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| 1 | GL3.3, a Novel QTL Encoding a GSK3/SHAGGY- like Kinase, Epistatically Interacts with GS3 to Produce Extra-long Grains in Rice显示文摘 | Duo Xia Nao Zhou Rongjia Liu Wenhan Dan Pingbo Li Bian Wu Junxiao Chen Lingqiang Wang Guanjun Gao Qinglu Zhang Yuqing He | 2018 | Molecular Plant2018，11，5： | 41 |
| 2 | Elimination of senescent cells byβ-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice显示文摘Cellular senescence,a persistent state of cell cycle arrest,accumulates in aged organisms,contributes to tissue dysfunction,and drives age-related phenotypes.The clearance of senescent cells is expected to decrease chronic,low-grade inflammation and improve tissue repair capacity,thus attenuating the decline of physical function in aged organisms.However,selective and effective clearance of senescent cells of different cell types has proven challenging.Herein,we developed a prodrug strategy to design a new compound based on the increased activity of lysosomalβ-galactosidase(β-gal),a primary characteristic of senescent cells.Our prodrug SSK1 is specifically activated byβ-gal and eliminates mouse and human senescent cells independently of senescence inducers and cell types.In aged mice,our compound effectively cleared senescent cells in different tissues,decreased the senescence-and age-associated gene signatures,attenuated low-grade local and systemic inflammation,and restored physical function.Our results demonstrate that lysosomalβ-gal can be effectively leveraged to selectively eliminate senescent cells,providing a novel strategy to develop anti-aging interventions. | Yusheng Cai Huanhuan Zhou Yinhua Zhu Qi Sun Yin Ji Anqi Xue Yuting Wang Wenhan Chen Xiaojie Yu Longteng Wang Han Chen Cheng Li Tuoping Luo Hongkui Deng | 2020 | Cell Research2020，30，7： | 12 |
| 3 | IL-17 sustains the plasma cell response via p38-mediated Bcl-xL RNA stability in lupus pathogenesis显示文摘Recent studies have demonstrated a central role for plasma cells in the development of autoimmune diseases,such as systemic lupus erythematosus(SLE).Currently,both the phenotypic features and functional regulation of autoreactive plasma cells during SLE pathogenesis remain largely unclear.In this study,we first found that a major subset of IL-17 receptor-expressing plasma cells potently produced anti-dsDNA IgG upon IL-17A(IL-17)stimulation in SLE patients and lupus mice.Using a humanized lupus mouse model,we showed that the transfer of Th17 cell-depleted PBMCs from lupus patients resulted in a significantly reduced plasma cell response and attenuated renal damage in recipient mice compared to the transfer of total SLE PBMCs.Moreover,long-term BrdU incorporation in lupus mice detected highly enriched long-lived BrdU+subsets among IL-17 receptor-expressing plasma cells.Lupus mice deficient in IL-17 or IL-17 receptor C(IL-17RC)exhibited a diminished plasma cell response and reduced autoantibody production with attenuated renal damage,while the adoptive transfer of Th17 cells triggered the plasma cell response and renal damage in IL-17-deficient lupus mice.In reconstituted chimeric mice,IL-17RC deficiency resulted in severely impaired plasma cell generation but showed no obvious effect on germinal center B cells.Further mechanistic studies revealed that IL-17 significantly promoted plasma cell survival via p38-mediated Bcl-xL transcript stabilization.Together,our findings identified a novel function of IL-17 in enhancing plasma cell survival for autoantibody production in lupus pathogenesis,which may provide new therapeutic strategies for the treatment of SLE. | Kongyang Ma Wenhan Du Fan Xiao Man Han Enyu Huang Na Peng Yuan Tang Chong Deng Lixiong Liu Yulan Chen Jingjing Li Shiwen Yuan Qin Huang Xiaoping Hong Dajun Hu Xiaoyan Cai Quan Jiang Dongzhou Liu Liwei Lu | 2021 | Cellular & Molecular Immunology2021，18，7： | 6 |
| 4 | GATA family members as inducers for cellular reprogramming to pluripotency显示文摘GATA 蛋白质家庭的成员在系说明和 transdifferentiation 起重要作用。以前的报告证明 GATA 蛋白质家庭罐头的一些成员也由代替 Oct4 在体的房间导致 pluripotency,一个关键联系 pluripotency 的因素。然而,连接指定系的暗示的机制和 pluripotency 的激活留下逃犯。这里,我们报导所有 GATA 家庭成员能代替让 Oct4 导致 pluripotency。我们发现 GATA 家庭的所有成员能禁止 overrepresented ectodermal 系基因,它与以前的报告显示不同指定系的力量的平衡为 pluripotency 的恢复是重要的一致。一根保存锌手指在 C 终点的 DNA 有约束力的领域是批评的让 GATA 家庭导致 pluripotency。用 RNA-seq 和 ChIP-seq,我们决定 pluripotency 相关的基因 Sall4 在 reprogramming 期间是 GATA 家庭成员的一个直接目标并且用作连接指定系的 GATA 家庭到 pluripotency 电路的一座桥。因此, GATA 家庭是所有成员能作为 reprogramming 进程的 inducers 工作并且能代替 Oct4 的第一个蛋白质家庭。我们的结果建议在 reprogramming 的 GATA 家庭的角色被低估了并且 GATA 家庭可以担任房间命运变换的一个重要调停人。 | Jian Shu Ke Zhang Minjie Zhang Yao Sida Shao Fengxia Du Caiyun Yang Wenhan Chen Chen Wu Weifeng Yang Yingli Sun Hongkui Deng | 2015 | Cell Research2015，25，2： | 5 |
| 5 | Fast-Suppressor Screening for New Components in Protein Trafficking,Organelle Biogenesis and Silencing Pathway in Arabidopsis thaliana Using DEX-Inducible FREE1-RNAi Plants显示文摘Membrane trafficking is essential for plant growth and responses to external signals.The plant unique FYVE domain-containing protein FREE1 is a component of the ESCRT complex(endosomal sorting complex required for transport).FREE1 plays multiple roles in regulating protein trafficking and organelle biogenesis including the formation of intraluminal vesicles of multivesicular body(MVB),vacuolar protein transport and vacuole biogenesis,and autophagic degradation.FREE1 knockout plants show defective MVB formation,abnormal vacuolar transport,fragmented vacuoles,accumulated autophagosomes,and seedling lethality.To further uncover the underlying mechanisms of FREE1 function in plants,we performed a forward genetic screen for mutants that suppressed the seedling lethal phenotype of FREE1-RNAi transgenic plants.The obtained mutants are termed as suppressors of free1(sof).To date,229 putative sof mutants have been identified.Barely detecting of FREE1 protein with M3plants further identified 84 FREE1-related suppressors.Also145 mutants showing no reduction of FREE1 protein were termed as RNAi-related mutants.Through next-generation sequencing(NGS)of bulked DNA from F2mapping population of two RNAi-related sof mutants,FREE1-RNAi T-DNA inserted on chromosome 1 was identified and the causal mutation of putative sof mutant is being identified similarly.These FREE1-and RNAi-related sof mutants will be useful tools and resources for illustrating the underlying mechanisms of FREE1 function in intracellular trafficking and organelle biogenesis,as well as for uncovering the new components involved in the regulation of silencing pathways in plants. | Qiong Zhao Caiji Gao PoShing Lee Lin Liu Shaofang Li Tangjin Hu Jinbo Shen Shuying Pan Hao Ye Yunru Chen Wenhan Cao Yong Cui Peng Zeng Sheng Yu Yangbin Gao Liang Chen Beixin Mo Xin Liu Shi Xiao Yunde Zhao Silin Zhong Xuemei Chen Liwen Jiang | 2015 | Journal of Genetics and Genomics2015，42，6： | 4 |
| 6 | First experimental constraints on WIMP couplings in the effective field theory framework from CDEX显示文摘We present weakly interacting massive particles(WIMPs) search results performed using two approaches of effective field theory from the China Dark Matter Experiment(CDEX), based on the data from both CDEX-1B and CDEX-10 stages. In the nonrelativistic effective field theory approach, both time-integrated and annual modulation analyses were used to set new limits for the coupling of WIMP-nucleon effective operators at 90% confidence level(C.L.) and improve over the current bounds in the low mχregion. In the chiral effective field theory approach, data from CDEX-10 were used to set an upper limit on WIMP-pion coupling at 90% C.L. We for the first time extended the limit to the m_(χ)<6 GeV/c^(2) region. | Yi Wang Zhi Zeng Qian Yue LiTao Yang KeJun Kang YuanJing Li Mehment Agartioglu HaiPeng An JianPing Chang JingHan Chen YunHua Chen JianPing Cheng Cheng Yi Chiang WenHan Dai Zhi Deng ChangHao Fang XinPing Geng Hui Gong QiuJu Guo XuYuan Guo HongJian He Li He ShengMing He JinWei Hu TuChen Huang HanXiong Huang HaiTao Jia LiPing Jia Xi Jiang HauBin Li JianMin Li Jin Li MingXuan Li RenMingJie Li Xia Li YuLan Li Bin Liao FongKay Lin ShinTed Lin ShuKui Liu YanDong Liu Yu Liu YuanYuan Liu ZhongZhi Liu Hao Ma YuCai Mao QiYuan Nie JinHua Ning Hui Pan NingChun Qi Jie Ren XiChao Ruan ChangSong Shang Vivek Sharma Ze She Lakhwinder Singh Monoj Kumar Singh TianXi Sun ChangJian Tang WeiYou Tang Yang Tian GuangFu Wang Li Wang Qing Wang Yu Chen Wang YunXiang Wang Zhen Wang Henry Tsz-King Wong ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue YuLu Yan Nan Yi ChunXu Yu HaiJun Yu JianFeng Yue Ming Zeng BingTao Zhang Lei Zhang FengShou Zhang ZhenYu Zhang KangKang Zhao MingGang Zhao JiFang Zhou ZuYing Zhou JingJun Zhu | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，8： | 3 |
| 7 | Spatio-temporal Characteristics of Area Coverage and Observation Geometry of the MISR Land-surface BRF Product: A Case Study of the Central Part of Northeast Asia显示文摘The Multi-angle imaging spectroradiometer(MISR) land-surface(LS) bidirectional reflectance factor(BRF) product(MILS_BRF) has unique semi-simultaneous multi-angle sampling and global coverage. However, unlike on-satellite observations, the spatio-temporal characteristics of MILS_BRF data have rarely been explicitly and comprehensively analysed. Results from 5-yr(2011–2015) of MILS_BRF dataset from a typical region in central Northeast Asia as the study area showed that the monthly area coverage as well as MILS_BRF data quantity varies significantly, from the highest in October(99.05%) through median in June/July(78.09%/75.21%) to lowest in January(18.97%), and a large data-vacant area exists in the study area during four consecutive winter months(December through March). The data-vacant area is mainly composed of crop lands and cropland/natural vegetation mosaic. The amount of data within the principal plane(PP)±30°(nPP) or cross PP ±30°(nCP), varies intra-annually with significant differences from different view zeniths or forward/backward scattering directions. For example, multiple off-nadir cameras have nPP but no nCP data for up to six months(September through February), with the opposite occurring in June and July. This study provides explicit and comprehensive information about the spatio-temporal characteristics of product coverage and observation geometry of MILS_BRF in the study area. Results provide required user reference information for MILS_BRF to evaluate performance of BRDF models or to compare with other satellite-derived BRF or albedo products. Comparing this final product to on-satellite observations, what was found here reveals a new perspective on product spatial coverage and observation geometry for multi-angle remote sensing. | LI Jian CHEN Shengbo QIN Wenhan Mike MUREFU WANG Yufei YU Yan ZHEN Zhijun | 2019 | Chinese Geographical Science2019，29，4： | 1 |
| 8 | Two-Dimensional Pnictogen for Field-Effect Transistors显示文摘Two-dimensional(2D)layered materials hold great promise for various future electronic and optoelectronic devices that traditional semiconductors cannot afford.2D pnictogen,group-VA atomic sheet(including phosphorene,arsenene,antimonene,and bismuthene)is believed to be a competitive candidate for next-generation logic devices.This is due to their intriguing physical and chemical properties,such as tunable midrange bandgap and controllable stability.Since the first black phosphorus fieldeffect transistor(FET)demo in 2014,there has been abundant exciting research advancement on the fundamental properties,preparation methods,and related electronic applications of 2D pnictogen.Herein,we review the recent progress in both material and device aspects of 2D pnictogen FETs.This includes a brief survey on the crystal structure,electronic properties and synthesis,or growth experiments.With more device orientation,this review emphasizes experimental fabrication,performance enhancing approaches,and configuration engineering of 2D pnictogen FETs.At the end,this review outlines current challenges and prospects for 2D pnictogen FETs as a potential platform for novel nanoelectronics. | Wenhan Zhou Jiayi Chen Pengxiang Bai Shiying Guo Shengli Zhang Xiufeng Song Li Tao Haibo Zeng | 2019 | Research2019，，1： | 1 |
| 9 | Epitope Prediction Based on Random Peptide Library Screening:Benchmark Dataset and Prediction Tools Evaluation 显示文摘 | SUN Pingping CHEN Wenhan HU Yanxin | 2011 | Molecules2011，16，6： | 1 |
| 10 | Glioma stem cells and neural stem cells respond differently to BMP4 signaling显示文摘Malignant glioma is a highly heterogeneous and invasive primary brain tumor characterized by high recurrence rates,resistance to combined therapy,and dismal prognosis.Glioma stem cells(GSCs)are likely responsible for tumor progression,resistance to therapy,recurrence,and poor prognosis owing to their high self-renewal and tumorigenic potential.As a family member of BMP signaling,bone morphogenetic protein4(BMP4)has been reported to induce the differentiation of GSCs and neural stem cells(NSCs).However,the molecular mechanisms underlying the BMP4-mediated effects in these two cell types are unclear.In this study,we treated hGSCs and hNSCs with BMP4 and com-pared the phenotypic and transcriptional changes between these two cell types.Phenotypically,we found that the growth of hGSCs was greatly inhibited by BMP4,but the same treatment only increased the cell size of hNSCs.While the RNA sequencing results showed that BMP4 treatment evoked significantly transcriptional changes in both hGSCs and hNSCs,the profiles of differentially expressed genes were distinct between the two groups.A gene set that specifically targeted the proliferation and differentiation of hGSCs but not hNSCs was enriched and then validated in hGSC culture.Our results suggested that hGSCs and hNSCs responded differently to BMP4 stimulation.Understanding and investigating different responses between hGSCs and hNSCs will benefit finding partner factors working together with BMP4 to further suppress GSCs proliferation and stemness without disturbing NSCs. | Xin-Xin Han Chunhui Cai Li-Ming Yu Min Wang Wenhan Yang Dai-Yu Hu Jie Ren Lu-Ying Zhu Jia-Jia Deng Qing-Qing Chen Hua He Zhengliang Gao | 2022 | Cell Regeneration2022，11，1： | 1 |
| 11 | Propelling polysulfide redox by Fe_(3)C-FeN heterostructure@nitrogendoped carbon framework towards high-efficiency Li-S batteries显示文摘Lithium-sulfur(Li-S) batteries hold great promise in next-generation high-energy-density energy storage systems,but the intractable shuttle effect and the sluggish redox kinetics of polysulfides hinder the practical implementation of Li-S batteries.Here,heterostructured Fe_(3)C-FeN nanoparticles dotted in the threedimensional-ordered nitrogen-doped carbon framework(Fe_(3)C-FeN@NCF) were synthesized by molecular engineering combined with heterointerface engineering,and were applied to regulate the immobilization-diffusion-conversion behavior of polar polysulfides.It is experimentally and theoretically demonstrated that the heterointerface between Fe_(3)C and FeN exhibits high sulfiphilicity and high electronic/ionic conductivity,thus effectively capturing polysulfides and accelerating the bidirectional conversion of sulfur species.Meanwhile,the holey carbon framework functions as the scaffold to highly disperse binary nanoparticles,ensuring the sufficient exposure of active sites and the easy accessibility for lithium ions and electrons.By virtue of these synergistic merits,the Li-S batteries based on Fe_(3)CFeN@NCF-modified separators afford excellent electrochemical performances including a high rate capacity of 858 mA h g^(-1)at 2 C and a low capacity decay rate of 0.07% per cycle after 800 cycles at 1C This work provides inspiration for the design of heterostructured compounds and sheds light on the potential of heterostructure in high-efficiency Li-S batteries. | Mengdi Zhang Jiawei Mu Yanan Li Yuanyuan Pan Zhiliang Dong Bei Chen Shiwei Guo Wenhan Yuan Haiqiu Fang Han Hu Mingbo Wu | 2023 | Journal of Energy Chemistry2023，，3： | 1 |
| 12 | Spatial Accessibility to Shopping Malls in Nanjing,China:Comparative Analysis with Multiple Transportation Modes显示文摘This study attempts to evaluate the rationality of the spatial layout of shopping malls and identify the urban area with poor shopping mall accessibility,as well as to provide a reference and assist decision-making for planning.Using the case of Nanjing,China,this study developed a method to evaluate the accessibility of shopping malls by three transport modes(car traffic,public transit,and bicycle).Specially,we divide the urban space into a regular hexagonal grid and harvest the total travel time from each of 7204 hexagon centroids to each of 129 shopping malls using the Baidu Internet map.The door-to-door travel time approach is used to evaluate all travel stages(walking,waiting,transfer,and transportation)based on travel time calculations.We further divide the shopping malls into two levels(super-regional and regional)based on the Dianping App’s information and develop the indicator of accessibility to shopping malls:the number of shopping malls within tolerance time thresholds and apply the closest facility and cumulative opportunities methods to measure accessibility scores.The results show that the accessibility estimations vary greatly with transport modes.The accessibility of shopping malls presents a concentric ring trend centered on the city center under the car traffic and bicycle modes.And public transit accessibility tends to axially extend due to the topology of bus routes and metro lines.In particular,we observe that the accessibility of shopping malls in Nanjing has an uneven spatial distribution pattern,with high accessibility values in the central urban areas and lots of underserved areas in urban fringe regions.Based on the accessibility measurements,we finally map the poor accessibility area and propose corresponding implications for urban planning. | LI Ang CHEN Jie QIAN Tianlu ZHANG Wenhan WANG Jiechen | 2020 | Chinese Geographical Science2020，30，4： | 1 |
| 13 | Visual Information Based Social Force Model for Crowd Evacuation显示文摘With the increase in large-scale incidents in real life, crowd evacuation plays a pivotal role in ensuring the safety of human crowds during emergency situations. The behavior patterns of crowds are well rendered by existing crowd dynamics models. However, most related studies ignore the information perception of pedestrians.To overcome this issue, we develop a visual information based social force model to simulate the interpretable evacuation process from the perspective of visual perception. Numerical experiments indicate that the evacuation efficiency and decision-making ability promote rapidly within a small range with the increase in unbalanced prior knowledge. The propagation of acceleration behavior caused by emergencies is asymmetric due to the anisotropy of visual information. Therefore, this model effectively characterizes the effect of visual information on crowd evacuation and provides new insights into the information perception of individuals in complex scenarios. | Wenhan Wu Maoyin Chen Jinghai Li Binglu Liu Xiaolu Wang Xiaoping Zheng | 2022 | Tsinghua Science and Technology2022，27，3： | 1 |
| 14 | Chemical composition and biological activities of volatile oil isolated from Curcumae rhizoma显示文摘Curcumae rhizoma(C.rhizoma),the rhizome of Curcuma Longa L.,Curcuma kwangsiensis L.and Curcuma wenyujin L.in the ginger family,is a treasure in traditional Chinese medicine.It has the effect of promoting qi and breaking blood,eliminating accumulation and relieving pain.With the development of modern medicine,the active ingredients and therapeutic mechanism of C.rhizoma have been gradually revealed.In this paper,the chemical composition and biological activities of volatile oil isolated from C.rhizoma are reviewed in detail,aiming to provide reference for further utilization of C.rhizoma volatile oil and provide more effective drug options for clinical treatment. | Wenhan Wang Yibo Wang Yuntian Xing Xinyao Wang Guanyi Zhao Yu Chen | 2023 | Asian Journal of Traditional Medicines2023，18，6： | 0 |
| 15 | Study on the resource utilization of high fluorine-containing organic waste through fluidized incineration显示文摘In this study,the method of fluidized incineration and water washing to recover hydrogen fluoride(HF)was proposed to dispose of high fluorine-containing organic waste.The resource utilization of the waste was investigated in a fluidized bed incinerator with a disposal capability of 10 t/d.The evolution characteristics of fluorine,operation conditions of the incineration system,absorption coefficient for HF by water washing,and HF corrosion during combustion were assessed.The results showed that HF and fluorocarbons were detected as the initial gaseous fluorides released during combustion.The release of HF could be divided into three stages,in which HF was generated from the volatilization of HF in the waste and the hydrolysis of fluorine in water-soluble salts(60–220℃),oxidative decomposition of fluorinated organic components and residual carbon(220–800℃),and hydrolysis of insoluble fluorinated inorganic minerals(800–1000℃).Fluorocarbons could be destroyed through reactions with free radicals H,O,and OH or through single-molecule decomposition.Enhancing the temperature in the furnace and increasing the content of oxygen and hydrogen in the incineration materials were conducive to reducing the generation of fluorocarbons.By sampling and analyzing the bottom slag,bag filter ash and exhaust gas during the field test,the relevant pollutant discharge could meet the national emission standards.The waste heat utilization of high-temperature flue gas and the recovery of hydrofluoric acid and hydrochloric acid were realized.In the recovery of HF by water washing,the total absorption coefficients for 1#to 4#packed absorbers were 52.38 kg/(h m^(2)),39.96 kg/(h m^(2)),5.98 kg/(h m^(2))and 3.89 kg/(h m^(2)),respectively.In the actual operation,alumina showed good corrosion resistance to high-temperature HF and could be used as bed materials or refractory materials.Low-temperature corrosion of HF occurred in the quenching heat exchanger,which was damaged after 6 months of continuous operation.High-temperature corrosion of HF occurred in the waste heat boiler.No significant corrosion was observed in the 24 months of operation. | Wenhan Li Zengyi Ma Jianhua Yan Qianming Huang Xingjian Wen Zian Zhai Bochen Huang Shuang Wang Yongqiang Chen | 2022 | Waste Disposal and Sustainable Energy2022，4，2： | 0 |
| 16 | Outcomes of allograft from donor kidney microthrombi and secondary recipient thrombotic microangiopathy: should we consider loosening the belt?显示文摘There is currently a huge worldwide demand for donor kidneys for organ transplantation.Consequently,numerous marginal donor kidneys,such as kidneys with microthrombi,are used to save patients'lives.While some studies have shown an association between the presence of microthrombi in donor kidneys and an increased risk for delayed graft function(DGF)(McCall et al.,2003;Gao et al.,2019),other studies have demonstrated that microthrombi negatively impact the rate of DGF(Batra et al.,2016;Hansen et al.,2018),but not graft survival rate(McCall et al.,2003;Batra et al.,2016;Gao et al.,2019).In contrast,Hansen et al.(2018)concluded that fibrin thrombi were not only associated with reduced graft function six months posttransplantation but also with increased graft loss within the first year of transplantation.On the other hand,Batra et al.(2016)found no significant differences in the DGF rate or one-year graft function between recipients in diffuse and focal microthrombi groups.To date,however,the overall influence of donor kidney microthrombi and the degree of influence on prognosis remain controversial,necessitating further research. | Yamei CHENG Luying GUO Xue REN Zhenzhen YANG Junhao LV Huiping WANG Wenhan PENG Hongfeng HUANG Jianyong WU Jianghua CHEN Rending WANG | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，6： | 0 |
| 17 | Interfacial passivation of n-ZnO/p-Si heterojunction by CuI thin layer显示文摘The ZnO/Si heterojunction diode can be integrated with the Si process, which has attracted great attention in recent years. However, the large number of interface states at the ZnO/Si heterojunction interface could adversely affect its optoelectronic properties. Here, n-type ZnO thin film was deposited on p-Si substrate for formation of an n-ZnO/p-Si heterojunction substrate. To passivate the ZnO/Si interface, a thin Cul film interface passivation layer was inserted at the ZnO/p-Si heterojunction interface. Electrical characterization such as I-V and C-V characteristic curves confirmed the significant improvement of the heterojunction properties e.g. enhancement of forward current injection, reduction of reverse current and improvement of the rectification ratio. These results showed that the passivation of interface is critical for ZnO/Si heterojunctions. | Chao Xiong Jin Xiao Lei Chen Wenhan Du Weilong Xu Dongdong Hou | 2018 | Journal of Semiconductors2018，39，12： | 0 |
| 18 | Outdoor Environmental Landscape Design of the Apartment for the Elderly in Southern Cities of China显示文摘On the basis of environmental psychology and environment-behavior science, this paper took Beijing Oriental Sun City Elderly Apartment for example to explore outdoor environmental landscape design schemes of the elderly apartment suitable for geomorphologic features, climatic conditions, and humanistic background of southern cities against the background of population aging in China, so as to provide references for the outdoor environment construction for the elderly apartment. | ZHOU Bo CHEN Sihua LI Xiaoyun YU Hanqing HUANG Wenhan | 2016 | Journal of Landscape Research2016，8，1： | 0 |
| 19 | Targeting LncRNA LLNLR-299G3.1 with antisense oligonucleotide inhibits malignancy of esophageal squamous cell carcinoma cells in vitro and in vivo显示文摘Accumulating evidence has indicated that long non-coding RNAs(lncRNAs)play critical roles in the development and progression of cancers,including esophageal squamous cell carcinoma(ESCC).However,the mechanisms of lncRNAs in ESCC are still incompletely understood and therapeutic attempts for in vivo targeting cancer-associated lncRNA remain a challenge.By RNA-sequencing analysis,we identified that LLNLR-299G3.1 was a novel ESCC-associated lncRNA.LLNLR-299G3.1 was up-regulated in ESCC tissues and cells and promoted ESCC cell proliferation and invasion.Silencing of LLNLR-299G3.1 with ASO(antisense oligonucleotide)resulted in opposite effects.Mechanistically,LLNLR-299G3.1 bound to cancerassociated RNA binding proteins and regulated the expression of cancer-related genes,including OSM,TNFRSF4,HRH3,and SSTR3.ChIRP-seq(chromatin isolation by RNA purification and sequencing)revealed that these genes contained enriched chromatin binding sites for LLNLR-299G3.1.Rescue experiments confirmed that the effects of LLNLR-299G3.1 on ESCC cell proliferation were dependent on interaction with HRH3 and TNFRSF4.Therapeutically,intravenous delivery of placental chondroitin sulfate A binding peptide-coated nanoparticles containing antisense oligonucleotide(pICSA-BP-ANPs)strongly inhibited ESCC tumor growth and significantly improved animal survival in vivo.Overall,our results suggest that LLNLR-299G3.1 promotes ESCC malignancy through regulating gene-chromatin interactions and targeting ESCC by pICSA-BP-ANPs may be an effective strategy for the treatment of lncRNA-associated ESCC. | LI TIAN YONGYI HUANG BAOZHEN ZHANG YI SONG LIN YANG QIANQIAN CHEN ZHENG WANG YILING WANG QIHAN HE WENHAN YANG SHUYONG YU TIANYU LU ZICHEN LIU KAIPING GAO XIUJUN FAN JIAN SONG RIHONG ZHAI | 2023 | Oncology Research2023，31，4： | 0 |
| 20 | Spinal cord conduits for spinal cord injury regeneration显示文摘Spinal cord injury(SCI),which causes irreversible damage in both sensory and motor function,is considered an insurmountable challenge in the field of medicine.The previous researchers have developed many kinds of biomaterials for SCI,and spinal cord conduits(SCCs)are an important classification for bridging spinal cord tissues while performing their corresponding functions.In this review,we first describe the original sources of the different polymers that determine the properties of the different SCCs.Afterwards,we focus on the different types of crosslinking methods used for preparing SCCs.Then,various practical applications and therapeutic effects of SCCs are summarized and discussed.Finally,we conclude the existing limitations of current SCCs.We hope that this paper will serve as a further inspiration for the development of SCCs in future. | Yanyu Ma Quanchi Chen Wenhan Li Haiwen Su Song Li Yitong Zhu Jie Zhou Zhenhua Feng Zhen Liu Saihu Mao Yong Qiu Huan Wang Zezhang Zhu | 2023 | Engineered Regeneration2023，4，1： | 0 |
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