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| 1 | Urban and river flooding:Comparison of flood risk management approaches in the UK and China and an assessment of future knowledge needs显示文摘Increased urbanisation,economic growth,and long-term climate variability have made both the UK and China more susceptible to urban and river flooding,putting people and property at increased risk.This paper presents a review of the current flooding challenges that are affecting the UK and China and the actions that each country is undertaking to tackle these problems.Particular emphases in this paper are laid on(1)learning from previous flooding events in the UK and China,and(2)which management methodologies are commonly used to reduce flood risk.The paper concludes with a strategic research plan suggested by the authors,together with proposed ways to overcome identified knowledge gaps in flood management.Recommendations briefly comprise the engagement of all stakeholders to ensure a proactive approach to land use planning,early warning systems,and water-sensitive urban design or redesign through more effective policy,multi-level flood models,and data driven models of water quantity and quality. | Matteo Rubinato Andrew Nichols Yong Peng Jian-min Zhang Craig Lashford Yan-peng Cai Peng-zhi Lin Simon Tait | 2019 | Water Science and Engineering2019，12，4： | 6 |
| 2 | Identification and characterization of a new member of the TNF family that induces apoptosis显示文摘 | Steven R. Wiley Ken Schooley Pamela J. Smolak Wenie S. Din Chang-Pin Huang Jillian K. Nicholl Grant R. Sutherland Terri Davis Smith Charles Rauch Craig A. Smith Raymond G. Goodwin | 1995 | Immunity1995，，6： | 6 |
| 3 | Molecular regulation of telomerase activity in aging显示文摘The process of aging is mitigated by the maintenance and repair of chromosome ends(telomeres),resulting in extended lifespan.This review examines the molecular mechanisms underlying the actions and regulation of the enzyme telomerase reverse transcriptase(TERT),which functions as the primary mechanism of telomere maintenance and regulates cellular life expectancy.Underpinning increased cell proliferation,telomerase is also a key factor in facilitating cancer cell immortalization.The review focuses on aspects of hormonal regulations of telomerase,and the intracellular pathways that converge to regulate telomerase activity with an emphasis on molecular interactions at protein and gene levels.In addition,the basic structure and function of two key telomerase enzyme components—the catalytic subunit TERTand the template RNA(TERC)are discussed briefly. | Craig Nicholls He Li Jian-Qiu Wang Jun-Ping Liu | 2011 | Protein & Cell2011，2，9： | 2 |
| 4 | Wisconsin Ginseng (Panax quinquefolius) to Improve Cancer-Related Fatigue: A Randomized, Double-Blind Trial, N07C2显示文摘 | Debra L. Barton Heshan Liu Shaker R. Dakhil Breanna Linquist Jeff A. Sloan Craig R. Nichols Travis W. McGinn Philip J. Stella Grant R. Seeger Amit Sood Charles L. Loprinzi | 2013 | JNCI Journal of the National Cancer Institute2013，，16： | 1 |
| 5 | Suppression of SHP-2 and ERK Signalling Promotes Self-Renewal of Mouse Embryonic Stem Cells显示文摘 | Tom Burdon Craig Stracey Ian Chambers Jennifer Nichols Austin Smith | 1999 | Developmental Biology1999，，1： | 1 |
| 6 | Extragonadal germ cell tumors of the mediastinum and retroperitoneum:Results from an international analysis显示文摘 | Craig R Nichols Jean-P Droz | 2002 | J Clin Oncol2002，20，： | 1 |
| 7 | Electrodeposition of aluminium film on P90 Li–Al alloy as protective coating against corrosion显示文摘 | U. Bardi S. Caporali M. Craig A. Giorgetti I. Perissi J.R. Nicholls | 2008 | Surface & Coatings Technology2008，，10： | 1 |
| 8 | TGF-beta receptor mediated telomerase inhibition, telomere shortening and breast cancer cell senescence显示文摘人的 telomerase 颠倒 transcriptase (hTERT ) 在为连续房间增长变长的 telomere 起一个中央作用,但是细胞外的暗示怎么调整 telomeres 变长的 telomerase,仍然保持不清楚。这里,我们报导形态基因的 protein-7 (BMP7 ) 导致的 cytokine 骨头在一个 BMPRII 受体依赖者的 hTERT 基因压抑和在人的乳癌房间的 Smad3 依赖的举止。到 BMP7 的人的乳癌房间的 Chonic 暴露导致短 telomeres,房间老朽和 apoptosis。BMPRII 受体的变化,然而并非 TGFbRII, ACTRIIA 或 ACTRIIB 受体,禁止 hTERT 基因倡导者活动的导致 BMP7 的压抑,导致增加了 telomerase 活动,变长的 telomeres 和继续的房间增长。hTERT 的表示阻止导致 BMP7 的乳癌房间老朽和 apoptosis。因此,我们的数据建议 BMP7 由包含 BMPRII 的机制导致乳癌房间老化 hTERT 基因的调停受体、调停 Smad3 的压抑。 | Lucy Cassar Craig Nicholls Alex R. Pinto Ruping Chen Lihui Wang He Li Jun-Ping Liu | 2017 | Protein & Cell2017，8，1： | 1 |
| 9 | Low-protein diet accelerates wound healing in mice post-acute injury显示文摘Background:Wound healing processes are influenced by macronutrient intake(protein,carbohydrate and fat).The most favourable diet for cutaneous wound healing is not known,although highprotein diets are currently favoured clinically.This experimental study investigates the optimal macronutrient balance for cutaneous wound healing using a mouse model and the Geometric Framework,a nutrient modelling method,capable of analyzing the individual and interactive effects of a wide spectrum of macronutrient intake.Methods:Two adjacent and identical full-thickness skin excisions(1 cm^(2))were surgically created on the dorsal area of male C57BL/6 mice.Mice were then allocated to one of 12 high-energy diets that varied in protein,carbohydrate and fat content.In select diets,wound healing processes,cytokine expression,energy expenditure,body composition,muscle and fat reserves were assessed.Results:Using the Geometric Framework,we show that a low-protein intake,coupled with a balanced intake of carbohydrate and fat is optimal for wound healing.Mice fed a low-protein diet progressed quickly through wound healing stages with favourable wound inflammatory cytokine expression and significantly accelerated collagen production.These local processes were associated with an increased early systemic inflammatory response and a higher overall energy expenditure,related to metabolic changes occurring in key macronutrient reserves in lean body mass and fat depots.Conclusions:The results suggest that a low-protein diet may have a greater potential to accelerate wound healing than the current clinically used high-protein diets. | Jonathan J.Hew Roxanne J.Parungao Craig P.Mooney Julian K.Smyth Sarah Kim Kevin H.-Y.Tsai Huaikai Shi Cassandra Chong Renee C.F.Chan Beba Attia Caroline Nicholls Zhe Li Samantha M.Solon-Biet David G.Le Couteur Stephen J.Simpson Marc G.Jeschke Peter K.Maitz Yiwei Wang | 2021 | Burns & Trauma2021，9，1： | 0 |
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