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| 1 | Anti-malaria drug chloroquine is highly effective in treating avian influenza A H5N1 virus infection in an animal model显示文摘 | Yiwu Yan Zhen Zou Yang Sun Xiao Li Kai-Feng Xu Yuquan Wei Ningyi Jin Chengyu Jiang | 2013 | Cell Research2013，23，2： | 36 |
| 2 | A retrospective of knowledge graphs显示文摘 | Jihong YAN Chengyu WANG Wenliang CHENG Ming GAO Aoying ZHOU | 2018 | Frontiers of Computer Science2018，12，1： | 25 |
| 3 | Herbal decoctosome is a novel form of medicine显示文摘Traditionally, herbal medicine is consumed by drinking decoctions produced by boiling herbs with water. The functional components of the decoction are heat stable. Small RNAs(sRNAs) were reported as a new class of functional components in decoctions. However, the mechanisms by which sRNAs survive heat treatment of the decoction and enter cells are unclear.Previous studies showed that plant-derived exosome-like nanoparticles(ELNs), which we call botanosomes, could deliver therapeutic reagents in vivo. Here, we report that heat-stable decoctosomes(ELNs) from decoctions have more therapeutic effects than the decoctions in vitro and demonstrate therapeutic efficacy in vivo. Furthermore, sRNAs, such as HJT-sRNA-m7 and PGY-sRNA-6, in the decoctosome exhibit potent anti-fibrosis and anti-inflammatory effects, respectively. Decoctosome is comprised of lipids, chemical compounds, proteins, and s RNAs. A medical decoctosome mimic is called bencaosome. A single lipid sphinganine(d22:0) identified in the decoctosome was mixed and heated with the synthesized sRNAs to form the simplest bencaosome. This simple bencaosome structure was identified by critical micelle concentration(cmc) assay that sRNAs coassembled with sphinganine(d22:0) to form the lipid layers of vesicles. The heating process facilitates co-assembly of sRNAs and sphinganine(d22:0) until a steady state is reached. The artificially produced sphinganine-HJT-sRNA-m7 and sphinganinePGY-sRNA-6 bencaosomes could ameliorate bleomycin-induced lung fibrosis and poly(I:C)-induced lung inflammation, respectively, following oral administration in mice. Our study not only demonstrates that the herbal decoctosome may represent a combinatory remedy in precision medicine but also provides an effective oral delivery route for nucleic acid therapy. | Xiaoyun Li Zhu Liang Jianchao Du Zhiqing Wang Song Mei Zhiqing Li Yan Zhao DANDan Zhao Yiming Ma Jun Ye Jiantao Xu Yu Zhao Jiahui Chang Yuhao Qin Lanlan Yu Chenxuan Wang Chengyu Jiang | 2019 | Science China(Life Sciences)2019，62，3： | 26 |
| 4 | IL-17 response mediates acute lung injury induced by the 2009 Pandemic Influenza A (HIN1) Virus显示文摘 | Chenggang Li Penghui Yang Yang Sun Taisheng Li Chen Wang Zhong Wang Zhen Zou Yiwu Yan Wei Wang Chen Wang Zhongwei Chen Li Xing Chong Tang Xiangwu Ju Feng Guo Jiejie Deng Yan Zhao Peng Yang Jun Tang Huanling Wang Zhongpeng Zhao Zhinan Yin Bin Cao Xiliang Wang Chengyu Jiang | 2012 | Cell Research2012，22，3： | 22 |
| 5 | Plant-derived phosphocholine facilitates cellular uptake of anti-pulmonary fibrotic HJT-sRNA-m7显示文摘Pulmonary fibrosis, a progressive chronic disease with a high mortality rate, has limited treatment options. Currently, lung transplantation remains the only effective treatment. Here we report that a small RNA, HJT-sRNA-m7, from a Chinese herbal medicine Hong Jing Tian(HJT, RHODIOHAE CRENULATAE RADIX ET RHIZOMA, Rhodiola crenulata) can effectively reduce the expressions of fibrotic hallmark genes and proteins both in alveolar in vitro and in mouse lung tissues in vivo. We also discovered over one hundred oil-soluble chemicals from HJT decoctions, most of which are found in lipid extracts from other Chinese herbals decoctions, including Pu Gong Ying(PGY, TARAXACI HERBA, Taraxacum mongolicum), Chuan Xin Lian(CXL, changed to 'ANDROGRAPHIS HERBA, Andrographis paniculata'), and Jin Yin Hua(JYH, lonicera japonica or Honeysuckle). We identified the active component in these decoctions as two forms of phosphocholines, PC(18:0/18:2) and PC(16:0/18:2). These PCs potentially could form liposomes with small RNAs to enter human alveolar and gastric cells. Our experimental results suggest an unprecendent lipid complex route through which botanic small RNA can enter human bodies.Our results provide an innovative treatment strategy for oral delivery of siRNAs as therapeutic medication. | Jianchao Du Zhu Liang Jiantao Xu Yan Zhao Xiaoyun Li Yanli Zhang DANDan Zhao Ruxuan Chen Yang Liu Trupti Joshi Jiahui Chang Zhiqing Wang Yanxu Zhang Jindong Zhu Qiang Liu Dong Xu Chengyu Jiang | 2019 | Science China(Life Sciences)2019，62，3： | 21 |
| 6 | Large-scale analysis of small RNAs derived from traditional Chinese herbs in human tissues显示文摘Plant-derived microRNAs have recently been reported to function in human blood and tissues. Controversy was immediately raised due to possible contamination and the lack of large sample sizes. Here, we report thousands of unique small RNAs derived from traditional Chinese medicine(TCM) herbs found in human blood cells and mouse lung tissues using a large-scale analysis.We extracted small RNAs from decoctions of 10 TCM plants(Ban Zhi Lian, Chai Hu, Chuan Xin Lian, Di Ding Zi Jin, Huang Qin, Jin Yin Hua, Lian Qiao, Pu Gong Ying, Xia Ku Cao, and Yu Xing Cao) and obtained millions of RNA sequences from each herb. We also obtained RNA-Seq data from the blood cells of humans who consumed herbal decoctions and from the lung tissues of mice administered RNAs from herbal decoctions via oral gavage. We identified thousands of unique small RNA sequences in human blood cells and mouse lung tissues. Some of these identified small RNAs from Chuan Xin Lian and Hong Jing Tian could be mapped to the genomes of the herbs, confirming their TCM plant origin. Small RNAs derived from herbs regulate mammalian gene expression in a sequence-specific manner, and thus are a superior novel class of herbal drug components that hold great potential as oral gene-targeted therapeutics, highlighting the important role of herbgenomics in their development. | Fengming Huang Jianchao Du Zhu Liang Zhichao Xu Jiantao Xu Yan Zhao Yexuan Lin Song Mei Quan He Jindong Zhu Qiang Liu Yanxu Zhang Yuhao Qin Wei Sun Jingyuan Song Shilin Chen Chengyu Jiang | 2019 | Science China(Life Sciences)2019，62，3： | 14 |
| 7 | Angiotensin II receptor blocker as a novel therapy in acute lung injury induced by avian influenza A H5N1 virus infection in mouse显示文摘Dear Editor,Since the first recognized case of human infection with avian influenza H5N1 virus in 1997,the worldwide spread and re-emergence of this highly pathogenic influenza virus have led to 694 human infection cases.Of these cases,402died from 2003 to 2015(http://gffzz36b398b81f8a4a4ch5ooxk9pxqp956x5u.ffgz.tsg.suse.edu.cn/influenza/humananimalinterface/ENGIP20150106CumulativeNumber H5N1cases.pdf?ua=1),with a morbidity rate | YAN YiWu LIU Qiang LI Ning DU JianChao LI Xiao LI Chang JIN NingYi JIANG ChengYu | 2015 | Science China(Life Sciences)2015，58，2： | 12 |
| 8 | A botanical medicine dragon’s blood exhibited clinical antithrombosis efficacy similar to low molecular weight heparin显示文摘Deep vein thrombosis(DVT)is a common complication following traumatic fracture with a 0.5%–1%annual incidence.Low molecular weight heparin(LMWH)is the most commonly used anticoagulation drug for DVT prevention,but treatment with LMWH is invasive.Our aim is to compare the antithrombotic effect of dragon’s blood,an oral botanical anticoagulant medicine approved by the Chinese FDA,with LMWH in patients undergoing hip fracture surgery and to explore the molecular mechanisms of anticoagulation treatment.Our study recruited patients and divided them into LMWH and dragon’s blood treatment group.Coagulation index tests,Doppler ultrasound and mRNA sequencing were performed before and after anticoagulation therapy.There was no significant difference in postoperative DVT incidence between the two groups(23.1%versus 15.4%,P=0.694).D-dimer(D-D)and fibrinogen degradation product(FDP)showed significant reductions in both groups after anticoagulation treatments.We identified SLC4A1,PROS1,PRKAR2B and seven other genes as being differentially expressed during anticoagulation therapy in both groups.Genes correlated with coagulation indexes were also identified.Dragon’s blood and LMWH showed similar effects on DVT and produced similar gene expression changes in patients undergoing hip fracture surgery,indicating that dragon’s blood is a more convenient antithrombosis medicine(oral)than LMWH(hypodermic injection). | Jiangbin Liang Song Mei Xiangyu Qiao Wei Pan Yan Zhao Shaohui Shi Yaling Zhai Haizhao Wen Guoping Wu Chengyu Jiang | 2021 | Science China(Life Sciences)2021，64，10： | 4 |
| 9 | The Zα domain of fish PKZ facilitates the B-Z conformational transition of oligonucleotide DNAs with d(GC), inserts显示文摘PKZ (象 PKR 一样) 在鱼作为 elF2 kinase 家庭的一个成员被发现,它在 C 终端并且也拥有 eIF2 kinase 的一个保存催化领域在 N 终端的二个 Z-DNA-binding 领域(Z1 和 Z2 ) 。PKZ 能通过 Z 的绑定被激活到 Z-DNA。然而, PKZ Z 的规章的功能仍然保持不清楚。调查 PKZ Z 怎么与 Z-DNA 交往的分子的机制,我们在 Escherichia coli 罗塞达碑紧张表示了 Z 多肽 Z12 并且在 Ni-NTA 上由亲密关系层析净化了树脂。oligonucleotide DNA 与的不同长度各种各样插入,也就是 d (GC ) n (n = 6, 8, 10, 13 ) , d (TA ) n (n = 6, 10 ) , non-d (GC ) ,和 non-d (TA ) ,被设计并且综合。圆形的二色性光谱和胶化活动性移动试金被用来在不同 oligonucleotide DNA 的 conformational 转变上调查 Z12 的效果。结果证明 oligonucleotide DNA 当 Z12 不在时保留了常规 B-DNA 符合构造。与 Z12 滴定的增加的数量, d (GC ) n 被认出并且在某种程度上把符合构造变换成 Z-DNA。与增加重复数字(从 n = 6 到 n = 13 ) , conformational 转变的趋势变得更明显。然而,有 n 插入的 d (TA ) 的 oligonucleotides 的符合构造面对 Z12 有点变化了,并且 Z12 没在有 non-d (GC ) 或 non-d (TA ) 的 oligonucleotides 的转变插入的 conformational 上有效果。胶化活动性移动试金进一步证明 Z12 能与 d (GC ) 绑在 oligonucleotide 10。换句话说, Z12 能与 n 插入到 Z-DNA 符合构造的 d (GC ) 转 oligonucleotides 并且与高亲密关系绑在它。 | Puzhong Lu Shoulong Deng Youlin Zhu Yongbin Yan Yong Liu Chengyu Hu | 2012 | Acta Biochimica et Biophysica Sinica2012，44，11： | 3 |
| 10 | Erratum to:Herbal decoctosome is a novel form of medicine显示文摘Following the published article,we noticed an error duplication in Figure 5G“control”and“PGY-6”that was introduced during the revised process,with an attempt to replace it with higher-resolution images.Here we provide the original data in the first submitted manuscript(Figure 5G). | Xiaoyun Li Zhu Liang Jianchao Du Zhiqing Wang Song Mei Zhiqing Li Yan Zhao Dandan Zhao Yiming Ma Jun Ye Jiantao Xu Yu Zhao Jiahui Chang Yuhao Qin Lanlan Yu Chenxuan Wang Chengyu Jiang | 2020 | Science China(Life Sciences)2020，63，9： | 2 |
| 11 | The Zα domain of fish PKZ converts DNA hairpin with d(GC)n inserts to Z-conformation显示文摘PKZ,蛋白质 kinase 包含 Z-DNA 领域,是脊椎动物 eIF2 kinase 家庭的一个新奇成员。在 N 终点在 C 终点和二个 Z-DNA 有约束力的领域(Z1 和 Z2 ) 包含一个催化领域, PKZ 能通过 Z 的绑定被激活到 Z-DNA。然而, PKZ Z 的规章的功能尚待被证实。这里,蛋白质被表示在 DNA conformational 转变,野类型的 Z1Z2 和 11 异种上理解 PKZ Z 的影响并且净化。同时, DNA hairpinsd (GC ) 的几不同长度 nT4 (GC ) n (n = 26 ) 并且 RNA hairpinr (GC ) 6T4 (GC ) 6 被综合。这些合成 DNA 或 RNA 发卡的符合构造上的 Z1Z2 和变异的蛋白质的效果被使用圆形的二色性光谱和胶化活动性移动试金调查。结果证明 DNA 发卡当 Z1Z2 不在时保留了常规 B-DNA 符合构造,当一些 DNA 发卡(n3 ) 在 Z1Z2 正式就职下面被变换成 Z 符合构造时。趋势按比例与 GC 重复的增加的数量被联系。与 Z1Z2 比较, Z1Z1 而非 Z2Z2 在变换 d (GC ) 显示了一个更高的能力 6T4 (GC ) 6 从 B- 到 Z-DNA。这些结果证明那 Z1 子域比 Z2 子域在 BZ conformational 转变的过程起了一个更必要的作用。变异的蛋白质(K34A, N38A, R39A, Y42A, P57A, P58A,和 W60A ) 不能变换 d (GC ) 6T4 (GC ) 6 进 Z-DNA,而 S35A 或 K56A 保留了一些部分活动。有趣地, Z1Z2 也能导致 r (GC ) 6T4 (GC ) 从 A 符合构造的 6 RNA 到在适当条件下面的 Z 符合构造。 | Puzhong Lu Shoulong Deng Chuxin Wu Youlin Zhu Yong Liu Gang Lin Yongbin Yan Chengyu Hu | 2013 | Acta Biochimica et Biophysica Sinica2013，45，12： | 2 |
| 12 | Identification of prognostic biomarkers in hepatitis B virus-related hepatocellular carcinoma and stratification by integrative multi-omics analysis显示文摘 | Ruoyu Miao Haitao Luo Huandi Zhou Guangbing Li Dechao Bu Xiaobo Yang Xue Zhao Haohai Zhang Song Liu Ying Zhong Zhen Zou Yan Zhao Kuntao Yu Lian He Xinting Sang Shouxian Zhong Jiefu Huang Yan Wu Rebecca A. Miksad Simon C. Robson Chengyu Jiang Yi Zhao Haita | 2014 | Journal of Hepatology2014，，： | 2 |
| 13 | Characteristics of the sea ice reflectance spectrum polluted by oil spills based on field experiments in the Bohai Sea显示文摘Oil spilled on the sea ice surface in the Bohai Sea of China is studied through the field measurements of the reflectance of a simulated sea ice-oil film mixed pixel. The reflection characteristics of sea ice and oil film are also analyzed. It is found that the mixed pixel of sea ice and oil film is a linear mixed pixel. The means of extracting sea ice pixels containing oil film is presented using a double-band ratio oil-film sea-ice index(DROSI) and a normalized difference oil-film sea-ice index(NDOSI) through the analysis of the reflectance curves of the sea iceoil film pixel for different ratios of oil film. The area proportion of the oil film in the sea ice-oil film pixel can be accurately estimated by the average reflectance of the band of 1 610–1 630 nm, and the volume of the spilled oil can be further estimated. The method of the sea ice-oil film pixel extraction and the models to estimate the proportion of oil film area in the sea ice-oil film pixel can be applied to the oil spill monitoring of the ice-covered area in the Bohai Sea using multispectral or hyperspectral remote sensing images in the shortwave infrared band(1 500–1 780 nm). | CHAO Jinlong LIU Chengyu LI Ying LIN Xia YAN Yu | 2017 | Acta Oceanologica Sinica2017，36，1： | 1 |
| 14 | Study on Free Amino Acid and Short Peptide Fertilizer Production by Solid State Fermented Castor Bean Meal显示文摘Using microbial fermentation to increase the content of free amino acids and short peptides in the organic fertilizer for castor bean meal can effectively promote plant growth and improve fruit quality.Using free amino acid and short peptide content as an indicator,through single factor and response surface optimization experiments,the process parameters(moisture content,fermentation time and inoculum quantity)of castor meal solid-state fermentation were optimized.The best process parameters for the solid-state fermentation were:the moisture content 62%,the fermentation time 20 d,and the inoculum quantity 0.23%.The moisture content had the greatest impact on the conversion rate of free amino acids and short peptides,and the protein conversion rate reached 65.6%.The scale-up experiment under the optimal conditions showed that the solid-state fermentation using the inoculum had a significant beneficial effect compared with other fermentation methods.The fermentation of castor cake fertilizer provides a theoretical and practical basis for production feasibility,and has important guiding significance for the effective utilization of castor bean meal. | Yan LI Xin JIANG Chengyue HOU Jialin JIANG Zhihui LI | 2020 | Agricultural Biotechnology2020，9，6： | 1 |
| 15 | Use of oxidoreduction potential as an indicator to regulate 1,3-propanediol fermentation by Klebsiella pneumoniae 显示文摘 | Du Chengyu Yan Hui Zhang Yanping | 2006 | Appl Microbiol Biotechnol2006，69，5： | 1 |
| 16 | Single-cell profiling reveals a potent role of quercetin in promoting hair regeneration显示文摘Hair loss affects millions of people at some time in their life,and safe and efficient treatments for hair loss are a significant unmet medical need.We report that topical delivery of quercetin(Que)stimulates resting hair follicles to grow with rapid follicular keratinocyte proliferation and replenishes perifollicular microvasculature in mice.We construct dynamic single-cell transcriptome landscape over the course of hair regrowth and find that Que treatment stimulates the differentiation trajectory in the hair follicles and induces an angiogenic signature in dermal endothelial cells by activating HIF-1αin endothelial cells.Skin administration of a HIF-1αagonist partially recapitulates the pro-angiogenesis and hair-growing effects of Que.Together,these findings provide a molecular understanding for the efficacy of Que in hair regrowth,which underscores the translational potential of targeting the hair follicle niche as a strategy for regenerative medicine,and suggest a route of pharmacological intervention that may promote hair regrowth. | Qian Zhao Yandong Zheng Dongxin Zhao Liyun Zhao Lingling Geng Shuai Ma Yusheng Cai Chengyu Liu Yupeng Yan Juan Carlos Izpisua Belmonte Si Wang Weiqi Zhang Guang-Hui Liu Jing Qu | 2023 | Protein & Cell2023，14，6： | 0 |
| 17 | Selective Hydrogenation of Phenylacetylene by Carbon Monoxide and Water显示文摘Catalytic selective hydrogenation of alkynes to the corresponding alkenes is an important process in industrial production.Modulating the selective hydrogenation of alkynes to the alkenes requires ingenuity since alkenes can easily be converted into the corresponding alkanes under reductive conditions.Applying different reductive reagents to prevent the direct usage of H_(2)can avoid difficulties in hydrogen storage and transportation.Herein,we demonstrate a tandem process to hydrogenate phenylacetylene by CO and H_(2)Oviathecouplingof thelow-temperaturewater-gas shift reaction and selective hydrogenation of phenylacetylene utilizing theα-MoC catalyst.The reductive reagent,CO,not only produces H_(2)from H_(2)O to drive the reaction forward,but it also regulates the selectivity of styrene by preventing further hydrogenation. | Xuetao Qin Ruiqi Zhang Ming Xu Yao Xu Lirong Zheng Chengyu Li Shixiang Yu Jie Yan Jinglin Xie Genghuang Wu Junfeng Rong Meng Wang Ding Ma | 2023 | CCS Chemistry2023，5，10： | 0 |
| 18 | Avian influenza viruses suppress innate immunity by inducingtrans-transcriptional readthrough via SSU72显示文摘Innate immunity plays critical antiviral roles. The highly virulent avian influenza viruses (AIVs) H5N1, H7N9, and H5N6 can betterescape host innate immune responses than the less virulent seasonal H1N1 virus. Here, we report a mechanism by whichtranscriptional readthrough (TRT)-mediated suppression of innate immunity occurs post AIV infection. By using cell lines, mouselungs, and patient PBMCs, we showed that genes on the complementary strand (“trans” genes) influenced by TRT were involved inthe disruption of host antiviral responses during AIV infection. The trans-TRT enhanced viral lethality, and TRT abolishmentincreased cell viability and STAT1/2 expression. The viral NS1 protein directly bound to SSU72, and degradation of SSU72 inducedTRT. SSU72 overexpression reduced TRT and alleviated mouse lung injury. Our results suggest that AIVs infection induce TRT byreducing SSU72 expression, thereby impairing host immune responses, a molecular mechanism acting through the NS1-SSU72-trans-TRT-STAT1/2 axis. Thus, restoration of SSU72 expression might be a potential strategy for preventing AIV pandemics. | Yan Zhao Fengming Huang Zhen Zou Yuhai Bi Yang Yang Cong Zhang Qiang Liu Daozhen Shang Yiwu Yan Xiangwu Ju Song Mei Peng Xie Xiao Li Mingyao Tian Shuguang Tan Huijun Lu Zongsheng Han Kangtai Liu Yuqing Zhang Junbo Liang Zhu Liang Qingchao Zhang Jiahui Chang William JLiu Cong Feng Tanshi Li Michael Q.Zhang Xiaoyue Wang George FGao Yingxia Liu Ningyi Jin Chengyu Jiang | 2022 | Cellular & Molecular Immunology2022，19，6： | 0 |
| 19 | OpNAC1 transcription factor regulates the biosynthesis of the anticancer drug camptothecin by targeting loganic acid O-methyltransferase in Ophiorrhiza pumila显示文摘Camptothecin(CPT) is an anticancer pentacyclic quinoline alkaloid widely used to treat cancer patients worldwide. However, the biosynthetic pathway and transcriptional regulation of camptothecin are largely unknown. Ophiorrhiza pumila, the herbaceous plant from the Rubiaceae family, has emerged as a model plant for studying camptothecin biosynthesis and regulation. In this study, a high-quality reference genome of O. pumila with estimated size of ~456.90Mb was reported, and the accumulation level of camptothecin in roots was higher than that in stems and leaves. Based on its spatial distribution in the plant, we examined gene functions and expression by combining genomics with transcriptomic analysis.Two loganic acid O-methyltransferase(OpLAMTs)were identified in strictosidine-producing plant O.pumila, and enzyme catalysis assays showed that OpLAMT1 and not OpLAMT2 could convert loganic acid into loganin. Further knock-out of OpL AMT1expression led to the elimination of loganin and camptothecin accumulation in O. pumila hairy roots.Four key residues were identified in OpLAMT1 protein crucial for the catalytic activity of loganic acid to loganin. By co-expression network, we identified a NAC transcription factor, OpNAC1, as a candidate gene for regulating camptothecin biosynthesis.Transgenic hairy roots and biochemical assays demonstrated that OpNAC1 suppressed OpLAMT1 expression. Here, we reported on two camptothecin metabolic engineering strategies paving the road for industrial-scale production of camptothecin in CPT-producing plants. | Xiaolong Hao Can Wang Wei Zhou Qingyan Ruan Chenhong Xie Yinkai Yang Chengyu Xiao Yan Cai Jingyi Wang Yao Wang Xuebin Zhang Itay Maoz Guoyin Kai | 2023 | Journal of Integrative Plant Biology2023，65，1： | 0 |
| 20 | Image Steganalysis Based on Deep Content Features Clustering显示文摘The training images with obviously different contents to the detected images will make the steganalysis model perform poorly in deep steganalysis.The existing methods try to reduce this effect by discarding some features related to image contents.Inevitably,this should lose much helpful information and cause low detection accuracy.This paper proposes an image steganalysis method based on deep content features clustering to solve this problem.Firstly,the wavelet transform is used to remove the high-frequency noise of the image,and the deep convolutional neural network is used to extract the content features of the low-frequency information of the image.Then,the extracted features are clustered to obtain the corresponding class labels to achieve sample pre-classification.Finally,the steganalysis network is trained separately using samples in each subclass to achieve more reliable steganalysis.We experimented on publicly available combined datasets of Bossbase1.01,Bows2,and ALASKA#2 with a quality factor of 75.The accuracy of our proposed pre-classification scheme can improve the detection accuracy by 4.84%for Joint Photographic Experts Group UNIversal WAvelet Relative Distortion(J-UNIWARD)at the payload of 0.4 bits per non-zero alternating current discrete cosine transform coefficient(bpnzAC).Furthermore,at the payload of 0.2 bpnzAC,the improvement effect is minimal but also reaches 1.39%.Compared with the previous steganalysis based on deep learning,this method considers the differences between the training contents.It selects the proper detector for the image to be detected.Experimental results show that the pre-classification scheme can effectively obtain image subclasses with certain similarities and better ensure the consistency of training and testing images.The above measures reduce the impact of sample content inconsistency on the steganalysis network and improve the accuracy of steganalysis. | Chengyu Mo Fenlin Liu Ma Zhu Gengcong Yan Baojun Qi Chunfang Yang | 2023 | Computers, Materials & Continua2023，76，9： | 0 |
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