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| 1 | Coordinated flight control of miniature fixed-wing UAV swarms: methods and experiments显示文摘In this paper,we present our recent advances in both theoretical methods and field experiments for the coordinated control of miniature fixed-wing unmanned aerial vehicle(UAV)swarms.We propose a multi-layered group-based architecture,which is modularized,mission-oriented,and can implement large-scale swarms.To accomplish the desired coordinated formation flight,we present a novel distributed coordinated-control scheme comprising a consensus-based circling rendezvous,a coordinated path-following control for the leader UAVs,and a leader-follower coordinated control for the follower UAVs.The current framework embeds a formation pattern reconfiguration technique.Moreover,we discuss two security solutions(inter-UAV collision avoidance and obstacle avoidance)in the swarm flight problem.The effectiveness of the proposed coordinated control methods was demonstrated in field experiments by deploying up to 21 fixed-wing UAVs. | Xiangke WANG Lincheng SHEN Zhihong LIU Shulong ZHAO Yirui CONG Zhongkui LI Shengde JIA Hao CHEN Yangguan YU Yuan CHANG Yajing WANG | 2019 | Science China(Information Sciences)2019，62，11： | 21 |
| 2 | Malnutrition and Quality of Life in Chinese Cancer Patients: a Clinical Study of 23,994 Subjects显示文摘Background Malnutrition is common in patients with cancer,and can negatively impact their quality of life(QoL)and even survival.However,there is currently no large data available on the prevalence of malnutrition in Chinese cancer patients.This study evaluated the prevalence of malnutrition and the QoL of Chinese patients with locoregional,recurrent or metastatic cancer.Methods We conducted a nationwide observational,multi-center,hospital-based cross-sectional study within the Chinese Society of Nutritional Oncology(CSNO)Network.All of the patients were diagnosed with one of the following 18 different types of malignant tumors:lung cancer,gastric cancer,liver cancer,colorectal cancer,breast cancer,esophageal cancer,cervical cancer,endometrial cancer,nasopharyngeal carcinoma,malignant lymphoma,leukemia,pancreatic cancer,ovarian cancer,prostate cancer,bladder cancer,brain cancer,biliary tract malignant tumors or gastrointestinal stromal tumors.These patients were enrolled from 72 hospitals located in different regions of China.The patients’nutritional status was evaluated based on the body mass index(BMI),loss of bodyweight,laboratory measurements and patient generated-subjective global assessment(PG-SGA)scores.The cancer patients’physical status and QoL were assessed by the Karnofsky Performance Status(KPS)questionnaire and the European Organization for Research and Treatment of Cancer(EORTC)QLQ-C30 questionnaire,respectively.Results From December 2013 to April 2016,23,994 patients hospitalized for cancer treatment(such as surgery,chemotherapy or radiotherapy)were enrolled in the study.The patients included 12,494(52.9%)males and 11,124(47.1%)females.The mean age was 55.8±13.7 years.The proportions of patients in cancer stagesⅠ,Ⅱ,Ⅲ,Ⅳand uncertain were 11.5%,20.3%,27.5%,30.2%and 10.5%,respectively.Among the 23,994 inpatients,the proportions of patients who were underweight(BMI<18.5 kg/m2),normal(18.5 kg/m2 | Hong Xia Xu Chun Hua Song Zhen Ming Fu Chang Wang Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua Wang Jing Wu Ying He Jia Jun Yang Cong Hua Xie Fu Xiang Zhou Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Min Weng Qing Hua Yao Jiu Wei Cui Wei Li Han Ping Shi the Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group | 2021 | Journal of Nutritional Oncology2021，6，1： | 8 |
| 3 | Comparison of cryoballoon ablation for atrial fibrillation guided by real-time three-dimensional transesophageal echocardiography vs. contrast agent injection显示文摘Background:Pulmonary vein (PV) occlusion generally depends on repetitive contrast agent injection when cryoballoon ablation for atrial fibrillation (AF). The present study was to compare the effect of cryoballoon ablation for AF guided by transesophageal echocardiography (TEE) vs. contrast agent injection.Methods:Eighty patients with paroxysmal AF (PAF) were enrolled in the study. About 40 patients underwent cryoballoon ablation without TEE (non-TEE group) and the other 40 underwent cryoballoon ablation with TEE for PV occlusion (TEE group). In the TEE group during the procedure, PVs were displayed in 3-dimensional images to guide the balloon to achieve PV occlusion. The patients were followed up at regularly scheduled visits every 2 months.Results:No differences were identified between the groups in regard to the procedure time and cryoablation time for each PV. The fluoroscopy time (6.7±4.2 min vs. 17.9±5.9 min, P<0.05) and the amount of contrast agent (3.0±5.1 mL vs.18.1±3.4 mL, P<0.05) in the TEE group were both less than the non-TEE group. At a mean of 13.0±3.3 mon follow-up, success rates were similar between the TEE group and non-TEE group (77.5% vs. 80.0%, P=0.88).Conclusions:Cryoballoon ablation with TEE for occlusion of the PV is both safe and effective. Less fluoroscopy time and a lower contrast agent load can be achieved with the help of TEE for PV occlusion during procedure. | Yuan-Jun Sun Xiao-Meng Yin Tao Cong Lian-Jun Gao Dong Chang Xian-Jie Xiao Qiao-Bing Sun Rong-Feng Zhang Xiao-Hong Yu Ying-Xue Dong Yan-Zong Yang Yun-Long Xia | 2019 | Chinese Medical Journal2019，，3： | 8 |
| 4 | Mutation of kri1l causes definitive hematopoiesis failure via PERK-dependent excessive autophagy induction显示文摘 | Xiao-E Jia Ke Ma Tao Xu Lei Gao Shuang Wu Cong Fu Wenjuan Zhang Zhizhang Wang Kaiyu Liu Mei Dong Changbin Jing Chunguang Ren Zhiwei Dong Yi Chen Yi Jin Qiuhua Huang Xing Chang Min Deng Li Li Lingfei Luo Jun Zhu Yongjun Dang Hung-Chun Chang Leonard I Zon Yi Zhou Saijuan Chen Weijun Pan | 2015 | Cell Research2015，25，8： | 8 |
| 5 | Photolysis of organic pollutants in wastewater with 206 nm UV irradiation显示文摘新型的紫外轻来源(206 nm ) 第一次在废水为器官的污染物质的降级被探索。triphenyltin 氯化物(TPTCl ) 的降级表演,暗淡乙醇 phthalate (DMP ) ,以及玫瑰精 B (RhB ) 被调查。结果显示了 50 mg/L RhB, 60 mg/L DMP 和 120 mg/L TPTCl 的那移动效率能分别地为 60 min, 50 min 和 75 min 到达 88.6% , 92.5% 和 89.4% 。由移动效率的比较,我们发现 206 nm 比在废水处理紫外的 253.7 nm 优异,暗示分解在废水的器官的污染物质是一种有效、有希望、值得的探索技术。 | Zhao Lian Ye Chang Qing Cao Jin Cong He Ren Xi Zhang Hui Qi Hou | 2009 | Chinese Chemical Letters2009，20，6： | 7 |
| 6 | Validity of the Chinese Version of the Patient-Generated Subjective Global Assessment (PG-SGA) in Lung Cancer Patients显示文摘The prevalence of malnutrition is high among oncology patients in China. Although the Patient- Generated Subjective Global Assessment (PG-SGA) is widely recognized as an important nutritional assessment tool, it has not been validated for Chinese cancer patients. The purpose of this study was to conduct an analysis of nutrition screening and assessment data to validate the Chinese version of the PG-SGA in Chinese patients with lung cancer. This was an observational, cross-sectional study of 2,000 consecutive adult patients with lung cancer treated at several tertiary hospitals in China. Anthropometric and patient descriptive data were collected. The PG-SGA generated a score for the nutritional risk and a global rating for the nutritional status. The internal consistency, external consistency, and construct validity were evaluated, and a known-groups comparison and principal component analyses were conducted to evaluate the reliability and validity of the PG-SGA. The known-groups comparison demonstrated the ability of the PG-SGA to differentiate lung cancer patients of different nutritional and body mass index (BMI) groups. A confirmatory factor analysis supported the original four-factor structure of the PG-SGA. In terms of the internal and external consistency, the PG-SGA demonstrated intra-class correlation coefficients (ICC) up to 0.987. Alternative form validity was also demonstrated between Box 4 of the PG-SGA and the Karnofsky Performance Status score, with excellent external consistency (r = 0.972, P < 0.001). The construct validity was supported, and selected questionnaire dimensions were evident in the principal component analysis. Significant Spearman correlations (P < 0.001) were demonstrated. The Chinese version of the PG-SGA demonstrated significant reliability and sufficient exploratory properties to support its validity. It seems to be a valid tool that can be used to access the nutritional status of Chinese lung cancer patients. The validity of the PG-SGA in Chinese cancer patients warrants further investigation in other cancer types. | Zhen Ming Fu Hong Xia Xu Chun Hua Song Wei Li Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua Wang Jing Wu Ying He Jia Jun Yang Cong Hua Xie Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Chang Wang Han Ping Shi The Investigation on Nutrition Status and Clinical Outcome of Common Cancers (INSCOC) Group | 2016 | Journal of Nutritional Oncology2016，1，1： | 7 |
| 7 | Infective viruses produced from full-length complementary DNA of swine vesicular disease viruses HK/70 strain显示文摘The full-length cDNA clone of swine vesicular disease virus HK/70 strain named pSVOK12 was constructed in order to study the antigenicity, replication, maturation and pathogenicity of swine vesicular disease virus. In vitro transcription RNA from pSVOK12 transfected IBRS-2 cells and the re- covered virus RNA were isolated and sequenced, then indirect hemagglutination test, indirect im- munofluorescence assays, eleectron microscope test, 50% tissue culture infecting dose (TCID50) assays and mouse virulence studies were performed to study the antigenicity and virulence of the recovered virus. The result showed that the infectious clones we ob- tained and the virus derived from pSVOK12 had the same biological properties as the parental strain HK/70. The full-length infectious cDNA clone, pSVOK12, will be very useful in studies of the anti- genicity, virulence, pathogenesis, maturation and replication of SVDV. | ZHENG Haixue LIU Xiangtao SHANG Youiun WU Jinyan BAI Xingwen JIN Ye SUN Shiqi GUO Huichen TIAN Hong FENG Xia YIN Shuanghui GUO Jianhong CONG Guozheng LIU Zaixin CHANG Huiyun MA Junwu XIE Qingge | 2006 | Chinese Science Bulletin2006，51，17： | 6 |
| 8 | Application of VP1 Protein to Develop Monoclonal Antibody against Foot-and-mouth Disease Virus Asia1 Type显示文摘In order to develop an anti-FMDV Asia1 type monoclonal antibody(mAb) ,BABL/c mice were immunized with recombinant FMDV VP1 protein. Three mAbs,1B8,5E1 and 5E2,were then further optimized. The result indicated that prepared anti-FMDV Asia1 mAbs had no cross-reactivity with Swine vesicular disease(SVD) and FMDV O,A and C type antigen. Their titers in abdomen liquor were 1:5×106,1:2×106 and 1:5×106,respectively. 1B8 was found to be of IgG1 subtype,5E1 and 5E2 belonged to IgG2b subtype. In this study,the prepared mAbs are specific for detecting FMDV type Asia1,and is potentially useful for pen-side diagnosis. | Tong LIN Jun-zheng DU Jun-jun SHAO Guo-zheng CONG Shuai SONG Shan-dian GAO Hui-yun CHANG | 2009 | Virologica Sinica2009，24，3： | 5 |
| 9 | Validity of the Chinese Version of the Patient-Generated Subjective Global Assessment (PG-SGA) in Gastric Cancer Patients显示文摘Purpose Malnutrition is severe among gastric cancer patients in China. While the Patient-Generated Subjective Global Assessment (PG-SGA) is a widely used nutritional assessment tool, the validation for Chinese patients with gastric cancer has not been performed yet. The aim of this research is to validate the Chinese version of the PGSGA in Chinese gastric cancer patients by conducting analyses of nutrition screening and assessment data. Methods Two thousand consecutive adult patients with gastric cancer were included in this observational, cross-sectional study in several tertiary hospitals in China. A survey was made among those patients, which included several questionnaires and some anthropometric parameters. We calculated the parameters to validate the use of PG-SGA categorizing the nutritional status of gastric cancer patients. Then we performed statistical analysis to evaluate the internal consistency, external consistency, and construct validity. Results This study verified the ability of the PG-SGA to differentiate gastric cancer patients into different nutritional groups. The confirmatory factor analysis verified the original four-factor structure of the PG-SGA. The internal and external consistency was measured by a concordance analysis which showed an intraclass correlation coefficients (ICC) of 0.987. The correlations of the Box 4 score with the Karnofsky performance status score demonstrated alternative form validity with good external consistency (Pearson, r = 0.643, P < 0.001). All three anthropometric dimensions of the PG-SGA were supported by principal component analysis. Spearman correlations (P < 0.001) were significant in the majority of tests. Conclusion The Chinese version of the PG-SGA is a valid tool to access the patients’ nutritional status for Chinese gastric patients. | Zhen Ming Fu Hong Xia Xu Chun Hua Song Wei Li Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua Wang Jing Wu Ying He Jia Jun Yang Cong Hua Xie Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Chang Wang Han Ping Shi The Investigation on Nutrition Status and Clinical Outcome of Common Cancers (INSCOC) Group | 2018 | Journal of Nutritional Oncology2018，3，4： | 5 |
| 10 | Light carbon isotope events of foraminifera attributed to methane release from gas hydrates on the continental slope, northeastern South China Sea显示文摘In 2013, the China Geological Survey and Guangzhou Marine Geological Survey conducted the second Chinese gas hydrate expedition in the northern South China Sea(SCS) and successfully obtained visible gas hydrate samples. Five of the thirteen drilling sites were cored for further research. In this work, Site GMGS2-08 is selected for the stable isotopic analysis of foraminifera present in the boreholes in order to reveal the carbon isotopic characteristics of the foraminifera and their response to methane release in the gas hydrate geological system. Our results show that the methane content at Site GMGS2-08 is extremely high, with headspace methane concentrations up to 39300 μmol L^(-1). The hydrocarbon δ^(13)C values, ranging from-69.4‰ to-72.3‰ PDB, distinctly indicate biogenic generation. Based on the δD analytical results(^(-1)83‰ to^(-1)85‰ SMOW), headspace methane is further discriminated to be microbial gas, derived from CO_2 reduction. By isotopic measurement, five light δ^(13)C events are found in the boreholes from Site GMGS2-08, with foraminiferal δ^(13)C values being apparently lower than the normal variation range found in the glacial-interglacial cycles of the SCS. The δ^(13)C values of benthic Uvigerina peregrina are extremely depleted(as low as^(-1)5.85‰ PDB), while those of planktonic Globigerinoides ruber reach-5.68‰ PDB. Scanning electron micrograph(SEM) studies show that foraminiferal tests have experienced post-depositional alteration, infilled with authigenic carbonate, and the diagenetic mineralization is unlikely to be related to the burial depths. The correlation calculation suggests that the anaerobic oxidation of organic matter has only weak influences on the δ^(13)C composition of benthic foraminifera. This means that the anomalous δ^(13)C depletions are predominantly attributed to the overprinting of secondary carbonates derived from the anaerobic oxidation of methane(AOM). Furthermore, the negative δ^(13)C anomalies, coupled with the positive δ18O anomalies observed at Site GMGS2-08, are most likely the critical pieces of evidence for gas hydrate dissociation in the geological history of the study area. | ZHUANG Chang CHEN Fang CHENG SiHai LU HongFeng WU Cong CAO Jun DUAN Xiao | 2016 | Science China Earth Sciences2016，59，10： | 4 |
| 11 | Development of Novel Visual-Plus Quantitative Analysis Systems for Studying DNA Double-Strand Break Repairs in Zebrafish显示文摘到分析 DNA 双海滨裂缝(DSB ) 的记者系统的使用修理,基于提高的绿色荧光灯蛋白质(EGFP ) 和象 I-Sce 那样的 meganuclease 我,通常与房间线被执行。在这研究,我们开发了三视觉加为相应再结合(HR ) 的量的试金系统,加入的非相应的结束(NHEJ )(SSA ) 并且单个海滨的退火在在 zebrafish 胚胎的 organismal 水平的 DSB 修理小径。为了开始 DNA DSB,修理,我们使用了二 I-Sce 我在相反的取向的识别地点而非平常的单个地点。NHEJ, HR 和 SSA 修理小径被三相应 I-Sce 我切割构造的注射独立触发,并且 DNA 损害的修理由 I-Sce 引起了我能被 EGFP 表示在胚胎追踪。除了监视绿荧光的紧张,修理频率能被量的即时聚合酶链反应(qPCR ) 精确也测量。在 DSB 地点的 DNA 序列的分析证明 NHEJ 在在 zebrafish 胚胎的这三条修理小径之中是占优势的。而且,当 HR 和 SSA 记者系统能有效地被减少由时 rad51 和 rad52 击倒分别地, NHEJ 能仅仅被损害由 ligaseIV (lig4 ) 击倒当 NHEJ 构造被 I-Sce 切时我在 vivo。更有趣地,与 lig4 瞬间堵住 NHEJ 增加了 HR 的频率,但是减少 SSA 的频率。我们的研究证明过去常修理 DNA DSB 的主要机制从 zebrafish 被保存到哺乳动物,并且 zebrafish 为在 organismal 水平学习并且操作 DNA DSB 修理提供一个优秀模型。 | Jingang Liu Lu Gong Changqing Chang Cong Liu Jinrong Peng Jun Chen | 2012 | Journal of Genetics and Genomics2012，39，9： | 4 |
| 12 | Differences in the Efficiency of Potassium(K) Uptake and Use in Five Apple Rootstock Genotypes显示文摘Plants that grow well while accumulating and transporting less potassium(K) perform better than more-sensitive plants when under deficiency conditions, which makes low-K-input and environmentally friendly agriculture possible. We conducted hydroponics and sand culture experiments to evaluate the efficiency of various apple(Malus domestica Borkh) rootstocks in their K uptake and utilization. Five genotypes were selected which are widely used in China- M. hupehensis Rehd, M. prunifolia Borkh, M. robusta Rehd, M. sieversii Roem, and M. rockii Rehd. Plant heights, root and shoot dry weights, and K concentrations were recorded. These genotypes differed markedly in dry weights, absolute and relative K concentrations, absolute and relative K accumulations, and their K efficiency ratio under deficient K conditions. The last parameter, expressed as relative shoot dry weight, was strongly and positively correlated with the other four parameters in each genotype. Therefore, we suggest that this parameter could serve as an index when selecting K-efficient genotypes. In this study, we have determined that M. sieversiiand M. rockii are K-inefficient genotypes; M. prunifolia is K-efficient genotype; M. hupehensis and M. robusta have moderate levels of potassium efficiency. | CHANG Cong LI Chao LI Cui-ying KANG Xiao-yu ZOU Yang-jun MA Feng-wang | 2014 | Journal of Integrative Agriculture2014，13，9： | 4 |
| 13 | Let-7b-5p regulates proliferation and apoptosis in multiple myeloma by targeting IGF1R显示文摘多重骨髓瘤(公里) 全球是从 hematological 恶意的死亡的最普通的原因,并且最近的研究表明了 let-7b-5p 能在 tumorigenesis 起一个禁止的作用。然而,在公里的 let-7b-5p 的角色仍然保持不清楚。这研究的目的是阐明 let-7b-5p 在公里由充当肿瘤 suppressor 的分子的机制。这里,量的即时聚合酶链反应结果证明 let-7b-5p 的表示显著地在公里纸巾和公里房间线(RPMI-8226 和 U266 房间) 被减少。而且, let-7b-5p 的在表示上显著地压制了 RPMI-8226 房间增长并且导致了 S/G2 房间周期拘捕和 apoptosis。酶记者试金结果证明(IGF1R ) 像胰岛素的生长因素受体 1 被 let-7b-5p 否定地在 post-transcriptional 水平调整。在 RPMI-8226 房间的 IGF1R 的 mRNA 和蛋白质层次由 let-7b-5p 是下面调整的。而且, let-7b-5p 禁止者改变的房间显型能被 IGF1R silencing (si-IGF1R ) 救。一起拿,我们的结果证明 let-7b-5p 在公里作为肿瘤 suppressor 工作,建议那 let-7b-5p 可以是为公里的一个潜在的治疗学的目标。 | Honghai Xu Cong Liu Yuelin Zhang Xiong Guo Zongzhi Liu Zhenqun Luo Yanhai Chang Shizhang Liu Zhengming Sun Xiaoqing Wang | 2014 | Acta Biochimica et Biophysica Sinica2014，46，11： | 4 |
| 14 | p53 isoform △113p53/△133p53 promotes DNA double-strand break repair to protect cell from death and senescence in response to DNA damage显示文摘在 DNA 双海滨的 p53 的禁止的角色裂缝(DSB ) 修理对它的压制肿瘤的性质似乎矛盾。p53 isoform Δ 113p53/Δ 133p53 是反对 p53 apoptotic 的 p53 目标基因活动。然而,它在 DNA 损坏修理的功能的信息正在缺乏。这里,我们报导那 Δ 113p53 表示被 γ 强烈导致; -irradiation, 然而并非由紫外照耀或热电震疗法。惊人地, Δ 113p53 支持 DNA DSB 修理小径包括相应再结合,非相应的结束加入并且单个海滨的退火。学习 Δ 的生物意义;在支持 DNA DSB 修理的 113p53,我们产生了 zebrafish Δ 113p53 经由抄写的 M/M 异种像使活跃之物的受动器核酸酶技术并且发现异种对 γ 更敏感;照耀。人的 ortholog, Δ 133p53,被 γ 仅仅也导致;照耀和功能修理支持 DNA DSB。Δ 133p53-knockdown 房间响应 γ 在以后的阶段在 G2 阶段被逮捕;照耀由于 unrepaired DNA DSB 的高水平,它最后导致了房间老朽。而且, Δ 113p53/Δ 133p53 经由 upregulating 支持 DNA DSB 修理由到在他们的倡导者的 p53 应答的元素的一种新奇类型的绑定的修理基因 rad51, lig4 和 rad52 的抄写。我们的结果表明那 Δ 113p53/Δ 133p53 是为由阻止 apoptosis 并且支持 DNA DSB 修理禁止房间老朽的 DNA 损坏应力的一个进化地保存的支持幸存的因素。我们的数据也建议 Δ 的正式就职;在正常房间或纸巾的 133p53 表示为癌症病人提供一个重要忍耐标记给放射疗法。 | Lu Gong Hongjian Gong Xiao Pan Changqing Chang Zhao Ou Shengfan Ye Le Yin Lina Yang Ting Tao Zhenhai Zhang Cong Liu David P Lane Jinrong Peng Jun Chen | 2015 | Cell Research2015，25，3： | 4 |
| 15 | Procaine Inhibiting Human Bladder Cancer Cell Proliferation by Inducing Apoptosis and Demethylating APAF1 CpG Island Hypermethylated显示文摘Studies have shown that aberrant DNA methylation of apoptotic protease activating factor-1(APAF1) is an important epigenetic mechanism of gene regulation in the progression of bladder cancer.In this article,we have proved that procaine,an inhibitor of DNA methyltransferases,could inhibit the proliferation of T24 and 5637 human bladder cancer cells by inducing their apoptosis.The mechanism studies reveal that procaine could induce demethylation of APAF1 gene in T24 or 5637 cells,subsequently activating caspase-3/9.It was also shown that the serum soluble fas ligand(sFasL) was activated,and the expression of matrix metallopeptidase 9(MMP-9) was down-regulated.Procaine seems to induce cell death by different pathways,and it might be used as a potential agent for bladder cancer treatment. | SUN Ran CHANG Li-ping WANG Kai-chen SUN Hong-yan CONG Xian-ling | 2012 | Chemical Research in Chinese Universities2012，28，6： | 3 |
| 16 | Extension Protocol for the Investigation on Nutrition Status and Clinical Outcome of Patients with Common Cancers in China(INSCOC)Study:2021 update显示文摘Background Malnutrition is common in patients with cancer,and this adversely affects the survival and quality of life of patients.Chinese Society for Nutritional Oncology issued a multi-center,large-scale,long-term follow-up prospective study,the Investigation on Nutrition Status and Clinical Outcome of Patients with Common Cancers in China(INSCOC study)since 2013.This is an extension to the previous 2013-2020 study protocol.This study still sought to:①address the prognostic impact of nutritional factors and quality of life on cancer patient survival;②describe the overall and cancer-specific incidence and/or distribution of malnutrition and different measurements of patient quality of life.Methods and study design This is an observational,multi-centered,hospital-based prospective cohort study.Data collection will be performed at baseline(within 48 hours after patient admission),during the hospital stay and 30 days after hospital admission.Follow-up will be conducted for 1-20 years after enrollment.The primary outcome will be the all-cause mortality/overall survival,and secondary outcomes will be the length of hospital stay and costs of hospitalization.Study factors will include demographic characteristics,tumor characteristics,information about chronic diseases,hematological measurements(e.g.,red blood cell count,total lymphocyte counts,hemoglobin,albumin,prealbumin,creatinine,C-reactive protein,IL-6),anthropometric measurements(e.g.,height,weight,arm circumference,arm muscle circumference,triceps skinfold thickness,and waist circumference),body composition parameters,PG-SGA scores,quality of life(as indicated by the QLQ-C30 questionnaire),muscle mass(as indicated by the calf circumference),muscle strength(as indicated by the handgrip strength),muscle function(as indicated by the six-meter walking speed test)and physical status assessments(as indicated by the Karnofsky Performance Status scores).This clinical study protocol was approved by local Ethics Committees of all the participating hospitals.Written informed consent is required for each subject included.Discussion This multi-center,large-scale,long-term follow up prospective study will help improve the diagnosis of malnutrition in cancer patients and identify the risk factors associated with adverse clinical outcomes.The anticipated results of this study will highlight the need for a truly scientific appraisal of nutrition therapy in Chinese oncology populations,and finally help treat the potentially reversible elements of malnutrition in cancer patients to improve their clinical outcomes in the future. | Hong Xia Xu Chun Hua Song Liang Yu Yin Chang Wang Zhen Ming Fu Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua Wang Jing Wu Ying He Jia Jun Yang Cong Hua Xie Fu Xiang Zhou Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Zhi Kang Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Xiang Hua Wu Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Min Weng Qing Hua Yao Ya Yin Yu Quan Jun Lyu Hong Qiu Ming Liu Wei Li Han Ping Shi The Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group | 2022 | Journal of Nutritional Oncology2022，7，2： | 3 |
| 17 | Seg-CapNet:A Capsule-Based Neural Network for the Segmentation of Left Ventricle from Cardiac Magnetic Resonance Imaging显示文摘Deep neural networks(DNNs)have been extensively studied in medical image segmentation.However,existing DNNs often need to train shape models for each object to be segmented,which may yield results that violate cardiac anatomical structure when segmenting cardiac magnetic resonance imaging(MRI).In this paper,we propose a capsulebased neural network,named Seg-CapNet,to model multiple regions simultaneously within a single training process.The Seg-CapNet model consists of the encoder and the decoder.The encoder transforms the input image into feature vectors that represent objects to be segmented by convolutional layers,capsule layers,and fully-connected layers.And the decoder transforms the feature vectors into segmentation masks by up-sampling.Feature maps of each down-sampling layer in the encoder are connected to the corresponding up-sampling layers,which are conducive to the backpropagation of the model.The output vectors of Seg-CapNet contain low-level image features such as grayscale and texture,as well as semantic features including the position and size of the objects,which is beneficial for improving the segmentation accuracy.The proposed model is validated on the open dataset of the Automated Cardiac Diagnosis Challenge 2017(ACDC 2017)and the Sunnybrook Cardiac Magnetic Resonance Imaging(MRI)segmentation challenge.Experimental results show that the mean Dice coefficient of Seg-CapNet is increased by 4.7%and the average Hausdorff distance is reduced by 22%.The proposed model also reduces the model parameters and improves the training speed while obtaining the accurate segmentation of multiple regions. | Yang-Jie Cao Shuang Wu Chang Liu Nan Lin Yuan Wang Cong Yang Jie Li | 2021 | Journal of Computer Science & Technology2021，36，2： | 3 |
| 18 | Adjuvant Effects of Dual Co-stimulatory Molecules on Cellular Responses to HIV Multiple-epitope DNA Vaccination显示文摘Designing adjuvants that can induce strong cytotoxic T cell responses is largely required for preparing DNA vaccines. In this study we explored dual costimulatory molecules 4-1BBL and OX40L as adjuvants to improve the efficiency of the HIV multiple-epitope DNA vaccine. When explored in the human dendritic cell-T cell based coculture system,dual costimulatory molecules significantly enhanced the anti-HIV T cell response of the HIV mul-tiple-epitope DNA vaccine,as detected by intracellular cytokine staining to HIV antigens,cytokines accumulation in the cultures,and antigen-specific cytotoxic T lymphocyte responses. These results suggest that dual costimulatory molecules 4-1BBL and OX40L can effectively increase the potential of the HIV multiple-epitope antigen DNA vaccine and may provide an exciting approach for HIV therapy. | SHEN Zhen-wei JIN Hong-tao LI Chang CONG Yan-zhao NAN Wen-long BAI Liang JIN Ning-yi | 2009 | Chemical Research in Chinese Universities2009，25，3： | 2 |
| 19 | Effect of mold rotation on inclusion distribution in bearing steel during electroslag remelting process显示文摘To remove the inclusions in the ingots by conventional electroslag remelting(ESR), the bearing steel was prepared using ESR process but with mold rotation in this study. Experimental results show a reduction in amount of large inclusions when the mold rotation rate is 6 r·min-1, and the inclusions are uniformly distributed in the ESR ingot. As comparison with the electroslag ingots of conventional ESR(stationary mold), the portion of the Al2O3 inclusions smaller than 1 μm in size increase from 38% to 41.4%, whereas that of the SiO2 inclusions increases from 48% to 74% in the ingots when mold rotation is applied. This phenomenon is caused by the decrease in metal droplet size, resulting in large contact area between the slag pool and metal droplets in ESR process with mold rotation. Moreover, the metal droplets have relatively long movement routes, leading to long metal contact time between the slag pool and metal droplets when a relative motion between the consumable electrodes and mold is present. However, when the mold rotation rate is increased to 45 r·min-1, inclusion removing effect decreases. An excessive rotation rate causes wild motion in the slag pool, which drives the molten metal droplets to move violently, and as a result, the slag is entrapped into the metal pool, decreasing the ability of slag absorbing inclusions. | Chang Lizhong Shi Xiaofang Wang Runxi Cong Junqiang Li Tao | 2014 | China Foundry2014，11，5： | 2 |
| 20 | Ultra-small hollow ternary alloy nanoparticles for efficient hydrogen evolution reaction显示文摘Hollow nanoparticles with large specific surface area and high atom utilization are promising catalysts for the hydrogen evolution reaction(HER). We describe herein the design and synthesis of a series of ultra-small hollow ternary alloy nanostructures using a simple one-pot strategy. The same technique was demonstrated for hollow PtNiCu nanoparticles, hollow PtCoCu nanoparticles and hollow CuNiCo nanoparticles. During synthesis, the displacement reaction and oxidative etching played important roles in the formation of hollow structures. Moreover, our hollow PtNiCu and PtCoCu nanoparticles were single crystalline, with an average diameter of 5 nm. Impressively, ultra-small hollow PtNiCu nanoparticles,containing only 10% Pt, exhibited greater electrocatalytic HER activity and stability than a commercial Pt/C catalyst. The overpotential of hollow Pt Ni Cu nanoparticles at 10 mA cm^(-2) was 28 mV versus reversible hydrogen electrode(RHE). The mass activity was 4.54 A mg Pt^(-1) at-70 mV versus RHE, which is 5.62-fold greater than that of a commercial Pt/C system(0.81 A mg Pt^(-1)). Through analyses of bonding and antibonding orbital filling, density functional theory calculations demonstrated that the bonding strength of different metals to the hydrogen intermediate(H*) was in the order of Pt > Co > Ni > Cu. The excellent HER performance of our hollow PtNiCu nanoparticles derives from moderately synergistic interactions between the three metals and H*. This work demonstrates a new strategy for the design of low-cost and high-activity HER catalysts. | Zhenxing Li Chengcheng Yu Yikun Kang Xin Zhang Yangyang Wen Zhao-Kui Wang Chang Ma Cong Wang Kaiwen Wang Xianlin Qu Miao He Ya-Wen Zhang Weiyu Song | 2021 | National Science Review2021，8，7： | 2 |
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