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| 1 | A complete sequence and comparative analysis of a SARS-associated virus(Isolate BJ01)显示文摘The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-associated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution, interpretation of transmission and pathogenesis, development of diagnostics, prevention by future vaccination, and treatment by developing new drugs. We report the complete genome sequence and comparative analysis of an isolate (BJ01) of the coronavirus that has been recognized as a pathogen for SARS. The genome is 29725 nt in size and has 11 ORFs (Open Reading Frames). It is composed of a stable region encoding an RNA-dependent RNA polymerase (composed of 2 ORFs) and a variable region representing 4 CDSs (coding sequences) for viral structural genes (the S, E, M, N proteins) and 5 PUPs (putative uncharacterized proteins). Its gene order is identical to that of other known coronaviruses. The sequence alignment with all known RNA viruses places this virus as a member in the family of Coronaviridae. Thirty putative substitutions have been identified by comparative analysis of the 5 SARS- associated virus genome sequences in GenBank. Fifteen of them lead to possible amino acid changes (non-synonymous mutations) in the proteins. Three amino acid changes, with predicted alteration of physical and chemical features, have been detected in the S protein that is postulated to beinvolved in the immunoreactions between the virus and its host. Two amino acid changes have been detected in the Mprotein, which could be related to viral envelope formation. Phylogenetic analysis suggests the possibility of non-human origin of the SARS-associated viruses but provides noevidence that they are man-made. Further efforts should focus on identifying the etiology of the SARS-associated virus and ruling out conclusively the existence of otherpossible SARS-related pathogen(s). | QIN E'de ZHU Qingyu YU Man FAN Baochang CHANG Guohui SI Bingyin YANG Bao PENG Wenming JIANG Tao LIU Bohua DENG Yongqiang LIU Hong ZHANG Yu WANG Cui LI Yuquan GAN Yonghua LI Xiaoyu L Fushuang TAN Gang CAO Wuchun, YANG Ruifu Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, Beijing 100071, China WANG Jian, LI Wei, XU Zuyuan, LI Yan, WU Qingfa, LIN Wei, CHEN Weijun, TANG Lin, DENG Yajun, HAN Yujun, LI Changfeng, LEI Meng, LI Guoqing, LI Wenjie, L Hong, SHI Jianping, TONG Zongzhong, ZHANG Feng, LI Songgang, LIU Bin, LIU Siqi, DONG Wei, WANG Jun, Gane K-S Wong, YU Jun & YANG Huanming* Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300 National Center for Genome Information, Beijing 101300, China | 2003 | Chinese Science Bulletin2003，48，10： | 121 |
| 2 | The 600-mm precipitation isoline distinguishes tree-ring-width responses to climate in China显示文摘The numerous temperature and precipitation reconstructions in China based on tree-ring-width data have played significant roles in furthering the understanding of past climate changes. However, the geographical variability in the responses of trees to climate variations in China remains largely undetermined. Here, we describe an important spatial boundary in the response of trees to climate variations, namely the 600-mm annual precipitation isoline. We found that, to the north of this line, tree-ring widths are usually positively correlated with precipitation and negatively correlated with growing-season temperature. To the south of this line, the tree-ring widths respond positively to temperature, and winter half-year temperatures are the main reconstructed parameters, especially on the third topographical step of China. We also found that precipitation reconstructions based on tree-ring data and the Palmer Drought Severity Index almost exclusively fall in the region of the 200- to 600-mm annual precipitation isolines, not other regions. Our findings indicate that, when using multiple tree-ring-width chronologies for large-scale past climate reconstructions, the climatic signal of each tree-ring-width series should be carefully considered. | Yu Liu Huiming Song Changfeng Sun Yi Song Qiufang Cai Ruoshi Liu Ying Lei Qiang Li | 2019 | National Science Review2019，6，2： | 8 |
| 3 | PtxCuy nanocrystals with hexa-pod morphology and their electrocatalytic performances towards oxygen reduction reaction显示文摘二金属的磅 x 有明确的昆虫形态学的 Cu y nanocrystals (NC ) 经由一条湿化学途径被综合。有约 20 nm 表演的尺寸的同样综合的凸的 NC 暴露了低索引(111 ) 种子上的方面和豆荚上的各种各样的高索引的方面。生长机制沿着 cuboctahedral 上的结晶的方向播种的 <100> 包含了比较喜欢的生长。合成协议能被用于磅 x 有各种各样的 Cu/Pt 比率的 Cu y NC。向氧减小反应(ORR ) 在碳黑色上支持的昆虫 PtxCuy NC 的电镀物品催化的活动被学习。昆虫 PtCu 2/C 催化剂展出最高特定的活动(3.7 妈 / 厘米 磅 2) 和集体活动(2.4 A/mg 磅 ) 报导了为磅 x Cu y 。有磅 x Cu y 显示提高的活动从词法因素发源。豆荚上的高索引的方面以及丰富的边和步的存在能相当解释提高的催化活动。昆虫磅 x Cu y /C 催化剂也在加速的耐久性测试以后显示出高词法的稳定性和活动。同样综合的昆虫磅 x Cu y NC 为质子交换膜燃料房间作为阴极电镀物品催化剂有高潜力。 | Yujing Li Fanxin Quan Enbo Zhu Lin Chen Yu Huang Changfeng Chen | 2015 | Nano Research2015，8，10： | 5 |
| 4 | SETD8 induces stemness and epithelial–mesenchymal transition of pancreatic cancer cells by regulating ROR1 expression显示文摘Pancreatic cancer(PC)is one of the most deadly diseases,and its incidence is increasing year by year.The methyltransferase SETD8 has been demonstrated to play an important role in tumor cell proliferation and metastasis.However,little is known about whether SETD8 could affect the invasion and metastasis of PC and the mechanism underlying the regulation.Based on our previous report,here,we further found that SETD8 could promote the invasion and migration of PC cells by inducing the expression of receptor tyrosine kinase-like orphan receptor 1(ROR1).ROR1 was predominantly upregulated in PC tissues and was correlated with lymph node metastasis and worse prognosis.Mechanistically,SETD8 mediated ROR1 activity and regulated PC cells invasion and migration,although promoting the expression of stemness and epithelial–mesenchymal transition-related molecules.This promotion effect disappeared when the catalytically inactive mutant SETD8 was overexpressed,which could be counteracted by the SETD8-specific methyltransferase inhibitor UNC0379.Collectively,our results demonstrate that SETD8 may be a novel prognostic factor and a therapeutic target of PC. | Mengqi Liu Yihua Shi Qiangsheng Hu Yi Qin Shunrong Ji Wensheng Liu Qifeng Zhuo Guixiong Fan Zeng Ye Changfeng Song Xianjun Yu Xiaowu Xu Wenyan Xu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，12： | 2 |
| 5 | Stable Functionalization of Small Semiconducting Polymer Dots via Covalent Cross‐Linking and Their Application for Specific Cellular Imaging显示文摘 | Jiangbo Yu Changfeng Wu Xuanjun Zhang Fangmao Ye Maria Elena Gallina Yu Rong I‐Che Wu Wei Sun Yang‐Hsiang Chan Daniel T. Chiu | 2012 | Adv. Mater2012，，26： | 1 |
| 6 | 显示文摘 | ChangFeng Yu Pang Lin | 1998 | J Mater SciLetl1998，17，7： | 1 |
| 7 | Dynamic crushing of cellular materials:a unified framework of plastic shock wave models显示文摘 | ZHENG Zhijun YU Jilin WANG Changfeng | 2013 | International Journal of Impact Engineering2013，53，1： | 1 |
| 8 | Dynamic crushingof cellular materials: a particle velocity-based analytical method and its application显示文摘Cellular material under high-velocity impacthas a typical feature oflayer-wise collapse.A cell-based finite element model is employed to simulate the direct impact of closed-cell foam, and one-dimensional velocity field distributionsareobtained to characterize thecrushing bandpropagating through a cellular material. An explicit expression of continuous velocity distribution is derivedbased on the features of velocity gradient distribution. The velocity distribution function is adopted to determine the dynamic stress-strain statesof cellular materials under dynamic loading.The local stress-strain history distribution reveals that sectional cells experience a process from the precursor of elastic behavior to the shock stress state, through the dynamic initial crushing state. A power-law relation between the dynamic initial crushing stress andthe strainrate isestablished, which confirms the strain-rate effect of cellular materials. By extracting the critical points immediately before the unloading stage on the local dynamic stress-strain history curves, the dynamic stress-strain statesof cellular materials are determined. They exhibit loading rate-dependence but are independent of the initial impact velocity.Furthermore, with the increase of relative density, the dynamic hardening behaviorof cellular specimen is enhanced and the crushing process event is advanced. The particle velocity-based analytical method is appliedto analyze the dynamic responses of cellular materials.This method is better than continuum-based shock models, since itdoes not require a pre-assumed constitutive relation.Therefore,the particle velocity-based analytical method proposed in this study may provide new ideas to carry out dynamic experimental measurement, which is especially applicable toinhomogeneous materials. | Shilong Wang Zhijun Zheng Yuanyuan Ding Changfeng Zhu Jilin Yu | 2019 | Acta Mechanica Sinica2019，35，4： | 1 |
| 9 | Structure and properties of moisture-resistant konjac glucomannan films coated with shellac/stearic acid coating显示文摘 | Xueqin Wei Jie Pang Changfeng Zhang Chengcheng Yu Han Chen Bingqing Xie | 2015 | Carbohydrate Polymers2015，，： | 1 |
| 10 | New Method on Constructing Analytic Potential Function of Diatomic Molecules显示文摘功能被介绍的构造分析势能上的一个新方法,然后为精确计算两价的分子和离子的系列的相对通用的分析势能功能被导出。而且,六种普通势能弯包含三主要潜在的弯曲即稳定的州的、亚稳的状态和排斥状态从这势能功能被获得。最后,包括 tc 的 13 个两价的分子和离子的分光镜的参数被使用潜在的函数计算,作为后果,所有计算结果在对试验性的数据的好同意。 | YU Changfeng WANG Jing | 2008 | Wuhan University Journal of Natural Sciences2008，13，2： | 1 |
| 11 | Dynamic crushing of cellular materials: A unified framework of plastic shock wave models显示文摘 | ZHENG Zhijtm YU Jilin WANG Changfeng | 2013 | International Journal oflmpactEngineering2013，53，： | 1 |
| 12 | Quantitative mechanisms behind the high strength and electrical conductivity of Cu-Te alloy manufactured by continuous extrusion显示文摘The microstructure,mechanical performance,and electrical conductivity of Cu-Te alloy fabricated by continuous extrusion were quantitatively investigated.The results demonstrate that the grain size of the Cu-Te alloy is refined significantly by incomplete dynamic recrystallization.The Cu2Te phase stimulates recrystallization and inhibits subgrain growth.After extrusion,the tensile strength increases from217.8±4.8 MPa to 242.5±3.7 MPa,the yield strength increases from 65.1±3.5 MPa to 104.3±3.8 MPa,and the yield to tensile strength ratio is improved from 0.293±0.015 to 0.43±.0.091,while the electrical conductivity of room temperature decreases from 95.8±0.38%International Annealed Cu Standard(IACS)to 94.0%±0.32%IACS.The quantitative analysis shows that the increment caused by dislocation strengthening and boundary strengthening account for 84.6%of the yield strength of the extruded Cu-Te alloy and the electrical resistivity induced by grain boundaries and dislocations accounts for 1.6%of the electrical resistivity of the extruded Cu-Te alloy.Dislocations and boundaries contribute greatly to the increase of yield strength,but less to the increase of electrical resistivity. | Qianqian Fu Bing Li Minqiang Gao Ying Fu Rongzhou Yu Changfeng Wang Renguo Guan | 2022 | Journal of Materials Science & Technology2022，，26： | 1 |
| 13 | 显示文摘 | Yu Changfeng Lin Pang | 1998 | J Mater Sci Lett1998，17，： | 1 |
| 14 | Association Between Methionine Synthase Reductase A66G Polymorphism and the Risk of Congenital Heart Defects: Evidence From Eight Case–Control Studies显示文摘 | Di Yu Lei Yang Shutong Shen Changfeng Fan Weiyan Zhang Xuming Mo | 2014 | Pediatric Cardiology2014，，7： | 1 |
| 15 | Manganese Activated Luminescence in ZnGa204 显示文摘 | YU Changfeng PANG Lin | 1996 | J Appl Phys1996，79，9： | 1 |
| 16 | First-principles study of hydrogen diffusion mechanism in Cr_2O_3显示文摘The system energy of H atom occupying different positions in Cr2O3 crystal lattice is calculated by adopting the first-principles calculation method based on density functional theory in this paper. The results indicate that the most stable position of H atom in Cr2O3 crystal lattice locates at the bilateral positions of the center of the unoccupied O octahedral interstice. The reason resulting in this situation is analyzed by comparing the change of Cr2O3 lattice distortion and density of states in Cr2O3_H system when H atom locates at different positions in octahedral interstice. The diffusion activation energy of H atom is 0.73 eV,which is determined by seeking the diffusion path and transition state of H atom in Cr2O3 crystal lattice. The effective attempt frequency of H atom in Cr2O3 crystal lattice is also calculated by using molecular dynamics. Combining with diffusion activation energy data,the diffusion coefficient of H atom in Cr2O3 crystal is determined. | CHEN ChangFeng YU HaoBo ZHENG ShuQi | 2011 | Science China(Technological Sciences)2011，54，1： | 1 |
| 17 | Structural homology of the strength for metallic glasses显示文摘The structure-property relationship,one of the central themes in materials science,is far from being well understood for metallic glasses(MGs)due to the great complexity of their amorphous structures.Based on the analysis of published experimental data for 165 MGs from more than 15 different alloy systems,the present study reveals a universal dependence of mechanical properties(Young’s moduli,shear moduli and yield strength)on simple structural parameters(the inter-atomic distance and/or valence electron density)originating from the interatomic potential and Fermi sphere-Brillouin zone interaction.This work establishes a structure-property relationship for metallic glasses and provides insights into the fundamentals of the mechanical properties of disordered systems. | Weiming Yang Xinfa Sun Haishun Liu Changfeng Yu Wenyu Li Akihisa Inoue DanielŞopud Jürgen Eckert Chunguang Tang | 2021 | Journal of Materials Science & Technology2021，，22： | 0 |
| 18 | Microstructural evolution and strengthening mechanism of Al–Mg alloys with fine grains processed by accumulative continuous extrusion forming显示文摘In this work,the mechanical properties and strengthening mechanisms induced by microstructural evolution in a rheo-extruded 5087 alloy processed via accumulative continuous extrusion forming(ACEF)were investigated.Electron back-scattered diffraction(EBSD)and transmission electron microscopy(TEM)were utilized to characterize the microstructure of the alloy subjected to ACEF with various passes.The grain refinement caused by continuous dynamic recrystallization(CDRX)was discussed.The results demonstrated that after 3 passes of ACEF,there was a significant grain refinement effect on the alloy,and the average grain size decreased from 45.6μm to 2.5μm;the ultimate tensile strength(UTS)and yield strength(YS)of the alloy increased to 362.8 MPa and 234.6 MPa,respectively.Dislocation cells/walls generated during deformation promoted the formation of low angle grain boundaries(LAGBs).The accumulative strain accelerated the transformation of LAGBs to high angle grain boundaries(HAGBs).Dislocation pile-up enhanced the driving force of CDRX,and nano-sized Al_6(Mn,Fe)phases at the grain boundaries inhibited the growth of grains due to the pinning effect.Based on the quantitative estimation,dislocation strengthening and grain boundary strengthening dominated the enhancement in YS of the ACEFed alloy. | Bowei Yang Yu Wang Minqiang Gao Changfeng Wang Renguo Guan | 2022 | Journal of Materials Science & Technology2022，，33： | 0 |
| 19 | Improvement of hydrogen permeation barrier performance by iron sulphide surface films显示文摘Fe–S compounds with hexagonal crystal structure are potential hydrogen permeation barrier during H2S corrosion. Hexagonal system Fe–S films were prepared on carbon steel through corrosion and CVD deposition, and the barrier effect of different Fe–S films on hydrogen permeation was tested using electrochemical hydrogen permeation method. After that, the electrical properties of Fe–S compound during phase transformation were measured using thermoelectric measurement system. Results show that the mackinawite has no obvious barrier effect on hydrogen penetration, as a p-type semiconductor, and pyrrhotite (including troilite) has obvious barrier effect on hydrogen penetration,as an n-type semiconductor. Hydrogen permeation tests showed peak permeation performance when the surface was deposited with a continuous film of pyrrhotite (Fe_(1–x)S) and troilite. The FeS compounds suppressed hydrogen permeation by the promotion of the hydrogen evolution reaction, semiconducting inversion from p-to n-type, and the migration of ions at the interface. | Pengpeng Bai Shaowei Li Jie Cheng Xiangli Wen Shuqi Zheng Changfeng Chen Yu Tian | 2023 | International Journal of Minerals,Metallurgy and Materials2023，30，9： | 0 |
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