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| 1 | Therapeutic effect in patients with coronary heart disease based on information analysis from Traditional Chinese Medicine four diagnostic methods显示文摘OBJECTIVE:To study information gained by Traditional Chinese Medicine(TCM)four diagnostic methods and characteristics of syndrome development before and after treatment in patients with coronary heart disease,and to probe into assessment indexes of therapeutic effects with distinctive TCM features.METHODS:Information from the four diagnostic methods before and after treatment in 100 patients with coronary heart disease was collected using the TCM interrogation scale,a pulse condition instrument,a tongue-face diagnosis instrument,anda voice diagnosis information collection system.Changes in the four diagnostic method results from before and after treatment were analyzed with frequency analysis and t-test methods.RESULTS:Before treatment,deficiency syndrome complicated with hyperactivity of pathogenic factors was most common.After treatment,deficiency syndrome was most common.This change from complex syndromes to single syndromes indicates disease and syndrome alleviation.Frequencies of symptoms gained by interrogation after treatment for syndrome of deficiency of heart-Qi,syndrome of deficiency of heart-Yin,and turbid phlegm syndrome were all less severe than those before treatment.Parameters of face color,color on all sub-regions of tongue,color of tongue fur,septic and greasy fur,and lip color after treatment all had significant changes.After treatment,part of the voice diagnosis parameters in the deficiency of heart-Yin and turbid phlegm syndromes had significant changes,but no significant changes were found in the deficiency of heart-Qi syndrome.CONCLUSION:Use of the TCM four diagnostic methods can provide an effective basis forTCM syndrome diagnosis,observation of development of state of illness,and evaluation of clinical therapeutic effects. | Yiqin Wang Jin Xu Rui Guo Chaoxia Xu Yiming Hao Chunfeng Chen Yijian Hong Xiangqun Xiao Wenjie Xu Jing Hong Zhao Lei | 2014 | Journal of Traditional Chinese Medicine2014，34，1： | 12 |
| 2 | Facile Fabrication of Hierarchically Porous Carbonaceous Monoliths with Ordered Mesostructure via an Organic Organic Self-Assembly显示文摘A simple strategy for the synthesis of macro-mesoporous carbonaceous monolith materials has been demonstrated through an organic organic self-assembly at the interface of an organic scaffold such as polyurethane(PU)foam.Hierarchically porous carbonaceous monoliths with cubic(Im m)or hexagonal(p6mm)mesostructure were prepared through evaporation induced self-assembly of the mesostructure on the three-dimensional(3-D)interconnecting struts of the PU foam scaffold.The preparation was carried out by using phenol/formaldehyde resol as a carbon precursor,triblock copolymer F127 as a template for the mesostructure and PU foam as a sacrificial monolithic scaffold.Their hierarchical pore system was macroscopically fabricated with cable-like mesostructured carbonaceous struts.The carbonaceous monoliths exhibit macropores of diameter 100450μm,adjustable uniform mesopores(3.87.5 nm),high surface areas(200870 m2/g),and large pore volumes(0.170.58)cm3/g.Compared with the corresponding evaporation induced self-assembly(EISA)process on a planar substrate,this facile process is a time-saving,labor-saving,space-saving,and highly effi cient pathway for mass production of ordered mesoporous materials. | Chunfeng Xue Bo Tu Dongyuan Zhao | 2009 | Nano Research2009，2，3： | 12 |
| 3 | Synthesis of pennogenin utilizing the intact skeleton of diosgenin显示文摘The first synthesis of pennogenin, an aglycone of bioactive components of Chinese traditional medicine named Chonglou(Paris), starting from diosgenin, has been reported, which displays a new strategy of utilizing the resource compounds. According to this new strategy, the full and rational utilization of the intact skeleton and functional groups of starting material has been realized in the conversion of diosgenin to pennogenin. The key step for synthesis of pen-nogenin is the regioselective transformation of cholest-5-en-16,22-dion-3,26-diol to cholest- 5,16-dien-22-on-3,26-diol, which can be used to synthesize other bioactive steroids such as cephalostatin and OSW-1. | TIAN Weisheng XU Qihai CHEN Ling ZHAO Chunfeng | 2004 | Science China Chemistry2004，47，2： | 7 |
| 4 | FOUR-PARAMETER AUTOMATIC TRANSMISSION TECHNOLOGY FOR CONSTRUCTION VEHICLE BASED ON ELMAN RECURSIVE NEURAL NETWORK显示文摘From the viewpoint of energy saving and improving transmission efficiency,the ZL50E wheel loader is taken as the study object. And the system model is analyzed based on the transmission system of the construction vehicle. A new four-parameter shift schedule is presented,which can keep the torque converter working in the high efficiency area. The control algorithm based on the Elman recursive neural network is applied,and four-parameter control system is developed which is based on industrial computer. The system is used to collect data accurately and control 4D180 power-shift gearbox of ZL50E wheel loader shift timely. An experiment is done on automatic transmission test-bed,and the result indicates that the control system could reliably and safely work and improve the efficiency of hydraulic torque converter. Four-parameter shift strategy that takes into account the power consuming of the working pump has important operating significance and reflects the actual working status of construction vehicle. | ZHANG Hongyan ZHAO Dingxuan TANG Xinxing Ding Chunfeng | 2008 | Chinese Journal of Mechanical Engineering2008，21，1： | 6 |
| 5 | Engineering an enthesis-like graft for rotator cuff repair:An approach to fabricate highly biomimetic scaffold capable of zone-specifically releasing stem cell differentiation inducers显示文摘Rotator cuff(RC)attaches to humerus across a triphasic yet continuous tissue zones(bone-fibrocartilage-tendon),termed“enthesis”.Regrettably,rapid and functional enthesis regeneration is challenging after RC tear.The existing grafts bioengineered for RC repair are insufficient,as they were engineered by a scaffold that did not mimic normal enthesis in morphology,composition,and tensile property,meanwhile cannot simultaneously stimulate the formation of bone-fibrocartilage-tendon tissues.Herein,an optimized decellularization approach based on a vacuum aspiration device(VAD)was developed to fabricate a book-shaped decellularized enthesis matrix(O-BDEM).Then,three recombinant growth factors(CBP-GFs)capable of binding collagen were synthesized by fusing a collagen-binding peptide(CBP)into the N-terminal of BMP-2,TGF-β3,or GDF-7,and zone-specifically tethered to the collagen of O-BDEM to fabricate a novel scaffold(CBP-GFs/O-BDEM)satisfying the above-mentioned requirements.After ensuring the low immunogenicity of CBP-GFs/O-BDEM by a novel single-cell mass cytometry in a mouse model,we interleaved urine-derived stem cell-sheets into this CBP-GFs/O-BDEM to bioengineer an enthesis-like graft.Its high-performance on regenerating enthesis was determined in a canine model.These findings indicate this CBP-GFs/O-BDEM may be an excellent scaffold for constructing enthesis-like graft to patch large/massive RC tears,and provide breakthroughs in fabricating graded interfacial tissue. | Can Chen Qiang Shi Muzhi Li Yang Chen Tao Zhang Yan Xu Yunjie Liao Shulin Ding Zhanwen Wang Xing Li Chunfeng Zhao Lunquan Sun Jianzhong Hu Hongbin Lu | 2022 | Bioactive Materials2022，7，10： | 4 |
| 6 | Efficacy and safety of rasagiline in Chinese patients with early Parkinson’s disease:a randomized, double-blind,parallel,placebo-controlled,fixed-dose study显示文摘Background:Rasagiline is a monoamine oxidase-B inhibitor used for Parkinson’s disease(PD)treatment,but its effectiveness on Chinese patients is unclear.This study aimed to evaluate the efficacy and safety of rasagiline monotherapy in Chinese patients with early PD.Methods:A 26-weeks,randomized,double-blind,placebo-controlled study has been performed at 15 sites in China and enrolled outpatients(≥35 years old)with idiopathic PD without a history of using any dopaminergic drugs.Participants were randomized 1:1 to receive rasagiline 1 mg once daily or placebo.The primary endpoint was the change of the Unified Parkinson’s Disease Rating Scale(UPDRS)total score from baseline to 26 weeks treatment.Secondary endpoints included changes in UPDRS subscale scores from part Ⅰ to Ⅲ.Health status was assessed with the PD Questionnaire(PDQ)-39 and EuroQol-Five-Dimension(EQ-5D)questionnaire.Safety profile was collected until 30 weeks after randomization.Results:A total of 130 patients(n=65/group)were recruited,and 127(rasagiline,n=64;placebo,n=63)were included in the full analysis set.Baseline characteristics were comparable between the two groups.The decrease in the mean UPDRS total score was greater in the rasagiline group than in the placebo group(−3.18±0.95 vs.−0.18±0.98,P=0.025),and the mean UPDRS part I non-motor symptoms score(−0.54±0.15 vs.-0.08±0.15,P=0.003)were significantly decreased in the rasagiline group compared with placebo treated patients.An improvement trend was observed in the active treatment group for the subscales evaluation with parts Ⅱ and Ⅲ,while the difference to placebo was not statistically significant.Life quality assessed by the EQ-5D visual analog scale improved in the rasagiline group but worsened in placebo treated patients.The overall incidence of treatment-emergent adverse events(AEs)was slightly lower in the rasagiline group(41.5%)than in the placebo group(46.2%).Conclusions:Rasagiline is effective,safe,and well tolerated as monotherapy for the treatment of Chinese PD patients. | Zhenxin Zhang Jian Wang Shengdi Chen Chunfeng Liu Baorong Zhang Rong Peng Shenggang Sun Xiangru Sun Gang Zhao Qiumin Qu Yansheng Li Suiqiang Zhu Xiaoping Pan Ming Shao Yanping Wang | 2018 | Translational Neurodegeneration2018，7，1： | 3 |
| 7 | A male-ABCD algorithm for hepatocellular carcinoma risk prediction in HBs Ag carriers显示文摘Objective: Hepatocellular carcinoma(HCC) development among hepatitis B surface antigen(HBs Ag) carriers shows gender disparity, influenced by underlying liver diseases that display variations in laboratory tests. We aimed to construct a risk-stratified HCC prediction model for HBs Ag-positive male adults.Methods: HBs Ag-positive males of 35-69 years old(N=6,153) were included from a multi-center populationbased liver cancer screening study. Randomly, three centers were set as training, the other three centers as validation. Within 2 years since initiation, we administrated at least two rounds of HCC screening using Bultrasonography and α-fetoprotein(AFP). We used logistic regression models to determine potential risk factors,built and examined the operating characteristics of a point-based algorithm for HCC risk prediction.Results: With 2 years of follow-up, 302 HCC cases were diagnosed. A male-ABCD algorithm was constructed including participant's age, blood levels of GGT(γ-glutamyl-transpeptidase), counts of platelets, white cells,concentration of DCP(des-γ-carboxy-prothrombin) and AFP, with scores ranging from 0 to 18.3. The area under receiver operating characteristic was 0.91(0.90-0.93), larger than existing models. At 1.5 points of risk score,26.10% of the participants in training cohort and 14.94% in validation cohort were recognized at low risk, with sensitivity of identifying HCC remained 100%. At 2.5 points, 46.51% of the participants in training cohort and 33.68% in validation cohort were recognized at low risk with 99.06% and 97.78% of sensitivity, respectively. At 4.5 points, only 20.86% of participants in training cohort and 23.73% in validation cohort were recognized at high risk,with positive prediction value of 22.85% and 12.35%, respectively.Conclusions: Male-ABCD algorithm identified individual's risk for HCC occurrence within short term for their HCC precision surveillance. | Yuting Wang Minjie Wang He Li Kun Chen Hongmei Zeng Xinyu Bi Zheng Zhu Yuchen Jiao Yong Wang Jian Zhu Hui Zhao Xiang Liu Chunyun Dai Chunsun Fan Can Zhao Deyin Guo Hong Zhao Jianguo Zhou Dongmei Wang Zhiyuan Wu Xinming Zhao Wei Cui Xuehong Zhang Jianqiang Cai Wanqing Chen Chunfeng Qu | 2021 | Chinese Journal of Cancer Research2021，33，3： | 3 |
| 8 | Numerical Simulation of Magnetic Pressure in Tube-electromagnetic Bulging with Die显示文摘Calculation of magnetic pressure is the basis of application of electromagnetic forming (EMF). This paper carries out a numerical simulation of magnetic pressure under the influence of die by means of finite element method. The analysis model of electromagnetic bulging with die is created by using ANSYS, and the distribution of magnetic pressure acting on the tube and the die is obtained. The differences between EMF and other technologies and the effect of die on tube formability are analyzed. The die has important influence upon the calculation accuracy. The simulating conclusions with different discharge energy and current frequency are verified through the technologic tests. The distribution of magnetic pressure acting on the tube agrees well with the measurements of the deformed tube. | Hongwei JIANG Chunfeng LI Haiping YU Zhiheng ZHAO | 2003 | Journal of Materials Science & Technology2003，19，z1： | 2 |
| 9 | Mechanical property and microstructure of aluminum alloy-steel tubes joint by magnetic pulse welding显示文摘 | Haiping Yu Zhidan Xu Zhisong Fan Zhixue Zhao Chunfeng Li | 2013 | Materials Science & Engineering A2013，，： | 2 |
| 10 | Chracteristics and formation setting of granodiorite in Zhalute County,Inner Mongolia显示文摘Based on field investigation and study of petrology, mineralogy, geochemistry and isotopic geochronology for the granodiorite, the authors discussed the formation setting of the granodiorite. The pluton is calci alkalic and peraluminous granite in which light rare earth elements (LREE) are intensively enriched, heavy rare earth elements are relatively poor, the ratio of LREE to heavy rare earth elements (HREE) is 7.12, and the fractionation of REE is good. The pluton formed in late orogenic setting which is relatively steady. | ZHAO Qingying LI Chunfeng WANG Guoliang LI Xuefei | 2009 | Global Geology2009，12，3： | 2 |
| 11 | Emerging R&D on membranes and systems for water reuse and desalination显示文摘Sustainable production of clean water is a global challenge.While we firmly believe that membrane technologies are one of the most promising solutions to tackle the global water challenges,one must reduce their energy consumption and fouling propensity for broad sustainable applications.In addition,different membranes face various challenges in their specific applications during long-term operations.In this short review,we will summarize the recent progresses in emerging membrane technologies and system integration to advance and sustain water reuse and desalination with discussion on their challenges and perspectives. | Tai-Shung Chung Dieling Zhao Jie Gao Kangjia Lu Chunfeng Wan Martin Weber Christian Maletzko | 2019 | Chinese Journal of Chemical Engineering2019，27，7： | 2 |
| 12 | Optimum location of tube blank in electromagnetic bulging显示文摘 | ZHAO Zhiheng LI Chunfeng YANG Yuying | | 0，，01： | 1 |
| 13 | Numerical simulation of the magnetic pressure in tube electromagnetic bulging显示文摘 | LI Chunfeng ZHAO Zhiheng LI Jianhui | | 0，，： | 1 |
| 14 | The effect of tube length on magnetic pressure in tube electromagnetic bulging显示文摘 | Chunfeng LI Zhiheng ZHAO Jianhui LI | | 0，，： | 1 |
| 15 | Magnetic pressure in electromagnetic aluminum tubecompression forming显示文摘 | YU Haiping LI Chunfeng ZHAO Zhiheng | | 0，，： | 1 |
| 16 | Kilogram-scale synthesis of ordered mesoporous carbons and their electrochemical performance显示文摘 | Jinxiu Wang Chunfeng Xue Yingying Lv Fan Zhang Bo Tu Dongyuan Zhao | 2011 | Carbon2011，，13： | 1 |
| 17 | Effect of field shaper on magnetic pressure in electromagnetic forming显示文摘 | YU Haiping LI Chunfeng ZHAO Zhiheng | | 0，，： | 1 |
| 18 | Effects of levodopa on dopaminergic neurons and induced dyskinesia A radio-imaging study显示文摘BACKGROUND: Radio-imaging has been used in neurological diagnosis,in particular for extrapyramidal disease.Moreover,it has been extensively utilized for early diagnosis of Parkinson’s disease (PD) patients and in animal studies.However,it has rarely been utilized to assess drug-induced side effects in PD.OBJECTIVE: To investigate changes in dopamine transporter expression in a rat model of PD through the use of radio-imaging taking 99mTc-TRODAT-1 as an imaging agent,and to explore the effect of levodopa (L-dopa) on dopaminergic neurons and the possible mechanisms of dyskinesia induction.DESIGN,TIME AND SETTING: A randomized,controlled,animal study was performed at the Laboratory of Department of Nuclear Medicine,Soochow University from April 2006 to June 2007.MATERIALS: 6-hydroxydopamine was purchased from Sigma,USA and L-dopa was purchased from Shanghai Fuda Pharmaceutical,China.99mTcO4-fresh elutriant was provided by the Department of Nuclear Medicine,First Hospital Affiliated to Soochow University.TRODAT-1 image kit was provided by Jiangsu Atomic Energy Research Establishment,China.The SN-695B radioimmunoassay gamma counter was purchased from Shanghai Hesuo Rihuan Photoelectric Instrument,China.The AZ-CA256eZ-Scope portable γ camera was purchased from Anzai Medical,Japan.METHODS: A total of 34 healthy,male,Sprague Dawley rats were selected.Thirty were used to establish a PD model by injecting 6-hydroxydopamine into the right medial forebrain bundle,and four were injected with normal saline and served as the sham-surgery group.At the end of 4 weeks,21 successful PD models were selected and randomly assigned to the L-dopa (n = 15,20 mg/kg per day),model (n = 6,normal saline),and sham-surgery (n = 4,no treatment) groups.After 1 month of treatment,involuntary movement was evaluated twice weekly in each rat.A total of 0.2 mL 99mTc-TRODAT-1 was injected into the tail vein 2 days following drug termination,and images of dopamine transporters were acquired 2 hours later.The rats were sacrificed and the ratios of specific radioactivity uptake were calculated.MAIN OUTCOME MEASURES: Manifestations of abnormal involuntary movement (AIM) were observed and total AIM scores were calculated.Images of dopamine transporters were acquired using an eZ-Scope portable γ camera,and radioactive γ quantification of 99mTc-TRODAT-1 in the rat brains was assayed.The ratios of the left and right corpora striata were determined.The number and function of dopamine transporters was evaluated according to specific radioactivity uptake ratio (R) from the left and right corpora striata.RESULTS: Of 15 PD rats,nine exhibited AIM following L-dopa treatment: five scored > 20,i.e.,severe grade,four scored 8–16,mild grade,and the remaining exhibited normal behavior.There were no differences in specific radioactivity uptake of dopamine transporter between the left and right corpora striata in the sham-surgery rats,and the images were clear and symmetrically distributed.Specific radioactivity uptake of the normal side (left) was significantly greater than the lesioned side (right) in the model group rats (P < 0.01),and the R value was significantly increased compared with the sham-surgery group (P < 0.01).The radio-ligand accumulation in the right corpus striatum was sparse.In the L-dopa group,specific radioactivity uptake was significantly decreased in the lesioned (right) side of the AIM rats,and the R value was increased compared with the model group (P < 0.05).The amount of radio-ligand in the right corpus striatum was diminished.The R value was significantly reduced in the non-AIM rats compared with the AIM rats (P < 0.05),and specific radioactivity uptake was significantly increased in the lesioned (right) side compared with the normal side (P < 0.05).Moreover,radio-ligand accumulation was observed in the right corpus striatum,and differences in radio-ligand accumulation between the two sides were reduced.CONCLUSION: Following L-dopa treatment,the number and function of dopamine transporter in some PD rats were reduced.L-dopa was shown to be toxic to dopaminergic neurons and induced dyskinesia. | Xiuying Cai Yan Kong Hongru Zhao Bin Zhang Chunfeng Liu | 2010 | Neural Regeneration Research2010，5，2： | 1 |
| 19 | Analysis of deep earth pressure around cast - in - place pile considering concrete property variation 显示文摘 | ZHAO Chunfeng Yang Yanzong ZHAO Cheng etal | 2013 | KSCE2013，17，1： | 1 |
| 20 | Regulation effects on abnormal glucose and lipid metabolism of TZQ-F, a new kind of Traditional Chinese Medicine显示文摘 | Wang Tao Zhang Deqin Li Yuhong Liu Hong Liu Zhanbiao Zhao Chunfeng Hu Limin Gao Xiumei | 2010 | Journal of Ethnopharmacology2010，，3： | 1 |
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