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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | The effect on motor cortical neuronal development of focal lesions to the sub-cortical white matter in the neonatal rat:a model for periventricular Ieukomalacia显示文摘 | Claire L Gibson I Gavin J | 2003 | Int J Devl Neurosci2003，21，： | 1 |
| 3 | The molecular hiology of the flavin-containing nlonooxygenases of man显示文摘 | Phillips I R Dolphin C T Clair P | 1995 | Chem Biol Interact1995，96，1： | 1 |
| 4 | Oblique lumbar interbody fixation:a biomeehanieal study in human spines 显示文摘 | St Clair S Tan JS Lieberman I | 2012 | J Spinal Disord Teeh2012，25，4： | 1 |
| 5 | Xerogelencapsulated W110A secondary alcohol dehydrogenase from Thermoanaerobacter ethanolicus performs asymmetric reduction of hydropbobic ketanes in organic solvents显示文摘 | MUSA M M KARLA I Z F CLAIRE V | 2007 | Angewandte Chemie2007，46，17： | 1 |
| 6 | The RNA-binding protein HuR promotes cell migration and cell invasion by stabilizing the beta-actin mRNA in a U-rich-element-dependent manner显示文摘 | Dormoy-Raclet V Menard I Clair E | 2007 | Mol Cell Bio12007，27，15： | 1 |
| 7 | Recent advances in iron oxide nanocrystal technology for medical imaging显示文摘 | Claire C Philippe R Jean M I | 2006 | Advanced drug delivery reviews2006，58，6： | 1 |
| 8 | A study of Salmonellain pigs from birth to carcass : Serotypes, genotypes,antibiotic resistance and virulence profiles 显示文摘 | DECLAN J B CLAIRE I DAVID M D | 2013 | InternationalJournal of Food Microbiology2013，160，3： | 1 |
| 9 | Ef- fect of supramaximal exercise on the electromyographic sig- nal显示文摘 | Hunter A M St Clair Gibson A Lambert M I | 2003 | Br J Sports Med2003，37，4： | 1 |
| 10 | The RNA-binding protein HuR promoles veil migration dan cell invasion by alahiliaing the beta-actin mRNA in a U-rich-element-dependent manner显示文摘 | Dormoy-Raclet V Manard I Clair E | 2007 | Mol Cell Biol2007，27，15： | 1 |
| 11 | Improvement of extraction of Penicilln acylase from Escherichia coil cells by a combined use of chemical methods显示文摘 | Novella I S Claire Fargues | 1994 | Biotech and Bioeng1994，44，3： | 1 |
| 12 | Gastric intestinal metaplasia development in African American predominant United States population显示文摘BACKGROUND Gastric cancer significantly contributes to cancer mortality globally.Gastric intestinal metaplasia(GIM)is a stage in the Correa cascade and a premalignant lesion of gastric cancer.The natural history of GIM formation and progression over time is not fully understood.Currently,there are no clear guidelines on GIM surveillance or management in the United States.AIM To investigate factors associated with GIM development over time in African American-predominant study population.METHODS This is a retrospective longitudinal study in a single tertiary hospital in Washington DC.We retrieved upper esophagogastroduodenoscopies(EGDs)with gastric biopsies from the pathology department database from January 2015 to December 2020.Patients included in the study had undergone two or more EGDswith gastric biopsy.Patients with no GIM at baseline were followed up until they developed GIM or until the last available EGD.Exclusion criteria consisted of patients age<18,pregnancy,previous diagnosis of gastric cancer,and missing data including pathology results or endoscopy reports.The study population was divided into two groups based on GIM status.Univariate and multivariate Cox regression was used to estimate the hazard induced by patient demographics,EGD findings,and Helicobacter pylori(H.pylori)status on the GIM status.RESULTS Of 2375 patients who had at least 1 EGD with gastric biopsy,579 patients were included in the study.138 patients developed GIM during the study follow-up period of 1087 d on average,compared to 857 d in patients without GIM(P=0.247).The average age of GIM group was 64 years compared to 56 years in the non-GIM group(P<0.001).In the GIM group,adding one year to the age increases the risk for GIM formation by 4%(P<0.001).Over time,African Americans,Hispanic,and other ethnicities/races had an increased risk of GIM compared to Caucasians with a hazard ratio(HR)of 2.12(1.16,3.87),2.79(1.09,7.13),and 3.19(1.5,6.76)respectively.No gender difference was observed between the study populations.Gastritis was associated with an increased risk for GIM development with an HR of 1.62(1.07,2.44).On the other hand,H.pylori infection did not increase the risk for GIM.CONCLUSION An increase in age and non-Caucasian race/ethnicity are associated with an increased risk of GIM formation.The effect of H.pylori on GIM is limited in low prevalence areas. | Akram I Ahmad Arielle Lee Claire Caplan Colin Wikholm Ioannis Pothoulakis Zaynab Almothafer NishthaRaval Samantha Marshall Ankit Mishra Nicole Hodgins In Guk Kang Raymond K Chang Zachary Dailey Arvin Daneshmand Anjani Kapadia Jae Hak Oh Brittney Rodriguez Abhinav Sehgal Matthew Sweeney Christopher B Swisher Daniel F Childers Corinne O'Connor Lynette M Sequeira Won Cho | 2022 | World Journal of Gastrointestinal Endoscopy2022，14，10： | 1 |
| 13 | Impact of trauroa stress ulcer prophylaxis guidelines on drug cost and fre-quency of major gastrointestinal bleeding 显示文摘 | I Devlin JW Claire KS Dulclmvaky SA etal | 1999 | Pharmacothera-py1999，19，4： | 1 |
| 14 | The influence of sensory cues on the performance of effort during exercise and central regulation of exercise performance显示文摘 | HAMPSON D B ST CLAIR GIBSON A LAMBERT M I | 2001 | Sports Med2001，，31： | 1 |
| 15 | Neural control of during maximal and submaximal exercise显示文摘 | ST CLAIR GIBSON A LAMEBERT M I NOAKES T D | 2001 | Sports Med2001，，31： | 1 |
| 16 | Hydroxyapatite-coated tapered cementless femoral components in total hip arthroplasty显示文摘 | Chambers B St Clair S F Froimson M I | 2007 | J Arthroplasty2007，22，41： | 1 |
| 17 | The consciousperception of the sensation of fatigue显示文摘 | ST CLAIR GIBSON A BADEN D A LAMBERT M I | 2003 | Sports Med2003，，33： | 1 |
| 18 | The evolution of CANMAT Bipolar Disorder Guidelines: past, present, and future显示文摘 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Schaffer Serge Beaulieu Martin Alda Claire O’Donovan Glenda MacQueen Roger S McIntyre Verinder Sharma Arun Ravindran L Trevor Young Roumen Milev David J Bond Benicio N Frey Benjamin I Goldstein | 2013 | Bipolar Disorders2013，，： | 1 |
| 19 | The operation of the century: total hip replacement 显示文摘 | LEARMONTH I D CLAIRE YOUNG CECIL RORABECK | 2007 | Lancet2007，370，27： | 1 |
| 20 | Pile monitoring with fiber optic sensors during axial compression,pullout,and flexure tests显示文摘 | Daniele B I Claire N | | 0，，08： | 1 |
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