhijing He Yan Luo Mingliang Chen Hanjiang Wu Zhengping Yu Huifeng Pi Zhou Zhou Zhiyuan Zhang | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 2 |
| 5 | Erratum to“Impact of satellite blood culture on early diagnosis of sepsis”[Journal of Intensive Medicine volume 2(2022)56–60]显示文摘The publisher regrets the article titled“Impact of satellite blood culture on early diagnosis of sepsis,”[1]published on pages 56-60,Issue 1,Volume 2 in Journal of Intensive Medicine(http://gffzz9a2937bbd76e4fd3su6uvoco6ww5x6cu9.ffgz.tsg.suse.edu.cn/science/article/pii/S2667100X21000475)contains a mistake in Abstract.The sentence in the Results“median ICU lengths of stay were 18.00 days and 23.50 days”should be“median lengths of hospital stays were 18.00 days and 23.50 days”.The publisher would like to apologize for any inconvenience caused. | Ziqi Guo Bo Guo Shanmei Wang Huifeng Zhang Wenxiao Zhang Bingyu Qin Huanzhang Shao | 2022 | Journal of Intensive Medicine2022，2，2： | 1 |
| 6 | Study on Application of Data Mining Technology to Modern Logistics Management Decision显示文摘 | Quan Congna Zhao Huifeng Li Bo | 2009 | Information Technology and Applications2009，18，14： | 1 |
| 7 | Growth Evolution and Decay Properties of the Abnormally Switched Domains in LiNbO3 Crystals 显示文摘 | Kan Yi Bo Huifeng Lu Xiaomei | 2008 | Appl Phys Lett2008，92，17： | 1 |
| 8 | Naive-LSTM based services awareness of edge computing elastic optical networks显示文摘Great challenges and demands are presented by increasing edge computing services for current elastic optical networks(EONs)to deal with serious diversity and complexity of these services.To improve the match degree between edge computing and optical network,the services awareness function is necessary for EON.This article proposes a Naive long short-term memory(Naive-LSTM)based services awareness strategy of the EON,where the Naive-LSTM model makes full use of the most simplified structure and conducts discretization of the LSTM model.Moreover,the proposed algorithm can generate the probability output result to determine the quality of service(Qo S)policy of EONs.After well learning operation,these Naive-LSTM classification agents in edge nodes of EONs are able to perform services awareness by obtaining data traffic characteristics from services traffics.Test results show that the proposed approach is feasible and efficient to improve edge computing ability of EONs. | HUO Chao BAI Huifeng YIN Zhibin YAN Bo | 2023 | Optoelectronics Letters2023，19，5： | 0 |
| 9 | Pull-out Behaviour of Axially Loaded Screwed-in Threaded Rods Embedded in CLT Elements: Experimental Study显示文摘Experimental investigation on the pull-out behaviour,including the withdrawal capacity,slip stiffness and inter-facial shear stress,of axially loaded screwed-in threaded rod embedded in cross laminated timber(CLT)was con-ducted.Specimens with varying embedment length and different number of threaded rods were tested in this study.To prevent premature splitting failure of timber,some specimens were reinforced in the direction perpen-dicular to the timber grain with self-tapping screws.Test results showed that the screwed-in threaded rod con-nections exhibited good pull-out behaviour with high withdrawal capacity and slip stiffness.Within a certain range,the withdrawal capacity increases considerably with the increase of embedment length,while the average interfacial shear stress shows the opposite tendency.The self-tapping screws played an important role on reducing the splitting of the timber and improving the withdrawal capacity and slip stiffness of the screwed-in threaded rod.Additionally,for the specimens with self-tapping screw reinforcements,the improvement of withdrawal capacity and stiffness when increasing the number of threaded rods are much more obvious than that of the speci-mens without the self-tapping screws,due to the change of failure modes. | Huifeng Yang Junfeng Ji Haotian Tao Benkai Shi Junbin Hu Bo Wen | 2022 | Journal of Renewable Materials2022，10，1： | 0 |
| 10 | Progress and development directions of stimulation techniques for ultra-deep oil and gas reservoirs显示文摘By reviewing the development history of stimulation techniques for deep/ultra-deep oil and gas reservoirs,the new progress in this field in China and abroad has been summed up,including deeper understanding on formation mechanisms of fracture network in deep/ultra-deep oil and gas reservoir,performance improvement of fracturing fluid materials,fine stratification of ultra-deep vertical wells,and mature staged multi-cluster fracturing technique for ultra-deep and highly deviated wells/horizontal wells.In light of the exploration and development trend of ultra-deep oil and gas reservoirs in China,the requirements and technical difficulties in ultra-deep oil and gas reservoir stimulation are discussed:(1)The research and application of integrated geological engineering technology is difficult.(2)The requirements on fracturing materials for stimulation are high.(3)It is difficult to further improve the production in vertical profile of the ultra-deep and hugely thick reservoirs.(4)The requirements on tools and supporting high-pressure equipment on the ground for stimulation are high.(5)It is difficult to achieve efficient stimulation of ultra-deep,high-temperature and high-pressure wells.(6)It is difficult to monitor directly the reservoir stimulation and evaluate the stimulation effect accurately after stimulation.In line with the complex geological characteristics of ultra-deep oil and gas reservoirs in China,seven technical development directions are proposed:(1)To establish systematic new techniques for basic research and evaluation experiments;(2)to strengthen geological research and improve the operational mechanism of integrating geological research and engineering operation;(3)to develop high-efficiency fracturing materials for ultra-deep reservoirs;(4)to research separated layer fracturing technology for ultra-deep and hugely thick reservoirs;(5)to explore fracture-control stimulation technology for ultra-deep horizontal well;(6)to develop direct monitoring technology for hydraulic fractures in ultra-deep oil and gas reservoirs;(7)to develop downhole fracturing tools with high temperature and high pressure tolerance and supporting wellhead equipment able to withstand high pressure. | LEI Qun XU Yun YANG Zhanwei CAI Bo WANG Xin ZHOU Lang LIU Huifeng XU Minjie WANG Liwei Li Shuai | 2021 | Petroleum Exploration and Development2021，48，1： | 0 |
| 11 | Genetic Architecture of Childhood Kidney and Urological Diseases in China显示文摘Kidney disease is manifested in a wide variety of phenotypes,many of which have an important hereditary component.To delineate the genotypic and phenotypic spectrum of pediatric nephropathy,a multicenter registration system is being imple-mented based on the Chinese Children Genetic Kidney Disease Database(CCGKDD).In this study,all the patients with kidney and urological diseases were recruited from 2014 to 2020.Genetic analysis was conducted using exome sequencing for families with multiple affected individuals with nephropathy or clinical suspicion of a genetic kidney disease owing to early-onset or extrarenal features.The genetic diagnosis was confirmed in 883 of 2256(39.1%)patients from 23 provinces in China.Phenotypic profiles showed that the primary diagnosis included steroid-resistant nephrotic syndrome(SRNS,23.5%),glomerulonephritis(GN,32.2%),congenital anomalies of the kidney and urinary tract(CAKUT,21.2%),cystic renal disease(3.9%),renal calcinosis/stone(3.6%),tubulopathy(9.7%),and chronic kidney disease of unknown etiology(CKDu,5.8%).The pathogenic variants of 105 monogenetic disorders were identified.Ten distinct genomic disorders were identified as pathogenic copy number variants(CNVs)in 11 patients.The diagnostic yield differed by subgroups,and was highest in those with cystic renal disease(66.3%),followed by tubulopathy(58.4%),GN(57.7%),CKDu(43.5%),SRNS(29.2%),renal calcinosis/stone(29.3%)and CAKUT(8.6%).Reverse phenotyping permitted correct identification in 40 cases with clinical reassessment and unexpected genetic conditions.We present the results of the largest cohort of children with kidney disease in China where diagnostic exome sequencing was performed.Our data demonstrate the utility of family-based exome sequencing,and indicate that the combined analysis of genotype and phenotype based on the national patient registry is pivotal to the genetic diagnosis of kidney disease. | Ye Fang Hua Shi Tianchao Xiang Jiaojiao Liu Jialu Liu Xiaoshan Tang Xiaoyan Fang Jing Chen Yihui Zhai Qian Shen Guomin Li Li Sun Yunli Bi Xiang Wang Yanyan Qian Bingbing Wu Huijun Wang Wenhao Zhou Duan Ma Jianhua Mao Xiaoyun Jiang Shuzhen Sun Ying Shen Xiaorong Liu Aihua Zhang Xiaowen Wang Wenyan Huang Qiu Li Mo Wang Xiaojie Gao Yubin Wu Fang Deng Ruifeng Zhang Cuihua Liu Li Yu Jieqiu Zhuang Qing Sun Xiqiang Dang Haitao Bai Ying Zhu Siguang Lu Bili Zhang Xiaoshan Shao Xuemei Liu Mei Han Lijun Zhao Yuling Liu Jian Gao Ying Bao Dongfeng Zhang Qingshan Ma Liping Zhao Zhengkun Xia Biao Lu Yulong Wang Mengzhun Zhao Jianjiang Zhang Shan Jian Guohua He Huifeng Zhang Bo Zhao Xiaohua LI Feiyan Wang Yufeng Li Hongtao Zhu Xinhui Luo Jinghai Li Jia Rao Hong Xu | 2021 | Phenomics2021，1，3： | 0 |
| 12 | Impact of satellite blood culture on early diagnosis of sepsis显示文摘Background:The aim of this study was to assess whether satellite blood culture(SBC)can improve turnaround times,antibiotic switching,and patient prognosis,relative to laboratory blood culture(LBC).Methods:Patients with sepsis treated in the intensive care units(ICUs)of Henan Provincial People’s Hospital from February 5,2018 to January 19,2019 who met the inclusion criteria were recruited to the study and divided into the SBC group and LBC group according to different blood culture methods.Patient demographics,blood culture,antibiotic adjustment,and prognosis data were collected and compared between the two groups.Results:A total of 204 blood culture sets from 52 ICU patients,including 100 from the medical microbiology LBC group and 104 from the SBC group,were analyzed in this study.There was no significant difference in the positive rates between the two groups.Time from specimen collection to incubation was significantly shorter in the SBC group than that in the LBC group(1.65 h vs.3.51 h,z=−4.09,P<0.001).The median time from specimen collection to notification of blood culture positivity was 24.83 h in the SBC group and 27.83 h in the LBC group.Median times from adjustment of antibiotics according to the first report were 26.05 h and 51.71 h in the SBC and LBC groups,respectively,while those according to the final report were 97.17 h and 111.45 h,respectively.Median ICU lengths of stay were 15.00 days and 17.00 days in the SBC and LBC groups,respectively,and median ICU lengths of stay were 18.00 days and 23.50 days,respectively.Mean hospitalization costs were 157.99 and 186.73 thousand yuan in the SBC and LBC groups,respectively.Conclusion:SBC can significantly reduce blood culture turnaround times;however,there were no significant differences between the two blood culture methods in initial reporting of positive cultures,time to adjustment of antibiotic therapy,or medical costs,despite a trend toward improvement. | Ziqi Guo Bo Guo Shanmei Wang Huifeng Zhang Wenxiao Zhang Bingyu Qin Huanzhang Shao | 2022 | Journal of Intensive Medicine2022，2，1： | 0 |
| 13 | Correction to:NUPR1 promotes the proliferation and metastasis of oral squamous cell carcinoma cells by activating TFE3-dependent autophagy显示文摘In the process of checking the raw data1,the authors noticed several inadvertent mistakes occurring in Fig.5a,b,c,d,f that need to be corrected after online publication of the article.During the preparation of Fig.5,the representative image showing TFE3 overexpression antagonized the NUPR1 KD-induced inhibition of OSCC cell proliferation and metastasis,were pasted and placed by mistake.The correct results should be as shown below.The authors apologize for these oversights and declare that these corrections do not affect the description,interpretation,or conclusions detailed in the original manuscript. | Tengfei Fan Xiaoning Wang Sheng Zhang Ping Deng Yi Jiang Yidan Liang Sheng Jie Qing Wang Chuwen Li Guocai Tian Zhen Zhang Zhenhu Ren Bo Li Yanrong Chen Zhijing He Yan Luo Mingliang Chen Hanjiang Wu Zhengping Yu Huifeng Pi Zhou Zhou Zhiyuan Zhang | 2022 | Signal Transduction and Targeted Therapy2022，7，10： | 0 |
| 14 | Expert Consensus on Nutritional Support for Children with Congenital Heart Disease(2023 Edition)显示文摘The second edition of the expert consensus on pediatric nutrition was formed based on a global update of pedia-tric nutrition guidelines or consensus worldwide,the management of congenital heart disease,and the results of multi-center clinical nutrition research for congenital heart disease following thefirst Chinese consensus edition of 2016.The consensus was also shaped by the results of three discussion sessions and two questionnaires con-ducted by the 13-member collaboration group.This process was informed by both clinical guidelines and expert consensus.The quality of literature,both in English and Chinese,and the level of recommendations were evaluated using the Grading of Recommendations Assessment,Development,and Evaluations(GRADE)system. | Xuming Mo Wei Cai Jirong Qi Zhuoming Xu Ying Wang Weihui Yan Shoujun Li Nianguo Dong Xinxin Chen Jinfen Liu Qiang Shu Jimei Chen Haibo Zhang Hao Zhang Quansheng Xing Qi An Xiaofeng Li Xu Wang Yan He Junwu Su Taibing Fan Teng Ming Weibing Tang Li Hong Jinghao Zheng Ming Ye Guocheng Sun Yiqun Ding Liang Tao Yifeng Yang Zhongshi Wu Hua Cao Qiang Wang Keming Yang Libing Zhang Ping Wen Yanqin Cui Bo Zhai Yong Zou Qingya Tang Rui Chen Chun Wu Zhiyu Feng Caixia Liu Yaping Mi Rufang Zhang Ke Lin Xin Li Mingan Pi Xiangming Fan Shanshan Shi Peng Huang Zhengxia Pan Jiafeng Qi Renwei Chen Shuguang Tao Yaqin Shu Huifeng Zhang Lan Jiang Min Da Nishant Patel Liang Hu Cardiac Surgery Group of Pediatric Surgery Society of Chinese Medical Association and Parenteral Enteral Nutrition Society of Chinese Medical Association | 2023 | Congenital Heart Disease2023，18，6： | 0 |
| 15 | Clinical Application of PES Membrane Dialyzer显示文摘Objective The dialysate membrane can be classified into acetate membrane and synthetic membrane,while the latter can be further divided into polysulfone,polyacrylonitrile,etc.Polyethersulfone membrane is high molecular membrane material with excellent biocompatibility,stable mechanical properties,high temperature and pressure resistance,and good cleaning performance,which has been applied for more than 10 years.This trial is to assess the safety and efficacy of hollow polysulfone membrane fiber dialyzer with pattern number Enttex^(TM)-16LF(E60)for hemodialysis in patients with acute or chronic renal failure due to multiple factors.Methods Totally 76 patients receiving maintenance hemodialysis were included in a two-site,random,open label,two-stage,positive crossover and non inferiority validation study.The clinical efficacy and safety of the test device were observed,which was a hollow fiber dialyzer produced by Guangzhou Enttex Medical Products Co.,Ltd.,with polyethersulfone membrane imported from Germany.It was a low flux dialyzer with the pattern number of EnttexTM-16LF(E60).Inclusion criteria:①patients with acute or chronic renal failure due to various reasons who needed hemodialysis;②18 to 80 years old,gender unlimited;③patients who received stable dialysis for more than 3 months,regular hemodialysis 3 times a week,4 h at each time,blood flow rate of 200~350ml/min;④using bicarbonate dialysate at a flow rate of 500ml/min;⑤patients with arteriovenous fistula or who received artificial blood vessel puncture dialysis;received anticoagulation by heparin or low molecular weight heparin.Exclusion criteria:①patients needing heparin free dialysis for severe anemia,tumor and active bleeding;②patients with severe cardiac(gradeⅢcardiac function),hepatic(severe hepatitis and cirrhosis)and pulmonary diseases(severe respiratory failure).Results Comparison of parameters,including the changes of Kt/V,general creatinine and urea clearance rates and URR(urea reduction rate)shows no statistical significance in differences between the two devices,indicating that the test and control devices can equally and effectively eliminate toxins including creatinine and urea,etc.PPP and MITTP results are consistent.Comparison of ultrafiltration rates between two groups of patients shows no statistical difference.PPP and MITTP results are consistent,indicating that both the test device and control device can effectively eliminate water.In MITTP,electrolytes including K^+,Na^+,Cl^-,Ca^2+,HCO3^-,etc.show no statistical significance in difference between the test and control devices before and after dialysis(P>0.05).After treating by using test and control devices,body weight,serum potassium and phos-phorus all significantly decrease(P<0.001);serum Ca^2+,PO2,PCO2and HCO3^-all significantly increase(P<0.001).These results indicate that both the test and control devices can effectively eliminate serum potassium and phosphorus,and eliminate excess water in body,maintain the balance between liquid and electrolytes in patients.PPP and MITTP results are consistent.Conclusion This clinical trial confirms that hollow polyethersulfone membrane fiber dialyzer can be safely and effectively used in hemodialysis therapy. | YUN Chen YANG Peidian LIANG Wenxue CHEN Yu CHEN Gangyi LIU Hongping OUYANG Zihua SONG Huifeng LI Yunyi YU Zongchao GUAN Baozhang DONG Xiangnan LIU Huanhuan Cao Rui ZHANG Zeyu FAN Lijing HU Bo HE Yongcheng SHI Mingjie XU Jun Yang Lifeng TANG Shuifu | 2019 | 临床医学工程2019，26，S01： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员