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| 1 | Variations in paleoproductivity and the environmental implications over the past six decades in the Changjiang Estuary显示文摘Total organic carbon and organic carbon stable isotope, biogenic silica, chlorin were measured from a high resolution sediment core to indicate the variation in paleoproductivity and the environmental implications over the past decades (1942 to 1997) in the Changjiang Estuary. Based on these biomarkers, the shift in the phytoplankton community structure in the past decades was discussed in response to the long-term variations in nutrient concentrations and nutrient ratios. The results showed that the δ 13 C values varied from –26.15‰ to –19.5‰, suggesting the combined organic carbon sources of riverine and marine organisms. Based on the biogenic proxies, paleoproductivity changes were categorized into three stages: low production before 1950; an increase in production with the dominance of diatoms during 1950 to 1980, consistent with increasing of nutrient concentrations; a decrease in production after 1980 when the diatom production decreased while the production of non-silicious phytoplankton increased due to high nutrient inputs, and high N/P and P/Si ratios in the Changjiang Estuary. The sedimentation records also indicated that the riverine organic carbon increased since 1980. | JIN Haiyan CHEN Jianfang WENG Huanxin LI Hongliang ZHANG Weiyan XU Jie BAI Youcheng WANG Kui | 2010 | Acta Oceanologica Sinica2010，29，3： | 8 |
| 2 | Mixing of Enriched Lithospheric Mantle-Derived and Crustal Magmas: Evidence from the Habo Cenozoic Porphyry in Western Yunnan显示文摘New zircon U–Pb ages, whole-rock geochemistry and zircon Hf isotopes from the Habo porphyry Western Yunnan, China, were determined to provide constraints on the timing of uplift of the Eastern Tibetan Plateau. The intrusive rocks consist of shoshonitic porphyry(syenite porphyry and monzonite porphyry). Zircon laser ablation inductively coupled plasma mass spectrometry(LA-ICPMS) U–Pb dating indicates coeval emplacement ages of ~35 Ma. The porphyries have alkaline affinities, enrichment in large ion lithophile elements(LILEs) and light rare earth elements(LREEs)(e.g., Rb, Th, U, Pb), with depletion of high field strength elements(HFSEs)(e.g., Nb, Ti, Ta) and weak Eu anomalies. They display uniform Lu–Hf isotopic compositions with negative zircon εHf(t) values ranging from-3.9 to-0.6. The chemical characteristics of the syenite porphyries indicated that they most likely originated from the lower crust, with mantle-derived material involved in their generation. Geochemically, the monzonite porphyries are similar to the syenite porphyries; however, the lower MgO contents suggest that they were produced by different degrees of partial melting of the same lower crust source. Combined with the geochemical and isotopic data in this paper, imply that the alkali-rich porphyries of the Habo polymetallic deposit were derived from the partial melting of lower crust, enriched by mantle magma, formed in a conversion stage from stress extrusion(a strike-slip shear process) to local stress relaxation(a strike-slip pull-apart process) at the Ailaoshao tectonic zone. | XIA Bin LU Ye YUAN Yajuan CHEN Weiyan ZHANG Xiao XU Chi YU Shengrui WAN Zhifeng | 2018 | Acta Geologica Sinica(English Edition)2018，92，5： | 2 |
| 3 | Optimization of fermentation medium for xylanase-producing strain Xw2显示文摘为了由优化发酵改进 xylanase 的发酵收益,为紧张 Xw2 调节,一个 Plackett 缅甸人图案被用来由紧张 Xw2 在 xylanase 生产上评估八个变量的效果。最陡峭(降下) 上升,方法被用来接近最佳的反应表面试验性的区域。最佳的发酵条件被中央合成设计和反应表面分析获得。结果证明最佳的发酵媒介的作文是玉米圆块 +1.5% 小麦糠(1:1 ) , 0.04% MnSO4, 0.04% | Bingying YE Ting XUE Shichao YE Shengyan XU Weiyan LI Jihua LU Fang WEI Wenjin HE Youqiang CHEN | 2013 | Frontiers in Biology2013，8，6： | 2 |
| 4 | Inflammation,epigenetics,and metabolism converge to cell senescence and ageing:the regulation and intervention显示文摘Remarkable progress in ageing research has been achieved over the past decades.General perceptions and experimental evidence pinpoint that the decline of physical function often initiates by cell senescence and organ ageing.Epigenetic dynamics and immunometabolic reprogramming link to the alterations of cellular response to intrinsic and extrinsic stimuli,representing current hotspots as they not only(re-)shape the individual cell identity,but also involve in cell fate decision.This review focuses on the present findings and emerging concepts in epigenetic,inflammatory,and metabolic regulations and the consequences of the ageing process.Potential therapeutic interventions targeting cell senescence and regulatory mechanisms,using state-of-the-art techniques are also discussed. | Xudong Zhu Zhiyang Chen Weiyan Shen Gang Huang John M.Sedivy Hu Wang Zhenyu Ju | 2021 | Signal Transduction and Targeted Therapy2021，6，7： | 2 |
| 5 | Serum MicroRNA Expression Profile as a Biomarker in the Diagnosis and Prognosis of Pancreatic Cancer显示文摘 | Liu Rui Chen Xi Du Yiqi Yao Weiyan Shen Lin Wang Cheng Hu Zhibin Zhuang Rui Ning Guang Zhang Chunni Yuan Yaozong Li Zhaoshen Zen Ke Ba Yi Zhang Chen-Yu | 2012 | Clinical Chemistry2012，，3： | 2 |
| 6 | A Statistical Analysis of Crystal Developments for Bi-Superconductors显示文摘 | Weiyan Chen Quan Li Li Qiu W. M. Chen S. S. Jiang | 2004 | Journal of Superconductivity: Incorporating Novel Magnetism2004，，4： | 1 |
| 7 | New3D line clipping algorithm against spherical surface window显示文摘 | DENG WEIYAN LU GUODONG CHEN LONG | 2006 | International Technology and Innovation Conference2006，，3： | 1 |
| 8 | Improved in situ sequencing for high-resolution targeted spatial transcriptomic analysis in tissue sections显示文摘Spatial transcriptomics enables the study of localization-indexed gene expression activity in tissues,providing the transcriptional landscape that in turn indicates the potential regulatory networks of gene expression.In situ sequencing(ISS)is a targeted spatial transcriptomic technique,based on padlock probe and rolling circle amplification combined with next-generation sequencing chemistry,for highly multiplexed in situ gene expression profiling.Here,we present improved in situ sequencing(IISS)that exploits a new probing and barcoding approach,combined with advanced image analysis pipelines for high-resolution targeted spatial gene expression profiling.We develop an improved combinatorial probe anchor ligation chemistry using a 2-base encoding strategy for barcode interrogation.The new encoding strategy results in higher signal intensity as well as improved specificity for in situ sequencing,while maintaining a streamlined analysis pipeline for targeted spatial transcriptomics.We show that IISS can be applied to both fresh frozen tissue and formalin-fixed paraffin-embedded tissue sections for single-cell level spatial gene expression analysis,based on which the developmental trajectory and cell-cell communication networks can also be constructed. | Xinbin Tang Jiayu Chen Xinya Zhang Xuzhu Liu Zhaoxiang Xie Kaipeng Wei Jianlong Qiu Weiyan Ma Chen Lin Rongqin Ke | 2023 | Journal of Genetics and Genomics2023，50，9： | 1 |
| 9 | Improvement of in situ LA-ICP-MS U-Pb dating method for carbonate minerals and its application in petroleum geology显示文摘In situ carbonate U-Pb dating is gaining popularity,and it has great potential for application in petroleum geology.However,the low U content(<10μg/g)and high common Pb content of carbonate minerals,along with the uneven distribution of U and Pb and the lack of matrix-matched reference material make carbonate U-Pb dating inaccurate and less successful,which limits the widespread application in geosciences.This study evaluated the limitations of in situ carbonate U-Pb dating and proposed a method to rationally determine the laser ablation parameters of samples by improving the experimental approach based on the laser ablation sector field inductively coupled plasma mass spectrometry(LA-SF-ICP-MS).By setting a different spot size and laser frequency for the reference material and unknown samples in the same session based on the U content of the sample,the ablation craters of the reference material and unknown samples were given the same depth/width ratio,avoiding systematic offset caused by differences in down-hole element fractionation and reducing the consume of reference material.Depending on the heterogeneous distribution of U and Pb contents in carbonate minerals,the method of grid screening and setting ablation spots during screening were used to quickly select domains with high U and low common Pb,which improves the efficiency of setting laser spots and the success rate of dating,as well as reduces the experimental time and economic cost.The accuracy and success rate of carbonate U-Pb dating were effectively improved by improving the experimental method,and the technique was applied to two carbonate samples with low U and high common Pb contents that were difficult to date by traditional methods.The two samples are the saddle dolomite in the central Sichuan Basin and the calcite cement in the sandstone reservoir of the Cretaceous Qingshuihe Formation in the South Junggar Basin.The robust ages have been obtained,which constrains the timing of the diagenetic and hydrocarbon accumulation process in the studied area. | Xuesong Lu Lili GUI Weiyan CHEN Shaobo LIU Shitou WU Junjia FAN Qiang LIU Jing SUN Liangliang ZHANG Yang XIAO Wenxia YANG Rizhou CAO | 2023 | Science China Earth Sciences2023，66，12： | 1 |
| 10 | A Statistical Analysis of Crystal Developments for Bi-Superconductors显示文摘 | Weiyan Chen Quan Li Li Qiu W. M. Chen S. S. Jiang | 2004 | Journal of Superconductivity: Incorporating Novel Magnetism2004，，4： | 1 |
| 11 | A Quantitative Study on Temperature Dependent of Outgrowth in Bi-2223 Tapes显示文摘 | W. M. Chen Quan Li Weiyan Chen H. Y. Ling S. S. Jiang | 2004 | Journal of Superconductivity: Incorporating Novel Magnetism2004，，3： | 1 |
| 12 | Foreign Direct Investment and Wages: A Cross-country Analysis 显示文摘 | MUNISAMY GOPINATH WEIYAN CHEN | 2003 | Journal of International Trade and Economic Development2003，12，3： | 1 |
| 13 | Discovery of Precambrian thick black mudstones and its implication for hydrocarbon exploration in the southwest Tarim Basin显示文摘Due to deep burial of Precambrian in Tarim Basin,no breakthrough in the hydrocarbon exploration has been achieved from these strata,and development of high-quality source rocks is also uncertain.More than 30 exploratory wells have been drilled in the southwest Tarim Basin and the pediment region of Kunlun Mountains with a total area of more than 100103 km2.Though some marine oil/gas fields such as Hetianhe,Bashituopu,Yubei and Luosi 2 have been discovered,the Cambrian or Ordovician source rocks have not been drilled,and hydrocarbon source still remain controversial.Recently,a set of thick black shales and mudstones has been found in the southwest Tarim Basin.The total thickness of mudstones is more than 140 m,and the total organic carbon mainly ranges from 0.6%to 1.9%with an average of 1.0%.Tmax is from 490C to 520C,equivalent to Ro from 1.99%to 2.99%.Pyrites are very rich in mudstone.According to stratigraphic contact relationship and isotopic chronology,this mudstone may have the age of more than 517 Ma,and is tentatively named as the“Western Kunlun black rock series”.Through the plate tectonic analysis,this set of thick black mudstones is possibly distributed widely in the southwest Tarim Basin,and its formation may be controlled by the aulacogen.This set of black mudstones may be an important source rocks in the southwest Tarim Basin,which suggest that the Precambrian-Cambrian strata in Tarim Basin has geological conditions for hydrocarbon accumulations.This discovery of the black thick mudstones in the southwest Tarim Basin will promote hydrocarbon exploration in the deep and ultra-deep strata of the Tarim Basin. | Guangyou Zhu Dedao Du Weiyan Chen Qisen Sun Tingting Li Zhiyao Zhang Zhiyong Chen | 2018 | Petroleum Research2018，3，2： | 1 |
| 14 | Vascular Endothelial Growth Factor‑Recruiting Nanofiber Bandages Promote Multifunctional Skin Regeneration via Improved Angiogenesis and Immunomodulation显示文摘Tissue injury leads to gradients of chemoattractants,which drive multiple processes for tissue repair,including the inflam-matory response as well as endogenous cell recruitment.However,a limited time window for the gradients of chemoattract-ants as well as their poor stability at the injury site may not translate into healthy tissue repair.Consequently,intelligent multifunctional scaffolds with the capability to stabilize injury-induced cytokines and chemokines hold great promise for tissue repair.Vascular endothelial growth factor(VEGF)plays a significant role in wound healing by promoting angiogen-esis.The overarching objective of this research was to develop intelligent multifunctional scaffolds with the capability to endogenously recruit VEGF and promote wound healing via angiogenic and immunomodulatory dual functions.Prominin-1-derived peptide(PR1P)was encapsulated into electrospun poly(L-lactide-coglycolide)/gelatin(P/G)-based bandages.The sustained release of PR1P recruited VEGF in situ,thereby stabilizing the protein concentration peak in vivo and affording a reparative microenvironment with an adequate angiogenic ability at the wound site.Meanwhile,PR1P-recruited VEGF-induced macrophage reprogramming towards M2-like phenotypes further conferred immunomodulatory functions to the bandages.These dual functions of proangiogenesis and immunomodulation formed a cascade amplification,which regulated matrix metalloproteinases(MMP-9)as well as inflammatory factors(nuclear factor(NF)-κb,tumor necrosis factor(TNF)-α)in the wound microenvironment via the VEGF/macrophages/microenvironment axis.Consequently,the bandages realized multifunctional regeneration in splinted excisional wounds in rats,with or without diabetes,affording a higher skin append-age neogenesis,sensory function,and collagen remodeling.Conclusively,our approach encompassing in situ recruitment of VEGF at the injury site with the capability to promote immunomodulation-mediated tissue repair affords a promising avenue for scarless wound regeneration,which may also have implications for other tissue engineering disciplines. | Yi Chen Zhengchao Yuan Weiyan Sun Muhammad Shafiq Jun Zhu Jiafei Chen Hai Tang Ling Hu Weikang Lin Yanxi Zeng Long Wang Lei Zhang Yunlang She Hui Zheng Guofang Zhao Dong Xie Xiumei Mo Chang Chen | 2023 | Advanced Fiber Materials2023，5，1： | 1 |
| 15 | Zinc-finger protein 382 antagonises CDC25A and ZEB1 signaling pathway in breast cancer显示文摘Our previous studies found that Zinc-finger protein 382(ZNF382)played as a tumor suppressor gene in esophageal and gastric cancers,and a positive correlation between the high expression of ZNF382 and better outcome in breast cancer patients.However,the biological roles and mechanisms of ZNF382 in breast cancer remains unclear.We detected ZNF382 expression by reverse-transcription PCR(RT-PCR)and real-time quantitative PCR(qRT-PCR)in breast cancer cells and tissues,and explored the impacts and mechanisms of ectopic ZNF382 expression in breast cancer cells in vitro and in vivo,respectively.Our results revealed that ZNF382 was significantly down-regulated in breast cancer tissues compared with adjacent non-cancer tissues.Restoration of ZNF382 expression in silenced breast cancer cells not only inhibited tumor cell colony formation,viability,migration and invasion,and epithelial-mesenchymal-transition(EMT),but also induced apoptosis and G0/G1 arrest.In conclusion,ZNF382 could induce G0/G1 cell cycle arrest through inhibiting CDC25A signaling,and,inhibit cell migration,invasion and EMT by antagonizing ZEB1 signaling in breast cancer cells. | Shuman Li Xiaoqian He Yan Wang Weihong Chen Ran Sun Shaorong Tian Sanxiu He Chunyun Pu Chen Li Dishu Zhou Yu Jiang Qian Tao Lili Li Lin Ye Yue Wu Weiyan Peng Tingxiu Xiang | 2023 | Genes & Diseases2023，10，2： | 1 |
| 16 | The UPFC intelligent control system based on human-simulated intelligent control显示文摘 | Zhong Chen WeiYan etc | 2003 | Proceedings of the 2003 International Conference on Machine Learning and Cybernetics2003，，2： | 1 |
| 17 | Forecast of natural gas supply and demand in China under the background of “Dual Carbon Targets”显示文摘As a kind of clean energy which creates little carbon dioxide, natural gas will play a key role in the process of achieving “Peak Carbon Dioxide Emission” and “Carbon Neutrality”. The Long-range Energy Alternatives Planning System(LEAP) model was improved by using new parameters including comprehensive energy efficiency and terminal effective energy consumption. The Back Propagation(BP) Neural Network–LEAP model was proposed to predict key data such as total primary energy consumption, energy mix, carbon emissions from energy consumption, and natural gas consumption in China. Moreover, natural gas production in China was forecasted by the production composition method. Finally, based on the forecast results of natural gas supply and demand, suggestions were put forward on the development of China’s natural gas industry under the background of “Dual Carbon Targets”. The research results indicate that under the background of carbon peak and carbon neutrality, China’s primary energy consumption will peak(59.4×10^(8)tce) around 2035, carbon emissions from energy consumption will peak(103.4×10^(8)t) by 2025, and natural gas consumption will peak(6100×10^(8)m^(3)) around 2040, of which the largest increase will be contributed by the power sector and industrial sector. China’s peak natural gas production is about(2800–3400)×10^(8)m^(3), including(2100–2300)×10^(8)m^(3)conventional gas(including tight gas),(600–1050)×10^(8)m^(3)shale gas, and(150–220)×10^(8)m^(3)coalbed methane. Under the background of carbon peak and carbon neutrality, the natural gas consumption and production of China will further increase, showing a great potential of the natural gas industry. | JIA Ailin CHENG Gang CHEN Weiyan LI Yilong | 2023 | Petroleum Exploration and Development2023，50，2： | 0 |
| 18 | Composition and origin of molecular compounds in the condensate oils of the Dabei gas field, Tarim Basin, NW China显示文摘The Dabei gas field in the Kuqa Depression of the Tarim Basin is the most complex and deep continental condensate gas field in China. Comprehensive two-dimensional gas chromatography?time of flight mass spectrometer (GC×GC-TOFMS) analysis was conducted on five condensate oil samples from this field. The results show that the samples have n-alkane series in complete preservation and rich adamantanes. According to the methyladamantane index, the condensate oil is the product of the source rock with vitrinite reflectance (Ro) of 1.3%–1.6%. According to the gas maturity calculated through carbon isotope and vitrinite reflectance, the natural gas is corresponding to Ro of 1.3%–1.7%, reflecting that the natural gas and condensate oil are basically formed during the same period at the high maturity stage of source rock. The Dabei gas field has favorable geological conditions for hydrocarbon accumulation: thick salt rock in the Paleogene acts as a regional high-quality caprock directly overlying the high-quality sandstone reservoir of the Cretaceous, the coal source rocks have high hydrocarbon generation intensity and provide continuous oil and gas, and the subsalt thrust structures develop in rows with rich faults, providing migration pathways for oil and gas migration. These factors together controlled the formation of the Dabei gas field. | ZHU Guangyou CHI Linxian ZHANG Zhiyao LI Tingting YANG Haijun CHEN Weiyan ZHAO Kun YAN Huihui | 2019 | Petroleum Exploration and Development2019，46，3： | 0 |
| 19 | Future directions for research on tissue-engineered trachea显示文摘As the only way for air to enter the lungs,the trachea plays an indispensable role in conducting,cleaning,and humidifying air.Tumors,trauma,and congenital disease of the trachea are serious threats to patients[1].Local tracheal disease can be treated with a balloon or stent,but for extensive tracheal disease,tracheal reconstruction after surgical resection is the only treatment[2–4].However,the tension of the anastomotic site also increases with expansion of the resection range,which causes a series of complications,such as poor anastomotic healing,anastomotic fistulae,and tracheal rupture,and even life-threatening complications in severe cases[5]. | Hai Tang Weiyan Sun Yi Chen Yunlang She Chang Chen | 2022 | Bio-Design and Manufacturing2022，5，3： | 0 |
| 20 | Correction to:Vascular Endothelial Growth Factor‑Recruiting Nanofiber Bandages Promote Multifunctional Skin Regeneration via Improved Angiogenesis and Immunomodulation显示文摘Correction to:Advanced Fiber Materials http://gffzzd3cc09b8251d45dfsx5b9bxx0unxn6qf5.ffgz.tsg.suse.edu.cn/10.1007/s42765-022-00226-8 In this article the author name Muhammad Shafiq was incorrectly written as Shafiq Muhammad.The original article has been corrected. | Yi Chen Zhengchao Yuan Weiyan Sun Muhammad Shafiq Jun Zhu Jiafei Chen Hai Tang Ling Hu Weikang Lin Yanxi Zeng Long Wang Lei Zhang Yunlang She Hui Zheng Guofang Zhao Dong Xie Xiumei Mo Chang Chen | 2023 | Advanced Fiber Materials2023，5，2： | 0 |
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