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| 1 | Air pollution and inhalation exposure to particulate matter of different sizes in rural households using improved stoves in central China显示文摘Household air pollution is considered to be among the top environmental risks in China.To examine the performance of improved stoves for reduction of indoor particulate matter(PM) emission and exposure in rural households, individual inhalation exposure to size-resolved PM was investigated using personal portable samplers carried by residents using wood gasifier stoves or improved coal stoves in a rural county in Central China.Concentrations of PM with different sizes in stationary indoor and outdoor air were also monitored at paired sites. The stationary concentrations of size-resolved PM in indoor air were greater than those in outdoor air, especially finer particles PM0.25. The daily averaged exposure concentrations of PM0.25, PM1.0, PM2.5 and total suspended particle for all the surveyed residents were 74.4 ± 41.1, 159.3 ± 74.3, 176.7 ± 78.1 and 217.9 ± 78.1 μg/m3,respectively. Even using the improved stoves, the individual exposure to indoor PM far exceeded the air quality guideline by WHO at 25 μg/m3. Submicron particles PM1.0 were the dominant PM fraction for personal exposure and indoor and outdoor air. Personal exposure exhibited a closer correlation with indoor PM concentrations than that for outdoor concentrations. Both inhalation exposure and indoor air PM concentrations in the rural households with gasifier firewood stoves were evidently lower than the reported results using traditional firewood stoves. However, local governments in the studied rural areas should exercise caution when widely and hastily promoting gasifier firewood stoves in place of improved coal stoves, due to the higher PM levels in indoor and outdoor air and personal inhaled exposure. | Weijian Liu Guofeng Shen Yuanchen Chen Huizhong Shen Ye Huang Tongchao Li Yilong Wang Xiaofang Fu Shu Tao Wenxin Liu Yibo Huang-Fu Weihao Zhang Chunyu Xue Guangqing Liu Fuyong Wu Minghung Wong | 2018 | Journal of Environmental Sciences2018，30，1： | 4 |
| 2 | Digital surface model applied to unmanned aerial vehicle based photogrammetry to assess potential biotic or abiotic effects on grapevine canopies显示文摘Accurate data acquisition and analysis to obtain crop canopy information are critical steps to understand plant growth dynamics and to assess the potential impacts of biotic or abiotic stresses on plant development.A versatile and easy to use monitoring system will allow researchers and growers to improve the follow-up management strategies within farms once potential problems have been detected.This study reviewed existing remote sensing platforms and relevant information applied to crops and specifically grapevines to equip a simple Unmanned Aerial Vehicle(UAV)using a visible high definition RGB camera.The objective of the proposed Unmanned Aerial System(UAS)was to implement a Digital Surface Model(DSM)in order to obtain accurate information about the affected or missing grapevines that can be attributed to potential biotic or abiotic stress effects.The analysis process started with a three-dimensional(3D)reconstruction from the RGB images collected from grapevines using the UAS and the Structure from Motion(SfM)technique to obtain the DSM applied on a per-plant basis.Then,the DSM was expressed as greyscale images according to the halftone technique to finally extract the information of affected and missing grapevines using computer vision algorithms based on canopy cover measurement and classification.To validate the automated method proposed,each grapevine row was visually inspected within the study area.The inspection was then compared to the digital assessment using the proposed UAS in order to validate calculations of affected and missing grapevines for the whole studied vineyard.Results showed that the percentage of affected and missing grapevines was 9.5%and 7.3%,respectively from the area studied.Therefore,for this specific study,the abiotic stress that affected the experimental vineyard(frost)impacted a total of 16.8%of plants.This study provided a new method for automatically surveying affected or missing grapevines in the field and an evaluation tool for plant growth conditions,which can be implemented for other uses such as canopy management,irrigation scheduling and other precision agricultural applications. | Su Baofeng Xue Jinru Xie Chunyu Fang Yulin Song Yuyang Sigfredo Fuentes | 2016 | International Journal of Agricultural and Biological Engineering2016，9，6： | 3 |
| 3 | Uncertainty-averse TRANSCO planning for accommodating renewable energy in CO_(2)reduction environment显示文摘The concern of the environment and energy sustainability requests a crucial target of CO_(2)abatement and results in a relatively high penetration of renewable energy generation in the transmission system.For maintaining system reliability and security,the transmission company(TRANSCO)has to make strategic planning to handle the uncertainty challenges from the intermittent renewable energy resources.In this paper,a stochastic multi-period multi-objective transmission planning(MPMOTP)model is proposed to reduce correlated uncertainties from renewable energy generation,conventional generation,demand-side variations,market price volatility,and transmission configuration.Three objectives,i.e.social CO_(2)reduction benefit,energy purchase and network expansion cost and power delivery profit,are optimized simultaneously by a developed two-phase multi-objective particle swarm optimization(MOPSO)method.The feasibility and effectiveness of the proposed uncertainty-averse MPMOTP model have been verified by the IEEE 24-bus test system. | Chunyu ZHANG Yi DING Qi WANG Yusheng XUE JacobØSTERGAARD | 2015 | Journal of Modern Power Systems and Clean Energy2015，3，1： | 2 |
| 4 | Differential gene expression profile in ischemic myo-cardium of Wistar rats with acute myocardial infarction显示文摘To determine the differential genes in ischemic myocardium of Wistar rats with acute myocardial in- farction (AMI), we constructed two differential gene expression profiles. AMI model was generated by ligation of the left anterior descending coronary artery in Wistar rats. Total RNA was extracted from the normal and the ischemic heart tissues under the ligation point at the 8th day after the operation. Dif- ferential gene expression profiles of the two samples were constructed by using long serial analysis of gene expression (LongSAGE). Real time fluorescence quantitative PCR (Q-PCR) was used to confirm the expression changes of partial target genes. The main results were as follows: a total of 15966 tags were screened from the normal and the ischemic LongSAGE maps, and 9646 tags in the normal tissue and 9563 tags in the ischemic tissue were obtained. Among them, 7665 novel tags were identified by NCBI BLAST search. In the ischemic tissue, 142 genes significantly changed compared to those in the normal tissue (P<0.05). These differentially expressed genes may play important roles in the pathways of oxidation and phosphorylation, ATP synthesis and glycolysis and so on. Partial genes identified by the LongSAGE were confirmed by Q-PCR. The results show that AMI causes a series of gene expres- sion changes in the regulation of the pathways related to energy metabolism. | GUO ChunYu YIN HuiJun JIANG YueRong XUE Mei SHI DaZhuo | 2008 | Chinese Science Bulletin2008，53，16： | 2 |
| 5 | Sinoatrial node pacemaker cells share dominant biological properties with glutamatergic neurons显示文摘Activation of the heart normally begins in the sinoatrial node(SAN).Electrical impulses spontaneously released by SAN pacemaker cells(SANPCs)trigger the contraction of the heart.However,the cellular nature of SANPCs remains controversial.Here,we report that SANPCs exhibit glutamatergic neuron-like properties.By comparing the single-cell transcriptome of SANPCs with that of cells from primary visual cortex in mouse,we found that SANPCs co-clustered with cortical neurons.Tissue and cellular imaging confirmed that SANPCs contained key elements of glutamatergic neurotransmitter system,expressing genes encoding glutamate synthesis pathway(G/s),ionotropic and metabotropic glutamate receptors(Grina,Gria3,Grm1 and Grm5)t and glutamate transporters(Slc17a7).SANPCs highly expressed cell markers of glutamatergic neurons(Snap25 and S/-c17a7)t whereas Gad1,a marker of GABAergic neurons,was negative.Functional studies revealed that inhibition of glutamate receptors or transporters reduced spontaneous pacing frequency of isolated SAN tissues and spontaneous Ca2+transients frequency in single SANPC.Collectively,our work suggests that SANPCs share dominant biological properties with glutamatergic neurons,and the glutamatergic neurotransmitter system may act as an intrinsic regulation module of heart rhythm,which provides a potential intervention target for pacemaker cell-associated arrhythmias. | Dandan Liang Zhigang Xue Jinfeng Xue Duanyang Xie Ke Xiong Huixing Zhou Fulei Zhang Xuling Su Guanghua Wang Qicheng Zou Yi Liu Jian Yang Honghui Ma Luying Peng Chunyu Zeng Gang Li Li Wang Yi-Han Chen | 2021 | Protein & Cell2021，12，7： | 1 |
| 6 | Enhanced bioproduction of chitin in engineered Pichia pastoris显示文摘Biopolymer chitin and its derivatives have a wide range of applications in different fields.Chitin is primarily produced from marine crustacean by strong acid and strong alkali treatment.To reduce the environmental hazardous in the production of chitin,post-fermentation fungal biomass waste like fungi cell walls provides a viable alternative source for chitin.In this study,improved chitin content in yeast cell wall was achieved by overexpressing chitin biosyntheic pathway related genes.The chitin content was 51.5μg/mg cell wall and 122.9μg/mg cell wall in strain GS-1.10(gfat,uap and chs1 genes overexpression)and strain GS-2.6(gfat,gna1,agm1,uap and chs1 genes overexpression),which were 44.3%and 244.4%higher than that in control strain GS115,respectively.By overexpressing another chitin synthase gene(chs3),the chitin content in strain GS-3.10 was further increased to 136.2μg/mg cell wall,which was 10.8%and 281.6%higher than that in GS-2.6 and in control GS115,respectively.Moreover,chitin yield was further improved by various culture conditions optimization,and reached 162.4μg/mg cell wall,which was 4.43 times of that in the starting strain GS115.The final titer of chitin was 2.23 g/L culture broth in 84 h fed-batch fermentation in a 5 L bioreactor.To our knowledge,this is the first report of chitin production in engineered Pichia pastoris via biosynthetic pathway enhancement. | Xue Zhang Chunyue Zhang Mian Zhou Quanming Xia Liqiang Fan Liming Zhao | 2022 | Food Bioscience2022，47，3： | 1 |
| 7 | Structure analysis of the fourth transmembrane domain of Nramp1 in model membranes显示文摘 | Rong Xue Shuo Wang Haiyan Qi Yuande Song Chunyu Wang Fei Li | 2008 | BBA - Biomembranes2008，，： | 1 |
| 8 | Microstructure of two polypropylene homopolymers with improved impact properties显示文摘 | Fan Yandi Zhang Chunyu Xue Yanhu | 2011 | Polymer2011，52，2： | 1 |
| 9 | Field assessment of straw pellet combustion in improved heating stoves in rural Northeast China显示文摘Straw pellets are widely promoted and expected to be a cleaner alternative fuel to unprocessed crop residues and rawcoal in rural China.However,the effectiveness of these dissemination programs is not well evaluated.In this field study,emission characteristics of burning strawpellets,rawcoal,and unprocessed corn cobs in heating stoveswere investigated in a pilot village in Northeast China.Emission measurements covering the whole combustion cycle(ignition,flaming,and smoldering phases)shows the promotion of improved heating stoves and straw pellets could reduce pollutant emissions(e.g.,SO_(2) and CO),but increase NO_(X) and PM_(2.5) emissions compared to the initial stove-fuel use pattern in the studied area.There is a significant variance in emission characteristics between different combustion phases.The normalized emission concentrations of the different stove-fuel combinations were higher than the limits in the Chinese national standard for heating stoves,indicating that the standard is not met for real-world emissions.Coal consumption was lower than official data.Household surveys were conducted to identify the barriers to fuel and stove access associated with existing promotion strategies,management,and policies.The pilot program was of the typical“subsidy-and-policy-dependence”pattern and was unlikely to be implemented on a large scale.Technological innovation,operational optimization,and proper policies considering the local socioeconomic factors are needed to sustain the promotion of biomass straw pellets and stoves. | Yafei Liu Zhimin Li Emily Floess You Zhang Nicholas Lam Sylvester K.Mawusi Prabin Shrestha Xinghua Li Chunyu Xue Guangqing Liu | 2023 | Journal of Environmental Sciences2023，，5： | 0 |
| 10 | Bias Analysis and Correction of Ground Surface Temperature Observations across China显示文摘Based on the ground surface temperature(GST)and snow surface temperature(SST)measurements during the period of adjustment from manual to automatic observation systems in China,the influence of observation methods on GST and its relationship with snow cover is analyzed.GST is corrected by SST,and the correction effect is evaluated.The results show that,during the parallel observation period,the winter GSTs from automatic observations are generally higher than those from manual observations,with the automatically observed national daily GST 1.18°C higher.The adjustment has a greater impact on GSTs at 0200,0800,and 2000 Beijing Time(BT)than at 1400 BT,and it has the greatest impact in Northeast and Northwest China,with deviations of 5.24 and 2.09°C,respectively.The GST deviation is closely related to the snow depth and annual snow totals.The average daily GST deviation increases at the rate of 0.66°C per 1-cm increase of snow depth when it is<15 cm,while it tends to be stable at around 10°C for snow depth over 15 cm.The GST deviation at a station is affected by its winter snow totals in Northeast and Northwest China,where the largest deviations are found where snow totals are all above 1000 cm.After the correction with SST,the mean deviation between the automatic and manual observations as well as the false trend can be effectively reduced.Following the correction,the mean deviation of daily GST decreases by 5.8°C,and its trend decreases from 1.87 to 0.65°C decade-1. | Yan CUI Wenhui XU Zijiang ZHOU Chunyu ZHAO Yihui DING Xue AO Xiaoyu ZHOU | 2020 | Journal of Meteorological Research2020，34，6： | 0 |
| 11 | Pre-placement of adhesive tape around wound sites can prevent air leakage in negative pressure wound therapy procedures显示文摘The introduction of negative pressure wound therapy has revolutionized the management of complicated wounds.However,the maintenance of an effective negative pressure environment is difficult in some instances,such as wounds in close proximity to an intestinal stoma or wounds surrounded by external fixations.We found that adhesive tape adheres more easily to itself than to wet skin or uneven surfaces.Therefore,we placed adhesive tape around surgical wounds prior to covering them with foam and sealing them with more tape.As a result of the strong adhesive force between pieces of tape,this method could provide a better environmental seal,even in situations where space is limited.Pre-placed adhesive tape around the wound site prior to foam placement could provide sufficient adhesion to maintain a continuous negative pressure environment during treatment. | Ran Tao Yukun Yang Chunyu Xue Chuan Lv | 2022 | Chinese Journal Of Plastic and Reconstructive Surgery2022，4，2： | 0 |
| 12 | Sequencing of phosphopeptides sulfonated by 4-sulfophenyl isothiocyanate using post-source decay matrix-assisted laser desorption/ionization time-of-flight mass spectrometry显示文摘Phosphorylation/dephosphorylation 可能是蛋白质的最普通、重要的可逆 translational 以后修正。分析 phosphorylation 的功能的效果对理解蛋白质的生物功能有用。phosphorylated 蛋白质的 phosphorylation 地点的鉴定是为关于 phosphorylation 的研究的一个前提。在这个工作,蛋白质 phosphorylation 地点的鉴定的一个有效、简单的方法被开发了。Phosphopeptides 有选择地与使不能调动的金属亲密关系层析(IMAC ) 被充实并且化学上随后由 4-sulfophenyl isothiocyanate,然后化学上修改的 phosphopeptides 修改了与来源以后的腐烂(PSD ) 被定序为检测 phosphorylation 地点的帮助矩阵的激光解吸附作用 / 电离(MALDI ) time-of-flight 团 spectrometry。由 4-sulfophenyl isothiocyanate 的 derivatization 的费用在肽的 N 终点介绍一个否定的酸性硫酸基的酸组,并且启用仅仅 C 终端 y 类型离子的一个单个系列的选择察觉。这个化学上帮助的方法极大地简化 PSD 碎片离子的极其复杂的模式并且使 PSD 系列更更容易被解释。综合模型 phosphopeptide 和人的 c-myc 蛋白质的 phosphorylation 地点被这个方法成功地识别了。 | TANG Jianguang WANG Yongjun ZHANG Hainan WANG Chunyu HU Zhiping XUE Zhigang XIA Kun SHI Xiaoliu | 2006 | Progress in Natural Science:Materials International2006，16，9： | 0 |
| 13 | Transposition Flaps for Reconstruction of Perianal Skin Defects After Tumor Resection显示文摘Objective To investigate the application of transposition flaps in the reconstruction of perianal skin defects after tumor resection.Methods From September 2018 to December 2019,16 cases of perianal skin defects were repaired with unilateral or bilateral transposition flaps.The wound size before closure ranged from 4 cm×8 cm to 7 cm×10 cm.Fourteen patients achieved primary healing.Wound dehiscence occurred in one patient at the flap tip,whereas a slight infection occurred in another patient,which healed after a dressing change.During the follow-up period of 3–6 months,all patients were satisfied with the perianal area both aesthetically and functionally.Conclusion Transposition flaps are a promising option for the repair of perianal skin defects after tumor removal.Owing to the simplicity of the flap design,the wide popularity of this flap type among surgeons is anticipated. | Haiying DAI Minliang WU Yuchong WANG Shuo FANG Zheng WANG Yu XIA Jianguo XU Chunyu XUE | 2020 | Chinese Journal Of Plastic and Reconstructive Surgery2020，2，4： | 0 |
| 14 | Developmental systems biology flourishing on new technologies显示文摘Organism development is a systems level process. It has benefited greatly from the recent technological advances in the field of systems biology. DNA microarray, phenome, interactome and transcriptome mapping, the new generation of deep sequencing technologies, and faster and better computational and modeling approaches have opened new frontiers for both systems biologists and developmental biologists to reexamine the old developmental biology questions, such as pattern formation, and to tackle new problems, such as stem cell reprogramming. As showcased in the International Developmental Systems Biology Symposium organized by Chinese Academy of Sciences, developmental systems biology is flourishing in many perspectives, from the evolution of developmental systems, to the underly-ing genetic and molecular pathways and networks, to the genomic, epigenomic and noncoding levels, to the computational analysis and modeling. We believe that the field will continue to reap rewards into the future with these new approaches. | Jing-Dong J. Han Yi Liu Huiling Xue Kai Xia Hong Yu Shanshan Zhu Zhang Chen Wei Zhang Zheng Huang Chunyu Jin Bo Xian Jing Li Lei Hou Yixing Han Chaoqun Niu Timothy C. Alcon | 2008 | Journal of Genetics and Genomics2008，35，10： | 0 |
| 15 | Biodegradable germanium electronics for integrated biosensing of physiological signals显示文摘Transient electronics that can disappear or degrade via physical disintegration or chemical reaction over a pre-defined operational period provide essential for their applications in implantable bioelectronics due to the complete elimination of the second surgical extraction.However,the dissolution of commonly utilized bioresorbable materials often accompanies hydrogen production,which may cause potential or irreparable harm to the human body.This paper introduces germanium nanomembrane-based bioresorbable electronic sensors,where the chemical dissolution of all utilized materials in biofluidic theoretically have no gaseous products.In particular,the superior electronic transport of germanium enables the demonstrated bioresorbable electronic sensors to successfully distinguish the crosstalk of different physiological signals,such as temperature and strain,suggesting the significant prospect for the construction of dual or multi-parameter biosensors.Systematical studies reveal the gauge factor and temperature coefficient of resistance comparable to otherwise similar devices with gaseous products during their dissolution. | Haonan Zhao Zhongying Xue Xiaozhong Wu Zhihuan Wei Qiuyu Guo Miao Xu Chunyan Qu Chunyu You Yongfeng Mei Miao Zhang Zengfeng Di Qinglei Guo | 2022 | npj Flexible Electronics2022，6，1： | 0 |
| 16 | Pathogenic roles of long noncoding RNAs in melanoma: Implications in diagnosis and therapies显示文摘Melanoma is one of the most dangerous types of cutaneous neoplasms,which are pigment-producing cells of neuroectodermal origin found all over the body.A great deal of research is focused on the mechanisms of melanoma to promote better diagnostic and treatment options for melanoma in its advanced stages.The progression of melanoma involves alteration in different levels of gene expression.With the successful implementation of next-generation sequencing technology,an increasing number of long noncoding RNAs(lncRNAs)sequences have been discovered,and a significant number of them have phenotypic effects in both in vitro and in vivo studies,implying that they play an important role in the occurrence and progression of human cancers,particularly melanoma.A number of evidence indicated that lncRNAs are important regulators in tumor cell proliferation,invasion,apoptosis,immune escape,energy metabolism,drug resistance,epigenetic regulation.To better understand the role of lncRNAs in melanoma tumorigenesis,we categorize melanomaassociated lncRNAs according to their cellular functions and associations with gene expression and signaling pathways in this review.Based on the mechanisms of lncRNA,we discuss the possibility of lncRNA-target treatments,and the application of liquid biopsies to detect lncRNAs in melanomadiagnosisandprognosis. | Yuai Xiao Yu Xia Yuchong Wang Chunyu Xue | 2023 | Genes & Diseases2023，10，1： | 0 |
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