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| 1 | Hydrogen peroxide homeostasis and signaling in plant cells显示文摘The increases of H2O2 concentrations in plant cells often occur under biotic and abiotic stress conditions (e.g. light, environmental stresses and plant hormone abscisic acid). Atmospheric H2O2 as an ancient signal molecule not only plays the key role in inducing evolution of oxygenic photosynthesis, but also modulates many physiological events, such as stomatal movement, hypersensitive responses, programmed cell death and gene expressions. H2O2 levels in cells must sustain a fine equilibrium between production and scavenging. H2O2 enters cells from the apoplast or generated sources, and in turn is distributed in sub-cellular compartments. H2O2 can modulate the activities of many components in signaling, such as protein phosphatases, protein kinases, transcription factors (TFs), and calcium channels. Elevated cytosolic calcium concentrations will initiate further downstream responses, via the action of calcium-binding proteins. On the other hand, the research of H2O2 as a signal molecule is still in a comparatively juvenile stage, for example, little is known about how the cells sense H2O2, what the rate-limiting steps and most important cellular events are in cell signaling and what kind of genes is specific or necessary to H2O2 signaling. The answers to all the questions depend on the functional genomic and molecular genetics analysis. | CHENG Yanli SONG Chunpen | 2006 | Science China(Life Sciences)2006，49，1： | 21 |
| 2 | Radiomics approach for preoperative identification of stages Ⅰ-Ⅱand Ⅲ-Ⅳ of esophageal cancer显示文摘Objective: To predict preoperative staging using a radiomics approach based on computed tomography(CT)images of patients with esophageal squamous cell carcinoma(ESCC).Methods: This retrospective study included 154 patients(primary cohort: n=114; validation cohort: n=40) with pathologically confirmed ESCC. All patients underwent a preoperative CT scan from the neck to abdomen. High throughput and quantitative radiomics features were extracted from the CT images for each patient. A radiomics signature was constructed using the least absolute shrinkage and selection operator(Lasso). Associations between radiomics signature, tumor volume and ESCC staging were explored. Diagnostic performance of radiomics approach and tumor volume for discriminating between stages Ⅰ-Ⅱ and Ⅲ-Ⅳ was evaluated and compared using the receiver operating characteristics(ROC) curves and net reclassification improvement(NRI).Results: A total of 9,790 radiomics features were extracted. Ten features were selected to build a radiomics signature after feature dimension reduction. The radiomics signature was significantly associated with ESCC staging(P<0.001), and yielded a better performance for discrimination of early and advanced stage ESCC compared to tumor volume in both the primary [area under the receiver operating characteristic curve(AUC): 0.795 vs. 0.694,P=0.003; NRI=0.424)] and validation cohorts(AUC: 0.762 vs. 0.624, P=0.035; NRI=0.834).Conclusions: The quantitative approach has the potential to identify stage Ⅰ-Ⅱ and Ⅲ-Ⅳ ESCC before treatment. | Lei WU Cong Wang Xianzheng Tan Zixuan Cheng Ke Zhao Lifen Yan Yanli Liang Zaiyi Liu Changhong Liang | 2018 | Chinese Journal of Cancer Research2018，30，4： | 14 |
| 3 | Chemical characteristics of precipitation at Nanping Mangdang Mountain in eastern China during spring显示文摘To study the characteristics of precipitation in eastern China,an automatic sampler was used to collect rainwater samples from 19 precipitation events at Mangdang Mountain,Nanping City,Fujiang Province,in the spring of 2009.We used ion chromatography to analyze the ionic components and concentrations,and inductively coupled plasma mass spectrometry (ICP-MS) to analyze element compositions and contents.The results demonstrated remarkable acidic characteristics:in more than 80% of precipitation events the pH was less than 5.6,with an average of 4.81.Mass concentration results showed SO 4 2 was the main anionic component (36.2% of the total anion mass),while NH 4+ was the main cationic component (47.7% of the total cation mass) and main ion for acidity neutralization in the rainwater.Organic acid content accounted for 30.9% of total anion mass.The main trace metals were Ca,K,and Na.The SO 4 2/NO 3 ratio was 1.4,indicating that precipitation in this region was influenced by complex air pollution-the product of individual coal-burning combined with vehicle exhaust pollution.Correlation analysis of the chemical composition of the precipitation indicated that acidity in this region was determined by a combination of all acidic and neutralization ions rather than any single ion component.The results also showed that Na+ and Cl contributions were mainly by seawater;Mg 2+ by seawater and crustal materials;the NH 4+,K+,Ca 2+,NO 3 and SO 4 2 by anthropogenic sources;the trace metals were from the Earth's crust;and organic acids were potentially from combustion of biomass. | Yanli Cheng Ying Liu Mingqun Huo Qian Sun Huixiang Wang Zhongming Chen Yuhua Bai | 2011 | Journal of Environmental Sciences2011，23，8： | 8 |
| 4 | Simulation of CO_2 variations at Chinese background atmospheric monitoring stations between 2000 and 2009: Applying a CarbonTracker model显示文摘We carried out a downscaling treatment over China using the CarbonTracker numerical model,which was applied using double grid nesting technology(3°×2°over the whole globe,1°×1°over China),simulating and analyzing atmospheric CO2concentrations over 10 recent years(2000–2009).The simulation results agreed very well with observed data from four background atmospheric monitoring stations in China(The periods for which the simulation results and observed values be compared were January2000 to December 2009 for the WLG station and June 2006 to December 2009 for the SDZ,LFS,and LAN stations),giving correlation coefficients of>0.7.The high-resolution simulation data correlated slightly better than the low resolution simulation data with the observed data for three of the regions’atmospheric background stations.Further analysis of the annual,seasonal CO2concentration variations at the background stations showed that the CO2concentration increased each year over the study period,with an average annual increase of more than 5%,and annual increases of more than 7%at the Shangdianzi and Lin’an stations.Seasonal CO2variations were greater at the Longfengshan station than at the Shangdianzi or Lin’an stations.However,the CO2concentrations were higher at the Shangdianzi and Lin’an stations because they are greatly affected by human activities in the Jingjinji and Changjiang Delta economic zones.Spatial distribution in CO2concentrations and fluxes were higher in eastern than in western China. | CHENG YanLi AN XingQin YUN FangHua ZHOU LingXi LIU LiXin FANG ShuangXi XU Lin | 2013 | Chinese Science Bulletin2013，58，32： | 8 |
| 5 | A strategy for generating rice apomixis by gene editing显示文摘Apomixis is an asexual reproduction way of plants that can produce clonal offspring through seeds.In this study,we introduced apomixis into rice(Oryza sativa)by mutating OsSPO11-1,OsREC8,OsOSD1,and OsMATL through a CRISPR/Cas9 system.The quadruple mutant showed a transformation from meiosis to mitosis and produced clonal diploid gametes.With mutated Osmatl,which gives rise to haploid induction in plants,the quadruple mutant is expected to be able to be produced apomictic diploid offspring.We named this quadruple mutant as AOP(Apomictic Offspring Producer)for its ability to produce apomictic offspring. | En Xie Yafei Li Ding Tang Yanli Lv Yi Shen Zhukuan Cheng | 2019 | Journal of Integrative Plant Biology2019，61，8： | 6 |
| 6 | A CRISPR evolutionary arms race: structural insights into viral anti-CRISPR/Cas responses显示文摘 | Jiuyu Wang Jun Ma Zhi Cheng Xu Meng Lilan You Min Wang Xinzheng Zhang Yanli Wang | 2016 | Cell Research2016，26，10： | 6 |
| 7 | Molecular Cytogenetic Characterization of a Wheat-Leymus mollis 3D(3Ns) Substitution Line with Resistance to Leaf Rust显示文摘Leymus mollis(Trin.)Pilger(NsNsXmXm,2n?28),a wild relative of common wheat,possesses many potentially valuable traits that could be transferred to common wheat during breeding programs.In this study,the karyotypic constitution of a wheat e L.mollis 3D(3Ns#1)disomic substitution line isolated from the F5progeny of octoploid Tritileymus M842-16 Triticum durum cv.D4286,which was designated as 10DM57,was determined using genomic in situ hybridization(GISH),fluorescent in situ hybridization(FISH),SSR markers,and ESTSTS markers.Screening of mitosis and meiosis showed that 10DM57 had a chromosome karyotype of 2n?42?21II.GISH indicated that10DM57 was a line with 40 chromosomes from wheat and two of the Ns chromosomes from L.mollis,which formed a ring bivalent in pollen mother cells at metaphase I.FISH analysis showed that the chromosome 3D may be replaced by 3Ns#1 in 10DM57.DNA markers,including SSR and EST-STS primers,showed that the pair of wheat chromosome 3D in 10DM57 was substituted by the pair of chromosome 3Ns#1from L.mollis.Evaluation of the agronomic traits showed that,compared with its common wheat relative 7182,10DM57 was resistant to leaf rust while the spike length and number of spikes per plant were improved significantly,which correlated with a higher wheat yield.The new germplasm,10DM57,could be exploited as an intermediate material in wheat genetic and breeding programs. | Yuhui Pang Xinhong Chen Jixin Zhao Wanli Du Xueni Cheng Jun Wu Yanli Li Liangming Wang Jing Wang Qunhui Yang | 2014 | Journal of Genetics and Genomics2014，41，4： | 6 |
| 8 | Web search and data mining of natural products and their bioactivities in PubChem显示文摘Natural products,as major resources for drug discovery historically,are gaining more attentions recently due to the advancement in genomic sequencing and other technologies,which makes them attractive and amenable to drug candidate screening.Collecting and mining the bioactivity information of natural products are extremely important for accelerating drug development process by reducing cost.Lately,a number of publicly accessible databases have been established to facilitate the access to the chemical biology data for small molecules including natural products.Thus,it is imperative for scientists in related fields to exploit these resources in order to expedite their researches on natural products as drug leads/candidates for disease treatment.PubChem,as a public database,contains large amounts of natural products associated with bioactivity data.In this review,we introduce the information system provided at PubChem,and systematically describe the applications for a set of PubChem web services for rapid data retrieval,analysis,and downloading of natural products.We hope this work can serve as a starting point for the researchers to perform data mining on natural products using PubChem. | HAO Ming CHENG Tiejun WANG Yanli BRYANT H. Stephen | 2013 | Science China Chemistry2013，56，10： | 5 |
| 9 | An improved specimen preparation method for marine shallow gasbearing sand sediments and its validations显示文摘Instabilities of shallow gas-charged seabed are potential geological hazards in ocean engineering.In practice,the conventional field sampling techniques failed to obtain undisturbed gas-bearing sediments from the seabed for laboratory mechanical testing because of sensitive gas exsolution and escape from sediments.However,preparation of representative remoulded gas-charged specimens is a challenging issue,because it is rather difficult to quantitatively control the gas content and obtain uniform distribution of gas bubbles within the specimen.Given the above problems,this work proposes a reliable approach to reconstitute the high-saturation specimen of gas-charged sediments in the laboratory by an improved multifunction integrated triaxial apparatus(MITA).This apparatus is developed based on an advanced stress path triaxial system by introducing a temperature-controlled system and a wavemonitoring system.The temperature-controlled system is used to accurately mimic the in situ environments of sediments in the seabed.The wave-monitoring system is utilized to identify exsolution point of free gas and examine the disturbance of gas to specimens during gas exsolution.The detailed procedure of gassy specimen preparation is introduced.Then,the quality of prepared specimens using our improved apparatus is validated by the high-resolution micro-X-ray computed tomography(mCT)scanning test,from which bubble occurrence and size distribution within the gassy sand specimen can be obtained;and preliminary mechanical tests on gassy sand specimens with various initial saturation degrees are performed.The proposed specimen preparation procedure succeeds in proving the postulated occurrence state of gas bubbles in coarse-grained sediments and accurately controlling the gas content. | Yong Wang Lingwei Kong Min Wang Yanli Wang Peng Cheng | 2021 | Journal of Rock Mechanics and Geotechnical Engineering2021，13，3： | 3 |
| 10 | Expression of CDC42 in cervical squamous cell carcinoma and its correlation with clinicopathologic characteristics显示文摘Objective:The high expression of cell division cycle 42 protein(CDC42)may be involved in the occurrence and progression of several tumors.However,the expression and function of CDC42 in cervical squamous cell carcinoma remains unclear.This study aimed to investigate the expression of CDC42 in cervical squamous cell carcinoma and its correlation with clinicopathologic characteristics.Methods:The expression of CDC42 in 162 cervical squamous cell carcinoma tissue samples and 33 normal cervical tissue samples was investigated by immunohistochemistry.The CDC42 mRNA expression was detected by reverse transcription-polymerase chain reaction(RT-PCR).Results:ThecervicalsquamouscellcarcinomagroupshowedasignificantlyhigherCDC42positiverate,compared to the normal cervical tissues(P<0.05).Furthermore,the tissues of stage II-IV carcinoma patients showed higher CDC42 expression levels compared to stage I patients(P=0.05).In addition,the expression of CDC42 was not correlated to age of patients,differentiation degree of cancer cells,or lymph node metastasis(P>0.05).Furthermore,compare with normal cervical tissues,the CDC42 mRNAexpressionincervicalcancerhadnosignificantdifference.Conclusions:CDC42 was up-regulated at protein level,but not mRNA level,in cervical squamous cell carcinoma.The high expression of CDC42 was correlated to the clinical stage of the patients,indicating that CDC42 might contribute to the progression of cervical squamous cell carcinoma. | Ding Ma Yuan Cheng Youyi Zhang Yanli Guo Zijian Li Geng Li | 2013 | Chinese Journal of Cancer Research2013，25，6： | 3 |
| 11 | The open-close mechanism of M2 channel protein in influenza A virus:A computational study on the hydrogen bonds and cation-π interactions among His37 and Trp41显示文摘The M2 protein from influenza A virus is a tetrameric ion channel. It was reported that the permeation of the ion channel is correlated with the hydrogen bond network among His37 residues and the cation-π interactions between His37 and Trp41. In the present study,the hydrogen bonding network of 4-methyl-imidazoles was built to mimic the hydrogen bonds between His37 residues,and the cation-π interactions between 4-methyl-imidazolium and indole systems were selected to represent the interac-tions between His37 and Trp41. Then,quantum chemistry calculations at the MP2/6-311G level were carried out to explore the properties of the hydrogen bonds and the cation-π interactions. The calcula-tion results indicate that the binding strength of the N-H···N hydrogen bond between imidazole rings is up to -6.22 kcal·mol-1,and the binding strength of the strongest cation-π interaction is up to -18.8 kcal·mol-1(T-shaped interaction) or -12.3 kcal·mol-1(parallel stacking interaction). Thus,the calcu-lated binding energies indicate that it is possible to control the permeation of the M2 ion channel through the hydrogen bond network and the cation-π interactions by altering the pH values. | CHENG JiaGao ZHU WeiLiang WANG YanLi YAN XiuHua LI Zhong TANG Yun JIANG HuaLiang | 2008 | Science China Chemistry2008，51，8： | 2 |
| 12 | A new method for quantitatively characterizing atmospheric oxidation capacity显示文摘Based on atmospheric chemical kinetics, the rate constant of overall pseudo-first order oxidation re-moval of gaseous pollutants (Kpor,T) is proposed to characterize the atmospheric oxidation capacity in troposphere. Being a quantitative parameter, Kpor,T can be used to address the issues related to at-mospheric oxidation capacity. By applying this method, the regional oxidation capacity of the atmos-phere in Pearl River Delta (PRD) is numerically simulated based on CBM-IV chemical mechanism. Re-sults show the significant spatio-temporal variation of the atmospheric oxidation capacity in PRD. It is found that OH initiated oxidations, heterogeneous oxidation of SO2, and photolysis of aldehydes are the three most important oxidation processes influencing the atmospheric oxidation capacity in PRD. | CHENG YanLi WANG XueSong LIU ZhaoRong BAI YuHua LI JinLong | 2008 | Science China Chemistry2008，51，11： | 2 |
| 13 | Influence of Spatial-Temporal and Environmental Factors on Larimichthys polyactis, Octopus variabilis, and Species Aggregated Set-Net CPUEs in Haizhou Bay, China显示文摘Set-nets are common alongshore fishing gear used in Haizhou Bay, which rely on flow to catch fish. The catch per unit effort(CPUE) of set-net is affected by spatial-temporal and environmental factors but no research has been conducted on this subject. In this study, we used generalized additive models(GAMs) to explore the influence of spatial-temporal and environmental factors on CPUEs of species aggregated, small yellow croaker(Larimichthys polyactis), and octopus(Octopus variabilis) based on logbooks investigations conducted at 4 stations in an alongshore area of Haizhou Bay from 2011 to 2012. The results showed that all CPUEs exhibited significant spatial-temporal differences at various scales. Aggregated CPUE was high when the sea surface temperature(SST) was 15-18℃ and 20-23℃, which was mainly determined by life history traits of the octopus and small yellow croaker(optimal SSTs 14-17℃ and 19-24℃, respectively). Chlorophyll-a concentration had significant influences on the aggregated, small yellow croaker and octopus CPUEs at optimal ranges of 3.8-6.2 mg m^(-3), 4.2-4.8 mg m^(-3) and 4.5-5.5 mg m^(-3), respectively. Flow through the net had positive relationships with CPUEs. The approximate logarithmic trends in regression curves had a critical point of 2.5 Mm^3 d^(-1), which was the dividing point that differentiated whether the major factor affecting CPUEs was the flow velocity or the fishery resource. Our results from this study will help guide fishery production and improve catch rate of set-net fishing in Haizhou Bay. | TANG Yanli MA Shuyang LIU Changdong WANG Xinmeng CHENG Shasha | 2018 | Journal of Ocean University of China2018，17，4： | 2 |
| 14 | Vertical distribution and temporal evolution of formaldehyde and glyoxal derived from MAX-DOAS observations:The indicative role of VOC sources显示文摘Formaldehyde(HCHO)and glyoxal(CHOCHO)are important oxidization intermediates of most volatile organic compounds(VOCs),but their vertical evolution in urban areas is not well understood.Vertical profiles of HCHO,CHOCHO,and nitrogen dioxide(NO_(2))were retrieved from ground-based Multi-Axis Differential Optical Absorption Spectroscopy(MAXDOAS)observations in Hefei,China.HCHO and CHOCHO vertical profiles prefer to occur at higher altitudes compared to NO_(2),which might be caused by the photochemistry-oxidation of longer-lived VOCs at higher altitudes.Monthly means of HCHO concentrations were higher in summer,while enhanced amounts of NO_(2)were mainly observed in winter.CHOCHO exhibited a hump-like seasonal variation,with higher monthly-averaged values not only occurred in warm months(July-August)but also in cold months(November-December).Peak values mainly occurred during noon for HCHO but emerged in the morning for CHOCHO and NO_(2),suggesting that HCHO is stronger link to photochemistry than CHOCHO.We further use the glyoxal to formaldehyde ratio(GFR)to investigate the VOC sources at different altitudes.The lowest GFR value is almost found in the altitude from 0.2 to 0.4 km,and then rises rapidly as the altitude increases.The GFR results indicate that the largest contributor of the precursor VOC is biogenic VOCs at lower altitudes,while at higher altitudes is anthropogenic VOCs.Our findings provide a lot more insight into VOC sources at vertical direction,but more verification is recommended to be done in the future. | Qianqian Hong Cheng Liu Qihou Hu Yanli Zhang Chengzhi Xing Jinping Ou Wei Tan Haoran Liu Xiaoqing Huang Zhenfeng Wu | 2022 | Journal of Environmental Sciences2022，34，12： | 1 |
| 15 | Research on an Adap- tive Solar Photovoltaic Array Using Shading Degree Model-based Reconfiguration Algorithm显示文摘 | Yanli Liu Zhichao Pang Ze Cheng | 2010 | Chinese Con- trol and Decision Conference2010，，： | 1 |
| 16 | Crystal structures of human IPP isomer- ase: new insights into the catalytic mechanism 显示文摘 | Cheng Zhang Lin Liu Hang Xu Zhiyi Weil Yanli Wang Ya- jing Lin Weimin Gong | 2007 | Journal of Molecular Biology2007，366，： | 1 |
| 17 | Porous catalytic membranes for CO_(2)conversion显示文摘Catalytic CO_(2)conversion has witnessed a dynamic growth in recent decades.Various materials have been applied to reduce CO_(2)into fuels and value-added chemicals.Normally,the powder-based catalysts cannot be directly utilized for CO_(2)conversion.Much attention was paid to the study of catalytic membranes in order to overcome this issue,since it is convenient for catalytic membranes to be employed in devices for practical applications.In this review,the recent research development of porous catalytic membranes for CO_(2)conversion is summarized.The preparations of representative porous catalytic membranes and their CO_(2)conversion methods,including electrocatalysis,photocatalysis,photoelectrocatalysis,thermalcatalysis and biocatalysis,are discussed in detail.This review is expected to provide deep understanding on the utilization of porous catalytic membranes for CO_(2)conversion. | Yi Guo Cheng Qian Yinglong Wu Jiawei Liu Xiaodong Zhang Dongdong Wang Yanli Zhao | 2021 | Journal of Energy Chemistry2021，30，12： | 1 |
| 18 | Effect of SiO_2/B_2O_3 Ratio on the Property of Borosilicate Glass Applied in Parabolic Trough Solar Power Plant显示文摘This work aimed to analyze the glass material used for sealing the end of a thermal collector in a parabolic trough solar power plant. Based on matched sealing requirements and application performance of glass and Kovar alloy 4J29, one borosilicate glass material(GD480S), whose expansion coefficient was similar to that of Kovar alloy 4J29, was studied. Moreover, the effect of the ratio of Si O2 to B2O3 on the glass properties was explored in detail by Fourier transform infrared spectroscopy. As the Si O2 to B2O3 ratio in the glass increased from 4.18 to 5.77, the expansion coefficient showed a decreasing trend from 4.95×10-6/ ℃ to 4.55×10-6/ ℃. In addition, the water resistance performance improved, enabling the glass material to seal well with the alloy for application in a trough solar power plant. Thus, the increase in the Si O2 to B2O3 ratio made the glass structure more compact and improved the glass performance to meet the requirements of an industrial tubular receiver. | 田英良 SHAO Yanli 陆平 CHENG Jinshu LIU Wencai | 2015 | Journal of Wuhan University of Technology(Materials Science)2015，30，1： | 1 |
| 19 | The metallic 1T-WS_(2)as cocatalysts for promoting photocatalytic N_(2) fixation performance of Bi_(5)O_(7)Br nanosheets显示文摘Recently,widespread attention has been devoted to the typical layered BiOCl or BiOBr because of the suitable nanostructure and band structure.However,owing to the fast carrier recombination,the photocatalytic performance of BiOX materials is not so satisfactory.Loading 1T phase WS_(2)nanosheets(NSs)onto Bi_(5)O_(7)Br NSs can improve the photocatalytic N_(2)fixation activity.Among these,the obtained 1T-WS_(2)@Bi_(5)O_(7)Br composites with optimum 5%1T-WS_(2)NSs display a significantly improved photocatalytic N_(2)fixation rate(8.43 mmol L^(−1)h^(−1)g^(−1)),2.51 times higher than pure Bi_(5)O_(7)Br(3.36 mmol L^(−1)h^(−1)g^(−1)).And the outstanding stability of 1T-WS_(2)@Bi_(5)O_(7)Br-5 composites is also achieved.Exactly,the photoexcited electrons from Bi_(5)O_(7)Br NSs are quickly transferred to conductive 1T phase WS_(2)as electron acceptors,which can promote the separation of carriers.In addition,1T-WS_(2)NSs can provide abundant active sites on the basal and edge planes,which can promote the efficiency of photocatalytic N_(2)fixation.This work offers a novel solution to improve the photocatalytic performance of Bi_(5)O_(7)Br NSs. | Pengyuan Qiu Jianwei Wang Zhangqian Liang Yanjun Xue Yanli Zhou Xiaoli Zhang Hongzhi Cui Guiqing Cheng Jian Tian | 2021 | Chinese Chemical Letters2021，32，11： | 1 |
| 20 | Evaluation of the toxicity of food additive silica nanoparticles on gastrointestinal cells显示文摘 | Yi‐Xin Yang Zheng‐Mei Song Bin Cheng Kun Xiang Xin‐Xin Chen Jia‐Hui Liu Aoneng Cao Yanli Wang Yuanfang Liu Haifang Wang | 2014 | J Appl Toxicol2014，，4： | 1 |
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