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| 1 | Exogenous pancreatic kininogenase protects against renal fibrosis in rat model of unilateral ureteral obstruction显示文摘Tissue kallikrein has protective function against various types of injury.In this study,we investigated whether exogenous pancreatic kininogenase(PK)conferred renoprotection in a rat model of unilateral ureteral obstruction(UUO)and H2O2-treated HK-2 cells in vitro.SD rats were subjected to UUO surgery,then PK(7.2 U/g per day,ip)was administered for 7 or 14 days.After the treatment,rats were euthanized;the obstructed kidneys were harvested for further examination.We found that PK administration significantly attenuated interstitial inflammation and fibrosis,and downregulated the expression of proinflammatory(MCP-1,TLR-2,and OPN)and profibrotic(TGF-β1 and CTGF)cytokines in obstructed kidney.UUO-induced oxidative stress,closely associated with excessive apoptotic cell death and autophagy via PI3K/AKT/FoxO1a signaling,which were abolished by PK administration.We further showed that PK administration increased the expression of bradykinin receptors 1 and 2(B1R and B2R)mRNA and the production of NO and cAMP in kidney tissues.Coadministration with either B1R antagonist(des-Arg9-[Leu8]-bradykinin)or B2R antagonist(icatibant)abrogated the renoprotective effects of PK,and reduced the levels of NO and cAMP in obstructed kidney.In H2O2-treated HK-2 cells,addition of PK(6 pg/mL)significantly decreased ROS production,regulated the expression of oxidant and antioxidant enzymes,suppressed the expression of TGF-β1 and MCP-1,and inhibited cell apoptosis.Our data demonstrate that PK treatment protects against the progression of renal fibrosis in obstructed kidneys. | Li-zhe Jin Hui-ying Li Jian Jin Shang-guo Piao Xiong-hu Shen Yan-ling Wu Jia-chong Xu Long-ye Zhang Yu-ji Jiang Hai-lan Zheng Ying-shun Jin Sheng Cui Kang Luo Yi Quan Can Li | 2020 | Acta Pharmacologica Sinica2020，41，12： | 9 |
| 2 | Distributed Photovoltaic Generation in the Electricity Market:Status,Mode and Strategy显示文摘With the increasingly serious climate change and energy crisis,photovoltaic(PV)generation,as one of the most important renewable energy resources,has experienced dramatic growth worldwide due to its environmental friendliness.How-ever,the uncertainty and intermittency of PV bring inevitable challenges to power systems.With the rapid development of distributed PV and the continuous evolution of the electricity market,increasingly high penetration levels of distributed PV generation have led to a series of problems in power system operations,such as voltage fluctuation,frequency deviation,etc.The market participation of distributed PV needs to be solved.Reasonable market participation form,market mechanism and bidding strategies are vital to the development of distributed PV in the electricity market.This paper comprehensively reviews the development and impacts of distributed PV in the electricity market and discusses the relevant market modes and bidding strategies in detail. | Sifan Jiang Can Wan Chen Chen Erbao Cao Yonghua Song | 2018 | CSEE Journal of Power and Energy Systems2018，4，3： | 7 |
| 3 | L-Carnitine protects against tacrolimus-induced renal injury by attenuating programmed cell death via PI3K/AKT/PTEN signaling显示文摘Reducing immunosuppressant-related complications using conventional drugs is an efficient therapeutic strategy.L-carnitine(LC)has been shown to protect against various types of renal injury.In this study,we investigated the renoprotective effects of LC in a rat model of chronic tacrolimus(TAC)nephropathy.SD rats were injected with TAC(1.5 mg·kg^(−1)·d^(−1),sc)for 4 weeks.Renoprotective effects of LC were assessed in terms of renal function,histopathology,oxidative stress,expression of inflammatory and fibrotic cytokines,programmed cell death(pyroptosis,apoptosis,and autophagy),mitochondrial function,and PI3K/AKT/PTEN signaling.Chronic TAC nephropathy was characterized by severe renal dysfunction and typical histological features of chronic nephropathy.At a molecular level,TAC markedly increased the expression of inflammatory and fibrotic cytokines in the kidney,induced oxidative stress,and led to mitochondrial dysfunction and programmed cell death through activation of PI3K/AKT and inhibition of PTEN.Coadministration of LC(200 mg·kg^(−1)·d^(−1),ip)caused a prominent improvement in renal function and ameliorated histological changes of kidneys in TAC-treated rats.Furthermore,LC exerted anti-inflammatory and antioxidant effects,prevented mitochondrial dysfunction,and modulated the expression of a series of apoptosis-and autophagy-controlling genes to promote cell survival.Human kidney proximal tubular epithelial cells(HK-2 cells)were treated with TAC(50μg/mL)in vitro,which induced production of intracellular reactive oxygen species and expression of an array of genes controlling programmed cell death(pyroptosis,apoptosis,and autophagy)through interfering with PI3K/AKT/PTEN signaling.The harmful responses of HK-2 cells to TAC were significantly attenuated by cotreatment with LC and the PI3K inhibitor LY294002(25μM).In conclusion,LC treatment protects against chronic TAC nephropathy through interfering the PI3K/AKT/PTEN signaling. | Hai-lan Zheng Hai-yue Zhang Chun-lian Zhu Hui-ying Li Sheng Cui Jian Jin Shang-guo Piao Yu-ji Jiang Mei-ying Xuan Ji-zhe Jin Ying-shun Jin Jung-pyo Lee Byung-ha Chung Bum-soon Choi Chul-woo Yang Can Li | 2021 | Acta Pharmacologica Sinica2021，42，1： | 7 |
| 4 | Molecular Characterization and Drug-resistance of Mycobacterium tuberculosis Strains in Xuzhou, China显示文摘To understand the genetic diversity and drug resistance status of Mycobacterium tuberculosis(M tuberculosis)circulating in Xuzhou of China,the spacer-oligonucleotide typing(Spoligotyping)and multi-loci VNTRs(variable number tandem repeats)analysis(MLVA)were utilized for the genotyping of the isolates.Drug susceptibility test(DST) | PANG Hui TONG Jing LIU Hai Can DU Yang Guang ZHAO Xiu Qin JIANG Yi WU Xiao Cui YANG Jin Chuan WAN Kang Lin | 2014 | Biomedical and Environmental Sciences2014，27，12： | 7 |
| 5 | Numerical and experimental investigation on dynamic performance of bump foil journal bearing based on journal orbit显示文摘Widespread usage of bump-type foil journal bearing(BFJB) in oil-free microturbomachinery requires accurate predictions of dynamic performance characteristics, although it remains a challenging issue because BFJB reflects nonlinear both structurally and aerodynamically.This paper presented a simple experimental method to semi-directly obtain the minimum film thickness and dynamic stiffness of BFJB using the journal orbit. Numerical calculations and simulations are conducted to validate the experimental method. The micro-deformation and interaction of various foils are taken into consideration to improve the model precision. The results from the numerical model regarding the BFJB dynamic characteristics are compared with the experimental results coming from a dedicated test rig, which shows that the experimental results fluctuate obviously and agree not well with the numerical results at the start stage due to the presence of dry friction at that time, nevertheless, they show fantastic agreement as soon as a gas film is gradually generated to separate the shaft from the top foil. Therefore, the proposed experimental method is effective to predict film thickness and dynamic characteristics during the period from the lift-off time to the land-off time. The dynamic characteristics, along with the journal orbits also can be used to rapidly predict the dynamics behavior of rotor-bearing systems. | Yu ZHOU Longtao SHAO Can ZHANG Fenzhu JI Jiang LIU Guo LI Shuiting DING Qi ZHANG Farong DU | 2021 | Chinese Journal of Aeronautics2021，34，2： | 6 |
| 6 | Nondestructive 3D Image Analysis Pipeline to Extract Rice Grain Traits Using X-Ray Computed Tomography显示文摘The traits of rice panicles play important roles in yield assessment,variety classification,rice breeding,and cultivation management.Most traditional grain phenotyping methods require threshing and thus are time-consuming and labor-intensive;moreover,these methods cannot obtain 3D grain traits.In this work,based on X-ray computed tomography,we proposed an image analysis method to extract twenty-two 3D grain traits.After 104 samples were tested,the R^(2) values between the extracted and manual measurements of the grain number and grain length were 0.980 and 0.960,respectively.We also found a high correlation between the total grain volume and weight.In addition,the extracted 3D grain traits were used to classify the rice varieties,and the support vector machine classifier had a higher recognition accuracy than the stepwise discriminant analysis and random forest classifiers.In conclusion,we developed a 3D image analysis pipeline to extract rice grain traits using X-ray computed tomography that can provide more 3D grain information and could benefit future research on rice functional genomics and rice breeding. | Weijuan Hu Can Zhang Yuqiang Jiang Chenglong Huang Qian Liu Lizhong Xiong Wanneng Yang Fan Chen | 2020 | Plant Phenomics2020，2，1： | 6 |
| 7 | Effect of side deep placement of nitrogen on yield and nitrogen use efficiency of single season late japonica rice显示文摘Side deep placement of nitrogen plays an important role in improving rice yield and nitrogen use efficiency.Few studies have examined the effects of reducing the times of nitrogen(RTN)application and reducing the nitrogen rate(RNR)of application on rice yield and nitrogen use efficiency under side deep placement of nitrogen in paddy fields.Therefore,a field experiment of RNT and RNR treatments was conducted with nine fertilization modes during the 2018–2019 rice growing seasons in a rice–wheat cropping system of the lower reaches of the Yangtze River,China.Rice yield and nitrogen use efficiency were investigated under side deep placement of nitrogen.We found that under the same nitrogen application rate,the yield of RTN3 increased by 9.64 and 10.18%in rice varieties NJ9108 and NJ5718,respectively,compared with the farmers’fertilizer practices(FFP).The nitrogen accumulation of RTN3 was the highest at heading stage,at 11.30 t ha^(–1)across 2018 and 2019.Under the same nitrogen application rate,the N agronomic use efficiency(NAE),N physiological efficiency(NPE)and N recovery efficiency(NRE)of RTN3 were 8.1–21.28%,8.51–41.76%and 0.28–14.52%higher than those of the other fertilization modes,respectively.RNR led to decreases in SPAD value,leaf area index(LAI),dry matter accumulation,nitrogen accumulation,and nitrogen use efficiency.These results suggest that RTN3 increased rice yield and nitrogen use efficiency under the side deep placement of nitrogen,and RNR1 could achieve the goals of saving cost and increasing resource use efficiency.Two fertilization modes RTN3 and RNR1 both could achieve the dual goals of increasing grain yield and resource use efficiency and thus are worth further application and investigation. | ZHAO Can HUANG Heng QIAN Zi-hui JIANG Heng-xin LIU Guang-ming XU Ke HU Ya-jie DAI Qigen HUO Zhong-yang | 2021 | Journal of Integrative Agriculture2021，20，6： | 5 |
| 8 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 9 | Facile Self-templating Melting Route Preparation of Biomass-derived Hierarchical Porous Carbon for Advanced Supercapacitors显示文摘 | WANG Can WANG Dianyu ZHENG Shuang FANG Xueqing ZHANG Wenli TIAN Ye LIN Haibo LU Haiyan JIANG Lei | 2018 | Chemical Research in Chinese Universities2018，34，6： | 5 |
| 10 | A new Multilocus Sequence Analysis Scheme for Mycobacterium tuberculosis显示文摘Objective Tuberculosis remains one of the most serious infectious diseases in the world. In this study, a scheme of Mycobacterium tuberculosis (M. tuberculosis) multilocus sequence analysis (MLSA) was established for the phylogenetic and epidemiology analysis. Methods To establish the scheme of M. tuberculosis MLSA, the genome of H37Rv, CCDC5079 and CCDC5180 were compared, and some variable genes were chosen to be the MLSA typing scheme. 44 M. tuberculosis clinical isolates were typed by MLSA, IS6110-RFLP, and soligotyping, to evaluate the MLSA methods. Results After comparison of the genome, seven high discrimination gene loci (recX, rpsL, rmlC, rpmG1, mprA, gcvH, ideR) were chosen to be the MLSA typing scheme finally. 11 variable SNP sites of those seven genes were found among the 44 M. tuberculosis isolate strains and 11 sequence types (STs) were identified. Based on the Hunter-Gaston Index (HGI), MLSA typing was not as good for discrimination at the strain level as IS6110-RFLP, but the HGI was much better than that of spoligotyping. In addition, the MEGA analysis result of MLSA data was similar to spoligotyping/PGG lineage, showing a strong phylogenetic signal in the modern strains of M. tuberculosis. The MLSA data analysis by eBURST revealed that 4 sequence types (ST) came into a main cluster, showing the major clonal complexes in those 44 strains. Conclusion MLSA genotyping not only can be used for molecular typing, but also is an ideal method for the phylogenetic analysis for M. tuberculosis. | LU Bing DONG Hai Yan ZHAO Xiu Qin LIU Zhi Guang LIU Hai Can ZHANG Yuan Yuan JIANG Yi WAN Kang Lin | 2012 | Biomedical and Environmental Sciences2012，25，6： | 4 |
| 11 | A review on Ti_(3)C_(2)T_(x)-based nanomaterials:synthesis and applications in gas and humidity sensors显示文摘Ti_(3)C_(2)T_(x),which is a novel two-dimensional(2 D)material,has received enormous interest in the field of sensor technology due to its large surface area,excellent electrical conductivity,and abundant active surface sites.In recent years,several Ti_(3)C_(2)T_(x)-based gases and humidity sensors have been developed and reported.In this review,we focus on the latest applications of Ti_(3)C_(2)T_(x)-based nanomaterials in gas and humidity sensors.First,the synthesis of Ti_(3)C_(2)T_(x) from the dangerous fluorine-containing etching process to the safe fluorine-free preparation method was discussed,and the structures of the Ti_(3)C_(2)T_(x) controlled by different delamination methods were also outlined.Subsequently,the functionalization of pristine Ti_(3)C_(2)T_(x) and composite strategies for enhancing its gas and humidity sensing performance were reviewed.In addition,the gas and humidity sensing mechanisms of sensors based on Ti_(3)C_(2)T_(x) were also summarized.Finally,the challenges and opportunities for the use of Ti_(3)C_(2)T_(x) gas and humidity sensors were discussed to provide guidance on the promising potential of Ti_(3)C_(2)T_(x) in this field. | Qiu-Ni Zhao Ya-Jie Zhang Zai-Hua Duan Si Wang Can Liu Ya-Dong Jiang Hui-Ling Tai | 2021 | Rare Metals2021，40，6： | 4 |
| 12 | An acoustic-wave theory for casing bond evaluation using viscoelastic slip boundary modeling显示文摘Slip boundary condition is commonly utilized to model elastic wave propagation through layered earth media. The same approach is used here to characterize acoustic wave propagation along a cased borehole with various cement bond conditions. By modeling the cement layer between casing and formation as a viscoelastic slip interface with complex coupling rigidity parameters, one can not only reduce the complexity in the classical elastic wave modeling of the problem, but also efficiently model various complicated wave phenomena that are difficult for the existing modeling. More specifically, the new theory can well describe the effect of the cement bond condition change and the location of the change(i.e., whether it is in the first interface between casing and cement, or the second interface between cement and formation) on the acoustic waves,demonstrating the good modeling capability and predicting power. Application of the theory to field data shows that the theory can correctly model the acoustic wave characteristics and interpret the cement bond condition, thus providing a useful fundament theory for casing bond evaluation using acoustic logging. | Xiaoming TANG Can JIANG YuANDa SU Xuelian CHEN | 2018 | Science China Earth Sciences2018，61，8： | 4 |
| 13 | Acrosin structure-based design,synthesis and biological activities of 7-azaindol derivatives as new acrosin inhibitors显示文摘一系列 7-azaindol 衍生物基于人的精子酵素的相应 3D 模型被设计。这些混合物被综合并且在 vitro 为他们的人的精子酵素评估了禁止的活动。混合物 7a, 7i, 7j, 7k 和 7n 对人的精子酵素显示出高度禁止的活动。三维的 structureactivity 关系通过一个 CoMFA 模型被调查,它提供了珍贵信息推进潜在的人的精子酵素禁止者的学习。 | Jun Hang Jiang Xue Fei Liu Can Hui Zhen You Jun Zhou Ju Zhu Jia Guo Lv Chun Quan Sheng | 2011 | Chinese Chemical Letters2011，22，3： | 3 |
| 14 | 3D microstructures of nuclear graphite:IG-110,NBG-18 and NG-CT-10显示文摘Molten salt is used as primary coolant flowing through graphite moderator channel of a molten salt reactor.Working at high temperature under radiation environment,the pore network structure of nuclear graphite should be well understood.In this paper,X-ray tomography is employed to study the 3D pore structure characteristics of nuclear grades graphite of IG-110,NBG-18 and NG-CT-10,and permeability simulation through geometries are performed.The porosity,number of pores and throats,coordination number and pore surface are obtained.NGCT-10 is of similar microstructure to IG-110,but differs significantly from NBG-18.The absolute permeabilities of IG-110,NG-CT-10 and NBG-18 are 0.064,0.090 and0.106 mD,respectively.This study provides basis for future research on graphite infiltration experiment. | Shi-Pei Jing Can Zhang Jie Pu Hong-Yan Jiang Hui-Hao Xia Fang Wang Xu Wang Jian-Qiang Wang Chan Jin | 2016 | Nuclear Science and Techniques2016，27，3： | 3 |
| 15 | Preliminary Study on Drug Susceptibility Profile and Resistance Mechanisms to Macrolides of Clinical Isolates of Non-tuberculous Mycobacteria from China显示文摘Objective Macrolide susceptibility and drug resistance mechanisms of clinical non-tuberculous mycobacteria(NTM) isolates were preliminarily investigated for more accurate diagnosis and treatment of the infection in China. Methods Four macrolides, including clarithromycin(CLAR), azithromycin(AZM), roxithromycin(ROX), and erythromycin(ERY), were used to test the drug susceptibility of 310 clinical NTM isolates from six provinces of China with the broth microdilution method. Two resistance mechanisms, 23 S r RNA and erm, were analyzed with nucleotide sequence analysis. Results Varied effectiveness of macrolides and species-specific resistance patterns were observed. Most Mycobacterium abscessus subsp. massiliense were susceptible and all M. fortuitum were highly resistant to macrolides. All the drugs, except for erythromycin, exhibited excellent activities against slow-growing mycobacteria, and drug resistance rates were below 22.2%. Only four highly resistant strains harbored 2,058/2,059 substitutions on rrl and none of other mutations were related to macrolide resistance. G2191 A and T2221 C on rrl were specific for the M. abscessus complex(MABC). Seven sites, G2140 A, G2210 C, C2217 G, T2238 C, T2322 C, T2404 C, and A2406 G, were specifically carried by M. avium and M. intracellulare. Three sites, A2192 G, T2358 G, and A2636 G, were observed only in M. fortuitum and one site G2152 A was specific for M. gordonae. The genes erm(39) and erm(41) were detected in M. fortuitum and M. abscessus and inducible resistance was observed in relevant sequevar. Conclusion The susceptibility profile of macrolides against NTM was demonstrated. The well-known macrolide resistance mechanisms, 23 S r RNA and erm, failed to account for all resistant NTM isolates, and further studies are warranted to investigate macrolide resistance mechanisms in various NTM species. | LI Fu LI Gui Lian PANG Hui LIU Hai Can XIAO Tong Yang LI Shuang Jun LUO Qiao JIANG Yi WANG Rui Bai WAN Kang Lin | 2018 | Biomedical and Environmental Sciences2018，31，4： | 3 |
| 16 | Roles of State Strategy of Adaptation to Climate Change in China显示文摘For the adverse impacts of climate change, China gov- ernment should place the problem of adaptation to climate change on the agenda. It is time to institute and implement a state adap- tive strategy to reduce the adverse impacts on economy, commu- nity and people's health and life by international cooperation and our own endeavor. A state strategy of adaptation to climate change should be closely linked with other current interrelated national strategies, and they should be supplemented and improved by each other. This paper discusses the roles of the state strategy of adaptation to climate change in the state climate change integra- tive strategy, the environmental protection strategy, and the sus- tainable development strategy in China. Furthermore, it proposes the main aims of the state adaptive strategy of China. | Jiang Dongmei Wang Can Huang Shanfeng Zhang Mengheng | 2007 | Chinese Journal of Population,Resources and Environment2007，5，4： | 3 |
| 17 | Optical fiber SPR biosensor complying with a 3D composite hyperbolic metamaterial and a graphene film显示文摘In the present study, an optical fiber surface plasmon resonance(SPR) biosensor was developed for measuring time-and concentration-dependent DNA hybridization kinetics. Its design complies with a 3D Au∕Al2O3 multilayer composite hyperbolic metamaterial(HMM), a graphene film, and a D-shaped plastic optical fiber.According to the numerical simulation and the experimental demonstration, the SPR peak of the designed biosensor can be effectively altered in the range of visible to near-infrared by varying the HMM structure. The sensitivity of the appliance was shown to achieve a value of up to 4461 nm/RIU, allowing its applicability for bulk refractive index sensing. Furthermore, a biosensor designed in this work displayed high-resolution capability(ranging from 10 pM to 100 nM), good linearity, and high repeatability along with a detection limit down to 10 pM, thus suggesting a vast potential for medical diagnostics and clinical applications. | Can Li Jinjuan Gao Muhammad Shafi Runcheng Liu Zhipeng Zha Dejun Feng Mei Liu Xuejian Du Weiwei Yue Shouzhen Jiang | 2021 | Photonics Research2021，9，3： | 3 |
| 18 | Identifi cation of national priority areas for adaptation to climate change in China显示文摘The problem of global warming has been identif ied as the f irst in the list of the top ten environmental prob-lems in the world.As climate change will seriously affect the social and natural world that people live in,so it may lay serious repercussions on economic progress,social improvement,and sustainable development.International bodies everywhere and many of the countries' governments are responding urgently to this call.In recent years,climate change has affected different regions in China in different ways.In its national agenda,the Chinese government should address the problem of climate change and its negative impact on socio-economic development.In this endeavor the nation should introduce policies which will help its people and economy to adapt to these effects and changes.Priorityf ields of adaptation to climate change are the sensitive areas or departments which are more vulnerable to the negative influences of climate change.The negative impacts of climate change in some parts of China are considered to be very serious indeed as they affect the whole economy and community.As a result,priority should be given to these more affected regions for the limited state f inancing.This paper def ines adaptation and discusses the basic principles and programs in the identif ication of national priority areas where adaptation should be exercised.Based on the past studies,four priority areas in China are identif ied,namely,disaster prevention and mitigation,water resources,agriculture,and ecosystem.An analysis on the identifi cation procedures,and the reasons and tasks involved are given for each. | Jiang Dongmei Wang Can Gao Fei Zhang Mengheng | 2008 | Ecological Economy2008，4，4： | 3 |
| 19 | Short- and Long-term Therapeutic Efficacies of Intravenous Transplantation of Bone Marrow Stem Cells on Cardiac Function in Rats with Acute Myocardial Infarction:A Meta-analysis of Randomized Controlled Trials显示文摘Objective To investigate the short- and long-term therapeutic efficacies of intravenous transplantation of bone marrow stem cells(MSCs) in rats with experimental myocardial infarction by metaanalysis.Methods Randomized controlled trials were systematically searched from Pub Med,Science Citation Index(SCI),Chinese journal full-text database(CJFD) up to December 2014.While the experimental groups(MSCs groups) were injected MSCs intravenously,the control groups were injected Delubecco's minimum essential medium(DMEM) or phosphate buffered saline(PBS).Subgroup analysis for each outcome measure was performed for the observing time point after the transplantation of MSCs.Weighted mean differences(WMD) and 95% confidence intervals(CI) were calculated for outcome parameters including ejection fraction(EF) and fractional shortening(FS),which were measured by echocardiogram after intravenous injection and analyzed by Rev Man 5.2 and STATA 12.0.Results Data from 9 studies(190 rats) were included in the meta-analysis.As compared to the control groups,the cardiac function of the experimental groups were not improved at day 7(EF:WMD=0.08,95%CI-1.32 to 1.16,P>0.01; FS:WMD=-0.12,95%CI-0.90 to 0.65,P>0.01) until at day 14 after MSCs' transplantation(EF:WMD=10.79,95%CI 9.16 to 12.42,P<0.01; FS:WMD=11.34,95%CI 10.44 to 12.23,P<0.01),and it lasted 4 weeks or more after transplantation of MSCs(EF:WMD=13.94,95%CI 12.24 to 15.64,P<0.01; FS:WMD=9.64,95%CI 7.98 to 11.31,P<0.01).Conclusion The therapeutic efficacies of MSCs in rats with myocardid infarction become increasing apparent as time advances since 2 weeks after injection. | Can Jiang Dong Zheng Yun-lu Feng Jun Guo Hai-rui Li Ai-dong Zhang | 2016 | Chinese Medical Sciences Journal2016，31，3： | 2 |
| 20 | Comparative assessment and essential analysis on new international GHG emission reduction proposals显示文摘Since Kyoto Protocol came into force on February 16, 2005, the endeavor by international society to combat the climate change has stepped into a new milestone. The greenhouse gas (GHG) abatement mechanisms in Kyoto Protocol have served a remarkable function but also been questioned during the practices of past three years about its environmental effectiveness. A lot of new international GHG emission reduction proposals are proposed from many new aspects, some of which especially impose pressure on developing countries. So it is of great importance to research on these new proposals in time for negotiation beyond Kyoto and institution of Chinese relevant climate policies. As this paper focuses on the way of commitment distribution of mechanisms, the mechanisms here are categorized in one of two types: those distribute commitment based on countries and those based on sectors. Some of the typical mechanisms are selected to be analyzed comparatively, especially about their influence on developing countries. | Jiang Dongmei Wang Can Lv Xuedu Huang Shanfeng | 2009 | Ecological Economy2009，5，1： | 2 |
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