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| 1 | ABO sequence analysis in an AB type with anti-B patient显示文摘ABO blood group system is the first to be discovered and the most clinically important in transfusion medicine.1The ABO gene encodes a glycosyltransferase which synthesize the oligosaccharide epitopes.The difference between the consensus A gene (A101 allele) usually used as the reference and the consensus B gene (B101 allele) are 7 in-frame single nucleotide polymorphisms (SNPs),among which only 4 alleles cause amino acid mutations in the enzyme.When A allele was inherited from one parent and B allele was inherited from the other which produced the AB blood group,this is known as trans-AB.Cis-AB is characterized as mutant ABO alleles encoding a glycosyltransferase capable of synthesizing both A and B antigens which is very rare. | Chen Qing Xiao Jianyu Wang Shuya Li Jiahuang Du Leilei Lu Le Huang Chengyin Li Min Li Ping | 2014 | Chinese Medical Journal2014，，5： | 17 |
| 2 | Reversing drug resistance of soft tumor-repopulating cells by tumor cell-derived chemotherapeutic microparticles显示文摘颠倒使人重新住入肿瘤的房间(TRC ) 的药抵抗或起源的发展中的新奇途径像房间的癌症房间是迫切临床的需要改进癌症病人的结果。这里,我们显示出用肿瘤颠倒 TRC 的药抵抗的一条创新途径包含反肿瘤药的导出房间的 microparticles (T-MPs ) 。由比区分的癌症房间更可变形的优点, TRC 优先地收起 T-MPs 在进入房间以后释放反肿瘤药,它接着导致 TRC 的死亡。内在的机制包括防碍药流出并且支持这些药的原子入口。我们的调查结果在用有希望的临床的应用程序颠倒 TRC 的药抵抗在 T-MPs 的举起和一条新奇途径的有效性表明肿瘤房间柔软的重要性。 | Jingwei Ma Yi Zhang Ke Tang Huafeng Zhang Xiaonan Yin Yong Li Pingwei Xu Yanling Sun Ruihua Ma Tiantian Ji Junwei Chen Shuang Zhang Tianzhen Zhang Shunqun Luo Yang Jin Xiuli Luo Chengyin Li Hongwei Gong Zhixiong Long Jinzhi Lu Zhuowei Hu Xuetao Cao Ning Wang Xiangliang Yang Bo Huang | 2016 | Cell Research2016，26，6： | 17 |
| 3 | Traditional Chinese medicine compound ShengJinRunZaoYangXue granules for treatment of primary Sjogren's syndrome: a randomized, double-blind, placebo-controlled clinical trial显示文摘 | Hu Wei Qian Xian Guo Feng Zhang Miaojia Lyu Chengyin Tao Juan Gao Zhong'en Zhou Zhengqiu | 2014 | Chinese Medical Journal2014，，15： | 5 |
| 4 | lonization and dissociation of acetonitrile by intense femtosecond laser pulse显示文摘Photoionization and photodissociation of CH3CN were studied by a linear time of flight mass spectrometer coupled with 800 nm, 50 fs laser pulses at intensities of 6.3×1013-1.2×1014 W/cm2. The laser power dependences for principal ions CH3CN+, CH2CN+, CHCN+ and CCN+ were measured, which are consistent with the numbers of photons required to produce the ions via multiphoton ionization and dissociation. The results show that eight-photon non-resonant multiphoton ionization is the main photoionization mechanism of the parent ion CH3CN+, while the fragment ions were produced through the dissociation of the molecules in the super-excited states. | WU Chengyin, XIONG Yijia, GAO Zhen, KONG Fan’ao, LU Haihe, YANG Xiaodong & XU ZhizhanInstitute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Shanghai 201800, China Correspondence should be addressed to Kong Fan’ao | 2000 | Chinese Science Bulletin2000，45，21： | 3 |
| 5 | A new approach to dissecting complex traits by combining quantitative trait transcript (QTT) mapping and diallel cross analysis显示文摘A promising way to uncover the genetic architectures underlying complex traits may lie in the ability to recognize the genetic variants and expression transcripts that are responsible for the traits' inheritance.However,statistical methods capable of investigating the association between the inheritance of a quantitative trait and expression transcripts are still limited.In this study,we described a two-step approach that we developed to evaluate the contribution of expression transcripts to the inheritance of a complex trait.First,a mixed linear model approach was applied to detect significant trait-associated differentially expressed transcripts.Then,conditional analysis were used to predict the contribution of the differentially expressed genes to a target trait.Diallel cross data of cotton was used to test the application of the approach.We proposed that the detected differentially expressed transcripts with a strong impact on the target trait could be used as intermediates for screening lines to improve the traits in plant and animal breeding programs.It can benefit the discovery of the genetic mechanisms underlying complex traits. | YANG DaiGang YE ChengYin MA XiongFeng ZHU ZhiHong ZHOU XiaoJian WANG HaiFeng MENG QingQin PEI XiaoYu YU ShuXun ZHU Jun | 2012 | Chinese Science Bulletin2012，57，21： | 3 |
| 6 | Structural health monitoring of bridges in the State of Connecticut显示文摘A joint effort between the Connecticut Department of Transportation and the University of Connecticut has been underway for more than 20 years to utilize various structural monitoring approaches to assess different bridges in Connecticut.This has been done to determine the performance of existing bridges,refine techniques needed to evaluate different bridge components,and develop approaches that can be used to provide a continuous status of a bridge's structural integrity.This paper briefly introduces the background of these studies,with emphasis on recent research and the development of structural health monitoring concepts.This paper presents the results from three different bridge types:a post-tensioned curved concrete box girder bridge,a curved steel box-girder bridge,and a steel multi-girder bridge.The structural health monitoring approaches to be discussed have been successfully tested using field data collected during multi-year monitoring periods,and are based on vibrations,rotations and strains.The goal has been to develop cost-effective strategies to provide critical information needed to manage the State of Connecticut's bridge infrastructure. | Chengyin Liu Joshua Olund Alan Cardini Paul D'Attilio Eric Feldblum John DeWolf | 2008 | Earthquake Engineering and Engineering Vibration2008，7，4： | 3 |
| 7 | Fabrication of Large-area 3-D Ordered Silvercoated Colloidal Crystals and Macroporous Silver Films Using Polystyrene Templates显示文摘The highly ordered silver-coated colloidal crystals arrays and macroporous silver films were derived through an electrostatics-induced adsorption effect using polystyrene(PS) as templates. Carboxyl-modified PS microspheres were prepared by emulsifier-free emulsion polymerization using methacrylic acid(MAA) as the functional monomer. PS microspheres were self-assembled into close packing colloidal crystals of facecentered cubic arrays to the substrate with vertical deposition method. These colloidal crystals were modified using dopamine(DA) to form poly-dopamine(PDA) during its oxidative polymerization. Through electrostatic interaction, the silver nanoparticles were deposited and adsorbed onto the surfaces of colloidal crystals templates by exposing [Ag(NH_3)_2]^+solution to infrared irradiation. Removal of the polymeric template by etching with methylbenzene solvent resulted in 3D ordered macroporous silver films. The structural and properties of the ordered silver-coated arrays and macroporous silver films were characterized by field emission scanning electron microscopy(FE-SEM), X-ray diffraction(XRD), UV-vis spectroscopy and surface-enhanced Raman spectroscopy(SERS). The results indicate that the prepared silver-coated arrays and macroporous silver films possess the features of ordered multilayer arrangement, uniformity and repeatability as well as an ideal SERS effect. | Wen Zhu Yuanyuan Wu Chengyin Wang Ming Zhang Guanxiu Dong | 2013 | Nano-Micro Letters2013，5，3： | 3 |
| 8 | Application of a Self-developed Proton Transfer Reaction-Mass Spectrometer to On-line Monitoring Trace Volatile Organic Compounds in Ambient Air显示文摘 | KANG Meng ZOU Xue LU Yan WANG Hongmei SHEN Chengyin JIANG Haihe CHU Yannan | 2016 | Chemical Research in Chinese Universities2016，32，4： | 2 |
| 9 | Development and validation of a TaqMan^(TM) fluorescent quantitative real-time PCR assay for the rapid detection of Edwardsiella tarda显示文摘Edwardsiella tarda is one of the most important emerging pathogens in the global aquaculture industries. As such, an accurate diagnosis and quantitative analytical methods are urgently needed for this bacterium. In this study, primers and a TaqMan probe specific to the conservative sequences of the 16S rRNA gene of E. tarda were designed. The concentration of primers and TaqMan probe were optimized to 200 nmol/L and 120 nmol/L, respectively. The detection sensitivity of the FQ-PCR assay was determined to be as low as five copies of the target sequence per reaction using the pGEM-16S rDNA recombinant plasmid as a template, which was 100 times more sensitive than conventional PCR. A standard curve by plotting the threshold cycle values (y) against the common logarithmic copies (log_10 n_c as x; n_c is copy number) of pGEM-16S rDNA was generated. The results of intra-and inter-assay variability tests demonstrate that the established FQ-PCR method was highly reproducible. The assay was specific for E. tarda as it showed that there was no cross-reactivity to eight additional bacterial pathogen strains in aquaculture. Thus, the FQ-PCR assay has the potential for diagnostic purposes and for other applications, especially for the rapid detection and quantification of low-grade E. tarda infections. | XIE Guosi HUANG Jie ZHANG Qingli HAN Nana SHI Chengyin WANG Xiuhua | 2012 | Acta Oceanologica Sinica2012，31，4： | 2 |
| 10 | Effect of temperature on modal variability of a curved concrete bridge under ambient loads显示文摘 | Liu Chengyin DeWolf John T | 2007 | Journal of Structural Engineering2007，133，12： | 1 |
| 11 | Influence of suffactant on the capacitive performance of manganese dioxide prepared at different temperatures 显示文摘 | ZHANG Huaihao WANG Yaqiong WANG Chengyin | 2013 | Energy Coversion and Management2013，74，： | 1 |
| 12 | Bird nest-like zinc oxide nanostructures for sensitive electrochemical glucose biosensor显示文摘In this research,a novel bird nest-like zinc oxide(BN-ZnO)nanostructures were prepared by a simple solvothermal method.A sensitive electrochemical glucose biosensor was for the first time developed based on the immobilization of glucose oxidase(GOx)on nanostructured BN-ZnO modified electrode.The BN-ZnO nanostructure and the resultant biosensor were characterized by scanning electron microscope,X-ray diffraction spectroscopy,Fourier transform infrared spectroscopy,and electrochemical impedance spectroscopy.BN-ZnO nanostructures have large specific surface area and can load large amounts of GOx molecules.Meanwhile,BN-ZnO provides an excellent microenvironment to retain the native bioactivity of enzymes and to promote direct electron transfer between GOx and electrode surface.The proposed biosensor shows a wide linear range of 0.005–1.6 mmol/L,high sensitivity of15.6 mA L mol^(-1)cm^(-2)with a low detection limit of 0.004 mmol/L.The resulting biosensor also shows excellent selectivity,acceptable stability and reproducibility,and can be successfully applied in the detection of glucose in human serum samples at-0.37 V. | Feng Shi Jinming Xu Zhongfang Hu Chuanli Ren Yadong Xue Yongcai Zhang Juan Li Chengyin Wang Zhanjun Yang | 2021 | Chinese Chemical Letters2021，32，10： | 1 |
| 13 | Improvement of decentralized random decrement technique for data processing in wireless sensor network显示文摘The Random Decrement Technique(RDT), based on decentralized computing approaches implemented in wireless sensor networks(WSNs), has shown advantages for modal parameter and data aggregation identification. However, previous studies of RDT-based approaches from ambient vibration data are based on the assumption of a broad-band stochastic process input excitation. The process normally is modeled by filtered white or white noise. In addition, the choice of the triggering condition in RDT is closely related to data communication. In this project, research has been conducted to study the nonstationary white noise excitations as the input to verify the random decrement technique. A local extremum triggering condition is chosen and implemented for the purpose of minimum data communication in a RDT-based distributed computing strategy. Numerical simulation results show that the proposed technique is capable of minimizing the amount of data transmitted over the network with accuracy in modal parameters identification. | Liu Chengyin Xu Chunchuan Teng Jun | 2016 | Earthquake Engineering and Engineering Vibration2016，15，3： | 1 |
| 14 | Determination of benzoyl peroxidelevels in wheat flour and pharmaceutical preparations by differentialpulse voltammetry in nonaqueous media显示文摘 | WANG Chengyin HU Xiaoya | 2005 | Anal Lett2005，38，13： | 1 |
| 15 | Mn304 nanopar- tieles embedded into graphene nanosheets: Preparation, characterization, and electrochemical properties for super- capacitors 显示文摘 | WANG Bei PARK J WANG Chengyin | 2010 | Electrochimica ACTA2010，55，22： | 1 |
| 16 | Mn304 nano- particles embedded into graphene nanosheets: Preparation, characterization, and electrochemical properties for superca- pacitors显示文摘 | Wang Bei Park Jinsoo Chengyin Wang | 2010 | Electroehim Acta2010，55，： | 1 |
| 17 | Determination of glyphosate and aminomethylphosphonic acid in water by LC using a new labeling reagent, 4-methoxybenzenesulfonyl fluoride 显示文摘 | SUN Yujie WANG Chengyin WEN Qunyin | 2010 | Chromatographia2010，72，78： | 1 |
| 18 | Insight into the formation of hollow silver nanoparticles using a facile hydrothermal strategy显示文摘 | Chengyin Li Hui Liu Penglei Cui Feng Ye Jun Yang | 2016 | Particuology2016，14，1： | 1 |
| 19 | Waterborne epoxy resin modified by AMPS显示文摘 | Chengyin Ma Cuiyan Deng Wenji Zheng | 2007 | Journal of Wuhan University of Technology - Mater Sci Ed2007，，4： | 1 |
| 20 | Safety and immunogenicity of a modified COVID-19 mRNA vaccine,SYS6006,as a fourth-dose booster following three doses of inactivated vaccines in healthy adults:an open-labeled Phase 1 trial显示文摘The continuous emergence of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)variants led to a rapid decline in protection efficacy and neutralizing titers even after three doses of COVID-19 vaccines.Here,we report an open-labeled Phase I clinical trial of a modified mRNA vaccine(SYS6006)as a fourth-dose booster in healthy adults.Eighteen eligible participants,who had completed three doses of inactivated COVID-19 vaccines,received a fourth boosting dose of SYS6006-20μg.Eighteen convalescent COVID-19 patients were enrolled for the collection of serum samples as a comparator of immunogenicity.The primary endpoint of this trial was titers of anti-receptor binding domain of spike glycoprotein(RBD)antibodies of the Omicron strain(BA.2 and BA.4/5)in serum;titers of neutralizing antibodies against pseudovirus of the Omicron strain(BA.2 and BA.4/5).The secondary endpoint was the incidence of adverse events within 30 days after the boosting.The exploratory endpoint was the cellular immune responses(interferon gamma,IFN-γ).This trial was registered with the Chinese Clinical Trial Registry website.No serious adverse events were reported within 30 days after vaccination.No Grade 3 fever or serious adverse event was reported in the SYS6006 group.Notably,SYS6006 elicited higher titers and longer increases in anti-RBD antibodies and neutralizing antibodies(>90 days)compared with the convalescent group(P<0.0001)against Omicron strain(BA.2 and BA.4/5).Besides,higher positive spots of T-cell-secreting IFN-γwere observed in the SYS6006 group than those in the convalescent group(P<0.05).These data demonstrated that SYS6006 was well tolerated and highly immunogenic,generating a stronger and more durable immune response against different variants of SARS-CoV-2. | Yuzhou Gui Ye Cao Jiajin He Chunyang Zhao Wei Zheng Ling Qian Jie Cheng Chengyin Yu Chen Yu Kun Lou Gangyi Liu Jingying Jia | 2023 | Life Metabolism2023，2，3： | 1 |
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