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| 1 | Recent advances in biosynthesis of bioactive compounds in traditional Chinese medicinal plants显示文摘Plants synthesize and accumulate large amount of specialized(or secondary) metabolites also known as natural products, which provide a rich source for modern pharmacy. In China, plants have been used in traditional medicine for thousands of years. Recent development of molecular biology, genomics and functional genomics as well as high-throughput analytical chemical technologies has greatly promoted the research on medicinal plants. In this article, we review recent advances in the elucidation of biosynthesis of specialized metabolites in medicinal plants,including phenylpropanoids, terpenoids and alkaloids. These natural products may share a common upstream pathway to form a limited numbers of common precursors, but are characteristic in distinct modifications leading to highly variable structures. Although this review is focused on traditional Chinese medicine, other plants with a great medicinal interest or potential are also discussed. Understanding of their biosynthesis processes is critical for producing these highly value molecules at large scale and low cost in microbes and will benefit to not only human health but also plant resource conservation. | Lei Yang Changqing Yang Chenyi Li Qing Zhao Ling Liu Xin Fang Xiao-Ya Chen | 2016 | Science Bulletin2016，61，1： | 23 |
| 2 | Progress of the key materials for organic solar cells显示文摘Organic solar cells have attracted academic and industrial interests due to the advantages like lightweight,flexibility and roll-to-roll fabrication.Nowadays,18%power conversion efficiency has been achieved in the state-of-the-art organic solar cells.The recent rapid progress in organic solar cells relies on the continuously emerging new materials and device fabrication technologies,and the deep understanding on film morphology,molecular packing and device physics.Donor and acceptor materials are the key materials for organic solar cells since they determine the device performance.The past 25 years have witnessed an odyssey in developing high-performance donors and acceptors.In this review,we focus on those star materials and milestone work,and introduce the molecular structure evolution of key materials.These key materials include homopolymer donors,D-A copolymer donors,A-D-A small molecular donors,fullerene acceptors and nonfullerene acceptors.At last,we outlook the challenges and very important directions in key materials development. | Yang Tong Zuo Xiao Xiaoyan Du Chuantian Zuo Yuelong Li Menglan Lv Yongbo Yuan Chenyi Yi Feng Hao Yong Hua Ting Lei Qianqian Lin Kuan Sun Dewei Zhao Chunhui Duan Xiangfeng Shao Wei Li Hin-Lap Yip Zhengguo Xiaol Bin Zhang Qingzhen Bian Yuanhang Cheng Shengjian Liu Ming Cheng Zhiwen Jin Shangfeng Yang Liming Ding | 2020 | Science China Chemistry2020，63，6： | 15 |
| 3 | Eco-city Planning and Practices from the Perspective of Environmental Performance Evaluation显示文摘By reviewing researches on environmental performance evaluation of current eco-city construction, this paper analyzed characteristics and deficiencies of the evaluation methods and index systems, and took Haizhu Eco-city for example to assess the environmental performance of eco-city construction from the perspectives of land, water environment, regional weather, and biodiversity. On this basis, a scientific, objective and feasible evaluation method and index system was basically formed so as to demonstrate the efficiency of eco-city construction, and to provide scientific support for the dynamic adjustment and optimization of eco-city construction. | CAI Yunnan LIU Chenyi | 2015 | Journal of Landscape Research2015，7，4： | 3 |
| 4 | A nomogram for individualized estimation of survival among adult patients with adrenocortical carcinoma after surgery:a retrospective analysis and multicenter validation study显示文摘Background:Clinical outcome of adrenocortical carcinoma(ACC)varies because of its heterogeneous nature and reliable prognostic prediction model for adult ACC patients is limited.The objective of this study was to develop and externally validate a nomogram for overall survival(OS)prediction in adult patients with ACC after surgery.Methods:Based on the data from the Surveillance Epidemiology,and End Results(SEER)database,adults patients diagnosed with ACC between January 1988 and December 2015 were identified and classified into a training set,comprised of 404 patients diagnosed between January 2007 and December 2015,and an internal validation set,com-prised of 318 patients diagnosed between January 1988 and December 2006.The endpoint of this study was OS.The nomogram was developed using a multivariate Cox proportional hazards regression algorithm in the training set and its performance was evaluated in terms of its discriminative ability,calibration,and clinical usefulness.The nomogram was then validated using the internal SEER validation,also externally validated using the Cancer Genome Atlas set(TCGA,82 patients diagnosed between 1998 and 2012)and a Chinese multicenter cohort dataset(82 patients diag-nosed between December 2002 and May 2018),respectively.Results:Age at diagnosis,T stage,N stage,and M stage were identified as independent predictors for OS.A nomo-gram incorporating these four predictors was constructed using the training set and demonstrated good calibration and discrimination(C-index 95%confidence interval[CI],0.715[0.679-0.751]),which was validated in the internal validation set(C-index[95%CI],0.672[0.637-0.707]),the TCGA set(C-index[95%CI],0.810[0.732-0.888])and the Chi-nese multicenter set(C-index[95%CI],0.726[0.633-0.819]),respectively.Encouragingly,the nomogram was able to successfully distinguished patients with a high-risk of mortality in all enrolled patients and in the subgroup analyses.Decision curve analysis indicated that the nomogram was clinically useful and applicable.Conclusions:The study presents a nomogram that incorporates clinicopathological predictors,which can accurately predict the OS of adult ACC patients after surgery.This model and the corresponding risk classification system have the potential to guide therapy decisions after surgery. | Jianqiu Kong Junjiong Zheng Jinhua Cai Shaoxu Wu Xiayao Diao Weibin Xie Xiong Chen Chenyi Liao Hao Yu Xinxiang Fan Chaowen Huang Zhuowei Liu Wei Chen Qiang Lv Haide Qin Jian Huang Tianxin Lin | 2019 | Cancer Communications2019，39，1： | 3 |
| 5 | Multifunctional succinate additive for flexible perovskite solar cells with more than 23%power-conversion efficiency显示文摘Flexible perovskite solar cells(FPSCs)have emerged as power sources in versatile applications owing to their high-efficiency characteristics,excellent flexibility,and relatively lowcost.Nevertheless,undesired strain in perovskite films greatly impacts the power-conversion efficiency(PCE)and stability of PSCs,particularly in FPSCs.Herein,a novel multifunctional organic salt,methylammonium succinate,which can alleviate strain and reinforce grain boundaries,was incorporated into the perovskite film,leading to relaxed microstrain and a lower defect concentration.As a result,a PCE of 25.4%for rigid PSCs and a record PCE of 23.6%(certified 22.5%)for FPSCs have been achieved.In addition,the corresponding FPSCs exhibited excellent bending durability,maintaining85%of their initial efficiency after bending at a 6 mm radius for 10000 cycles. | Minghao Li Junjie Zhou Liguo Tan Hang Li Yue Liu Chaofan Jiang Yiran Ye Liming Ding Wolfgang Tress Chenyi Yi | 2022 | The Innovation2022，3，6： | 2 |
| 6 | Changes of immunocytic phenotypes and functions from human colorectal adenomatous stage to cancerous stage: Update显示文摘 | Yanhong Shi Zhenfeng Li Wei Zheng Xia Liu Chenyi Sun Jann-Birger Laugsand Zhanju Liu Guanglin Cui | 2015 | Immunobiology2015，，10： | 1 |
| 7 | Design and formal verification of a CEM protoco with transparent TTP显示文摘 | Zhiyuan LIU Jun PANG Chenyi ZHANG | 2013 | Frontiers of Computer Science2013，7，2： | 1 |
| 8 | 4‑Terminal Inorganic Perovskite/Organic Tandem Solar Cells Offer 22%Efficiency显示文摘After fast developing of single-junction perovskite solar cells and organic solar cells in the past 10 years,it is becoming harder and harder to improve their power conversion efficiencies.Tandem solar cells are receiving more and more attention because they have much higher theoretical efficiency than single-junction solar cells.Good device performance has been achieved for perovskite/silicon and perovskite/perovskite tandem solar cells,including 2-terminal and 4-terminal structures.However,very few studies have been done about 4-terminal inorganic perovskite/organic tandem solar cells.In this work,semi-transparent inorganic perovskite solar cells and organic solar cells are used to fabricate 4-terminal inorganic perovskite/organic tandem solar cells,achieving a power conversion efficiency of 21.25%for the tandem cells with spin-coated perovskite layer.By using drop-coating instead of spin-coating to make the inorganic perovskite films,4-terminal tandem cells with an efficiency of 22.34%are made.The efficiency is higher than the reported 2-terminal and 4-terminal inorganic perovskite/organic tandem solar cells.In addition,equivalent 2-terminal tandem solar cells were fabricated by connecting the sub-cells in series.The stability of organic solar cells under continuous illumination is improved by using semi-transparent perovskite solar cells as filter. | Ling Liu Hanrui Xiao Ke Jin Zuo Xiao Xiaoyan Du Keyou Yan Feng Hao Qinye Bao Chenyi Yi Fangyang Liu Wentao Wang Chuantian Zuo Liming Ding | 2023 | Nano-Micro Letters2023，15，2： | 1 |
| 9 | Drain-engineered carbon-nanotube-film field-effect transistors with high performance and ultra-low current leakage显示文摘A small bandgap and light carrier effective mass(mo)lead to obv ous ambipolar transport behavior in carbon nanotube(CNT)fild-effect transistors(FE Ts),including a high off-state current and severe degradation of the subthreshold swing(SS)with increasing drain bias voltage.We demonstrate a drain-engineered method to cope with this common problem in CNT-film FETs with a sub-μum channel length,i.e.,suppressing the ambipolar behavion while maintaining high on-state performance by adopting a feedback gate(FBG)structure to extend the drain region from the CNT/metal contact to the proximate CNT channels to suppress the tunneling current.Sub-400-nm-channel-length FETs with a FBG structure statistially present a high on/off ratio of up to 10*and a sub-200 mV/dec SS under a high drain bias of up to-2 V whle maintaining a high on-state current of 0.2 mA/μm or a peak transconductance of 0.2 mS/um.By lowering the supply voltage to 1.5 V,FBG CNT-fim FETs can meet the requirement of standard-pertormance ultra large scale integrated circuits(ULSICs).Therefore,the introduction of the drain engineering structure enables applications of CNT-film-based FETs in ULSICs and could also be widely extended to other small-bandgap semiconductor-based FETs for an improvement in their off-state property. | Lijun Liu Chenyi Zhao Li Ding Lianmao Peng Zhiyong Zhang | 2020 | Nano Research2020，13，7： | 1 |
| 10 | A 1-GS/s FFT/ IFFT processor for UWB applications显示文摘 | Lin Yuwer Liu Hsuanyu Lee Chenyi | 2005 | IEEE JournalofSoIicl-State Circuits2005，40，8： | 1 |
| 11 | Understanding the interfacial behaviors of benzene alkylation with butene using chloroaluminate ionic liquid catalyst: A molecular dynamics simulation显示文摘To better understand the benzene alkylation with chloroaluminate ionic liquids(ILs) as catalyst, the interfacial properties between the benzene/butene binary reactants and chloroaluminate ILs with varying cation alkyl chain length and different anions were investigated using molecular dynamics(MD) simulations. The results indicate that ILs can obviously improve the interfacial width, solubility and diffusion of reactants compared to H_(2)SO_(4). The longer alkyl chains of cations present a density enrichment at the interface and protrude into the binary reactants phase. Furthermore, the ILs consisting of 1-octyl-3-methylimidazolium cations([Omim]^(+)) and the stronger acidity heptachlorodialuminate anions([Al_(2)Cl_(7)]^(-)) are more beneficial to promote the interfacial width and facilitate the dissolution and diffusion of benzene in both the IL bulk and the interfacial region in comparison to the ones with shorter alkyl chains cations and weaker acidity anions. The information gives us a better guideline for the design of ILs for benzene alkylation. | Jialei Sha Chenyi Liu Zhihong Ma Weizhong Zheng Weizhen Sun Ling Zhao | 2023 | Chinese Journal of Chemical Engineering2023，54，2： | 0 |
| 12 | Analysis and Discussion on Subway Construction Accidents from Geological Perspective显示文摘Several cave-in accidents often occur in subway construction,causing personnel and economic losses.This paper has carried on the statistics and analysis of some typical subway construction accidents in recent years.Taking the collapse accident of a subway station in Hangzhou as the engineering background,the causes of the collapse of the foundation pit were analyzed.The analysis found that groundwater,earthwork over-excavation,weak support design and inadequate monitoring are the main reasons.These factors should be highlighted in the construction of similar projects in the future to avoid similar tragedies. | Yuanjian Lin Jiangfeng Liu Ronghao Lv Chenyi Sun Zhendong Fan | 2019 | Journal of Geological Research2019，1，2： | 0 |
| 13 | 机械力诱导MHC-Ⅰ构象变化增强TCR抗原识别及T细胞活化显示文摘CD8+T细胞主要通过T细胞表面受体(T cell recep tor,TCR)识别并与Ⅰ型主要组织性复合物提呈的抗原(pMHC-Ⅰ)相互作用[1]。TCR对刺激型抗原的识别在CD8+T细胞毒性和适应性免疫中发挥着关键作用。许多证据表明机械力可以延长TCR与刺激性pMHC作用的键合时间(bond lifetime)形成抗原特异性逆锁键(catch bond)[2],并且这种逆锁键对抗原识别非常重要。然而,机械力调控TCR抗原识别的具体结构机制仍不清楚。通过分子动力学模拟、单分子生物膜力学探针、磁镊、T细胞活化实验和动物模型对此问题展开了系统的研究[4]。发现作用在TCR-pMHC-Ⅰ复合体上的拉力可以作用在TCR-pMHC-Ⅰ复合体上的拉力可以打破MHC-I分子内部α1-α2和β2结构域间的相互作用,导致α1-α2结构域旋转并发生构象变化。力诱导的MHC-I构象变化可以进一步别构地调节TCR与刺激性抗原肽及α1-α2结构域的构象及相互作用,诱导产生新的氢键,增强TCR-pMHC-Ⅰ之间的键合时间,但并不能增强TCR与抑制性pMHC-Ⅰ之间的作用。当用点突变阻断这些新形成的氢键,或者α1-α2和β2结构域被二硫键锁住时,最佳力诱导的TCR-pMHC-Ⅰ作用的键合时间明显缩短并且T细胞的活化受到抑制。另外,在人TCR和HLA-A2相互作用中发现了类似机制,并且与肿瘤相关的HLA-A2点突变[3]可以通过限制HLA-A2α1--α2和β2结构域之间的构象打开减弱TCR对肿瘤抗原的识别及T细胞的功能。研究结果表明,机械力诱导的MHC-I构象变化对TCR抗原识别和T细胞活化非常重要,进一步地阐明了机械力调控TCR抗原识别机制,为临床肿瘤的免疫治疗和药物设计提供了新思路和新靶点。 | Peng Wu Tongtong Zhang Baoyu Liu Panyu Fei Lei Cui Rui Qin Huaying Zhu Danmei Yao Ryan Martinez Wei Hu Chenyi An Yong Zhang Junwei Liu Weiwei Yin Jie Sun Chun Zhou Xun Zeng Jianan Wang Brian Evavold Cheng Zhu Jizhong Lou Wei Chen | 2019 | 医用生物力学2019，34，A01： | 0 |
| 14 | ARM3D:Attention-based relation module for indoor 3D object detection显示文摘Relation contexts have been proved to be useful for many challenging vision tasks.In the field of3D object detection,previous methods have been taking the advantage of context encoding,graph embedding,or explicit relation reasoning to extract relation contexts.However,there exist inevitably redundant relation contexts due to noisy or low-quality proposals.In fact,invalid relation contexts usually indicate underlying scene misunderstanding and ambiguity,which may,on the contrary,reduce the performance in complex scenes.Inspired by recent attention mechanism like Transformer,we propose a novel 3D attention-based relation module(ARM3D).It encompasses objectaware relation reasoning to extract pair-wise relation contexts among qualified proposals and an attention module to distribute attention weights towards different relation contexts.In this way,ARM3D can take full advantage of the useful relation contexts and filter those less relevant or even confusing contexts,which mitigates the ambiguity in detection.We have evaluated the effectiveness of ARM3D by plugging it into several state-of-the-art 3D object detectors and showing more accurate and robust detection results.Extensive experiments show the capability and generalization of ARM3D on 3D object detection.Our source code is available at http://gffzz188fe103f8f1460asvfx9u9q59v9v6x90.ffgz.tsg.suse.edu.cn/lanlan96/ARM3D. | Yuqing Lan Yao Duan Chenyi Liu Chenyang Zhu Yueshan Xiong Hui Huang Kai Xu | 2022 | Computational Visual Media2022，8，3： | 0 |
| 15 | Brominated PEAI as Multi-Functional Passivator for High-Efficiency Perovskite Solar Cell显示文摘The interfaces of perovskite solar cells(PSCs)are well known to be rich in deep-level carrier traps,which serve as non-radiative recombination centers and limit the open-circuit voltage(Voc)and power conversion efficiency(PCE)of PSCs.Defect chemistry and surface passivators have been researched extensively and mainly focused on the neutralization of uncoordinated lead or anion defects.Herein,a novel brominated passivator 2-bromophenethylammonium iodide(2-Br-PEAI)is introduced for a multi-functional passivation effect at the perovskite interface.The brominated species readily form 2D perovskite on top of the 3D perovskite and multi-interact with the 3D perovskite surface.Apart from the halide vacancy filling and anion bonding ability,the Br atoms on the benzene ring can interact with the FA cations via strong hydrogen bonding N-H…Br and interact with the[PbI_(6)]^(4−)inorganic framework.The interface defects in the PSCs are well passivated,minimizing non-radiative recombination and enhancing device performance.As a result,a champion PCE of 24.22%was achieved with high V_(oc)and fill factor.In addition,modified devices also showed enhanced operational stability(retention of>95%initial PCE after 400 h)and humidity resistance(>90%initial PCE maintained after 1500 h under~50%RH). | Minghao Li Junjie Zhou Liguo Tan Yue Liu Siyang Wang Chaofan Jiang Hang Li Xing Zhao Xingyu Gao Wolfgang Tress Liming Ding Chenyi Yi | 2023 | Energy & Environmental Materials2023，6，3： | 0 |
| 16 | Development and Characterization of Nanobody-Derived CD47 Theranostic Pairs in Solid Tumors显示文摘Overexpression of CD47 is frequently observed in various types of human malignancies,inhibiting myeloidmediated elimination of tumor cells and affecting the prognosis of cancer patients.By mapping biomarker expression,immuno-positron emission tomography has been increasingly used for patient screening and response monitoring.By immunization alpacas with recombinant human CD47,we prepared a CD47-targeting nanobody C2 and developed[^(68)Ga]Ga-NOTA-C2,followed by an exploration of the diagnostic value in CD47-expressing tumor models including gastric-cancer patient-derived xenograft models.By fusing C2 to an albumin binding domain(ABD),we synthesized ABDC2,which had increased in vivo half-life and improved targeting properties.We further labeled ABDC2 with^(68)Ga/^(89)Zr/177Lu to develop radionuclide theranostic pairs and evaluated the pharmacokinetics and theranostic efficacies of the agents in cell-and patient-derived models.Both C2 and ABDC2 specifically reacted with human CD47 with a high KD value of 23.50 and 84.57 pM,respectively.[^(68)Ga]Ga-NOTA-C2 was developed with high radiochemical purity(99>%,n=4)and visualized CD47 expression in the tumors.In comparison to the rapid renal clearance and short half-life of[^(68)Ga]Ga-NOTA-C2,both[^(68)Ga]Ga-NOTA-ABDC2 and[^(89)Zr]Zr-DFOABDC2 showed prolonged circulation and increased tumor uptake,with the highest uptake of[^(89)Zr]Zr-DFO-ABDC2 occurring at 72 h post-injection.Moreover,[177Lu]Lu-DOTA-ABDC2 radioimmunotherapy suppressed the tumor growth but was associated with toxicity,warranting further optimization of the treatment schedules.Taken together,we reported a series of nanobody-derived CD47-targeted agents,of which[^(68)Ga]Ga-NOTA-C2 and[^(89)Zr]Zr-DFO-ABDC2 are readily translatable.Optimization and translation of CD47-targeted theranostic pair may provide new prospects for CD47-targeted management of solid tumors. | You Zhang Di Zhang Shuxian An Qiufang Liu Chenyi Liang Juan Li Ping Liu Changfeng Wu Gang Huang Weijun Wei Jianjun Liu | 2023 | Research2023，，4： | 0 |
| 17 | Automatic Sleep Staging Algorithm Based on Random Forest and Hidden Markov Model显示文摘In the field of medical informatics,sleep staging is a challenging and timeconsuming task undertaken by sleep experts.According to the new standard of the American Academy of Sleep Medicine(AASM),the stages of sleep are divided into wakefulness(W),rapid eye movement(REM)and non-rapid eye movement(NREM)which includes three sleep stages(N1,N2 and N3)that describe the depth of sleep.This study aims to establish an automatic sleep staging algorithm based on the improved weighted random forest(WRF)and Hidden Markov Model(HMM)using only the features extracted from double-channel EEG signals.The WRF classification model focuses on reducing the bias of the imbalance data,while the HMM model focuses on improving the detection rate of sleep staging through the relationship between adjacent sleep stages.In particular,the improved weighted RF classification model can increase the recognition rate of the N1 stage.In addition,the method of removing features with low variance is used to select meaningful and contributing feature parameters for model training.This is an innovative content of this paper.The sleep EEG data are first segmented into 30 s epochs,and the feature parameters of the epoch data are extracted from the double-channel by applying continuous wavelet packet transform(WPT).Each epoch is then segmented into 29 subepochs of 2 s long with 1 s overlap,and the frequency domain features and statistical features of each subepoch are extracted.The performance of the proposed method is tested by evaluating the accuracy(AC),Kappa coefficient,Recall(R),Precision(P)and F1-score(F1).In the Sleep-EDF database,the overall AC and Kappa coefficient obtained by WRF are 93.20%and 0.890,respectively using the subject-non-independent test.In the 10 sc*and 10 st*Sleep-EDF Expanded database,the overall AC and Kappa coefficient obtained by proposed method are 91.97%and 0.874,respectively using the subject-independent test.The best AC and Kappa coefficient of single subject can reach 96.3%and 0.912,respectively.Experimental results show that the performance of the proposed method is competitive with the most current methods and results,and the recognition rate of N1 stage is significantly improved. | Junbiao Liu Duanpo Wu Zimeng Wang Xinyu Jin Fang Dong Lurong Jiang Chenyi Cai | 2020 | Computer Modeling in Engineering & Sciences2020，，4： | 0 |
| 18 | Electro-triggered Joule heating method to synthesize single-phase CuNi nano-alloy catalyst for efficient electrocatalytic nitrate reduction toward ammonia显示文摘Electrochemical nitrate reduction reaction(NO_(3)RR)has great potential for ammonia(NH_(3))synthesis benefiting from its environmental friendliness and sustainability.Cu-based alloys with elemental diversity and adsorption tunability are widely used as electrocatalyst to lower the reaction overpotential for NO_(3)RR catalysis.However,phase separation commonly found in alloys leads to uneven distribution of elements,which limits the possibility of further optimizing the catalytic activity.Herein,an electrotriggered Joule heating method,possessing unique superiority of flash heating and cooling that lead to well-dispersed nanoparticles and uniform mixing of various elements,was adopted to synthesize a single-phase CuNi nano-alloy catalyst evenly dispersed on carbon fiber paper,CFP-Cu_(1)Ni_(1),which exhibited a more positive NO_(3)RR initial potential of 0.1 V versus reversible hydrogen electrode(vs.RHE)than that of pure copper nanoparticles at 10 mA·cm^(−2)in 0.5 mol·L^(−1)Na_(2)SO_(4)+0.1 mol·L^(−1)KNO_(3)solution.Importantly,CFP-Cu_(1)Ni_(1) presented high electrocatalytic activity with a Faradaic efficiency of 95.7%and NH_(3)yield rate of 180.58μmol·h^(−1)·cm^(−2)(2550μmol·h^(−1)·mg_(cat)^(−1))at−0.22 V vs.RHE.Theoretical calculations showed that alloying Cu with Ni into single-phase caused an upshift of its d-band center,which promoted the adsorption of NO_(3)−and weakened the adsorption of NH_(3).Moreover,the competitive adsorption of hydrogen ions was restrained until−0.24 V.This work offers a rational design concept with clear guidance for rapid synthesis of uniformly dispersed single-phase nano-alloy catalyst for efficient electrochemical NO_(3)RR toward ammonia. | Zunjie Zhang Yang Liu Xiaozhi Su Ziwei Zhao Zhenkun Mo Chenyi Wang Yaling Zhao Ye Chen Shuyan Gao | 2023 | Nano Research2023，16，5： | 0 |
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