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| 1 | Incidence and mortality of stomach cancer in China,2014显示文摘Objective: In this study,we aimed to estimate the updated incidence and mortality rate of stomach cancer based on the cancer registration data in 2014,collected by the National Central Cancer Registry of China(NCCRC).Methods: In 2017,339 registries' data were qualified based on the criteria of data quality control of the NCCRC.Cases of stomach cancer were retrieved from the national database.We estimated numbers of stomach cancer cases and deaths in China using age-specific rates and corresponding national population stratified by area,sex,agegroup(0,1–4,5–9,10–14,…,85+).Chinese standard population in 2000 and Segi's world population were applied for age-standardized incidence and mortality rates.Results: In 2014,410,400 new stomach cancer cases and 293,800 cancer-associated deaths were estimated to have occurred in China.The crude incidence rate of stomach cancer was 30.00/100,000,age-standardized incidence rates by Chinese standard population(ASIRC) and by world standard population(ASIRW) were 19.62/100,000 and19.51/100,000,respectively.The crude mortality rate of stomach cancer was 21.48/100,000,age-standardized mortality rates by Chinese(ASMRC) and by world standard population(ASMRW) were 13.44/100,000 and13.30/100,000,respectively.Incidence and mortality rates in rural areas were both higher than that in urban areas.Stomach cancer has a strong relationship with gender and age.The disease has occurred more frequently among men than women with a male to female ratio of 2.4 for ASIRC.After age group of 40-44 years,incidence rates are substantially higher in men than in women,same pattern was seen for age-specific mortality rates.Conclusions: There is still a heavy burden of stomach cancer in China.The incidence and mortality patterns of stomach cancer show substantial gender and regional disparities.Great effort is needed to provide more accessible health services,sufficient financial resources,and adequate cancer-care infrastructure for the Chinese population,especially for people living in rural areas. | Lei Yang Rongshou Zheng Ning Wang Yannan Yuan Shuo Liu Huichao Li Siwei Zhang Hongmei Zeng Wanqing Chen | 2018 | Chinese Journal of Cancer Research2018，30，3： | 114 |
| 2 | Programmable time-domain digital-coding metasurface for non-linear harmonic manipulation and new wireless communication systems显示文摘Optical non-linear phenomena are typically observed in natural materials interacting with light at high intensities, and they benefit a diverse range of applications from communication to sensing. However,controlling harmonic conversion with high efficiency and flexibility remains a major issue in modern optical and radio-frequency systems. Here, we introduce a dynamic time-domain digital-coding metasurface that enables efficient manipulation of spectral harmonic distribution. By dynamically modulating the local phase of the surface reflectivity, we achieve accurate control of different harmonics in a highly programmable and dynamic fashion, enabling unusual responses, such as velocity illusion. As a relevant application, we propose and realize a novel architecture for wireless communication systems based on the time-domain digital-coding metasurface, which largely simplifies the architecture of modern communication systems, at the same time yielding excellent performance for real-time signal transmission. The presented work, from new concept to new system, opens new pathways in the application of metamaterials to practical technology. | Jie Zhao Xi Yang Jun Yan Dai Qiang Cheng Xiang Li Ning Hua Qi Jun Chen Ke Guo Dong Bai Shuo Liu Shi Jin Andrea Alù Tie Jun Cui | 2019 | National Science Review2019，6，2： | 46 |
| 3 | Exotic origin of the Chinese continental shelf: new insights into the tectonic evolution of the western Pacific and eastern China since the Mesozoic显示文摘The effect of paleo-Pacific subduction on the geological evolution of the western Pacific and continental China is likely complex. Nevertheless, our analysis of the distribution of Mesozoic granitoids in the eastern continental China in space and time has led us to an interesting conclusion: The basement of the continental shelf beneath East and South China Seas may actually be of exotic origin geologically unrelated to the continental lithosphere of eastern China. By accepting the notion that the Jurassic–Cretaceous granitoids in the region are genetically associated with western Pacific subduction and the concept that subduction may cease to continue only if the trench is being jammed, then the termination of the granitoidmagmatism throughout the vast region at *88 ± 2 Ma manifests the likelihood of ‘‘sudden'', or shortly beforehand(*100 Ma), trench jam of the Mesozoic western Pacific subduction. Trench jam happens if the incoming‘‘plate'' or portion of the plate contains a sizeable mass that is too buoyant to subduct. The best candidate for such a buoyant and unsubductable mass is either an oceanic plateau or a micro-continent. We hypothesize that the basement of the Chinese continental shelf represents such an exotic, buoyant and unsubductable mass, rather than seaward extension of the continental lithosphere of eastern China. The locus of the jammed trench(i.e., the suture) is predictably located on the shelf in the vicinity of, and parallel to, the arc-curved coastal line of the southeast continental China. It is not straightforward to locate the locus in the northern section of the East China Sea shelf because of the more recent(\20 Ma) tectonic re-organization associated with the opening of the Sea of Japan. We predict that the trench jam at *100 Ma led to the re-orientation of the Pacific plate motion in the course of NNW direction as inferred from the age-progressive Emperor Seamount Chain of Hawaiian hotspot origin(its oldest unsubdued Meiji and Detroit seamounts are *82 Ma),making the boundary between the Pacific plate and the newly accreted plate of eastern Asia a transform fault at the location east of the continental shelf of exotic origin. This explains the apparent *40 Myr magmatic gap from *88to *50 Ma prior to present-day western Pacific subduction initiation. We propose that basement penetration drilling on well-chosen sites is needed to test the hypothesis in order to reveal the true nature of the Chinese continental shelf basement. This testing becomes critical and cannot longer be neglected in order to genuinely understand the tectonic evolution of the western Pacific and its effect on the geology of eastern China since the Mesozoic, includingthe cratonic lithosphere thinning, related magmatism/mineralization, and the mechanism of the subsequent South China Sea opening, while also offering novel perspectives on aspects of the plate tectonics theory. We also suggest the importance of future plate tectonic reconstruction of the western Pacific to consider the nature and histories of the Chinese continental shelf of exotic origin as well as the probable transform plate boundary from *100 to*50 Ma. Effort is needed to reveal the true nature and origin of the *88 ± 2 Ma granitic gneisses in Taiwan and the 110–88 Ma granitoids on the Hainan Island. | Yaoling Niu Yi Liu Qiqi Xue Fengli Shao Shuo Chen Meng Duan Pengyuan Guo Hongmei Gong Yan Hu Zhenxing Hu Juanjuan Kong Jiyong Li Jinju Liu Pu Sun Wenli Sun Lei Ye Yuanyuan Xiao Yu Zhang | 2015 | Science Bulletin2015，60，18： | 32 |
| 4 | Broadband diffusion of terahertz waves by multi-bit coding metasurfaces显示文摘The terahertz region is a special region of the electromagnetic spectrum that incorporates the advantages of both microwaves and infrared light waves.In the past decade,metamaterials with effective medium parameters or gradient phases have been studied to control terahertz waves and realize functional devices.Here,we present a new approach to manipulate terahertz waves by using coding metasurfaces that are composed of digital coding elements.We propose a general coding unit based on a Minkowski closed-loop particle that is capable of generating 1-bit coding(with two phase states of 0 and 180°),2-bit coding(with four phase states of 0,90°,180°,and 270°),and multi-bit coding elements in the terahertz frequencies by using different geometric scales.We show that multi-bit coding metasurfaces have strong abilities to control terahertz waves by designing-specific coding sequences.As an application,we demonstrate a new scattering strategy of terahertz waves—broadband and wide-angle diffusion—using a 2-bit coding metasurface with a special coding design and verify it by both numerical simulations and experiments.The presented method opens a new route to reducing the scattering of terahertz waves. | Li-Hua Gao Qiang Cheng Jing Yang Shao-Jie Ma Jie Zhao Shuo Liu Hai-Bing Chen Qiong He Wei-Xiang Jiang Hui-Feng Ma Qi-Ye Wen Lan-Ju Liang Biao-Bing Jin Wei-Wei Liu Lei Zhou Jian-Quan Yao Pei-Heng Wu Tie-Jun Cui | 2015 | Light(Science & Applications)2015，4，1： | 31 |
| 5 | 3D printing of bone tissue engineering scaffolds显示文摘Tissue engineering is promising in realizing successful treatments of human body tissue loss that current methods cannot treat well or achieve satisfactory clinical outcomes.In scaffold-based bone tissue engineering,a high performance scaffold underpins the success of a bone tissue engineering strategy and a major direction in the field is to produce bone tissue engineering scaffolds with desirable shape,structural,physical,chemical and biological features for enhanced biological performance and for regenerating complex bone tissues.Three-dimensional(3D)printing can produce customized scaffolds that are highly desirable for bone tissue engineering.The enormous interest in 3D printing and 3D printed objects by the science,engineering and medical communities has led to various developments of the 3D printing technology and wide investigations of 3D printed products in many industries,including biomedical engineering,over the past decade.It is now possible to create novel bone tissue engineering scaffolds with customized shape,architecture,favorable macro-micro structure,wettability,mechanical strength and cellular responses.This article provides a concise review of recent advances in the R&D of 3D printing of bone tissue engineering scaffolds.It also presents our philosophy and research in the designing and fabrication of bone tissue engineering scaffolds through 3D printing. | Chong Wang Wei Huang Yu Zhou Libing He Zhi He Ziling Chen Xiao He Shuo Tian Jiaming Liao Bingheng Lu Yen Wei Min Wang | 2020 | Bioactive Materials2020，5，1： | 20 |
| 6 | Field-observation for an anticyclonic mesoscale eddy consisted of twelve gliders and sixty-two expendable probes in the northern South China Sea during summer 2017显示文摘An intensive field observation experiment using 12 Chinese gliders equipped with conductivity-temperature-depth (CTD) sensors and 62 expendable CTD probes (XCTDs) was performed to investigate the 3-D structure and time evolution of an anticyclonic eddy in the northern South China Sea (NSCS). The observed results showed that the anticyclonic eddy had a horizontal radius of about 80 km at surface and a vertical depth of impact of more than 1000 m. The largest temperature and salinity anomalies compared with the averaged values of the temperature and salinity profiles were 3.5°C and 0.4 psu at 120 m depth, respectively. Combined analysis of altimeter sea level and water mass properties indicated that the anticyclonic eddy was shed from the Kuroshio loop current. The vertical axis of the anticyclonic eddy tilted from surface to the observed maximum depth (1000 m) along its translation direction against the 2000 m isobath. The center of the anticyclonic eddy remained in the region east of Dongsha Island for more than half a month. During this time, the long axis direction of the eddy changed from across the slope to along the slope. Then, the eddy moved southward along the 2000 m isobaths. Both the geostrophic current and temperature distribution revealed that the eddy intensity weakened during the observation period gradually. These observations indicated strong interaction between the anticyclonic eddy and the slope topography of Dongsha Island. | Yeqiang SHU Ju CHEN Shuo LI Qiang WANG Jiancheng YU Dongxiao WANG | 2019 | Science China Earth Sciences2019，62，2： | 19 |
| 7 | The influence of stage at diagnosis and molecular subtype on breast cancer patient survival: a hospital.based multi.center study显示文摘Background: Stage at diagnosis and molecular subtype are important clinical factors associated with breast cancer patient survival. However, subgroup survival data from a large study sample are limited in China.To estimate the survival differences among patients with different stages and various subtypes of breast cancer, we conducted a hospital-based multi-center study on breast cancer in Beijing, China.Methods: All resident patients diagnosed with primary, invasive breast cancer between January 1,2006 and December 31,2010 from four selected hospitals in Beijing were included and followed up until December 31,2015. Hospitalbased data of stage at diagnosis, hormone receptor status, and selected clinical characteristics, including body mass index(BMI), menopausal status, histological grade, and histological type, were collected from the medical records of the study subjects. Overall survival(OS) and cancer-specific survival(CSS) were estimated. Cox proportional hazards models were employed to evaluate the associations of stage at diagnosis and molecular subtype with patient survival.Results: The 5-year OS and CSS rates for all patients were 89.4% and 90.3%. Survival varied by stage and molecular subtype. The 5-year OS rates for patients with stage I, Ⅱ, Ⅲ, and IV diseases were 96.5%, 91.6%, 74.8%, and 40.7%,respectively, and the corresponding estimates of 5-year CSS rates were 97.1%, 92.6%, 75.6%, and 42.7%, respectively.The 5-year OS rates for patients with luminal A, luminal B, HER2, and triple-negative subtypes of breast cancer were92.6%, 88.4%, 83.6%, and 82.9%, respectively, and the corresponding estimates of 5-year CSS rates were 93.2%, 89.1 %,85.4%, and 83.5%, respectively. Multivariate analysis showed that stage at diagnosis and molecular subtype were important prognostic factors for breast cancer.Conclusions: Survival of breast cancer patients varied significantly by stage and molecular subtype. Cancer screening is encouraged for the early detection and early diagnosis of breast cancer. More advanced therapies and health care policies are needed on HER2 and triple-negative subtypes. | Tingting Zuo Hongmei Zeng Huichao Li Shuo Liu Lei Yang Changfa Xia Rongshou Zheng Fei Ma Lifang Liu Ning Wang Lixue Xuan Wanqing Chen | 2017 | Chinese Journal of Cancer2017，36，11： | 18 |
| 8 | Epidemiological and risk analysis of the H7N9 subtype influenza outbreak in China at its early stage显示文摘Dozens of human cases infected with H7N9 subtype avian influenza virus (AIV) have been confirmed in China since March, 2013. Distribution data of sexes, ages, professions and regions of the cases were analyzed in this report. The results showed that the elderly cases, especially the male elderly, were significantly more than expected, which is different from human cases of H5N1 avian influenza and human cases of the pandemic H1N1 influenza. The outbreak was rated as a Grade Ⅲ (severe) outbreak, and it would evolve into a Grade IV (very severe) outbreak soon, using a method reported previously. The H7N9 AIV will probably circulate in humans, birds and pigs for years. Moreover, with the driving force of natural selection, the virus will probably evolve into highly pathogenic AIV in birds, and into a deadly pandemic influenza virus in humans. Therefore, the H7N9 outbreak has been assumed severe, and it is likely to become very or extremely severe in the future, highlighting the emergent need of forceful scientific measures to eliminate any infected animal flocks. We also described two possible mild scenarios of the future evolution of the outbreak. | ZHUANG QingYe WANG SuChun WU MeiLi LIU Shuo JIANG WenMing HOU GuangYu LI JinPing WANG KaiCheng YU JianMin CHEN JiMing CHEN JiWang | 2013 | Chinese Science Bulletin2013，58，26： | 18 |
| 9 | Simple and cost-effective methods for precise analysis of trace element abundances in geological materials with ICP-MS显示文摘Inductively coupled plasma mass spectrometry(ICP-MS) is the most commonly used technique to determine the abundances of trace elements in a wide range of geological materials. However, incomplete sample digestion, isobaric interferences and instrumental drift remain obvious problems that must be overcome in order to obtain precise and accurate results. For this reason, we have done many experiments and developed a set of simple, cost-effective and practical methods widely applicable for precise and rapid determination of trace element abundances in geological materials using ICP-MS. Commonly used high-pressure digestion technique is indeed effective in decomposing refractory phases, but this inevitably produces fluoride complexes that create new problems. We demonstrate that the fluoride complexes formed during high-pressure digestion can be readily re-dissolved using high-pressure vessel at 190 °C for only 2 h for 50 mg sample. In the case of isobaric interferences, although oxide(e.g., MO+/M+) and hydroxide(e.g., MOH+/M+) productivity is variable between runs, the(MO+/M+)/(Ce O+/Ce+)and(MOH+/M+)/(Ce O+/Ce+) ratios remain constant, making isobaric interference correction for all other elements of interest straightforward, for which we provide an easy-to-use off-line procedure. We also show that mass-time-intensity drift curve is smooth as recognized previously, for which the correction can be readily done by analyzing a quality-control(QC) solution and using off-line Excel VBA procedure without internal standards. With these methods, we can produce data in reasonable agreement with recommended values of international rock reference standards with a relative error of <8% and precision generally better than 5%. Importantly, compared to the widely used analytical practice, we can effectively save >60% of time(e.g., <24 h vs. >60 h). | Shuo Chen Xiaohong Wang Yaoling Niu Pu Sun Meng Duan Yuanyuan Xiao Pengyuan Guo Hongmei Gong Guodong Wang Qiqi Xue | 2017 | Science Bulletin2017，62，4： | 17 |
| 10 | PM_(2.5)-bound polycyclic aromatic hydrocarbons(PAHs) in Beijing:Seasonal variations,sources,and risk assessment显示文摘Polycyclic aromatic hydrocarbons(PAHs) have been of health concern due to its carcinogenesis and mutagenesis. In this study, we aimed to assess the variations, sources, and lifetime excessive cancer risk(ECR) attributable to PAHs bound to ambient particulate matters with aerodynamic diameter less than 2.5 μm(PM_(2.5)) in metropolitan Beijing, China. We collected24-hour integrated PM_(2.5) samples on daily basis between November 2014 and June 2015 across both central heating(cold months) and non-heating(warm months) seasons, and further analyzed the PAH components in these daily PM_(2.5) samples. Our results showed that total concentrations of PM_(2.5)-bound PAHs varied between(88.6 ± 75.4) ng/m^3 in the cold months and(11.0 ± 5.9) ng/m^3 in the warm months. Benzo[a]pyrene(Ba P), the carcinogenic marker of PAHs,averaged at 5.7 and 0.4 ng/m^3 in the cold and warm months, respectively. Source apportionment analyses illustrated that gasoline, biomass burning, diesel, coal combustion and cooking were the major contributors, accounting for 12.9%, 17.8%, 24.7%, 24.3% and 6.4% of PM_(2.5)-bound PAHs, respectively. The BaP equivalent lifetime ECR from inhalation of PM_(2.5)-bound PAHs was 16.2 cases per million habitants. Our results suggested that ambient particulate reduction from energy reconstruction and adaption of clean fuels would result in reductions PM_(2.5)-bound PAHs and its associated cancer risks. However, as only particulate phased PAHs was analyzed in the present study, the concentration of ambient PAHs could be underestimated. | Baihuan Feng Lijuan Li Hongbing Xu Tong Wang Rongshan Wu Jie Chen Yi Zhang Shuo Liu Steven Sai Hang Ho Junji Cao Wei Huang | 2019 | Journal of Environmental Sciences2019，31，3： | 17 |
| 11 | Experimental Study of Wastewater Treatment of Reactive Dye by Phys-Chemistry Method显示文摘Wastewater, which involves easy-soluble reactive dyes, especially non-degradable dyes, is very difficult to decolor efficiently by normal processes such as coagulation process and biological treatment. The high chromaticity se- riously hinders the reuse of reactive dye waste water. In this paper, a new method by bentonite adsorption and coagulation (PAC) is employed for removing color from synthetic dye waste water which contains reactive red K-2G, K-RN blue, K-GR blue, X-3B red, K-GN orange, KB-3G yellow, K-2BP red, K-RN yellow and K-6G yellow. Bentonite pre- treated by 4% CTMAB and milled to 160 order screen is proven to the best decoloring agent. For a 100 mL reactive red K-2G sample (CODcr 400 mg/L, 25 000 chromaticity color), 0.5 g bentonite pretreated and 2.5 mL PAC is enough to decolor wastewater up to 99.92% and the sediment time is short. Non-degradable dyes such as active red X-3B and K-GN orange are declored completely as well. Raw sewage (low chromaticity color) is decolored completely at a ben-tonite dosage of 0.001g. More researches prove the high practical value of this process. | YANG Yan-wu ZHOU Tong-ling QIAO Qi-cheng CHEN Shuo | 2007 | Journal of China University of Mining and Technology2007，17，1： | 15 |
| 12 | MiR-27a Promotes Hepatocellular Carcinoma Cell Proliferation Through Suppression of its Target Gene Peroxisome Proliferator-activated Receptor γ显示文摘 | Shuo Li Jing Li Bing-Yuan Fei Dan Shao Yue Pan Zhan-Hao MO Bao-Zhen Sun Dan Zhang Xiao Zheng Ming Zhang Xue-Wen Zhang Li Chen | 2015 | Chinese Medical Journal2015，，7： | 15 |
| 13 | TLR4 deficiency has a protective effect in the MPTP/probenecid mouse model of Parkinson’s disease显示文摘Parkinson's disease(PD)is a multifactorial disorder characterized by progressive loss of dopaminergic(DA)neurons in the substantia nigra pars compacta(SNpc)and the presence of Lewy bodies(LBs)consisting of misfolded α-synuclein protein.The etiology of PD is still not clear but systemic inflammation is proved to trigger and exacerbate DA neurons degeneration.Toll-like receptor 4(TLR4)is a pattern-recognition receptor(PRR)and plays a major role in promoting the host immune.TLR4-mediated signal pathways induce the release of many inflammatory cytokines.It is reasonable to hypothesize that TLR4 is the mediator in microglia contributing to the damage of DA neurons in the SNpc.In this study,we evaluated the role of TLR4 in the chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)/probenecid mouse model.Both TLR4-deficient and wild-type(WT)mice were injected with probenecid(250 mg/kg,i.p.)followed by injection of MPTP(25 mg/kg,s.c.)every 4 days for 10 times.From D43 to D47,the behavioral performance in pole test and wire hang test was assessed.Then the mice were euthanized,and SN and striatum were dissected out for biochemical tests.We showed that compared with MPTP-treated WT mice,TLR4 deficiency significantly attenuated MPTP-induced motor deficits and TH-protein expression reduction in SNpc and striatum,suppressed MPTP-induced α-synuclein abnormality and neuroinflammation mediated through oxidative stress,glial activation,NF-κB and the NLRP3 inflammasome signaling pathways.These findings highlight the neuroprotective effect of TLR4-pathways in the chronic MPTP-induced PD mouse model. | Qian-hang Shao Ying Chen Fang-fang Li Shuo Wang Xiao-ling Zhang Yu-he Yuan Nai-hong Chen | 2019 | Acta Pharmacologica Sinica2019，40，12： | 15 |
| 14 | Ammonium removal pathways and microbial community in GAC-sand dual media filter in drinking water treatment显示文摘A GAC-sand dual media filter(GSF) was devised as an alternative solution for drinking water treatment plant to tackle the raw water polluted by ammonium in place of expensive ozone-GAC processes or bio-pretreatments.The ammonium removal pathways and microbial community in the GSFs were investigated.The concentrations of ammonium,nitrite and nitrate nitrogen were monitored along the filter.Total inorganic nitrogen(TIN) loss occurred during the filtration.For 1 mg ammonium removal,the TIN loss was as high as 0.35 mg,DO consumption was 3.06 mg,and alkalinity consumption was 5.55 mg.It was assumed that both nitrification and denitrification processes occur in the filters to fit the TIN loss and low DO consumption.During the filtration,nitritation,nitrification and nitritation-anaerobic ammonium oxidation processes probably occur,while traditional nitrification and denitrification and simultaneous nitrification and denitrification processes may occur.In the GSFs,Nitrosomonas and Nitrospira are likely to be involved in nitrification processes,while Novosphingobium,Comamonadaceae and Oxalobacteraceae may be involved in denitrification processes. | Shuo Feng Shuguang Xie Xiaojian Zhang Zhiyu Yang Wei Ding Xiaobin Liao Yuanyuan Liu Chao Chen | 2012 | Journal of Environmental Sciences2012，24，9： | 14 |
| 15 | Addition of prokinetics to PPI therapy in gastroesophageal reflux disease:A meta-analysis显示文摘AIM:To investigate the efficacy of adding prokinetics to proton pump inhibitors(PPIs)for the treatment of gastroesophageal reflux disease(GERD).METHODS:PubMed,Cochrane Library,and Web of Knowledge databases(prior to October 2013)were systematically searched for randomized controlled trials(RCTs)that compared therapeutic efficacy of PPI alone(single therapy)or PPI plus prokinetics(combined therapy)for GERD.The primary outcome of those selected trials was complete or partial relief of non-erosive reflux disease symptoms or mucosal healing in erosive reflux esophagitis.Using the test of heterogeneity,we established a fixed or random effects model where the risk ratio was the primary readout for measuring efficacy.RESULTS:Twelve RCTs including 2403 patients in total were enrolled in this study.Combined therapy was not associated with significant relief of symptoms or alterations in endoscopic response relative to single therapy(95%CI:1.0-1.2,P=0.05;95%CI:0.66-2.61,P=0.44).However,combined therapy was associated with a greater symptom score change(95%CI:2.14-3.02,P<0.00001).Although there was a reduction in the number of reflux episodes in GERD[95%CI:-5.96-(-1.78),P=0.0003]with the combined therapy,there was no significant effect on acid exposure time(95%CI:-0.37-0.60,P=0.65).The proportion of patients with adverse effects undergoing combined therapy was significantly higher than for PPI therapy alone(95%CI:1.06-1.36,P=0.005)when the difference between 5-HT receptor agonist and PPI combined therapy and single therapy(95%CI:0.84-1.39,P=0.53)was excluded.CONCLUSION:Combined therapy may partially improve patient quality of life,but has no significant effect on symptom or endoscopic response of GERD. | Li-Hua Ren Wei-Xu Chen Li-Juan Qian Shuo Li Min Gu Rui-Hua Shi | 2014 | World Journal of Gastroenterology2014，20，9： | 14 |
| 16 | Deep cleaning of a metallurgical zinc leaching residue and recovery of valuable metals显示文摘Huge quantities of zinc leaching residues(ZLRs) generated from zinc production are dumped continuously around the world and pose a potential environmental threat because of their considerable amounts of entrained heavy metals(mainly lead). Most ZLRs have not been properly treated and the valuable metals in them have not yet been effectively recovered. Herein, the deep cleaning of a ZLR and recovery of valuable metals via a hydrometallurgical route were investigated. The cleaning process consists of two essential stages: acid leaching followed by calcium chloride leaching. The optimum conditions for extracting zinc, copper, and indium by acid leaching were a sulfuric acid concentration of 200 g·L^(-1), a liquid/solid ratio of 4:1(m L/g), a leaching time of 2 h, and a temperature of 90°C. For lead and silver extractions, the optimum conditions were a calcium chloride concentration of 400 g·L^(-1), a pH value of 1.0, a leaching time of 1 h, and a temperature of 30°C. After calcium chloride leaching, silver and lead were extracted out and the lead was finally recovered as electrolytic lead by electrowinning. The anglesite phase, which poses the greatest potential environmental hazard, was removed from the ZLR after deep cleaning, thus reducing the cost of environmental management of ZLRs. The treatment of chlorine and spent electrolyte generated in the process was discussed. | Peng Xing Bao-zhong Ma Peng Zeng Cheng-yan Wang Ling Wang Yong-lu Zhang Yong-qiang Chen Shuo Wang Qiu-yin Wang | 2017 | International Journal of Minerals,Metallurgy and Materials2017，24，11： | 13 |
| 17 | Impact of dissolved organic matter on the photolysis of the ionizable antibiotic norfloxacin显示文摘Norfloxacin(NOR), an ionizable antibiotic frequently used in the aquaculture industry, has aroused public concern due to its persistence, bacterial resistance, and environmental ubiquity.Therefore, we investigated the photolysis of different species of NOR and the impact of a ubiquitous component of natural water — dissolved organic matter(DOM), which has a special photochemical activity and normally acts as a sensitizer or inhibiter in the photolysis of diverse organics; furthermore, scavenging experiments combined with electron paramagnetic resonance(EPR) were performed to evaluate the transformation of NOR in water. The results demonstated that NOR underwent direct photolysis and self-sensitized photolysis via hydroxyl radical(U OH) and singlet oxygen(1O2) based on the scavenging experiments. In addition, DOM was found to influence the photolysis of different NOR species, and its impact was related to the concentration of DOM and type of NOR species. Photolysis of cationic NOR was photosensitized by DOM at low concentration, while zwitterionic and anionic NOR were photoinhibited by DOM, where quenching of U OH predominated according to EPR experiments, accompanied by possible participation of excited triplet-state NOR and1O2. Photo-intermediate identification of different NOR species in solutions with/without DOM indicated that NOR underwent different photodegradation pathways including dechlorination, cleavage of the piperazine side chain and photooxidation, and DOM had little impact on the distribution but influenced the concentration evolution of photolysis intermediates. The results implied that for accurate ecological risk assessment of emerging ionizable pollutants, the impact of DOM on the environmental photochemical behavior of all dissociated species should not be ignored. | Chen Liang Huimin Zhao Minjie Deng Xie Quan Shuo Chen Hua Wang | 2015 | Journal of Environmental Sciences2015，27，1： | 11 |
| 18 | Acanthopanax senticosus polysaccharides-induced intestinal tight junction injury alleviation via inhibition of NF-κB/MLCK pathway in a mouse endotoxemia model显示文摘AIM To examine the effects of Acanthopanax senticosus polysaccharides(ASPS) on intestinal tight junction(TJ) disruption and nuclear factor-kappa B(NF-κB)/myosin light chain kinase(MLCK) activation in endotoxemia.METHODS BALB/C mice(6-8-weeks-old) received continuous intragastric gavage of ASPS for 7 d before injection of lipopolysaccharide(LPS), or received ASPS once after LPS injection. Blood and intestinal mucosal samples were collected 6 h after LPS challenge. Clinical symptoms, histological injury, intestinal permeability,TJ ultrastructure, and TJ protein expression were determined.RESULTS Compared with mice in the LPS group, pretreatment with ASPS improved clinical and histological scores by 390.9%(P < 0.05) and 57.89%(P < 0.05), respectively, and gut permeability change in endotoxemic mice was shown by a 61.93% reduction in reduced leakage of fluorescein isothiocyanate-dextran 6 h after LPS injection(P < 0.05). ASPS pretreatment also prevented LPS-induced TJ ultrastructure breakdown supported by increased electron dense materials between adjoining cells, sustained redistribution and expression of occludin(0.597 ± 0.027 vs 0.103 ± 0.009, P < 0.05) and zonula occludens-1(0.507 ± 0.032 vs 0.125 ± 0.019, P < 0.05), and suppressed activation of the NF-κB/MLCK pathway indicated by reduced expression of NF-κB, phospho-inhibitor kappa B-alpha, MLCK and phospho-myosin light-chain-2 by 16.06%(P < 0.05), 54.31%(P < 0.05), 66.10%(P < 0.05) and 64.82%(P < 0.05), respectively. CONCLUSION ASPS pretreatment may be associated with inhibition of the NF-κB/MLCK pathway and concomitant amelioration of LPS-induced TJ dysfunction of intestinal epithelium in endotoxemia. | Jie Han Ji-Hong Li Guang Bai Guo-Shun Shen Jing Chen Jia-Nan Liu Shuo Wang Xian-Jun Liu | 2017 | World Journal of Gastroenterology2017，23，12： | 11 |
| 19 | Structural insights into a novel histone demethylase PHF8显示文摘histone methylation/demethylation 的动态规定在开发期间起一个重要作用。在人的植物 homeodomain (哲学博士) 的变化和截断摸蛋白质 8 (PHF8 ) 与 X 连接智力迟钝和面部异例被联系,例如一张长脸,宽广鼻音尖端,劈开 lip/cleft 腭和大手,然而,它的分子的功能和结构的基础仍然保持不清楚。这里,我们在高分辨率报导 PHF8 的催化核心的水晶结构与或没有伪 - ketoglutarate (伪 - KG ) 。生物化学、结构的研究表明 PHF8 是为甲醇化物 di 、单音甲醇化物的 histone H3 离氨酸 9,然而并非为 H3K9me3 特定的新奇 histone demethylase (H3K9me2/1 ) 。我们的分析也揭示人的 PHF8 怎么在 methylation 状态之间区别并且为 methylated H3K9 完成顺序特性。在里面 vitro demethylation 试金也证明在临床的病人观察的 F279S 异种不拥有 demethylation 活动,建议酶的活动的那损失为 PHF8 病人的致病是关键的。一起拿,这些结果将使位于联系 PHF8 的发展、神经病学的疾病下面的分子的机制清楚些。 | Lin Yu Yang wang Shuo Huang Jianjun Wang Zengqin Deng Qi Zhang Wei Wu Xingliang Zhang Zhao Liu Weimin Gong Zhongzhou Chen | 2010 | Cell Research2010，20，2： | 11 |
| 20 | Chimeric antigen receptor (CAR)-modified natural killer cell-based immunotherapy and immunological synapse formation in cancer and HIV显示文摘 | Dongfang Liu Shuo Tian Kai Zhang Wei Xiong Ndongala Michel Lubaki Zhiying Chen Weidong Han | 2017 | Protein & Cell2017，8，12： | 11 |
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