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| 1 | Genetic dissection of rice appearance quality and cooked rice elongation by genome-wide association study显示文摘Appearance and cooked rice elongation are key quality traits of rice. Although some QTL for these traits have been identified, understanding of the genetic relationship between them remains limited. In the present study, large phenotypic variation was observed in 760 accessions from the 3 K Rice Genomes Project for both appearance quality and cooked rice elongation. Most component traits of appearance quality and cooked rice elongation showed significant pairwise correlations, but a low correlation was found between appearance quality and cooked rice elongation. A genome-wide association study identified 74 QTL distributed on all 12 chromosomes for grain length, grain width, length to width ratio, degree of endosperm with chalkiness, rice elongation difference, and elongation index. Thirteen regions containing QTL stably expressed in multiple environments and/or exerting pleiotropic effects on multiple traits were detected. By gene-based association analysis and haplotype analysis, 46 candidate genes, including five cloned genes, and 49 favorable alleles were identified for these 13 QTL. The effect of the candidate gene Wx on rice elongation difference was validated by a transgenic strategy. These results shed light on the genetic bases of appearance quality and cooked rice elongation and provide gene resources for improving rice quality by molecular breeding. | Xianjin Qiu Jing Yang Fan Zhang Yanan Niu Xiuqing Zhao Congcong Shen Kai Chen Sheng Teng Jianlong Xu | 2021 | The Crop Journal2021，9，6： | 5 |
| 2 | WSe2 2D p-type semiconductor-based electronic devices for information technology:Design,preparation,and applications显示文摘The pioneering exfoliation of monolayer tungsten diselenide has greatly inspired researchers toward semiconducting applications.WSe2 belongs to a family of transition-metal dichalcogenides.Similar to graphene,WSe2 and analogous dichalcogenides have layered structures with weak van der Waals interactions between two adjacent layers.First,the readers are presented with the fundamentals of WSe2,such as types,morphologies,and properties.Here,we report the characterization principles and practices such as microscopy,spectroscopy,and diffraction.Second,the methods for obtaining high-quality WSe2,such as exfoliation,hydrothermal and chemical vapor deposition,are briefly listed.With advantages of light weight,flexibility,and high quantum efficiency,2D materials may have a niche in optoelectronics as building blocks in p-n junctions.Therefore,we introduce a state-of-the-art demonstration of heterostructure devices employing the p-type WSe2 semiconductor.The device architectures include field-effect transistors,photodetectors,gas sensors,and photovoltaic solar cells.Due to its unique electronic,optical,and energy band properties,WSe2 has been increasingly investigated due to the conductivity of the p-type charge carrier upon palladium contact.Eventually,the dynamic research on WSe2 and van der Waals heterostructures is summarized to arouse the passion of the 2D research community. | Qilin Cheng Jinbo Pang Dehui Sun Jingang Wang Shu Zhang Fan Liu Yuke Chen Ruiqi Yang Na Liang Xiheng Lu Yanchen Ji Jian Wang Congcong Zhang Yuanhua Sang Hong Liu Weijia Zhou | 2020 | InfoMat2020，2，4： | 5 |
| 3 | A haplotype map of genomic variations and genome-wide association studies of agronomic traits in foxtail millet(Setaria italica)显示文摘 | Guanqing Jia Xuehui Huang Hui Zhi Yan Zhao QiangZhao Wenjun Li Yang Chai Lifang Yang Kunyan Liu Hengyun Lu Chuanrang Zhu Yiqi Lu Congcong Zhou Danlin Fan Qijun Weng Yunli Guo Tao Huang LeiZhang Tingting Lu Qi Feng Hangfei Hao HongkuanLiu Ping Lu Ning Zhang Yuhui Li Erhu Guo ShujunWang Suying Wang Jinrong Liu Wenfei Zhang GuoqiuChen Baojin Zhang Wei Li Yongfang Wang HaiquanLi Baohua Zhao Jiayang Li Xianmin Diao Bin HanJia | 2013 | Nature Genetics2013，45，8： | 1 |
| 4 | Genetic mechanism of heterosis for rice milling and appearance quality in an elite rice hybrid显示文摘Development of hybrid rice with high yield and grain quality is a goal of rice breeding.To investigate the genetic mechanism of heterosis for rice milling and appearance quality in indica/xian rice,QTL mapping was conducted using 1061 recombinant inbred lines(RILs)derived from a cross of the xian rice cultivars Quan 9311B(Q9311B)and Wu-shan-si-miao(WSSM),and a backcross F_(1)(BC_(1)F_(1)) population developed by crossing the RILs with Quan 9311A(Q9311A),combined with phenotyping in two environments.The F_(1) hybrid(Q9311A×WSSM)showed various degrees of heterosis for milling and appearance quality.A total of 142 main-effect QTL(M-QTL)and 407 pairs of epistatic QTL(E-QTL)were identified for five milling and appearance quality traits and grain yield per plant(GYP)in the RIL,BC_(1)F_(1) and mid-parental heterosis(H_(MP)) populations.Differential detection of QTL in three populations revealed that most additive loci detected in the RILs did not show heterotic effects,but some of them did contribute to BC_(1)F_(1) trait performance.Unlike heterosis of GYP,single-locus overdominance and epistasis were the main contributors to heterosis for milling and appearance quality.Epistasis contributed more to the heterosis for milling quality than to that for appearance quality.Three(four)QTL regions harboring opposite(consistent)directions of favorable allele effects for GYP and grain quality were identified,indicating the presence of partial genetic overlaps between GYP and grain quality.Three strategies are proposed to develop hybrid rice with high yield and good grain quality:1)pyramiding favorable alleles with consistent directions of gene effects for GYP and grain quality at the M-QTL on different chromosomes;2)introgressing favorable alleles for GYP and grain quality into the parents and then pyramiding and fixing these additive effects in hybrids;and 3)pyramiding overdominant and dominant loci and minimizing or eliminating underdominant loci from the parents. | Hui You Sundus Zafar Fan Zhang Shuangbing Zhu Kai Chen Congcong Shen Xiuqin Zhao Wenzhong Zhang Jianlong Xu | 2022 | The Crop Journal2022，10，6： | 1 |
| 5 | Porcine Picornavirus 3C Protease Degrades PRDX6 to Impair PRDX6-mediated Antiviral Function显示文摘Peroxiredoxin-6(PRDX6)is an antioxidant enzyme with both the activities of peroxidase and phospholipase A2(PLA2),which is involved in regulation of many cellular reactions.However,the function of PRDX6 during virus infection remains unknown.In this study,we found that the abundance of PRDX6 protein was dramatically decreased in foot-and-mouth disease virus(FMDV)infected cells.Overexpression of PRDX6 inhibited FMDV replication.In contrast,knockdown of PRDX6 expression promoted FMDV replication,suggesting an antiviral role of PRDX6.To explore whether the activity of peroxidase and PLA2 was associated with PRDX6-mediated antiviral function,a specific inhibitor of PLA2(MJ33)and a specific inhibitor of peroxidase activity(mercaptosuccinate)were used to treat the cells before FMDV infection.The results showed that incubation of MJ33 but not mercaptosuccinate promoted FMDV replication.Meanwhile,overexpression of PRDX6 slightly enhanced type I interferon signaling.We further determined that the viral 3Cprowas responsible for degradation of PRDX6,and 3Cpro-induced reduction of PRDX6 was independent of the proteasome,lysosome,and caspase pathways.The protease activity of 3Cprowas required for induction of PRDX6 reduction.Besides,PRDX6 suppressed the replication of another porcine picornavirus Senecavirus A(SVA),and the 3Cproof SVA induced the reduction of PRDX6 through its proteolytic activity as well.Together,our results suggested that PRDX6 plays an important antiviral role during porcine picornavirus infection,and the viral 3Cproinduces the degradation of PRDX6 to overcome PRDX6-mediated antiviral function. | Congcong Wang Huanhuan Feng Xiangle Zhang Kangli Li Fan Yang Weijun Cao Huisheng Liu Lili Gao Zhaoning Xue Xiangtao Liu Zixiang Zhu Haixue Zheng | 2021 | Virologica Sinica2021，36，5： | 1 |
| 6 | Identification of A-to-I RNA editing profiles and their clinical relevance in lung adenocarcinoma显示文摘Adenosine-to-inosine(A-to-I)RNA editing is a widespread posttranscriptional modification that has been shown to play an important role in tumorigenesis.Here,we evaluated a total of 19,316 RNA editing sites in the tissues of 80 lung adenocarcinoma(LUAD)patients from our Nanjing Lung Cancer Cohort(NJLCC)and 486 LUAD patients from the TCGA database.The global RNA editing level was significantly increased in tumor tissues and was highly heterogeneous across patients.The high RNA editing level in tumors was attributed to both RNA(ADAR1 expression)and DNA alterations(mutation load).Consensus clustering on RNA editing sites revealed a new molecular subtype(EC3)that was associated with the poorest prognosis of LUAD patients.Importantly,the new classification was independent of classic molecular subtypes based on gene expression or DNA methylation.We further proposed a simplified model including eight RNA editing sites to accurately distinguish the EC3 subtype in our patients.The model was further validated in the TCGA dataset and had an area under the curve(AUC)of the receiver operating characteristic curve of 0.93(95%CI:0.91-0.95).In addition,we found that LUAD cell lines with the EC3 subtype were sensitive to four chemotherapy drugs.These findings highlighted the importance of RNA editing events in the tumorigenesis of LUAD and provided insight into the application of RNA editing in the molecular subtyping and clinical treatment of cancer. | Cheng Wang Mingtao Huang Congcong Chen Yuancheng Li Na Qin Zijian Ma Jingyi Fan Linnan Gong Hui Zeng Liu Yang Xianfeng Xu Jun Zhou Juncheng Dai Guangfu Jin Zhibin Hu Hongxia Ma Fengwei Tan Hongbing Shen | 2022 | Science China(Life Sciences)2022，65，1： | 1 |
| 7 | Yak rumen microbiome elevates fiber degradation ability and alters rumen fermentation pattern to increase feed efficiency显示文摘Rumen microbes play an important role in ruminant energy supply and animal performance.Previous studies showed that yak(Bos grunniens)rumen microbiome and fermentation differ from other ruminants.However,little is understood about the features of the rumen microbiome that make yak adapted to their unique environmental and dietary conditions.This study was to investigate the rumen microbiome and metabolome to understand how yak adapt to the coarse forage and harsh environment in the Qinghai-Tibetan plateau.Nine female Qaidam yellow cattle(Bos taurus),9 dzomo(hybrids of cattle and yak)and 9 female plateau yak(B.grunniens),about 5 to 6 years old,were used in this study.Rumen fermentation parameters,fibrolytic enzyme activities,and rumen metataxonomic were determined.Then 18(6 samples per group)were selected for rumen metagenomic and metabolome analysis.Metataxonomic analysis revealed that the rumen microbiota was significantly different among plateau yak,Qaidam yellow cattle,and dzomo(P<0.05).Metagenomic analysis displayed a larger gene pool encoding a richer repertoire of carbohydrate-active enzymes in the rumen microbiome of plateau yak and dzomo than Qaidam yellow cattle(P<0.05).Some of the genes encoding glycoside hydrolases that mediate the digestion of cellulose and hemicellulose were significantly enriched in the rumen of plateau yak than Qaidam yellow cattle,but glycoside hydrolase 57 that primarily includes amylases was abundant in Qaidam yellow cattle(P<0.05).The rumen fermentation profile differed also,Qaidam yellow cattle having a higher molar proportion of acetate but a lower molar proportion of propionate than dzomo and plateau yak(P<0.05).Based on metabolomic analysis,rumen microbial metabolic pathways and metabolites were different.Differential metabolites are mainly amino acids,carboxylic acids,sugars,and bile acids.Changes in rumen microbial composition could explain the above results.The present study showed that the rumen microbiome of plateau yak helps its host to adapt to the Qinghai-Tibetan plateau.In particular,the plateau yak rumen microbiome has more enzymes genes involved in cellulase and hemicellulase than that of cattle,resulting higher fibrolytic enzyme activities inyak,further providing stronger fiber degradation function. | Congcong Zhao Lamei Wang Shanlin Ke Xinhua Chen Akos Kenez Wei Xu Dangdang Wang Fan Zhang Yong Li Zhanhong Cui Yu Qiao Jing Wang Wenjuan Sun Jianhua Zhao Junhu Yao Zhongtang Yu Yangchun Cao | 2022 | Animal Nutrition2022，，4： | 1 |
| 8 | Biological traits and life history of Pagiophloeus tsushimanus(Coleoptera:Curculionidae),a weevil pest on camphor trees in China显示文摘Cinnamomum camphora(L.)J.Presl.(Laurales:Lauraceae)is widely cultivated as an important landscape tree species in many urban areas in South China,especially in Shanghai City.Pagiophloeus tsushimanus Morimoto has become a destructive insect pest of C.camphora plantations in Shanghai,but the biological and ecological traits of this pest remain largely unknown.In this study,we investigated the damage and life history and determined the larval instar of P.tsushimanus.The results indicated that P.tsushimanus is a monophagous weevil pest,and C.camphora is the unique host tree species.C.camphora plantations in all administrative districts of Shanghai have been seriously damaged by P.tsushimanus.Adults often aggregate for feeding on the tender bark of twigs and occasionally on newly emerged buds.After experiencing damage,the twigs shrink and crack and the buds will shrink.Adults tend to repeatedly mate and oviposit,and all females lay single eggs at a time.Eggs will be covered with a mixture of secretions and wood chips by female adults.Larvae(1 st-2 nd instar)feed on the phloem,while 3 rd-5 th instar can bore into the phloem and the cambium.Massive tunnels,including three shapes(inverted'L',inverted'T',and inverted'Z'),were observed in the trunk of each tree,and resulted in swelling of the outer bark.P.tsushimanus has one life cycle per year in Shanghai.Both adults and larvae(3 rd-5 th instar)overwinter from early November to early April.Adults overwinter in grooves on the underside of branches or at branch nodes,and larvae overwinter in tunnels.Five larval instars of P.tsushimanus were determined according to Dyar’s and Crosby’s rules.The biological traits and life history of P.tsushimanus have been identified and can provide guidance in terms of pest control and plantation management. | Cong Chen Congcong Zhang Shouyin Li Han Zhu Binqi Fan Yan Wang Peng Su Yangyang Han Dejun Hao | 2021 | Journal of Forestry Research2021，32，5： | 0 |
| 9 | Effects of high hydrostatic pressure treatment on bacterial composition in donkey milk studied by high throughput sequencing显示文摘High hydrostatic pressure has become a non-thermal alternative to thermal pasteurization in dairy product processing.In this study,we investigated the effects of the treatment of high hydrostatic pressure on the bacterial composition in donkey milk using high-throughput sequencing technology and culture-dependent methods.Compared with the microbial composition in the untreated donkey milk,the relative percentage of Pseudomonas and Acinetobacter in donkey milk after high hydrostatic pressure was significantly decreased by 4.92%and 4.82%,respectively.Beta diversity analysis demonstrated that the treatment of high hydrostatic pressure affected the microbial composition in donkey milk significantly.The potential probiotic Enterococcus casseliflavus isolated from the untreated donkey milk has a good acidifying ability.This study revealed the effects of high hydrostatic pressure treatment on the microbial composition in donkey milk,exhibiting its practical industrial application and the potential use of biological resources in the future. | Jiaqi Kong Wahafu Luoyizha Liang Zhao Congcong Fan Hehe Li Hui Li | 2023 | Food Innovation and Advances2023，2，2： | 0 |
| 10 | Effects of Aromatic Stabilization Energies on Photochromism of New Asymmetrical Azaindole-Containing Diarylethenes显示文摘包含 azaindole 一半和一枚可变 heteroaryl 戒指的三新不均匀的 diarylethenes 被综合了。他们的性质例如对光反应变色,疲劳抵抗,热稳定性, acidichromism,和荧光,系统地被调查阐明 heteroaryl 一半的芳香的稳定精力(ASE ) 的效果。结果显示那热稳定性在 thiazyl 的顺序与可变 heteroaryl 戒指的芳香的稳定精力的增长减少了 < thienyl < pyrrolyl。而且,这些包含 azaindole diarylethenes 的双切换行为被酸 / 底和光的刺激也学习。到这些 diarylethenes 的答案的 trifluoroacetic 酸的增加导致了明显的染色过浅的移动,并且他们的 N-protonated 形式也展出了有利对光反应变色。 | Zhiyuan Sun Congcong Zhang Hui Li Congbin Fan Gang Liu Shouzhi Pu | 2015 | Chinese Journal of Chemistry2015，33，7： | 0 |
| 11 | Cr-doped Na_(3)V_(2)(PO_(4))_(3)@C enables high-capacity with V^(2+)/V^(5+)reaction and stable sodium storage显示文摘Due to its abundant sodium content and low cost,sodium-ion battery(SIB)has become an effective substitute and supplement for lithium-ion batteries,which has a broad development prospect in largescale energy storage systems.Na-super-ionic conductor(NASICON)structural materials have stable 3D skeleton structures and open Na+transport channels,which is a very promising SIB cathode material.But in the typical NASICON material Na_(3)V_(2)(PO_(4))_(3)(NVP),the number of electrons involved in NVP per formula unit is less than 2 at the stable voltage window,which limits the further improvement of battery performance.In this work,we report another NASICON structured Na_(3)V_(4/3)Cr_(2/3)(PO_(4))_(3)@C(NVCP@C),which is obtained by Cr-doped NVP through spray drying.By taking full advantage of the voltage platforms of V^(5+/4+),V^(4+/3+),and V^(3+/2+)in the window of 1.5-4.4 V,NVCP@C delivered a high discharge capacity(175 mAh g^(-1))and durable cyclability(86%capacity retention for 2000 cycles).In-situ X-ray diffraction results demonstrate that the reversible structural evolution accompanies by solid-solution reaction and two-phase reaction mechanisms co-exist during charge/discharge processes.When coupled with Na^(+)preembedded hard carbon(HC),the assembled NVCP@C//HC full cell delivers a high capacity(105 mAh g^(-1))and long cycling performance(70%after 1000 cycles).This Cr-doped NVP method offers new insights into the design of high-energy NASICON-structured cathode materials. | Bo Mai Boyu Xing Yunfan Yue Nianyao Cai Congcong Cai Sitian Lian Hao Fan Mengyu Yan Ting Zhu Ping Hu Xuewen Wang Liqiang Mai | 2023 | Journal of Materials Science & Technology2023，，34： | 0 |
| 12 | Correction to: Porcine Picornavirus 3C Protease Degrades PRDX6 to Impair PRDX6-mediated Antiviral Function显示文摘Correction to:Virologica Sinica(2021)36:948-957 http://gffzzd3cc09b8251d45dfsn9kwocvbxbnq6n5w.ffgz.tsg.suse.edu.cn/10.1007/s12250-021-00352-4 Due to our negligence,the original version of this article,published online on March 15,2021,contained a mistake in Figure 2E(The Knockdown band of Western blotting was provided incorrectly).The correct Fig.2E is given below.We apologize for this error and state that this does not change the scientific conclusions of the article in any way. | Congcong Wang Huanhuan Feng Xiangle Zhang Kangli Li Fan Yang Weijun Cao Huisheng Liu Lili Gao Zhaoning Xue Xiangtao Liu Zixiang Zhu Haixue Zheng | 2021 | Virologica Sinica2021，36，6： | 0 |
| 13 | Association between the M98K variant of the OPTN gene and the risk for primary open angle glaucoma:an updated meta-analysis显示文摘Background:The association between optineurin(OPTN)M98K variant and primary open angle glaucoma(POAG)has been widely investigated.However,the results remain controversial among published meta-analyses.Therefore,we conducted an updated meta-analysis to further explore the association between M98K and POAG and its subgroups.Methods:PubMed,Embase,Web of Science,and China National Knowledge Infrastructure(CNKI)databases were searched to find all articles describing the relationships between the M98K variant and POAG,which were published from the inception to 31 December,2019.The associations between M98K and overall POAG,normal tension glaucoma(NTG),high tension glaucoma(HTG),POAG in Asian and non-Asian populations,juvenile open angle glaucoma(JOAG)and adult-onset POAG were evaluated by calculating the pooled odds ratio(OR)and 95%confidence interval(CI).The Bonferroni correction was used to determine the statistically significant genetic models.Results:A total of 34 eligible articles involving 7,310 POAG patients and 5,173 controls were identified in the present meta-analysis.The articles achieved an average of 6.21 stars for quality assessment by the Newcastle-Ottawa Scale(NOS).Evidence from the pooled results indicated significant association between M98K and overall POAG susceptibility under the dominant model(OR=1.30,95%CI,1.12-1.52;P<0.001).In the subgroup analyses,no significant associations were found between M98K and the risks of NTG,HTG,JOAG,adult-onset POAG,Asian POAG or non-Asian POAG.Conclusions:The updated meta-analysis revealed that OPTN M98K was significantly associated with the susceptibility to overall POAG. | Congcong Guo Xiaowei Yu Dandan Zhang Zhenni Zhao Jiamin Zhang Miao Zhang Nannan Sun Zhigang Fan | 2021 | Annals of Eye Science2021，，2： | 0 |
| 14 | A Highly Selective Chemosensor for Cu^2+ Based on a Diarylethene Linking an Aminoquinoline Unit显示文摘 | Congcong Zhang Congbin Fan Shouzhi Pu Gang Liu | 2015 | Chinese Journal of Chemistry2015，33，11： | 0 |
| 15 | Monaural noisy speech separation combining sparse non-negative matrix factorization and deep attractor network显示文摘The performance of the monaural speech separation method is limited when the speech mixture is disordered by background noise.To obtain the enhanced separated speech from the noisy mixture,a monaural noisy speech separation method combining sparse nonnegative matrix factorization(SNMF)and deep attractor network(DANet)is proposed.This method firstly decomposes the noisy mixture into coefficients of speech and noise respectively.Then the speech coefficient is projected to a high-dimensional embedding space and a DANet is trained to force the embeddings to move to different clusters.The attractor points are used to separate the speech coefficients by masking method,and finally the enhanced separated speeches are reconstructed by the speech basis and their corresponding coefficients.Experimental results in various background noise environments show that the proposed algorithm effectively suppress the noises without decreasing the quality of reconstructed speech by comparison with different baseline methods. | GE Wanying ZHANG Tianqi FAN Congcong ZHANG Tian | 2021 | Chinese Journal of Acoustics2021，40，2： | 0 |
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