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| 1 | MicroRNA expression profiling in diabetic GK rat model显示文摘MicroRNAs (miRNAs ) 是小搁浅单人赛的非编码的 RNA 的一个最新识别的班,经由 post-transcriptional 调整他们的目标基因小径。miRNAs 在许多生物过程起重要作用,这被证明了。为了更好理解 miRNA,在类型 2 糖尿病上工作,我们使用了 oligonucleotide microarray 监视 GotoKakizaki (GK ) 和 Wistar 老鼠的骨胳的肌肉的 miRNA 表达式侧面。七 miRNAs 是下面表示的,二 miRNAs 在 GK 老鼠的肌肉是过去表示的,这被发现。在他们之中, miR-24 显示出最突出的变化。p38 MAPK,是 miR-24 的一个直接目标,也显示出表示差别。所有数据给 miR-24 可能通过 p38 MAPK 的下面规定与糖尿病被联系的线索。 | Bing Huang Wenming Qin Botao Zhao Yi Shi Chengguo Yao Jin Li Huasheng Xiao Youxin Jin | 2009 | Acta Biochimica et Biophysica Sinica2009，41，6： | 17 |
| 2 | BMPRII is a direct target of miR-21显示文摘MicroRNAs (miRNAs ) 是在 post-transcriptional 阶段调整血缘的 mRNA 表情的小非编码的 RNA 的一种类型。尽管几 miRNAs 被知道涉及各种各样的生物进程,包括发展预定, patterning, embryogenesis,区别和 organogenesis,生长控制,和 apoptosis,许多目标基因和大多数 miRNAs 的函数仍然是不清楚的。因为仅仅在动物房间在 miRNAs 和他们的目标之间有部分补充,为给定的 miRNA 识别特定的目标基因并且阐明是困难的它的功能。在这研究,我们证实了形态基因的蛋白质受体 II (BMPRII ) 是的那根骨头 miR-21 的一个直接目标,并且也证明 BMPRII 的蛋白质水平在 PC3 和 Lncap 房间与 miR-21 的数量相反地相关。这些调查结果建议 miR-21 可以在由调整 BMPRII 的表示调整恶意和前列腺癌症房间并且在干细胞的自强的变形能力有一个潜在的角色。 | Wenming Qin Botao Zhao Yi Shi Chengguo Yao Li Jin Youxin Jin | 2009 | Acta Biochimica et Biophysica Sinica2009，41，7： | 5 |
| 3 | Cloning of Novel Repeat-associated Small RNAs Derived from Hairpin Precursors in Oryza sativa显示文摘包括 microRNAs (miRNAs ) 种小非编码的 RNA,小介入 RNA (siRNAs ) 和交易的 siRNAs,在房间在 modulating 基因表达起重要作用。这里,我们孤立 21 个新奇内长的小 RNA 分子,从 18 ~ 24 核苷酸,在能被印射到 111 位发卡先锋的 Oryza sativa。进一步的分析显示大多数这些发卡序列从通常认为的缩小的转换重复的 transposable 元素发源, miRNA 内长的 siRNAs 经常是的像发卡的先锋和植物是特征的 DNA transposon.Considering 的一种主要类型在转座子定位了区域,我们假设了我们的克隆的小 RNA 可能在在 siRNAs 和 miRNAs.Northern 污点分析之间的进化进程代表中间的产品,这显示他们中的五个更富有地与另外的纸巾相比在花被表示,在开花期暗示他们的潜在的函数。在结论,我们的结果充实米饭小 RNA 数据并且在植物为小 RNA 注解提供一个有意义的观点。 | Chengguo YAO Botao ZHAO Wei LI Yang LI Wenming QIN Bing HUANG Youxin JIN | 2007 | Acta Biochimica et Biophysica Sinica2007，39，11： | 2 |
| 4 | Synthesis of an ordered porous carbon with the dual nitrogen-doped interfaces and its ORR catalysis performance显示文摘Both nitrogen-doping feature and pore structure are critical factors for developing nitrogen-doped carbons based catalysts with a high performance toward oxygen reduction reaction(ORR).Herein,a simple one-step CVD of acetylene and acetonitrile vapor method using silanized SBA-15 as a template has been developed to synthesize an ordered porous carbon(OPC) with dual nitrogen-doped interfaces.The optimized sample as prepared with the CVD of 4 h at 750℃ contains two types of ordered mesopores that one type is the ordered cylindrical pores inheriting from the pores of SBA-15 and has a pore width of4.0~5.0 nm,the other type is the ordered quasi-hexagonal pores with a width of 3.0~4.0 nm produced by etching the pore walls of SBA-15.These two types of pores whose pore walls are built by the nitrogen doped carbon layers resulted by the CVD and thus it actually makes the dual nitrogen-doped interfaced OPC(DN-OPC).Meanwhile,DN-OPC contains a few of micropores and a large SSA of 1430 m~2/g.This dualordered pores and dual nitrogen-doped interfaces cannot only facilitate mass transport but also utilize the active sites of DN-OPC for ORR.Therefore,as metal-free ORR catalyst,DN-OPC exhibits a good activity close to commercial Pt/C catalyst,and an excellent durability and methanol tolerance. | Hongwei Zhao Yanqiu Zhang Li Lixiang Xin Geng Haiming Yang Weimin Zhou Chengguo Sun Baigang An | 2021 | Chinese Chemical Letters2021，32，1： | 2 |
| 5 | Administration of dendritic cells dual expressing DcR3 and GAD65 mediates the suppression of T cells and induces long-term acceptance of pancreatic-islet transplantation显示文摘 | Qiansheng Li Chengguo Ge Rongrong Liu Keqin Zhang Gang Wu Wenqian Huo | 2010 | Vaccine2010，，52： | 1 |
| 6 | Particle shape effect on the viscosity and thermal conductivity of ZnO nanofluids显示文摘 | Jisun Jeong Chengguo Li Younghwan Kwon Jaekeun Lee Soo Hyung Kim Rin Yun | 2013 | International Journal of Refrigeration2013，，8： | 1 |
| 7 | Specific Regulation of m^(6)A by SRSF7 Promotes the Progression of Glioblastoma显示文摘Serine/arginine-rich splicing factor 7(SRSF7),a known splicing factor,has been revealed to play oncogenic roles in multiple cancers.However,the mechanisms underlying its oncogenic roles have not been well addressed.Here,based on N6-methyladenosine(m^(6)A)co-methylation network analysis across diverse cell lines,we find that the gene expression of SRSF7 is positively correlated with glioblastoma(GBM)cell-specific m^(6)A methylation.We then indicate that SRSF7 is a novel m^(6)A regulator,which specifically facilitates the m^(6)A methylation near its binding sites on the mRNAs involved in cell proliferation and migration,through recruiting the methyltransferase complex.Moreover,SRSF7 promotes the proliferation and migration of GBM cells largely dependent on the presence of the m^(6)A methyltransferase.The two m^(6)A sites on the mRNA for PDZ-binding kinase(PBK)are regulated by SRSF7 and partially mediate the effects of SRSF7 in GBM cells through recognition by insulin-like growth factor 2 mRNA-binding protein 2(IGF2BP2).Together,our discovery reveals a novel role of SRSF7 in regulating m^(6)A and validates the presence and functional importance of temporal-and spatial-specific regulation of m^(6)A mediated by RNA-binding proteins(RBPs). | Yixian Cun Sanqi An Haiqing Zheng Jing Lan Wenfang Chen Wanjun Luo Chengguo Yao Xincheng Li Xiang Huang Xiang Sun Zehong Wu Yameng Hu Ziwen Li Shuxia Zhang Geyan Wu Meisongzhu Yang Miaoling Tang Ruyuan Yu Xinyi Liao Guicheng Gao Wei Zhao Jinkai Wang Jun Li | 2023 | Genomics, Proteomics & Bioinformatics2023，21，4： | 1 |
| 8 | Aberrant expression of microRNAs in gastric cancer and biological significance of miR-574-3p显示文摘 | Yingying Su Zhaohui Ni Guoqing Wang Juan Cui Chengguo Wei Jihan Wang Qing Yang Ying Xu Fan Li | 2012 | International Immunopharmacology2012，，4： | 1 |
| 9 | Expression and characterization of rice putative PAUSED gene显示文摘在 Arabidopsis,暂停了(PSD ) 编码 los1p/exportin-t 的 ortholog,它调停在酵母和哺乳动物的转移 RNA (tRNA ) 的原子出口。在象米饭那样的 monocot 植物,然而,相应 ortholog 的知识被限制,并且它在生长开发和生产率的效果仍然保持未知。在这研究,我们验证了一根米饭 transfer-DNAinsertional 异种 psd 线并且分析了它的显型;异种与野类型的米饭相比包括延迟的开发和低富饶显示了严重词法缺点。与在野类型、变异的叶织物之间的北污点分析在细胞质、原子的部分检验 intronless tRNA-Tyr 和包含 intron pre-tRNA-Ala 表示层次建议米饭 PSD 可能从原子核涉及 tRNA 出口到细胞质。另外,反向的抄写聚合酶链反应分析表明那个 PSD 抄本在整个正常米饭植物开发被表示,并且 subcellular 本地化试金证明那米饭 PSD 蛋白质在原子核和细胞质是在场的。在摘要,我们的数据暗示通常认为的 PSD 基因可能为正常米饭开发是不可缺少的,它的函数可能与 Arabidopsis PSD 的一样。 | Chengguo Yao Liangfa Ge Wei Li Botao Zhao Chaoqun Li Kangcheng Ruan Hongxuan Lin Youxin Jin | 2008 | Acta Biochimica et Biophysica Sinica2008，40，10： | 1 |
| 10 | Melting purifi- cation process and refining effect of 5083 AI-Mg alloy显示文摘 | Ma Chengguo Qi Shuyan Li Shuang | 2014 | Trans Nonferrous Metals Soc China2014，24，： | 1 |
| 11 | Development of biobased unsaturated polyester resin containing highly functionalized castor oil显示文摘 | Chengguo Liu Jun Li Wen Lei Yonghong Zhou | 2014 | Industrial Crops & Products2014，，： | 1 |
| 12 | Network traffic classification via HMM under the guidance of syntactic structure显示文摘 | Yin Chengguo Li Shuangqing Li Qi | 2012 | Computer Networks2012，56，6： | 1 |
| 13 | 6-44 Studying of Residual Activity Induced by 300 MeV/u Carbon Ion in Copper Target显示文摘Activation of accelerator components due to beam losses is an important issue for a high-energy heavy ion accelerator.The induced components may become a main source of exposure to maintenance workers and a serious access-restriction for“hand-on”maintenance,and also have a certain radiation influence over the environment.In this work,experimental of residual activation induced by 300 MeV/u carbon ions was studied at the deep-therapy terminal of HIRFL. | Xu Junkui Su Youwu Li Wuyuan Pang Chengguo Yan Weiwei Xu Chong Mao Wang | 2016 | IMP & HIRFL Annual Report2016，，1： | 0 |
| 14 | 6-42 Radiation Safety Report of HIRFL in 2015显示文摘The total operation time of HIRFL is 7 536 h in 2015; the user beam time is about 5 451.5 (from 21 Dec.2014 to 21 Dec. 2015); 4 836 h were used for experiments; 615.5 h were used for accelerator research. There are 26 heavy ions beams were provided by HIRFL in 2015. The highest ions energy provided is 464 MeV/u, the maximum accumulated ion intensity is 1 400 A for carbon ion. | Su Youwu Xu Junkui Li Zongqiang Mao Wang Li Wuyuan Xu Chong Yan Weiwei Pang Chengguo | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
| 15 | Protective effects of IRG1/itaconate on acute colitis through the inhibition of gasdermins-mediated pyroptosis and inflammation response显示文摘Inflammatory bowel disease(IBD)is a chronic relapsing gastrointestinal disorder,while the treatment effect is not satisfactory.Immune responsive gene 1(IRG1)is a highly ex-pressed gene in macrophage in response to inflammatory response and catalyzes the production of itaconate.Studies have reported that IRG1/itaconate has a significant antioxidant effect.This study aimed to investigate the effect and mechanism of IRG1/itaconate on dextran sulfate so-dium(DSS)-induced colitis in vivo and in vitro.In vivo experiments,we found IRG1/itaconate ex-erted protective effects against acute colitis by increasing mice weight,the length of colon,reducing disease activity index and colonic inflammation.Meanwhile,IRG1 deletion aggravated the macrophages/CD4+/CD8+T-cell accumulation,and increased the release of interleukin(IL)-1b,tumor necrosis factor-a(TNF-a),IL-6,the activation of nuclear factor-kB(NF-kB)/mitogen-activated protein kinase(MAPK)signaling pathway,and gasdermin D(GSDMD)mediated pyrop-tosis.Four-octyl itaconate(4-OI),a derivative of itaconate,attenuated these changes,therefore relieved DSS-induced colitis.In vitro experiment,we found 4-OI inhibited the reactive oxygen species production,thereby inhibiting the activation of MAPK/NF-kB signaling pathway in RAW264.7 and murine bone-marrow-derived macrophages.Simultaneously,we found 4-OI inhib-ited caspase1/GSDMD-mediated pyroptosis to reduce the release of cytokines.Finally,we found anti-TNF-a agent reduced the severity of DSS-induced colitis and inhibited gasdermin E(GSDME)-mediated pyroptosis in vivo.Meanwhile,our study revealed that 4-OI inhibited caspase3/GSDME-mediated pyroptosis induced by TNF-a in vitro.Taken together,IRG1/itaconate exerted a pro-tective role in DSS-induced colitis by inhibiting inflammatory response and GSDMD/GSDME-medi-ated pyroptosis,which could be a promising candidate for IBD therapy. | Wenchang Yang Yaxin Wang Tao Wang Chengguo Li Liang Shi Peng Zhang Yuping Yin Kaixiong Tao Ruidong Li | 2023 | Genes & Diseases2023，10，4： | 0 |
| 16 | PLSCR1 promotes apoptosis and clearance of retinal ganglion cells in glaucoma pathogenesis显示文摘Glaucoma is the leading cause of irreversible blindness worldwide.In the pathogen-esis of glaucoma,activated microglia can lead to retinal ganglion cells(RGCs)apoptosis and death,however,the molecular mechanisms remain largely unknown.We demonstrate that phospholipid scramblase 1(PLSCR1)is a key regulator promoting RGCs apoptosis and their clearance by microglia.As evidenced in retinal progenitor cells and RGCs of the acute ocular hypertension(AOH)mouse model,overexpressed PLSCR1 induced its translocation from the nucleus to the cytoplasm and cytomembrane,as well as elevated phosphatidylserine exposure and reactive oxygen species generation with subsequent RGCs apoptosis and death.These damages were effectively attenuated by PLSCR1 inhibition.In the AOH model,PLSCR1 led to an increase in M1 type microglia activation and retinal neuroinflammation.Upregulation of PLSCR1 resulted in strongly elevated phagocytosis of apoptotic RGCs by activated microglia.Taken together,our study provides important insights linking activated microglia to RGCs death in the glaucoma pathogenesis and other RGC-related neurodegenerative diseases. | Jingyi Luo Qing Lian Deliang Zhu Minglei Zhao Tingfang Mei Bizhi Shang Zeqiu Yang Chujun Liu Wenchang Xu Lan Zhou Keling Wu Xinqi Liu Yuhua Lai Fuxiang Mao Weihua Li Chengguo Zuo Kang Zhang Mingkai Lin Yehong Zhuo Yizhi Liu Lin Lu Ling Zhao | 2023 | Genes & Diseases2023，10，4： | 0 |
| 17 | 3-82 Study of Particle Fragments and Its Contribution in Carbon Ion Therapy显示文摘Carbon ions offer significant advantages for deep-seated local tumors therapy due to their physical and biologicalproperties, for heavy ions has a fixed range in the target matter, and characterized by a small entrance dose anda distinct maximum (Bragg peak) near the end of range. In 2006, IMP carried out some heavy ion cancer therapyexperiments. During the process of carbon ions cancer therapy, various kinds of secondary particle fragments arecreated from heavy ion reaction which will influence the treatment dose and healthy tissue of patient. Neutron isthe most abundant secondary particles in heavy ion reaction, which may influence largely patient body due to itsstrong penetrating power. Thus it is important to know the neutron contribution in heavy ion therapy to evaluatethe neutron impact and assess the patient safety. Particle fragments and its contribution from 430 MeV/u carbonions stopping in thick water target were calculated by Fluka Monte Carlo code[1]. | Xu Junkui Su Youwu Li Wuyuan Pang Chengguo | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 18 | Electrochemical capacitance-voltage characterization of plasma-doped ultra-shallow junctions显示文摘Ultra-shallow Si p^(+)n junctions formed by plasma doping are characterized by electrochemical capacitance-voltage(ECV).By comparing ECV results with those of secondary ion mass spectroscopy(SIMS),it is found that the dopant concentration profiles in heavily-doped p+layer as well as junction depths measured by ECV are in good agreement with those measured by SIMS.However,the ECV measurement of dopant concentration in the underlying lightly doped n-type substrate is significantly influenced by the upper heavily-doped layer.The ECV technique is also easy to control and reproduce.The ECV results of ultra-shallow junctions(USJ)formed by plasma doping followed by different annealing processes show that ECV is capable of reliably characterizing a Si USJ with junction depth as low as 10 nm,and dopant concentration up to 10^(21) cm^(-3).Also,its depth resolution can be as fine as 1 nm.Therefore,it shows great potential in application for characterizing USJ in the sub-65 nm technology node CMOS devices. | Huizhen WU Guoping RU Yonggang ZHANG Chengguo JIN Bunji MIZUNO Yulong JIANG Xinping QU Bingzong LI | 2008 | Frontiers of Electrical and Electronic Engineering in China2008，3，1： | 0 |
| 19 | 6-22 Radiation Safety Report of HIRFL in 2014显示文摘The total operation time of HIRFL is 7 272 h in 2014, and the user beam time is about 4 964.5 h(from 21stDec.2013 to 21st Dec. 2014). 3 749 h for physics experiment, 332 h for life science research, 883.5 h for materialscience and single particle effect research, and 235 h for machine research. There are 24 heavy ions beams wereprovided by HIRFL in 2014. The highest ions energy provided is 487 MeV/u, and the maximum accumulated ionintensity is 1 000 A. | Su Youwu Xu Junkui Li Zongqiang Mao Wang Li Wuyuan Xu Chong Yan Weiwei Pang Chengguo | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 20 | Alternative splice site recognition based on a new fuzzy support vector machine显示文摘 | Xiaoxia Li Bo Sun Chengguo Li | 2013 | Acta Biochimica et Biophysica Sinica2013，45，5： | 0 |
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