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| 1 | Identification of Cognitive Dysfunction in Patients with T2DM Using Whole Brain Functional Connectivity显示文摘Majority of type 2 diabetes mellitus(T2DM)patients are highly susceptible to several forms of cognitive impairments,particularly dementia.However,the underlying neural mechanism of these cognitive impairments remains unclear.We aimed to investigate the correlation between whole brain resting state functional connections(RSFCs)and the cognitive status in 95 patients with T2DM.We constructed an elastic net model to estimate the Montreal Cognitive Assessment(MoCA)scores,which served as an index of the cognitive status of the patients,and to select the RSFCs for further prediction.Subsequently,we utilized a machine learning technique to evaluate the discriminative ability of the connectivity pattern associated with the selected RSFCs.The estimated and chronological MoCA scores were significantly correlated with R=0.81 and the mean absolute error(MAE)=1.20.Additionally,cognitive impairments of patients with T2DM can be identified using the RSFC pattern with classification accuracy of 90.54%and the area under the receiver operating characteristic(ROC)curve(AUC)of 0.9737.This connectivity pattern not only included the connections between regions within the default mode network(DMN),but also the functional connectivity between the task-positive networks and the DMN,as well as those within the task-positive networks.The results suggest that an RSFC pattern could be regarded as a potential biomarker to identify the cognitive status of patients with T2DM. | Zhenyu Liu Jiangang Liu Huijuan Yuan Taiyuan Liu Xingwei Cui Zhenchao Tang Yang Du Meiyun Wang Yusong Lin Jie Tian | 2019 | Genomics, Proteomics & Bioinformatics2019，17，4： | 4 |
| 2 | Improved image resolution on thoracic carcinomas by quantitative 18F-FDG coincidence SPECT/CT in comparison to 18F-FDG PET/CT显示文摘Currently,18F-FDG coincidence SPECT(Co-SPECT)/CT scan still serves as an important tool for diagnosis,staging,and evaluation of cancer treatment in developing countries.We implemented full physical corrections(FPC) to Co-SPECT(quantitative Co-SPECT) to improve the image resolution and contrast along with the capability for image quantitation.FPC included attenuation,scatter,resolution recovery,and noise reduction.A standard NEMA phantom filled with 10:1 F-18 activity concentration ratio in spheres and background was utilized to evaluate image performance.Subsequently,15 patients with histologically confirmed thoracic carcinomas were included to undergo a 18 F-FDG Co-SPECT/CT scan followed by a 18 F-FDG PET/CT scan.Functional parameters as SUVmax,SUVmean,SULpeak,and MTV from both quantitative Co-SPECT and PET were analyzed.Image resolution of Co-SPECT for NEMA phantom was improved to reveal the smallest sphere from a diameter of 28 mm to 22 mm(17 mm for PET).The image contrast was enhanced from 1.7 to 6.32(6.69 for PET) with slightly degraded uniformity in background(3.1% vs.6.7%)(5.6% for PET).Patients’ SUVmax,SUVmean,SULpeak,and MTV measured from quantitative Co-SPECT were overall highly correlated with those from PET(r=0.82-0.88).Adjustment of the threshold of SUVmax and SUV to determine SUVmean and MTV did not further change the correlations with PET(r=0.81-0.88).Adding full physical corrections to Co-SPECT images can significantly improve image resolution and contrast to reveal smaller tumor lesions along with the capability to quantify functional parameters like PET/CT. | Yuming Zheng Chaoling Jin Huijuan Cui Haojie Dai Jue Yan Pingping Han Bailing Hsu | 2020 | The Journal of Biomedical Research2020，34，4： | 2 |
| 3 | Effects of atorvastatin loading prior to primary percutaneous coronaryintervention on endothelial function and inflammatory factors in patients withST?segment elevation myocardial infarction显示文摘 | Huijuan Yong Xin Wang Lin Mi Lijun Guo Wei Gao Yongzhen Zhang Ming Cui | 2014 | Experimental and Therapeutic Medicine2014，，： | 1 |
| 4 | Synthesis and characterization of terbium-trimesic acid luminescent complex in polyvinylpyrrolidone matrix 显示文摘 | Cui Zhenfeng Ren Huijuan Liu Guixia Hong Guangyan | 2006 | Journal of Rare Earths2006，24，5： | 1 |
| 5 | Gene expression profile analysis of tobacco leaf trichomes 显示文摘 | Cui Hong Zhang Songtao Yang Huijuan | 2011 | BMC Plant Biol2011，17，： | 1 |
| 6 | Association of ele-vated transcript levels of interferon-inducible chemokines withdisease activity and organ damage in systemic lupus erythe-matosus patients 显示文摘 | Fu Q Chen XQ Huijuan Cui HJ | 2008 | Arthritis Res Ther2008，10，： | 1 |
| 7 | Fabricating high-performance sodium ion capacitors with P2-Na_(0.67)Co_(0.5)Mn_(0.5)O_2 and MOF-derived carbon显示文摘Sodium ion capacitors(SICs) have been considered as a kind of promising devices to achieve both high power and energy density. However, it is still a challenge to achieve high energy output at elevated power delivery due to the poor rate capability of battery-type electrode materials and the kinetic mismatch with capacitor-type electrode materials. In this work, to fabricate SICs, P2-Na_(0.67)Co_(0.5)Mn_(0.5)O_2(P2-NCM)was chosen as the battery-type cathode material, and a typical metal-organic framework(MOF) material,zeolitic imidazolate framework-8(ZIF-8) derived carbon(ZDC) was utilized as the capacitor-type anode material. Due to the kinetic match and high-rate performance of both electrodes, the ZDC//P2-NCM SICs exhibited an energy output of 18.8 Wh kg^(-1) at a high power delivery of 12.75 kW kg^(-1). | Haichen Gu Lingjun Kong Huijuan Cui Xianlong Zhou Zhaojun Xie Zhen Zhou | 2019 | Journal of Energy Chemistry2019，28，1： | 1 |
| 8 | Speech enhancement algorithm based on spectral subtraction显示文摘 | Li Ye Cui Huijuan Tang Kua | 2006 | Journal of Tsinghua University2006，46，10： | 1 |
| 9 | Voice activity detection in non-stationary noise显示文摘 | Li Ye Wang Tong Cui Huijuan | 2006 | IMACS Multi- conference on Computational Engineering in Systems Application (CESA)2006，，： | 1 |
| 10 | Paclitaxel liposome for injection (Lipusu) plus cisplatin versus gemcitabine plus cisplatin in the first-line treatment of locally advanced or metastatic lung squamous cell carcinoma: A multicenter, randomized, open-label, parallel controlled clinical study显示文摘Background:Lipusu is the first commercialized liposomal formulation of pacli-taxel and has demonstrated promising efficacy against locally advanced lung squamous cell carcinoma(LSCC)in a small-scale study.Here,we conducted a multicenter,randomized,phase 3 study to compare the efficacy and safety of cis-platin plus Lipusu(LP)versus cisplatin plus gemcitabine(GP)as first-line treat-ment in locally advanced or metastatic LSCC.Methods:Patients enrolled were aged between 18 to 75 years,had locally advanced(clinical stage IIIB,ineligible for concurrent chemoradiation or surgery)or metastatic(Stage IV)LSCC,had no previous systemic chemother-apy and at least one measurable lesion as per the Response Evaluation Criteria in Solid Tumors(version 1.1)before administration of the trial drug.The primary endpoint was progression-free survival(PFS).The secondary endpoints included objective response rate(ORR),disease control rate(DCR),overall survival(OS),and safety profiles.To explore the possible predictive value of plasma cytokines for LP treatment,plasma samples were collected from the LP group at baseline and first efficacy evaluation time and were then subjected to analysis by 45-Plex ProcartaPlex Panel 1 to detect the presence of 45 cytokines using the Luminex xMAP technology.The correlation between treatment outcomes and dynamic changes in the levels of cytokines were evaluated in preliminary analyses.Results:The median duration of follow-up was 15.4 months.237 patients in the LP group and 253 patients in the GP group were included in the per protocol set(PPS).In the PPS,the median PFS was 5.2 months versus 5.5 months in the LP and GP group(hazard rtio[HR]:1.03,P=0.742)respectively.The median OS was 14.6 months versus 12.5 months in the LP and GP group(HR:0.83,P=0.215).The ORR(41.8%versus 45.9%,P=0.412)and DCR(90.3%versus 88.1%,P=0.443)were also similar between the LP and GP group.A significantly lower proportion of patients in the LP group experienced adverse events(AEs)leading to treatment interruptions(10.9%versus 26.4%,P<0.001)or treatment termination(14.3%versus 23.1%,P=0.011).The analysis of cytokine levels in the LP group showed that low baseline levels of 27 cytokines were associated with an increased ORR,and 15 cytokines were associated with improved PFS,with 14 cytokines,including TNF-a,IFN-y,IL-6,and IL-8,demonstrating an overlapping trend.Conclusion:The LP regimen demonstrated similar PFS,OS,ORR and DCR as the GP regimen for patients with locally advanced or metastatic LSCC but had more favorable toxicity profiles.The study also identified a spectrum of different cytokines that could be potentially associated with the clinical benefit in patients who received the LP regimen. | Jie Zhang Yueyin Pan Qin Shi Guojun Zhang Liyan Jiang Xiaorong Dong Kangsheng Gu Huijuan Wang Xiaochun Zhang Nong Yang Yuping Li Jianping Xiong Tienan Yi Min Peng Yong Song Yun Fan Jiuwei Cui Gongyan Chen Wei Tan Aimin Zang Qisen Guo Guangqiang Zhao Ziping Wang Jianxing He Wenxiu Yao Xiaohong Wu Kai Chen Xiaohua Hu Chunhong Hu Lu Yue Da Jiang Guangfa Wang Junfeng Liu Guohua Yu Junling Li Jianling Bai Wenmin Xie Weihong Zhao Lihong Wu Caicun Zhou | 2022 | Cancer Communications2022，42，1： | 1 |
| 11 | Tangeretin inhibits fungal ferroptosis to suppress rice blast显示文摘Flavonoids are polyphenolic secondary metabolites that function as signaling molecules,allopathic compounds,phytoalexins,detoxifying agents and antimicrobial defensive compounds in plants.Blast caused by the fungus Magnaporthe oryzae is a serious disease affecting rice cultivation.In this study,we revealed that a natural flavonoid,tangeretin,substantially delays the formation of M.oryzae appressoria and blocks the development of blast lesions on rice plants.Our data suggest that tangeretin has antioxidant activity that interferes with conidial cell death/ferroptosis,which is critical for M.oryzae pathogenicity.Tangeretin showed a ferroptosis inhibition efficacy comparable to the well-established liproxstatin-1.Furthermore,overexpression of the NADPH oxidases NOX1 or NOX2 significantly decreased sensitivity toward tangeretin treatment,suggesting Nox-mediated lipid peroxidation as a possible target for tangeretin in regulating redox signaling and ferroptosis in M.oryzae.Our nursery and field tests showed that application of tangeretin can effectively mitigate overall disease symptoms and prevent leaf blast.Our study reveals the plant-derived fungal ferroptosis inhibitor tangeretin as a potential and novel antifungal agrochemical for the sustainable prevention of the devastating blast disease in important cereal crops. | Meiling Liang Huijuan Ye Qing Shen Xianya Jiang Guobing Cui Wenxiang Gu Lian-Hui Zhang Naweed I.Naqvi Yi Zhen Deng | 2021 | Journal of Integrative Plant Biology2021，63，12： | 1 |
| 12 | Switch-type hybrid hard decision decoding algorithms for regular low-density paritycheck codes显示文摘 | GONG CHEN LIU QI CUI HUIJUAN | 2008 | IEEE Transactions on Information Theory2008，54，7： | 1 |
| 13 | A high quality 4 kb/s multiple pulse-dispersion ACELP speech coder显示文摘 | LI Yue TANG Kun CUI Huijuan | 2004 | IEEE International Conference on Communications Circuits and Systems2004，26，： | 1 |
| 14 | Sinusoidal excitation LPC vocoder 显示文摘 | JIANG Hao CUI Huijuan TANG Kun | 1998 | Chinese Journal of Electronics1998，7，3： | 1 |
| 15 | Methylation across the central dogma in health and diseases: new therapeutic strategies显示文摘The proper transfer of genetic information from DNA to RNA to protein is essential for cell-fate control,development,and health.Methylation of DNA,RNAs,histones,and non-histone proteins is a reversible post-synthesis modification that finetunes gene expression and function in diverse physiological processes.Aberrant methylation caused by genetic mutations or environmental stimuli promotes various diseases and accelerates aging,necessitating the development of therapies to correct the disease-driver methylation imbalance.In this Review,we summarize the operating system of methylation across the central dogma,which includes writers,erasers,readers,and reader-independent outputs.We then discuss how dysregulation of the system contributes to neurological disorders,cancer,and aging.Current small-molecule compounds that target the modifiers show modest success in certain cancers.The methylome-wide action and lack of specificity lead to undesirable biological effects and cytotoxicity,limiting their therapeutic application,especially for diseases with a monogenic cause or different directions of methylation changes.Emerging tools capable of site-specific methylation manipulation hold great promise to solve this dilemma.With the refinement of delivery vehicles,these new tools are well positioned to advance the basic research and clinical translation of the methylation field. | Ruochen Liu Erhu Zhao Huijuan Yu Chaoyu Yuan Muhammad Nadeem Abbas Hongjuan Cui | 2023 | Signal Transduction and Targeted Therapy2023，8，9： | 0 |
| 16 | Low Power Embedded Multimedia Processor Architecture显示文摘 | WEN Shuhong CUI Huijuan TANG Kun | 2007 | Chinese Journal of Electronics2007，16，1： | 0 |
| 17 | SPEECH ENHANCEMENT USING HARMONICS REGENERATION BASED ON MULTIBAND EXCITATION显示文摘This paper proposes an algorithm that adopts the harmonic regeneration as post-processing to improve the performance of speech enhancement using traditional Short Time Spectral Amplitude(STSA).The proposed algorithm aims to alleviate the distortion of the high harmonics of enhanced speech via the traditional STSA,and consequently improves the speech quality.We first detect the pitch,or fundamental frequency,of the enhanced speech via the traditional STSA,and then,divide the whole spectrum into multiple sub-bands which center on each harmonic.After that,a series of specially designed windows centered on each harmonic are applied to all the sub-bands,in order to redistribute the energy in the sub-bands.The results of experiment demonstrate that the method has both theo-retical and practical basis. | Zhang Yanfang Tang Kun Cui Huijuan | 2011 | Journal of Electronics(China)2011，28，4： | 0 |
| 18 | Etoposide,dexamethasone,and pegaspargase with sandwiched radiotherapy in early-stage natural killer/T-cell lymphoma:A randomized phase III study显示文摘Methotrexate,etoposide,dexamethasone,and pegaspargase(MESA)with sandwiched radiotherapy is known to be effective for early-stage extranodal natural killer/T-cell lymphoma,nasal type(NKTCL).We explored the efficacy and safety of reduced-intensity,non-intravenous etoposide,dexamethasone,and pegaspargase(ESA)with sandwiched radiotherapy.This multicenter,randomized,phase III trial enrolled patients aged between 14 and 70 years with newly diagnosed early-stage nasal NKTCL from 27 centers in China.Patients were randomly assigned(1:1)to receive ESA(pegaspargase 2,500 IU/m^(2)intramuscularly on day 1,etoposide 200 mg orally,and dexamethasone 40 mg orally on days 2–4)or MESA(methotrexate 1 g/m^(2)intravenously on day 1,etoposide 200 mg orally,and dexamethasone 40 mg orally on days 2–4,and pegaspargase 2,500 IU/m^(2)intramuscularly on day 5)regimen(four cycles),combined with sandwiched radiotherapy. | Huijuan Zhong Shu Cheng Xi Zhang Bing Xu Jiayi Chen Xufeng Jiang Jie Xiong Yu Hu Guohui Cui Juying Wei Wenbin Qian Xiaobing Huang Ming Hou Feng Yan Xin Wang Yongping Song Jianda Hu Yuanhua Liu Xuejun Ma Fei Li Chongyang Wu Junmin Chen Li Yu Ou Bai Jingyan Xu Zunmin Zhu Li Liu Xin Zhou Li Huang Yin Tong Ting Niu Depei Wu Hao Zhang Chaofu Wang Binshen Ouyang Hongmei Yi Qi Song Gang Cai Biao Li Jia Liu Zhifeng Li Rong Xiao Luqun Wang Yujie Jiang Yanyan Liu Xiaoyun Zheng Pengpeng Xu Hengye Huang Li Wang Saijuan Chen Weili Zhao | 2023 | The Innovation2023，4，3： | 0 |
| 19 | Realtime robust speech communication based on iterative joint source-channel decoding and demodulation algorithm for MELP vocoder显示文摘 | 彭坦 Cui Huijuan Tang Kun | 2010 | High Technology Letters2010，16，2： | 0 |
| 20 | Overexpression of PSAT1 regulated by G9A sustains cell proliferation in colorectal cancer显示文摘Dear Editor,Colorectal cancer(CRC)is one of the most common cancers that contributes to cancer morbidity and mortality according to the National Cancer Institute’s report.The standard of care is still surgical resection and neoadjuvant chemoradiation therapy,which may result in serious effects on quality of life in patients.1 Currently,many efforts have been aimed at precision medicine in CRC,which highlights the urgent need to identify accurate biomarkers for diagnosis and treatment that can be translated into clinical use. | Huijuan Wang Longzhen Cui Dandan Li Ming Fan Zhangnan Liu Chunqi Liu Sijing Pan Lei Zhang Hailong Zhang Yinglan Zhao | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
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