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| 1 | Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25显示文摘堵住抗体 ipilimumab 的细胞毒素的 T 淋巴细胞 antigen-4 (CTLA-4 ) 在很少的病人导致变形黑瘤的调停免疫者的长期的控制。尽管 ipilimumab 无疑经由 immunostimulation 施加它的治疗学的效果,这样远的临床上有用的、 immunologically 相关的 biomarkers 预言治疗效率是逃犯的。这里,我们显示出 IL-2 的那中立化或堵住 α并且 βIL-2 受体的子单元(CD25 和 CD122,分别地) 否则在现出症状之前的潜的老鼠模型由 CTLA-4 封锁导致了,废除了 antitumor 效果和 intratumoral T 受动器对规章的房间(Tregs ) 的比率的伴随的改进,它是。CTLA-4 封锁导致了在失去了 FoxP3 表示并且在 regressing 肿瘤积累了的 IL-2-producing 受动器房间与伴随物上升表示 Lag3, ICOS, IL-10 和 Egr2 的一个镇压 CD4 + T 房间子集的减小。当 recombinant IL-2 改进了 CTLA-4 封锁的治疗学的功效时,圈套 IL-2 受体 α(IL-2Rα, sCD25 ) 禁止了 CTLA-4 的 anticancer 效果封锁。在收到 ipilimumab 的 262 个变形黑瘤病人, sCD25 的基线浆液集中代表了全面幸存的独立指示物,与预言到治疗的抵抗的高水平。总的来说,这些结果解开为在 CTLA-4 的 anticancer 活动的 IL-2 和 IL-2 受体的一个角色封锁。重要地,我们的学习提供第一 immunologically 相关的 biomarker,也就是提高的浆液 sCD25,那与黑瘤在病人预言抵抗到 CTLA-4 封锁。 | Dalil Hannani Marie Vetizou David Enot Sylvie Rusakiewicz Nathalie Chaput David Klatzmann Melanie Desbois Nicolas Jacquelot Nadege Vimond Salem Chouaib Christine Mateus James P Allison Antoni Ribas Jedd D Wolchok Jianda Yuan Philip Wong Michael Postow Andrzej Mackiewicz Jacek Mackiewicz Dirk Schadendorff Dirk Jaeger Alan J Korman Keith Bahjat Michele Maio Luana Calabro Michele WL Teng Mark J Smyth Alexander Eggennont Caroline Robert Guido Kroemer Laurence Zitvogel | 2015 | Cell Research2015，25，2： | 14 |
| 2 | Preservation of platelet function in patients with cirrhosis and thrombocytopenia undergoing esophageal variceal ligation显示文摘Background:Thrombocytopenia is a possible risk factor for bleeding after band ligation of esophageal varices.However,elevated von Willebrand factor(VWF)in cirrhosis improves platelet function and could decrease this risk.Our objective was to assess platelet function in patients with cirrhosis undergoing esophageal variceal ligation(EVL).Methods:The assessment consisted of platelet count,antigen and activity of VWF and VWF-cleaving protease ADAMTS-13 activity,and a platelet adhesion and aggregation test simulating vascular flow in vivo(Impact-RR)prior to EVL.Results:Totally 111 patients were divided into three groups according to platelet count:(1)<50×109/L(n=38,34.2%);(2)50×109/L to 100×109/L(n=47,42.3%);and(3)>100×109/L(n=26,23.4%).No statistically significant difference was found in the aggregate size of platelets[group 1:41.0(31.8–67.3)μm 2;group 2:47.0(33.8–71.3)μm 2;and group 3:47.0(34.0–66.0)μm 2;P=0.60]and no significant correlation was found between aggregate size and platelet count(Spearman r=0.07;P=0.47).Surface coverage was 4.1%(2.8%–6.7%),8.5%(4.0%–10.0%),and 9.0%(7.1%–12.0%)(P<0.001)in groups 1,2 and 3,respectively and correlated with platelet count(Spearman r=0.39;P<0.0001).There was no significant difference between groups in VWF or ADAMTS-13.Post-EVL bleeding occurred in six(5.4%)patients(n=2 in group 1,n=1 in group 2,and n=3 in group 3;P=0.32).Patients with bleeding had higher MELD scores[15.0(11.3–20.3)versus 12.0(10.0–15.0);P=0.025],but no difference was demonstrated for platelet function parameters.Conclusion:Platelet function is preserved even in the presence of thrombocytopenia,including in the patients with post-EVL bleeding. | Evandro de Oliveira Souza Elbio Antonio D’Amico Tania Rubia Flores da Rocha Caroline Marcondes Ferreira Juliana Medeiros Batista Luiz Augusto CarneiroD’Albuquerque Flair Jose Carrilho Alberto Queiroz Farias | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，6： | 3 |
| 3 | Gut microbiota disturbance during antibiotic therapy: a multi-omic approach显示文摘 | Ana Elena Pérez-Cobas María José Gosalbes Anette Friedrichs Henrik Knecht Alejandro Artacho Kathleen Eismann Wolfgang Otto David Rojo Rafael Bargiela Martin von Bergen Sven C Neulinger Carolin D?umer Femke-Anouska Heinsen Amparo Latorre Coral Barbas Jana | 2013 | Gut2013，，11： | 2 |
| 4 | Use of calcium or calcium in combination with vitamin D supplementation to prevent fractures and bone loss in people aged 50 years and older: a meta-analysis显示文摘 | Benjamin MP Tang Guy D Eslick Caryl Nowson Caroline Smith Alan Bensoussan | 2007 | The Lancet2007，，9588： | 2 |
| 5 | Abdominal Visceral and Subcutaneous Adipose Tissue Compartments: Association With Metabolic Risk Factors in the Framingham Heart Study显示文摘 | Caroline S. Fox Joseph M. Massaro Udo Hoffmann Karla M. Pou Pal Maurovich-Horvat Chun-Yu Liu Ramachandran S. Vasan Joanne M. Murabito James B. Meigs L Adrienne Cupples Ralph B. D’Agostino Christopher J. O’Donnell | 2007 | Circulation2007，，1： | 2 |
| 6 | Cytopmteetive effects of aluronic acid carbomtr934p in ocular surface显示文摘 | Caroline D | 2002 | Epithelial Cells Loves2002，43，11： | 1 |
| 7 | Hydrolysis of wheat straw by a thermostable eodoxylanase:Adsorption and kinetic studies显示文摘 | CAROLINE Z PHILIPPE D | 1998 | Enxyme and microbial technology1998，，22： | 1 |
| 8 | Silk-based biomaterials 显示文摘 | Gregory H Frank D Caroline J | 2003 | Biomaterials2003，24，3： | 1 |
| 9 | Gymsbipolar deetrovaporization verfius transurethral resection of the prostate:a randomized prospective trial with 1-year fallow-up显示文摘 | Christopher JL Caroline D Tmng P | 2003 | J Urol2003，169，4： | 1 |
| 10 | Trends in Cardiovascular Disease Risk Factors in Individuals With and Without Diabetes Mellitus in the Framingham Heart Study显示文摘 | Sarah Rosner Preis Michael J. Pencina Shih-Jen Hwang Ralph B. D’Agostino Peter J. Savage Daniel Levy Caroline S. Fox | 2009 | Circulation2009，，3： | 1 |
| 11 | The kinetic properties and sensitivities to inhibitors of lactate dehydrogenases (LDH1 and LDH2) from Toxoplasma gondii:comparisons with pLDH from Plasmodium falciparum显示文摘 | Caroline D Eric RS Lucy AH | 2001 | Mol and Bio Parasitol2001，118，1： | 1 |
| 12 | Effect of high oxygen modified atmosphere packaging on microbial growth and sensorial qualities of fresh-cut produce显示文摘 | Liesbeth J Frank D Caroline V | 2001 | Internation Journal of Food Microbiology2001，71，： | 1 |
| 13 | Carboxymethyl chitosan as a matrix material for platinum 显示文摘 | Michael J Laudenslager Jessica D Schi-ff- man Caroline L Schauer | 2008 | Biomacromolecules2008，9，10： | 1 |
| 14 | Inhibition of breast cancer cell adhesion and bone metastasis by the extracellular adherence protein of Staphylococcus aureus显示文摘 | Darius S Lucy L Carolin D | 2007 | Biochemi Bioph Res Commun2007，357，1： | 1 |
| 15 | Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans显示文摘 | Rhee Eugene P Cheng Susan Larson Martin G Walford Geoffrey A Lewis Gregory D McCabe Elizabeth Yang Elaine Farrell Laurie Fox Caroline S O’Donnell Christopher J Carr Steven A Vasan Ramachandran S Florez Jose C Clish Clary B Wang Thomas J Ger | 2011 | Journal of Clinical Investigation2011，，4： | 1 |
| 16 | The Onecut Transcription Factor Hepatocyte Nuclear Factor-6 Controls B Lymphopoiesis in Fetal Liver1显示文摘 | Caroline Bouzin Frédéric Clotman Jean-Christophe Renauld | 2003 | The Journal of Immunology2003，171，3： | 1 |
| 17 | Predicting intraindividual changes in teacher burnout: The role of perceived school environment and motivational factors显示文摘 | Claude Fernet Frédéric Guay Caroline Senécal Stéphanie Austin | 2011 | Teaching and Teacher Education2011，，4： | 1 |
| 18 | Assessing depression in youth:relation between the Children's Depression Inventory and a structured interview显示文摘 | Benedikte T Caroline B Laura D | 2004 | Journal for Clinical Child and Adoles- cent Psychology2004，33，1： | 1 |
| 19 | Cytoproteetive effects of hijaluronic acid carbomtr 934p in ocular surface 显示文摘 | Caroline D | 2002 | Epithelial Cells Loves2002，43，11： | 1 |
| 20 | Aminotransferase Levels and 20-Year Risk of Metabolic Syndrome, Diabetes, and Cardiovascular Disease显示文摘 | Wolfram Goessling Joseph M. Massaro Ramachandran S. Vasan Ralph B. D’Agostino R. Curtis Ellison Caroline S. Fox | 2008 | Gastroenterology2008，，6： | 1 |
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