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| 1 | Targeting cancer stem cell pathways for cancer therapy显示文摘Since cancer stem cells(CSCs)were first identified in leukemia in 1994,they have been considered promising therapeutic targets for cancer therapy.These cells have self-renewal capacity and differentiation potential and contribute to multiple tumor malignancies,such as recurrence,metastasis,heterogeneity,multidrug resistance,and radiation resistance.The biological activities of CSCs are regulated by several pluripotent transcription factors,such as OCT4,Sox2,Nanog,KLF4,and MYC.In addition,many intracellular signaling pathways,such as Wnt,NF-κB(nuclear factor-κB),Notch,Hedgehog,JAK-STAT(Janus kinase/signal transducers and activators of transcription),PI3K/AKT/mTOR(phosphoinositide 3-kinase/AKT/mammalian target of rapamycin),TGF(transforming growth factor)/SMAD,and PPAR(peroxisome proliferator-activated receptor),as well as extracellular factors,such as vascular niches,hypoxia,tumor-associated macrophages,cancer-associated fibroblasts,cancer-associated mesenchymal stem cells,extracellular matrix,and exosomes,have been shown to be very important regulators of CSCs.Molecules,vaccines,antibodies,and CAR-T(chimeric antigen receptor T cell)cells have been developed to specifically target CSCs,and some of these factors are already undergoing clinical trials.This review summarizes the characterization and identification of CSCs,depicts major factors and pathways that regulate CSC development,and discusses potential targeted therapy for CSCs. | Liqun Yang Pengfei Shi Gaichao Zhao Jie Xu Wen Peng Jiayi Zhang Guanghui Zhang Xiaowen Wang Zhen Dong Fei Chen Hongjuan Cui | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 12 |
| 2 | Spatial Distribution and Risk Assessment of Heavy Metals in Paddy Soils of Yongshuyu Irrigation Area from Songhua River Basin,Northeast China显示文摘There is an increasing concern for potentially hazardous metals pollution, which can threaten crops production and human health. In this study, the spatial distribution and environmental risks of eight heavy metals in surface soil samples collected from the paddy fields in Yongshuyu irrigation area, Northeast China were investigated. The mean concentrations of Pb, Cr, Cu, Ni, Zn, Cd, Hg and As were 34.6 ± 4.67, 82.8 ± 9.51, 17.3 ± 4.09, 21.2 ± 12.0, 88.6 ± 17.9, 0.18 ± 0.15, 0.22 ± 0.07 and 8.77 ± 2.47 mg/kg, respectively, which were slightly higher than their corresponding background values of Jilin Province, indicating enrichment of these metals in the paddy soils, especially for Ni, Cd and Hg. The spatial distribution of heavy metals was closely correlated with local anthropogenic activities, such as agricultural production, mining and transportation. The hot-spot areas of As and Cd were mainly concentrated in the up-midstream where were associated with agricultural activities. Cr and Cu showed similar spatial distributions with hot-spot areas distributed the whole irrigation area uniformly. Ni was mainly distributed in the downstream where Ni quarries concentrated, while the spatial distribution patterns of Hg was mainly located in the upstream and downstream where the soil was significantly influenced by irrigation and coal mining emission. The spatial distributions of Pb and Zn were mainly concentrated along the highway side. The pollution levels of Yongshuyu irrigation area were estimated through index of geo-accumulation(Igeo), Nemerow integrated pollution index(NIPI) and potential ecological risk index(PERI). The results showed that Cd and Hg were the main pollutants in the study area. Health risk assessment results indicated that children were in higher non-carcinogenic and carcinogenic risks than adults with the carcinogenic metal of As. Ingestion was the main exposure pathway to non-carcinogenic and carcinogenic risk for both adults and children. Principal component analysis(PCA) indicated that Cr and Cu were mainly from parent materials, while Cd and As were mainly affected by agricultural activities. Pb and Zn were controlled by traffic activities, and the accumulations of Ni and Hg were associated with mining activities. This study would be valuable for preventing heavy metals inputs and safety in rice production of the Songhua river basin. | CUI Zhengwu WANG Yang ZHAO Na YU Rui XU Guanghui YU Yong | 2018 | Chinese Geographical Science2018，28，5： | 9 |
| 3 | Refined chronology of prehistoric cultures and its implication for re-evaluating human-environment relations in the Hexi Corridor,northwest China显示文摘The reconstruction of high-resolution chronologies for prehistoric cultures is a prerequisite for understanding the history of human evolution and its relationship with environmental change, and is valuable for exploring the trajectory of transcontinental cultural exchanges in prehistoric time. The Hexi Corridor of northwest China was one of the earliest centers for long-distance culture exchange in the prehistoric world. The timing and sequence of cultural changes in this area remains poorly understood resulting from the lack of radiometric age control. This paper presents a refined radiocarbon(14 C) chronology to resolve the timing of human occupation and cultural evolution in the Hexi Corridor. Radiocarbon dating of crop remains, which have an annual life cycle, has the advantage of eliminating problems such as the carbon stored in ‘old wood’. As a result,14C dates from crop remains are used to test the validity of the14C dates derived from charcoal, bone and plant remains. The resultant database of ages is modelled using the Bayesian approach. The updated chronology presented in this paper shows generally good agreement with the original dates used to constrain cultural evolution in the Hexi Corridor. However, the occupation of the corridor by the Shajing and Shanma Late Bronze Age-Early Iron Age cultures appears to have taken place ~300 years later than previously thought. On the basis of comparing this updated chronology of cultural evolution with palaeoclimatic and historical records, it is proposed that the collapse of the Shajing and Shanma cultures occurred as a result of geopolitical impact rather than climate change. | Yishi YANG Shanjia ZHANG Chris OLDKNOW Menghan QIU Tingting CHEN Haiming LI Yifu CUI Lele REN Guoke CHEN Hui WANG Guanghui DONG | 2019 | Science China Earth Sciences2019，62，10： | 5 |
| 4 | Carbon nanotubes for supercapacitors:Consideration of cost and chemical vapor deposition techniques显示文摘In this topic,we first discussed the requirement and performance of supercapacitors using carbon nanotubes(CNTs) as the electrode,including specific surface area,purity and cost.Then we reviewed the preparation technique of single walled CNTs(SWNTs) in relatively large scale by chemical vapor deposition method.Its catalysis on the decomposition of methane and other carbon source,the reactor type and the process control strategies were discussed.Special focus was concentrated on how to increase the yield,selectivity,and purity of SWNTs and how to inhibit the formation of impurities,including amorphous carbon,multiwalled CNTs and the carbon encapsulated metal particles,since these impurities seriously influenced the performance of SWNTs in supercapacitors.Wish it be helpful to further decrease its product cost and for the commercial use in supercapacitors. | Chao Zheng Weizhong Qian Chaojie Cui Guanghui Xu Mengqiang Zhao Guili Tian Fei Wei | 2012 | Journal of Natural Gas Chemistry2012，21，3： | 3 |
| 5 | Research and prac- tice of mobile navigation system显示文摘 | SHAO Zhiju CUI Guanghui | 2008 | Graduate University of Chinese Academy of Sciences2008，，： | 1 |
| 6 | A genome-wide identification of the BLH gene family reveals BLH1 involved in cotton fiber development显示文摘Background:Cotton is the world’s largest and most important source of renewable natural fiber.BEL1-like homeodomain(BLH)genes are ubiquitous in plants and have been reported to contribute to plant development.However,there is no comprehensive characterization of this gene family in cotton.In this study,32,16,and 18 BLH genes were identified from the G.hirsutum,G.arboreum,and G.raimondii genome,respectively.In addition,we also studied the phylogenetic relationships,chromosomal location,gene structure,and gene expression patterns of the BLH genes.Results:The results indicated that these BLH proteins were divided into seven distinct groups by phylogenetic analysis.Among them,25 members were assigned to 15 chromosomes.Furthermore,gene structure,chromosomal location,conserved motifs,and expression level of BLH genes were investigated in G.hirsutum.Expression profiles analysis showed that four genes(GhBLH1_3,GhBLH1_4,GhBLH1_5,and GhBLH1_6)from BLH1 subfamily were highly expressed during the fiber cell elongation period.The expression levels of these genes were significantly induced by gibberellic acid and brassinosteroid,but not auxin.Exogenous application of gibberellic acid significantly enhanced GhBLH1_3,GhBLH1_4,and GhBLH1_5 transcripts.Expression levels of GhBLH1_3 and GhBLH1_4 genes were significantly increased under brassinosteroid treatment.Conclusions:The BLH gene family plays a very important role in many biological processes during plant growth and development.This study deepens our understanding of the role of the GhBLH1 gene involved in fiber development and will help us in breeding better cotton varieties in the future. | LIU Cuixia LI Zhifang DOU Lingling YUAN Yi ZOU Changsong SHANG Haihong CUI Langjun XIAO Guanghui | 2020 | Journal of Cotton Research2020，3，3： | 1 |
| 7 | Fast analysis of reverberation chamber using FDTD and improved matrix pencil method显示文摘 | Cui Yaozhong Wei Guanghui Wang Song | 2013 | IEEE Antennas and Wireless Propagation Letters2013，，12： | 1 |
| 8 | Desilicationfrom illite by thermochemical activation 显示文摘 | Jiang Tao Cui Zhixin LI Guanghui | 2004 | Transactions of Nonferrous Metals Society of China2004，14，10： | 1 |
| 9 | Neuronal differentiation effects of vascular endothelial factor on bone marrow stromal cells显示文摘BACKGROUND:Studies have demonstrated that bone marrow stromal cells (BMSCs) undergo neuronal differentiation under certain in vitro conditions.However,very few inducers of BMSC differentiation have been used in clinical application.The effects of vascular endothelial growth factor (VEGF) on in vitro neuronal differentiation of BMSCs remain poorly understood.OBJECTIVE:To investigate the effect of VEGF on neuronal differentiation of BMSCs in vitro,and to determine the best VEGF concentration for experimental induction.DESIGN,TIME AND SETTING:In vitro comparative study was performed at the Central Laboratory and Laboratory of Male Reproductive Medicine,Shenzhen Hospital of Peking University from October 2008 to August 2009.MATERIALS:Recombinant human VEGF165 was purchased from Peprotech Asia,Rehovot,Israel.Neuron-specific enolase (NSE) was purchased from Beijing Biosynthesis Biotechnology,China.METHODS:BMSCs were harvested from adult Sprague Dawley rats.The passaged cells were pre-induced with 10 ng/mL basic fibroblast growth factor for 24 hours,followed by differentiation induction with 0,5,10,and 20 ng/mL VEGF,respectively.MAIN OUTCOME MEASURES:Morphological changes in BMSCs prior to and following VEGF induction.Expression of NSE following induction was determined by immunocytochemistry.RESULTS:Shrunken,round cells,with a strong refraction and thin bipolar or multipolar primary and secondary branches were observed 3 days after induction with 5,10,and 20 ng/mL VEGF.However,these changes were not observed in the control group.At 10 days after induction,the number of NSE-positive cells was greatest in the 10 ng/mL VEGF-treated group (P < 0.05).The number of NSE-positive cells was least in the control group at 3 and 10 days post-induction (P < 0.05).Moreover,the number of NSE-positive cells was greater at 10 days compared with at 3 days after induction (P < 0.05).CONCLUSION:Of the VEGF concentrations tested,10 ng/mL induced the greatest number of neuronal-like cells in vitro from BMSCs. | Li Yi Qiaoyun Liu Jinling Han Jing Ye Fangting Zhang Guanghui Cui Zhuqing Zhou | 2010 | Neural Regeneration Research2010，5，9： | 1 |
| 10 | A review of SAGD technology development and its possible application potential on thin-layer super-heavy oil reservoirs显示文摘Super-heavy oil is a significant unconventional energy source,and more than 30 years of research have shown that steam-assisted gravity drainage(SAGD)technology is suitable for thick super-heavy oil reservoirs.Recently,more and more thin-layer super-heavy oil reservoirs have been discovered in China,while their deep buried depth and serous heterogeneity make the existing SAGD technology difficult to apply,so it is urgent to improve the existing SAGD technology for the thin-layer super-heavy oil.To this end,this paper focuses on the enlightenment of field application in SAGD technology.Firstly,based on typical SAGD field projects,the development history of SAGD technology in the world was reviewed,and the influence of reservoir physical properties on the application of SAGD technology in thin-layer superheavy oil reservoirs was analyzed.Secondly,the well pattern,wellbore structure,pre-heating,artificial lift,and monitor technique of SAGD were detailed described,and their adjustment direction was expounded for the development of thin-layer super-heavy oil reservoirs.Lastly,the gas-and solventassistant SAGD were comprehensively evaluated,and their application potential in thin-layer superheavy oil reservoirs was studied.The research results can provide theoretical guidance for the application of SAGD technology in thin-layer super-heavy oil reservoirs. | Guodong Cui Ting Liu Jingyu Xie Guanghui Rong Lihong Yang | 2022 | Geoscience Frontiers2022，13，4： | 0 |
| 11 | 一个中央杏仁核—无名质神经环路编码厌恶增强信号(英文)显示文摘文章简介Aversive stimuli can impact motivation and support associative learning as reinforcers.However,the neural circuitry underlying the processing of aversive reinforcers has not been elucidated.Here,we report | Yuting Cui Guanghui Lv Sen Jin Jie Peng Jing Yuan Xiaobin He Hui Gong Fuqiang Xu 许彤辉 李浩洪 | 2018 | 科学新闻2018，0，4： | 0 |
| 12 | Paternally imprinted LATE-FLOWERING2 transcription factor contributes to paternal-excess interploidy hybridization barriers in wheat∞显示文摘Interploidy hybridization between hexaploid and tetraploid genotypes occurred repeatedly during genomic introgression events throughout wheat evolution,and is commonly employed in wheat breeding programs.Hexaploid wheat usually serves as maternal parent because the reciprocal cross generates progeny with severe defects and poor seed germination,but the underlying mechanism is poorly understood.Here,we performed detailed analysis of phenotypic variation in endosperm between two interploidy reciprocal crosses arising from tetraploid(Triticum durum,AABB)and hexaploid wheat(Triticum aestivum,AABBDD).In the paternal‐versus the maternal‐excess cross,the timing of endosperm cellularization was delayed and starch granule accumulation in the endosperm was repressed,causing reduced germination percentage.The expression profiles of genes involved in nutrient metabolism differed strongly between these endosperm types.Furthermore,expression patterns of parental alleles were dramatically disturbed in interploidy versus intraploidy crosses,leading to increased number of imprinted genes.The endosperm‐specific TaLFL2 showed a paternally imprinted expression pattern in interploidy crosses partially due to allele‐specific DNA methylation.Paternal TaLFL2 binds to and represses a nutrient accumulation regulator TaNAC019,leading to reduced storage protein and starch accumulation during endosperm development in paternal‐excess cross,as confirmed by interploidy crosses between tetraploid wild‐type and clustered regularly interspaced palindromic repeats(CRISPR)–CRISPR‐associated protein 9 generated hexaploid mutants.These findings reveal a contribution of genomic imprinting to paternal‐excess interploidy hybridization barriers during wheat evolution history and explains why experienced breeders preferentially exploit maternal‐excess interploidy crosses in wheat breeding programs. | Guanghui Yang Man Feng Kuohai Yu Guangxian Cui Yan Zhou Lv Sun Lulu Gao Yumei Zhang Huiru Peng Yingyin Yao Zhaorong Hu Vincenzo Rossi Ive De Smet Zhongfu Ni Qixin Sun Mingming Xin | 2023 | Journal of Integrative Plant Biology2023，65，12： | 0 |
| 13 | Spatiotemporal variation of agricultural patterns in different geomorphologic and climatic environments in the eastern Loess Plateau,north-central China during the late Neolithic and Bronze Ages显示文摘Human settlement and agricultural development are closely linked to local geomorphological and climatic environments.However,the variation in agricultural systems in different environmental and prehistoric contexts remains unknown.We report new archaeobotanical and radiocarbon dates from 34 Neolithic and Bronze Age sites in the Hutuo River Valley(HTRV)in north-central China and compare them with updated archaeobotanical studies in the Sushui River Valley(SSRV)and Henan Province(HNP),to explore the similarities and differences of agricultural patterns under different geomorphologic and climatic environments in north-central China.Our results reveal that humans consistently cultivated foxtail and broomcorn millet in the HTRV from the Miaodigou(6000–5700 cal.a BP)to the Shang-Zhou(3600–2256 cal.a BP)period,despite the introduction of wheat and barley into the area around 4000 a BP.Climate conditions and hilly landforms in the HTRV,SSRV and some parts of the HNP led people to develop foxtail and broomcorn millet dry land farming practices between 7000 and 3000 a BP.Alternatively,in other areas of the HNP,the climate conditions and alluvial plains enabled people to develop a mixed agriculture of millets,soybeans,and rice from 7000 to 4000 a BP,with the addition of wheat between 4000 and 3000 a BP.Farmers’different agricultural technologies and interactions with foreign cultures may have also influenced the formation of different agricultural patterns in the three regions between 7000 and 3000 a BP.Population growth during 7000–3000 a BP can explain the overall propensity of the higher-yield foxtail millet rather than broomcorn millet as the main cultivated crop.In the HTRV,however,higher proportions of broomcorn millet(as compared to the SSRV and HNP),may reflect the greater drought and heat tolerance of broomcorn millet,representing an adaptive agricultural strategy in the river valley. | Haiming LI Yifu CUI Nathaniel JAMES Melissa RITCHEY Fengwen LIU Junna ZHANG Minmin MA Guanghui DONG | 2022 | Science China Earth Sciences2022，65，5： | 0 |
| 14 | From the Cognition of the Sick at Heart to the Cognition of Ghosts: The Knowledge Transformation of Cognitive Psychology in the Late Qing/Republican Era(1895-1949)显示文摘In examining the historical changes in cognitive psychology from 1895 to 1949, it is necessary to transform cognitive psychology into cognitive practice. In the late Qing and early Republic era(1895-1919), cognitive practice mainly appeared as the cognition of the sick at heart. Against the background of the late Qing importation of Western learning aimed at securing national salvation, the intellectual class, represented by Tan Sitong,hastily dressed the wound to the traditional Chinese learning of Heaven and man inflicted by late nineteenth century scientific knowledge from Europe and America. They regarded cognition as the understanding gained in the practice of self-cultivation, as affording man a spiritual resting place between Heaven and Earth. By the time of the Republic of China(1920-1949), the main form of cognitive practice had become ghostly cognition.Under the banner of saving the country by means of science, higher education researchers,represented by Lu Zhiwei, explored cognition with the help of such intermediaries as physiological mechanisms and language structure. Men could easily become ghosts trapped in intermediaries when they plunged into the conceptual world in search of truth,as their cognitive practice evolved into the conceptual grasp of ghosts. This ghostly cognition continued into later information processing psychology and was disseminated among the mass of the public. A deeper level of the cognition of the sick at heart remains for future study, on the lengthy road home. | Cui Guanghui Guo Benyu 黄德远 | 2022 | Social Sciences in China2022，43，4： | 0 |
| 15 | Inhibition of non-small-cell lung cancer cell proliferation by Pbx1显示文摘Lung cancer is one of the most deadly human cancers and continues to be a major unsolved health problem worldwide. Here, we evaluate the function of Pbx1 in the proliferation of non-smallcell lung cancer(NSCLC). In contrast with its known proliferative function, we found that Pbx1 inhibits the proliferation of lung cancer cells. In particular, Pbx1-specific RNA interference resulted in increased proliferation in lung cancer cells. In addition, histone H3 phosphorylation was also increased following inhibition of Pbx1 expression. In contrast, Pbx1 overexpression repressed the proliferation of lung cancer cells and inhibited DNA synthesis. Collectively, our data indicate that Pbx1 inhibits proliferation in lung cancer cells, suggesting a complex role for Pbx1 in modulating the proliferation of cancer cells and making this protein a potential new target for lung cancer therapy. | Weihao Li Kai Huang Haizhou Guo Guanghui Cui Song Zhao | 2014 | Chinese Journal of Cancer Research2014，26，5： | 0 |
| 16 | Pedotransfer functions for predicting bulk density of coastal soils in East China显示文摘Soil bulk density(BD) is an important physical property and an essential factor for weight-to-volume conversion. However, BD is often missing from soil databases because its direct measurement is labor-intensive, time-consuming, and sometimes impractical, particularly on a large scale. Therefore, pedotransfer functions(PTFs) have been developed over several decades to predict BD. Here, six previously revised PTFs(including five basic functions and stepwise multiple linear regression(SMLR)) and two new PTFs, partial least squares regression(PLSR) and support vector machine regression(SVMR), were used to develop BD-predicting PTFs for coastal soils in East China. Predictor variables included soil organic carbon(SOC) and particle size distribution(PSD). To compare the robustness and reliability of the PTFs used, the calibration and prediction processes were performed 1 000 times using the calibration and validation sets divided by a random sampling algorithm. The results showed that SOC was the most important predictor, and the revised PTFs performed reasonably although only SOC was included. The PSD data were useful for a better prediction of BD, and sand and clay fractions were the second and third most important properties for predicting BD. Compared to the other PTFs, the PLSR was shown to be slightly better for the study area(the average adjusted coefficient of determination for prediction was 0.581). These results suggest that PLSR with SOC and PSD data can be used to fill in the missing BD data in coastal soil databases and provide important information to estimate coastal carbon storage, which will further improve our understanding of sea-land interactions under the conditions of ongoing global warming. | Guanghui ZHENG Caixia JIAO Xianli XIE Xuefeng CUI Gang SHANG Chengyi ZHAO Rong ZENG | 2023 | Pedosphere2023，33，6： | 0 |
| 17 | Axially Chiral Dodecanuclear Lanthanide Clusters Constructed by“Bottom-Up” Self-assembly for Enantioselective Sensing显示文摘Via the bottom-up synthetic strategy,we synthesized a pair of dodecanuclear metal clusters of Eu_(12)(C_(2)O_(4))_(9)(R/S-BNP)_(18)(EtOH)_(6)-(H_(2)0)_(6)·8EtOH-7H_(2)0(complex 2),which represent the largest axial chiral lanthanide metal clusters.In the structure,rare four-pointed star coordination mode of oxalic acid is reported by this work.In addition,as a fluorescence sensor,the complex 2 exhibits high enantioselectivity for R-/S-BINOL-TF_(2)(EF=2.87)and other chiral binaphthyl derivatives. | Honglei Zhao Dongxu Cui Junning Kou Haijuan Gao Guanghui Yu Chunyi Sun Xinlong Wang Zhongmin Su | 2022 | Chinese Journal of Chemistry2022，40，10： | 0 |
| 18 | INFLUENCE OF CaF_(2)-4LiF ADDITIVE ON SINTERING AND ENERGY STORAGE PERFORMANCE OF SrTiO_(3)CERAMICS显示文摘The CaF_(2)-4LiF additive was added into SrTiO_(3)ceramics in order to decrease the sintering temperature for compact pulse power application.The crystalline structure,microstructure and energy storage performance of sintered ceramics were studied.Incorporating CaF_(2)-4LiF additive to SrTiO_(3)ceramics contributes to a notably enhancement of the energy storage density.The great enhancement in energy storage density occurred due to the notable increase in breakdown strength and the refinement of microstructure.With 2 at%additive,the samples exhibited an average breakdown strength of 31.8kV/mm,and an energy storage density of 1.212 J/cm^(3)which is about 1.4 times higher than pure SrTiO_(3). | YIQIU LI HANXING LIU GUANGHUI ZHAO JING XU YUNJIANG CUI MINGHE CAO HUA HAO ZHIYONG YU | 2011 | Journal of Advanced Dielectrics2011，1，2： | 0 |
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