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| 1 | Ozone mini-hole occurring over the Tibetan Plateau in December 2003显示文摘By analyzing the total ozone data from TOMS and ground-based observations, it is found that a large area with extremely low ozone occurred over the Tibetan Plateau during December 14-17, 2003. After correcting the bias in TOMS data, the area with the total ozone < 220 DU is found to be over 2500000 km2, and the minimum value is only 190 DU. It is the first time that an ozone mini-hole or an extremely low ozone event is found to occur over the Tibetan Plateau. | BIAN Jianchun WANG Gengchen CHEN Hongbin QI Donglin LUE Daren ZHOU Xiuji | 2006 | Chinese Science Bulletin2006，51，7： | 19 |
| 2 | Chemical vapor deposition growth of large-scale hexagonal boron nitride with controllable orientation显示文摘有一致厚度的大域的六角形的硼氮化物(h-BN ) 的化学蒸汽免职(CVD ) 合成是很挑战性的,主要由于这材料的极其高的成核密度。此处,我们报导晶片规模的成功的生长,有大单人赛水晶的领域尺寸的高质量的 h-BN 单层电影,吗直到~ 72 ??????????????????????????慮潮档湡敮獬???????慮潮畴敢??洠獥灯牯???? ?? | Xiuju Song Junfeng Gao Yufeng Nie Teng Gao Jingyu Sun Donglin Ma Qiucheng Li Yubin Chen Chuanhong Jin Alicja Bachmatiuk Mark H. Rummeli Feng Ding Yanfeng Zhang Zhongfan Liu | 2015 | Nano Research2015，8，10： | 12 |
| 3 | Effect of pyrolytic carbon interphase on mechanical properties of mini T800-C/SiC composites显示文摘The effect of pyrolytic carbon(PyC) thickness on the tensile property of mini T800 carbon fiber reinforced SiC matrix composites(C/SiC) was studied. PyC interphase was prepared by chemical vapor infiltration(CVI) process using C3H6–Ar as gas source, the PyC thickness was adjusted from 0 to 400 nm, and then the SiC matrix was prepared by CVI process using methyltrichlorosilane(MTS)–H2–Ar as precursor and gas source. The results showed that the tensile strength of mini T800-C/SiC increased first and then decreased with the increase of the PyC thickness. When the thickness of PyC was 100 nm, the average strength reached the maximum value of 393 ± 70 MPa. The Weibull modulus increased from 2.0 to 8.06 with the increase of PyC thickness, and the larger the Weibull modulus, the smaller the dispersion, which indicated that the regulation of PyC thickness was conducive to improve tensile properties. | Donglin Zhao Tong Guo Xiaomeng Fan Chao Chen Yue Ma | 2021 | Journal of Advanced Ceramics2021，10，2： | 6 |
| 4 | Experimental study of mode distortion induced by stimulated Raman scattering in high-power fiber amplifiers显示文摘The experimental investigation of mode distortion induced by stimulated Raman scattering(SRS)in a high-power fiber amplifier,which includes the evolutions of optical spectra,spatial beam profiles,and time-frequency characteristics,has been carried out in detail.Temporal-frequency characteristics have been studied for the first time,to the best of our knowledge,by using a low-speed camera and high-speed photodiode traces,which revealed that temporal-frequency characteristics of SRS-induced mode distortion are different from traditional dynamic mode instability(MI).The experimental results show that the output beam profile remains stable before the mode distortion occurs and fluctuates obviously after the onset of SRS-induced MI but on a time scale of seconds,which is much lower than that of Yb-gain-induced MI featuring millisecond-level beam profile fluctuation.It also shows that the mode distortion became measurable in company with the onset of inter-mode four-wave mixing(IM-FWM)when the ratio of Raman light reaches 3%;further,the beam quality factor M2degrades gradually from 1.4 to 2.1 as the ratio of Raman light increases.The mode distortion is accompanied by an obvious temperature increase of the output passive fiber,which further confirms that the mode distortion originates from SRS.The cause of the mode distortion induced by SRS has been explained in the context of core-pumped SRS effect,and the investigation on the accompanying IM-FWM effect indicates that the main content of the SRSinduced high-order mode is the LP21 mode. | QIUHUI CHU QIANG SHU ZENG CHEN FENGYUN LI DONGLIN YAN CHAO GUO HONGHUAN LIN JIANJUN WANG FENG JING CHUANXIANG TANG RUMAO TAO | 2020 | Photonics Research2020，8，4： | 6 |
| 5 | Simulated effect of soil freeze-thaw process on surface hydrologic and thermal fluxes in frozen ground region of the Northern Hemisphere显示文摘Soil freeze-thaw process is closely related to surface energy budget,hydrological activity,and terrestrial ecosystems.In this study,two numerical experiments(including and excluding soil freeze-thaw process)were designed to examine the effect of soil freeze-thaw process on surface hydrologic and thermal fluxes in frozen ground region in the Northern Hemisphere based on the state-of-the-art Community Earth System Model version 1.0.5.Results show that in response to soil freeze-thaw process,the area averaged soil temperature in the shallow layer(0.0175−0.0451 m)decreases by 0.35℃in the TP(Tibetan Plateau),0.69℃in CES(Central and Eastern Siberia),and 0.6℃in NA(North America)during summer,and increases by 1.93℃in the TP,2.28℃in CES and 1.61℃in NA during winter,respectively.Meanwhile,in response to soil freeze-thaw process,the area averaged soil liquid water content increases in summer and decrease in winter.For surface heat flux components,the ground heat flux is most significantly affected by the freeze-thaw process in both summer and winter,followed by sensible heat flux and latent heat flux in summer.In the TP area,the ground heat flux increases by 2.82 W/m2(28.5%)in summer and decreases by 3.63 W/m2(40%)in winter.Meanwhile,in CES,the ground heat flux increases by 1.89 W/m2(11.3%)in summer and decreases by 1.41 W/m2(18.6%)in winter.The heat fluxes in the Tibetan Plateau are more susceptible to the freeze-thaw process compared with the high-latitude frozen soil regions.Soil freeze-thaw process can induce significant warming in the Tibetan Plateau in winter.Also,this process induces significant cooling in high-latitude regions in summer.The frozen ground can prevent soil liquid water from infiltrating to deep soil layers at the beginning of thawing;however,as the frozen ground thaws continuously,the infiltration of the liquid water increases and the deep soil can store water like a sponge,accompanied by decreasing surface runoff.The influence of the soil freeze-thaw process on surface hydrologic and thermal fluxes varies seasonally and spatially. | Di Ma SiQiong Luo DongLin Guo ShiHua Lyu XianHong Meng BoLi Chen LiHui Luo | 2021 | Research in Cold and Arid Regions2021，13，1： | 4 |
| 6 | Advances in 3D bioprinting technology for cardiac tissue engineering and regeneration显示文摘Cardiovascular disease is still one of the leading causes of death in the world,and heart transplantation is the current major treatment for end-stage cardiovascular diseases.However,because of the shortage of heart donors,new sources of cardiac regenerative medicine are greatly needed.The prominent development of tissue engineering using bioactive materials has creatively laid a direct promising foundation.Whereas,how to precisely pattern a cardiac structure with complete biological function still requires technological breakthroughs.Recently,the emerging three-dimensional(3D)bioprinting technology for tissue engineering has shown great advantages in generating micro-scale cardiac tissues,which has established its impressive potential as a novel foundation for cardiovascular regeneration.Whether 3D bioprinted hearts can replace traditional heart transplantation as a novel strategy for treating cardiovascular diseases in the future is a frontier issue.In this review article,we emphasize the current knowledge and future perspectives regarding available bioinks,bioprinting strategies and the latest outcome progress in cardiac 3D bioprinting to move this promising medical approach towards potential clinical implementation. | Nanbo Liu Xing Ye Bin Yao Mingyi Zhao Peng Wu Guihuan Liu Donglin Zhuang Haodong Jiang Xiaowei Chen Yinru He Sha Huang Ping Zhu | 2021 | Bioactive Materials2021，6，5： | 4 |
| 7 | Development of nanoscale drug delivery systems of dihydroartemisinin for cancer therapy: A review显示文摘Dihydroartemisinin(DHA),a first-line antimalarial drug,has demonstrated great anticancer effects in many types of tumors,including liver cancer,glioblastoma,and pancreatic cancer.Due to its abilities to induce programmed cell death(PCD;apoptosis,autophagy and ferroptosis),inhibit tumor metastasis and angiogenesis,and modulate the tumor microenvironment,DHA could become an antineoplastic agent in the foreseeable future.However,the therapeutic efficacy of DHA is compromised owing to its inherent disadvantages,including poor stability,low aqueous solubility,and short plasma halflife.To overcome these drawbacks,nanoscale drug delivery systems(NDDSs),such as polymeric nanoparticles(NPs),liposomes,and metal-organic frameworks(MOFs),have been introduced to maximize the therapeutic efficacy of DHA in either single-drug or multidrug therapy.Based on the beneficial properties of NDDSs,including enhanced stability and solubility of the drug,prolonged circulation time and selective accumulation in tumors,the outcomes of DHA-loaded NDDSs for cancer therapy are significantly improved compared to those of free DHA.This reviewfirst summarizes the current understanding of the anticancer mechanisms of DHA and then provides an overview of DHA-including nanomedicines,aiming to provide inspiration for further application of DHA as an anticancer drug. | Ka Hong Wong Donglin Yang Shanshan Chen Chengwei He Meiwan Chen | 2022 | Asian Journal of Pharmaceutical Sciences2022，17，4： | 3 |
| 8 | Loss of Lkb1 impairs Treg function and stability to aggravate graft-versus-host disease after bone marrow transplantation显示文摘Accumulating evidence suggests that a reduction in the number of Foxp3^(+) regulatory T cells(Tregs)contributes to the pathogenesis of acute graft-versus-host disease(aGVHD),which is a major adverse complication that can occur after allogeneic hematopoietic stem cell transplantation(allo-HSCT).However,the precise features and mechanism underlying the defects in Tregs remain largely unknown.In this study,we demonstrated that Tregs were more dramatically decreased in bone marrow compared with those in peripheral blood from aGVHD patients and that bone marrow Treg defects were negatively associated with hematopoietic reconstitution.Tregs from aGVHD patients exhibited multiple defects,including the instability of Foxp3 expression,especially in response to IL-12,impaired suppressor function,decreased migratory capacity,and increased apoptosis.Transcriptional profiling revealed the downregulation of Lkb1,a previously identified critical regulator of murine Treg identity and metabolism,and murine Lkb1-regulated genes in Tregs from aGVHD patients.Foxp3 expression in human Tregs could be decreased and increased by the knockdown and overexpression of the Lkb1 gene,respectively.Furthermore,a loss-of-function assay in an aGVHD murine model confirmed that Lkb1 deficiency could impair Tregs and aggravate disease severity.These findings reveal that Lkb1 downregulation contributes to multiple defects in Tregs in human aGVHD and highlight the Lkb1-related pathways that could serve as therapeutic targets that may potentially be manipulated to mitigate aGVHD. | Xiuhua Su Qianqian Wang Wei Guo Xiaolei Pei Qing Niu Maolan Liu Yuanyuan Liu Song Chen Sizhou Feng Yi He Donglin Yang Rongli Zhang Qiaoling Ma Weihua Zhai Aiming Pang Jialin Wei Yong Huang Yuechen Luo Mingzhe Han Xiaoming Feng Erlie Jiang | 2020 | Cellular & Molecular Immunology2020，17，5： | 3 |
| 9 | The Initial Case of COVID-19—Shulan City,Jilin Province,China,May 8,2020显示文摘Coronavirus disease 2019(COVID-19)was designated a global pandemic by the World Health Organization(WHO)on March 11,2020(1).After great effort,COVID-19 has been well-controlled in China,but new challenges have emerged due to increasing numbers of imported cases from outside of China.On May 8,the Health Commission of Jilin Province reported a confirmed COVID-19 case of a 45-year-old laundry woman from Shulan City in the northeast of China.This case was suspected to be associated with a possible importation event. | Cao Chen Xiang Zhao Dayan Wang Juan Li Ao Wang Donglin Wu Zhixiao Chen Yuchao Wu Yao Meng Weifeng Shi George FGao Guizhen Wu Biao Huang Wenbo Xu | 2020 | China CDC weekly2020，2，25： | 2 |
| 10 | Mn atomic layers under inert covers of graphene and hexagonal boron nitride prepared on Rh(111)显示文摘进 graphene 和它的支持的底层的接口的金属原子的置闰为削弱联合并且构造金属的接口的缘故成为了一个吸引人的话题在惰性的封面下面的原子层。然而,这新奇行为很少在类似的六角形的硼氮化物(h-BN ) 上被报导了在金属底层上综合了。这里,我们描述 Mn 置闰的比较研究进 graphene/Rh (111 ) 和 h-BN/Rh (111 ) 的接口,由使用解决 atomically 的扫描通道显微镜学(STM ) 和密度功能的理论(DFT ) 计算。置闰被退火执行同样扔的 Mn 簇,和进 h-BN/Rh (111 ) 的 Mn 置闰的开始的温度被发现是 80 瑩 ?? 数歡瀠睯牥搠湥楳祴漠 ??? ″坭洯吗? | Yu Zhang Yanfeng Zhang Donglin Ma Qingqing Ji Wei Fang Jianping Shi Teng Gao Mengxi Liu Yabo Gao Yubin Chen Limei Xu Zhongfan Liu | 2013 | Nano Research2013，6，12： | 2 |
| 11 | Paclitaxel formulation with stable sustained-release behavior and its biological safety evaluation显示文摘Biological safety and stable sustained-release of the drug are two crucial issues involved in the formulation of paclitaxel.Focusing on these issues, by using the FDA approved polylactide as carrier material, soybean lecithin as surfactant and maltodextrin as thickener, paclitaxel loaded PLA microspheres were simply prepared by solvent evaporation, thus guaranteeing the biological safety. The introduction of maltodextrin as a thickener aided to a stable sustained-release of paclitaxel. Surface morphology, particle size, drug loading rate, encapsulation efficiency and in vitro drug release behavior were investigated.Biological safety evaluations such as acute toxicity, allergies, hemolysis, skin stimulation and genotoxicity test were also carried out. Results showed that the obtained microspheres were biocompatible and could release paclitaxel at a desirable constant rate.Therefore, the simply prepared paclitaxel formulation with good biological safety and desirable release behavior exhibited great potential of local injection of paclitaxel for the clinical use in the future. | LI XuePing ZHAN Qi QI HongZhao HAN DongLin QIN YaoYao CHEN Ning LONG LiXia ZHAO Jin HOU Xin YUAN XuBo YANG XianJin | 2019 | Science China(Technological Sciences)2019，62，7： | 2 |
| 12 | Computational Identification of Protein-Protein Interactions in Rice Based on the Predicted Rice Interactome Network显示文摘Plant protein-protein interaction networks have not been identified by large-scale experiments. In order to better understand the protein interactions in rice, the Predicted Rice Interactome Network (PRIN; http://gffzz138305caccaf4191hcpqcu6obxwk56qnb.ffgz.tsg.suse.edu.cn/ prin/) presented 76,585 predicted interactions involving 5,049 rice proteins. After mapping genomic features of rice (GO annotation, subcellular localization prediction, and gene expression), we found that a well-annotated and biologically significant network is rich enough to capture many significant functional linkages within higher-order biological systems, such as pathways and biological processes. Furthermore, we took MADS-box do- main-containing proteins and circadian rhythm signaling pathways as examples to demonstrate that functional protein complexes and biological pathways could be effectively expanded in our predicted network. The expanded molecular network in PRIN has considerably improved the capability of these analyses to integrate existing knowledge and provide novel insights into the function and coordination of genes and gene networks. | Pengcheng Zhu Haibin Gu Yinming Jiao Donglin Huang Ming Chen | 2011 | Genomics, Proteomics & Bioinformatics2011，9，4： | 2 |
| 13 | On the technologies of Hα imaging spectrograph for the CHASE mission显示文摘The Hα imaging spectrograph(HIS) is the scientific payload of the first solar space mission, the Chinese Hα solar explorer(CHASE), supported by the China National Space Administration(CNSA). The CHASE/HIS achieves, for the first time in space, Hα spectroscopic observations with high spectral and temporal resolutions. Separate channels for the raster scanning mode(RSM) and continuum imaging mode(CIM) are integrated into one, and a highly integrated design is achieved through multiple folding of the optical path and ultra-light miniaturized components. The design of HIS implements a number of key technologies such as high-precision scanning of the optical field of view(FOV), high-precision integrated manufacturing inspection, a large-tolerance pre-filter window, and full-link solar radiation calibration. The HIS instrument has a pixel spectral resolution of 0.024 ? and can complete a full-Sun scanning within 46 s. | Qiang Liu Hongjiang Tao Changzheng Chen Chengshan Han Zhe Chen Gui Mei Liang Yang Qinglong Hu Hongwei Xin Xiansheng Li Hongyu Guan Donglin Xue Mingchao Zhu Changhong Hu Qinghua Ha Yukun He Cheng Fang Chuan Li Zhen Li | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，8： | 2 |
| 14 | Risk factors associated with hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation显示文摘Hemorrhagic cystitis(HC)is a common complication of allogeneic hematopoietic stem cell transplantation(HSCT).The incidence is about 7%to 68%,and some patients have to suffer a long period of frequent,urgent,and painful urination,which brings great pain.This study aimed to analyze risk factors of HC and its effect on patient survival.We collected the medical records of 859 patients who underwent HSCT at our hospital between August 2016 and August 2020.Patients with and without HC were matched using propensity score matching at a 1:1 ratio based on sex,age,and diagnosis,and logistic regression analyses were used to identify factors associated with HC.We used Kaplan–Meier curves to analyze the survival rates of patients in the HC and non-HC groups.We also analyzed the relationship between BK viral load and the occurrence of HC using receiver operating characteristic curve(ROC)analysis.After propensity score matching,there were 131 patients each in the HC and non-HC groups.In the HC group,89 patients(67.9%)had mild HC(stage II°)and 43(32.1%)had severe HC(stage III–IV).The median interval between stem cell transplantation and HC development was 31(3–244)days.Univariate analysis indicated that donor age,hematopoietic stem cell source,HLA,acute graft-versus-host disease,busulfan,anti-thymocyte globulin(ATG),total body irradiation,cytomegalovirus(CMV)(urine),and BK polyomavirus(BKV)(urine)were significantly associated with HC.ATG,CMV(urine),and BKV(urine)were independent risk factors for HC based on the multivariate analysis.The Kaplan–Meier survival analysis showed no significant difference between the HC and non-HC groups(P=0.14).The 1-and 2-year survival rates in the HC group were 78.4%and 69.6%,respectively,and the corresponding rates in the non-HC group were 84.4%and 80.7%,respectively.ROC analysis indicated that a urine BKV load of 1×10^(7) copies/mL was able to stratify the risk of HC.In conclusion,when the BKV load is>1×10^(7),we needtobe aware of the potential for the development of HC. | Biao Shen Yueshen Ma Haixiao Zhang Mingyang Wang Jia Liu Jiaxin Cao Wenwen Guo Dan Feng Donglin Yang Rongli Zhang Xin Chen Qiaoling Ma Weihua Zhai Sizhou Feng Mingzhe Han Aiming Pang Erlie Jiang 无 | 2022 | Blood Science2022，4，2： | 2 |
| 15 | Magnetic properties and microstructure of nanocrystalline bulk Nd-Fe-B with Ce-Co addition显示文摘The influence of Ce-Co alloy addition and sintering holding time on permanent magnetic properties and micro structure of nanocrystalline Nd-Fe-B bulk alloy were investigated.The coercivity of Nd-Fe-B bulk alloy can be enhanced greatly by more than 100% after adding Ce-Co powders.However,when the concentration of Ce-Co is up to 30 wt%,the density of the magnet can reach the maximum value of 7.58 g/cm^(3),but the coercivity does not increase significantly.On the other hand,with the increase of holding time to 10 min,the density and coercivity of magnets increase gradually,reaching up to 7.55 g/cm^(3) and 1134.3 kA/m,respectively.After the addition of Ce-Co alloy,Ce-Co may easily diffuse into the Nd-Fe-B matrix during hot-pressing and under the high pressure and temperature,thus increasing the content of grain boundary phase and the pinning effect of grain boundary,which leads to the increase of coercivity.The extension of the hot-pressing holding time may be more conducive to the diffusion of CeCo into the Nd-Fe-B matrix.In addition,the effect of Ce-Co addition on the magnetic properties of Nd-FeB with different content of rare earth was also studied.The addition of Ce-Co can effectively increase the coercivity of nanocomposite Nd_(2)Fe_(14)B/α-Fe magnets.The addition of Nb to the parent alloy can further improve the coercivity.For Nd_(11)Fe_(81.5)Nb_(1)Ga_(0.5)B_(6) alloy with 10 wt% Ce-Co addition,the coercivity can increase from 740.28 to 1098.48 kA/m. | Yilong Ma Qiqi Yang Xiaoli Chen Ying He Wenbo Xiang Jiaqi Lai Bin Shao Donglin Guo Dengming Chen Kejian Li | 2021 | Journal of Rare Earths2021，39，6： | 1 |
| 16 | Experimental investigation on the feasibility of movable heat-insulation device显示文摘 | Chuguang Zheng | 2002 | Applied Thermal Engineering2002，22，17： | 1 |
| 17 | An Ambipolar Conducting Covalent Organic Framework with Self‐Sorted and Periodic Electron Donor‐Acceptor Ordering显示文摘 | Xiao Feng Long Chen Yoshihito Honsho Oraphan Saengsawang Lili Liu Lu Wang Akinori Saeki Stephan Irle Shu Seki Yuping Dong Donglin Jiang | 2012 | Adv Mater2012，，22： | 1 |
| 18 | Effect of pH, Ionic Strength and Humic Substances on the Adsorption of Uranium (VI) onto Na-rectorite显示文摘 | Zhao Donglin Yang Shubin Chen Shaohua Guo Zhiqiang Yang Xin | 2011 | Journal of RadioAnalytical and Nuclear Chemistry2011，287，2： | 1 |
| 19 | The adsorption of Pb(II) on Mg 2 Al layered double hydroxide显示文摘 | Donglin Zhao Guodong Sheng Jun Hu Changlun Chen Xiangke Wang | 2011 | Chemical Engineering Journal2011，，1： | 1 |
| 20 | Deforming TC6 titanium alloys at ultrahigh strain rates during multiple laser shock peening显示文摘 | Liucheng Zhou Yinghong Li Weifeng He Guangyu He Xiangfan Nie Donglin Chen Zhilin Lai Zhibin An | 2013 | Materials Science & Engineering A2013，，： | 1 |
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