|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Molecular Epidemiological Characteristics of Streptococcus pyogenes Strains Involved in an Outbreak of Scarlet Fever in China,2011显示文摘Objective To investigate molecular characterization of streptococcus pyogenes isolates involved in an outbreak of scarlet fever in China in 2011.Methods Seventy-four Streptococcal pyogenes involved in an outbreak of scarlet fever were isolated from pediatric patients in the areas with high incidence in China from May to August of 2011.Emm genotyping,pulsed-field gel electrophoresis (PFGE),superantigen (SAg) genes and antimicrobial susceptibility profiling were analyzed for these isolates.Results A total of 4 different emm types were identified.Emm12 was the most prevalent type which contained four predominating PFGE patterns corresponding to four different virulence and superantigen profiles.Emm12 (79.7%) and emml (14.9%) accounted for approximately 94%of all the isolates.The speA gene was all negative in emm12 isolates and positive in emml isolates.All strains were resistant to erythromycin,and 89.4%of them were resistant to erythromycin,tracycline,and clindamycin simultaneously.Conclusion Several highly diversified clones with a high macrolide resistance rate comprise a predominant proportion of circulating strains,though no new emm type was found in this outbreak.The data provide a baseline for further surveillance of scarlet fever,which may contribute to the explanation of the outbreak and development of a GAS vaccine in China. | YOU Yuan Hai SONG Yan Yan YAN Xiao Mei WANG Hai Bin ZHANG Meng Han TAO Xiao Xia Li Lei Lei ZHANG Yu Xin JIANG Xi Hong ZHANG Bing Hua ZHOU Hao XIAO Di JIN Lian Mei FENG Zi Jian LUO Feng Ji ZHANG Jian Zhong | 2013 | Biomedical and Environmental Sciences2013，26，11： | 15 |
| 2 | Involvement of Plasma Membrane H+-ATPase in Adaption of Rice to Ammonium Nutrient显示文摘The preference of paddy rice for NH4+ rather than NO3ˉ is associated with its tolerance to low pH since a rhizosphere acidification occurs during NH4+ absorption.However,the adaptation of rice root to low pH has not been fully elucidated.The plasma membrane H+-ATPase is a universal electronic H+ pump,which uses ATP as energy source to pump H+ across the plasma membranes into the apoplast.The key function of this enzyme is to keep pH homeostasis of plant cells and generate a H+ electrochemical gradient,thereby providing the driving force for the active influx and efflux of ions and metabolites across the plasma membrane.This study investigated the acclimation of plasma membrane H+-ATPase of rice root to low pH.This mechanism might be partly responsible for the preference of rice plants to NH4+ nutrition. | Yi-yong ZHU Juan LIAN Hou-qing ZENG Liu GAN Ting-jun DI Qi-rong SHEN Guo-hua XU | 2011 | Rice science2011，18，4： | 4 |
| 3 | Intravaginal Misoprostol for Cervical Ripening and Labor Induction in Nulliparous Women: A Double-blinded, Prospective Randomized Controlled Study显示文摘 | Yu Zhang Hao-Ping Zhu Jian-Xia Fan Hong Yu Li-Zhou Sun Lian Chen Qing Chang Nai-Qing Zhao Wen Di | 2015 | Chinese Medical Journal2015，，20： | 4 |
| 4 | The Axin/TNKS complex interacts with KIF3A and is required for insulin-stimulated GLUT4 translocation显示文摘由葡萄糖 transporter GLUT4 的刺激胰岛素的葡萄糖举起在整个身体的葡萄糖动态平衡起一个中央作用,哪个导致类型 2 糖尿病的 dysregulation。然而,调整刺激胰岛素的葡萄糖举起的分子的部件和机制仍然保持大部分不清楚。这里,我们证明 Axin 与 ADP-ribosylase tankyrase 交往 2 (TNKS2 ) 并且 kinesin 马达蛋白质 KIF3A,响应胰岛素形成为 GLUT4 translocation 关键的第三的建筑群。特定到血浆膜的复杂稀释刺激胰岛素的 GLUT4 translocation 的单个部件击倒。重要地, TNKS2 −/− 老鼠展出减少的胰岛素敏感和更高的血葡萄糖层次什么时候在 fasting 以后的 re-fed。机械学地,我们证明当胰岛素不在时, Axin, TNKS 和 KIF3A 与 trans-Golgi 网络上的 GLUT4 是 co 局部性的。胰岛素处理压制 TNKS 的 ADP-ribosylase 活动,导致在自动数据处理 ribosylation 和 ubiquitination 的减小 Axin 和 TNKS,和建筑群的并发的稳定。Akt 的抑制,胰岛素发信号的主要受动器 kinase,废除调停胰岛素的复杂稳定。我们因此阐明了直接在刺激胰岛素的 GLUT4 translocation 与马达蛋白质 kinesin 被联系的新蛋白质建筑群。 | Hui-Ling Guo Cixiong Zhang Qi Liu Qinxi Li Guili Lian Di Wu Xuebin Li Wei Zhang Yuemao Shen Zhiyun Ye Slau-Yong Lin Sheng-Cai Lin | 2012 | Cell Research2012，22，8： | 4 |
| 5 | Widely tunable,heterogeneously integrated quantum-dot O-band lasers on silicon显示文摘Heterogeneously integrated lasers in the O-band are a key component in realizring low-power optical interconnects for data centers and high-performance computing.Quantum-dot-based materials have been particularly appealing for light generation due to their ultralow lasing thresholds,small linewidth enhancement factor,and low sensitivity to reflections.Here,we present widely tunable quantum-dot lasers heterogencously integrated on silicon-on-insulator substrate.The tuning mechanism is based on Vernier dual-ring geometry,and a 47nm tuning range with 52 dB side-mode suppression ratio is observed.These parameters show an increase to 52nm and 58 dB,respectively,when an additional wavelength filter in the form of a Mach-Zehnder interferometer is added to the cavity.The Lorentzian linewidth of the lasers is measured as low as 5.3 kHz. | ADITYA MALIK JOEL GUO MINH A.TRAN GEZA KURCZVEIL DI LIAN JOHN EBOWERS | 2020 | Photonics Research2020，8，10： | 4 |
| 6 | Broadband mid-infrared molecular spectroscopy based on passive coherent optical–optical modulated frequency combs显示文摘Mid-infrared dual-comb spectroscopy is of great interest owing to the strong spectroscopic features of trace gases,biological molecules,and solid matter with higher resolution,accuracy,and acquisition speed. However,the prerequisite of achieving high coherence of optical sources with the use of bulk sophisticated control systems prevents their widespread use in field applications. Here we generate a highly mutually coherent dual midinfrared comb spectrometer based on the optical–optical modulation of a continuous-wave (CW) interband or quantum cascade laser. Mutual coherence was passively achieved without post-data processes or active carrier envelope phase-locking processes. The center wavelength of the generated mid-infrared frequency combs can be flexibly tuned by adjusting the wavelength of the CW seeds. The parallel detection of multiple molecular species,including C_(2)H_(2),CH_(4),H_(2)CO,H_(2)S,COS,and H_(2)O,was achieved. This technique provides a stable and robust dual-comb spectrometer that will find nonlaboratory applications including open-path atmospheric gas sensing,industrial process monitoring,and combustion. | ZHONG ZUO CHENGLIN GU DAOWANG PENG XING ZOU YUANFENG DI LIAN ZHOU DAPING LUO YANG LIU WENXUE LI | 2021 | Photonics Research2021，9，7： | 3 |
| 7 | Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial显示文摘Recent evidence suggests that CD147 serves as a novel receptor for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection.Blocking CD147 via anti-CD147 antibody could suppress the in vitro SARS-CoV-2 replication.Meplazumab is a humanized anti-CD147 IgG_(2) monoclonal antibody,which may effectively prevent SARS-CoV-2 infection in coronavirus disease 2019(COVID-19)patients.Here,we conducted a randomized,double-blinded,placebo-controlled phase 1 trial to evaluate the safety,tolerability,and pharmacokinetics of meplazumab in healthy subjects,and an open-labeled,concurrent controlled add-on exploratory phase 2 study to determine the efficacy in COVID-19 patients.In phase 1 study,59 subjects were enrolled and assigned to eight cohorts,and no serious treatment-emergent adverse event(TEAE)or TEAE grade≥3 was observed.The serum and peripheral blood Cmax and area under the curve showed non-linear pharmacokinetic characteristics.No obvious relation between the incidence or titer of positive anti-drug antibody and dosage was observed in each cohort.The biodistribution study indicated that meplazumab reached lung tissue and maintained>14 days stable with the lung tissue/cardiac blood-pool ratio ranging from 0.41 to 0.32.In the exploratory phase 2 study,17 COVID-19 patients were enrolled,and 11 hospitalized patients were involved as concurrent control.The meplazumab treatment significantly improved the discharged(P=0.005)and case severity(P=0.021),and reduced the time to virus negative(P=0.045)in comparison to the control group.These results show a sound safety and tolerance of meplazumab in healthy volunteers and suggest that meplazumab could accelerate the recovery of patients from COVID-19 pneumonia with a favorable safety profile. | Huijie Bian Zhao-Hui Zheng Ding Wei Aidong Wen Zheng Zhang Jian-Qi Lian Wen-Zhen Kang Chun-Qiu Hao Jing Wang Rong-Hua Xie Ke Dong Jie-Lai Xia Jin-Lin Miao Wen Kang Guoquan Li Di Zhang Mingru Zhang Xiu-Xuan Sun Likun Ding Kui Zhang Junfeng Jia Jin Ding Zhiqin Li Yanyan Jia Lin-Na Liu Zhe Zhang Zhao-Wei Gao Hong Du Na Yao Qing Wang Ke Wang Jie-Jie Geng Bin Wang Ting Guo Ruo Chen Yu-Meng Zhu Li-Juan Wang Qian He Rui-Rui Yao Ying Shi Xiang-Min Yang Jian-Sheng Zhou Yi-Nan Ma Ya-Tao Wang Xue Liang Fei Huo Zhe Wang Yang Zhang Xu Yang Ye Zhang Lu-Hua Gao Ling Wang Xiao-Chun Chen Hao Tang Shuang-Shuang Liu Qing-Yi Wang Zhi-Nan Chen Ping Zhu | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 2 |
| 8 | The MING proposal at SHINE:megahertz cavity enhanced X‑ray generation显示文摘The cavity-based X-ray free-electron laser(XFEL)has promise in producing fully coherent pulses with a bandwidth of a few meV and very stable intensity,whereas the currently existing self-amplified spontaneous emission(SASE)XFEL is capable of generating ultra-short pulses with chaotic spectra.In general,a cavity-based XFEL can provide a spectral brightness three orders of magnitude higher than that of the SASE mode,thereby opening a new door for cutting-edge scientific research.With the development of superconducting MHz repetition-rate XFEL facilities such as FLASH,European-XFEL,LCLS-II,and SHINE,practical cavity-based XFEL operations are becoming increasingly achievable.In this study,megahertz cavity enhanced X-ray generation(MING)is proposed based on China’s first hard XFEL facility-SHINE,which we refer to as MING@SHINE. | Nan‑Shun Huang Zi‑Peng Liu Bang‑Jie Deng Zi‑Han Zhu Shao‑Hua Li Tao Liu Zheng Qi Jia‑Wei Yan Wei Zhang Sheng‑Wang Xiang Yang‑Yang Lei Ya Zhu Yong‑Zhou He Qi‑Bing Yuan Fei Gao Rong‑Bing Deng Sen Sun Zhi‑Di Lei Zhi‑Qiang Jiang Meng‑Qi Duan Yuan Zhuan Xue‑Fang Huang Peng‑Cheng Dong Zhong‑Liang Li Shang‑Yu Si Lian Xue Si Chen Yong‑Fang Liu Ya‑Jun Tong Hai‑Xiao Deng Zhen‑Tang Zhao | 2023 | Nuclear Science and Techniques2023，34，1： | 2 |
| 9 | RHOBTB3 promotes proteasomal degradation of HIFa through facilitating hydroxylation and suppresses the Warburg effect显示文摘 | Chen-Song Zhang Qi Liu Mengqi Li Shu-Yong Lin Yongying Peng Di Wu Terytty Yang Li Qiang Fu Weiping Jia Xinjun Wang Teng Ma Yue Zong Jiwen Cui Chengfei Pu Guili Lian Huiling Guo Zhiyun Ye Sheng-Cai Lin | 2015 | Cell Research2015，25，9： | 2 |
| 10 | Effect of the lenticles on moisture migration in capillary zone of tailings dam显示文摘Small-particle interlayers(lenticles)show some characteristic hydraulic properties and can affect the movement of unsaturated water.In this study,we developed a novel online capillary-water-absorption monitoring device and conducted three groups of comparison tests to simulate lenticle positions and thicknesses with respect to the capillary rise.The results show that the characteristic wetting front exhibits a fast rise in the early stage,a slow rise in the middle stage,and stability in the later stage.The motion of the capillary water in the lenticle is mainly transversal,with the upward curve being'flat,'and the longer is'flat,'the longer is the time needed for the water to move.The interlayer can form a capillary stagnation zone with moisture content close to saturation.The high interlayer may form a discontinuous corrugated capillary zone.Thus,when the wetting front reaches the'coarse-grain(lower)-fine-grain(upper)'interface,the'anti-capillary barrier effect'results in more moisture in the upper layer.Thus,when the wetting front of the capillary water reaches the'fine-grain(upper)-coarse-grain(lower)'interface,the'capillary barrier effect'causes the moisture content of the upper tailings to decreases sharply because of the horizontal movement of the water in the fine medium.It is clear that the presence of lenticles can retard the rise of capillary water by storing water. | Di Liu Min-jie Lian Cai-wu Lu Wen Zhang | 2020 | International Journal of Minerals,Metallurgy and Materials2020，27，8： | 2 |
| 11 | Efficient production of pronuclear embryos in breeding and nonbreeding season for generating transgenic sheep overexpressing TLR4显示文摘Background: Brucella is a zoonotic Gram-negative pathogen that causes abortion and infertility in ruminants and humans. TLR4 is the receptor for LPS which can recognize Brucella and initiate antigen-presenting cell activities that affect both innate and adaptive immunity. Consequently, transgenic sheep over-expressing TLR4 are an suitable model to investigate the effects of TLR4 on preventing Brucellosis. In this study, we generated transgenic sheep overexpressing TLR4 and aimed to evaluate the effects of different seasons(breeding and non-breeding season) on superovulation and the imported exogenous gene on growth.Results: In total of 43 donor ewes and 166 recipient ewes in breeding season, 37 donor ewes and 144 recipient ewes in non-breeding season were selected for super-ovulation and injected embryo transfer to generate transgenic sheep.Our results indicated the no. of embryos recovered of donors and the rate of pronuclear embryos did not show any significant difference between breeding and non-breeding seasons(P > 0.05). The positive rate of exogenous TLR4 tested were 21.21 % and 22.58 % in breeding and non-breeding season by Southern blot. The expression level of TLR4 in the transgenic sheep was 1.5 times higher than in the non-transgenic group(P < 0.05). The lambs overexpressing TLR4 had similar growth performance with non-transgenic lambs, and the blood physiological parameters of transgenic and non-transgenic were both in the normal range and did not show any difference.Conclusions: Here we establish an efficient platform for the production of transgenic sheep by the microinjection of pronuclear embryos during the whole year. The over-expression of TLR4 had no adverse effect on the growth of the sheep. | Yan Li Di Lian Shoulong Deng Xiaosheng Zhang Jinlong Zhang Wenting Li Hai Bai Zhixian Wang Hongping Wu Juncai Fu Hongbing Han Jianzhong Feng Guoshi Liu Ling Lian Zhengxing Lian | 2017 | Journal of Animal Science and Biotechnology2017，8，1： | 2 |
| 12 | The hepatitis B virus X protein promotes hepatocellular carcinoma metastasis by upregulation of matrix metalloproteinases显示文摘 | Di‐PengOu Yi‐MingTao Fa‐QingTang Lian‐YueYang | 2007 | Int J Cancer2007，，6： | 1 |
| 13 | Down‐regulated desmocollin‐2 promotes cell aggressiveness through redistributing adherens junctions and activating beta‐catenin signalling in oesophageal squamous cell carcinoma显示文摘 | Wang‐Kai Fang Lian‐Di Liao Li‐Yan Li Yang‐Min Xie Xiu‐E Xu Wei‐Jiang Zhao Jian‐Yi Wu Meng‐Xiao Zhu Zhi‐Yong Wu Ze‐Peng Du Bing‐Li Wu Dong Xie Ming‐Zhou Guo Li‐Yan Xu En‐Min Li | 2013 | J Pathol2013，，2： | 1 |
| 14 | A study of the initial adhesive force of cells on silk fibroin-based materials using micropipette aspiration显示文摘With the development of biomaterials,more attention is paid to the adhesion characteristics between cells and materials.It is necessary to study the adhesive force with a suitable method.Silk fibroin(SF)is widely investigated in biomedical application due to its novel biocompatibility and mechanical properties.In this article,the micropipette aspiration method and measurement pattern of uniform cells in round shape(UCR)was used to study the initial adhesive force of three types of cells on pure silk fibroin films(SFFs).We also compared the adhesive forces of modified SFFs with that of pure SFFs.The results of adhesive force in the initial adhesive stage were in concordance with the results of MTT assay andmicroscope observation,which were confirmed by the above three cell lines and four kinds of SFFs.The results indicated UCR was an efficient and quantitative measurement pattern in initial adhesion stage.This article also provides a useful method in identifying initial cell-materials interactions. | Xiaojie Lian Shichao Liu Liming Liu Rui Xu Miaomiao Du Song Wang Hesun Zhu Qiang Lu Quanyou Zhang Yali Wu Di Huang Yan Wei | 2018 | Regenerative Biomaterials2018，5，3： | 1 |
| 15 | Class reunion: PTEN joins the nuclear crew 显示文摘 | Lian Z Di Cristofano A | 2005 | Oncogene2005，24，50： | 1 |
| 16 | MiR‐142‐3p as a potential prognostic biomarker for esophageal squamous cell carcinoma显示文摘 | Rui‐Jun Lin Da‐Wei Xiao Lian‐Di Liao Tao Chen Ze‐Feng Xie Wei‐Zhe Huang Wei‐Sen Wang Tai‐Feng Jiang Bing‐Li Wu En‐Min Li Li‐Yan Xu | 2012 | J. Surg. Oncol2012，，2： | 1 |
| 17 | Assembly of flower-like VS_(2)/N-doped porous carbon with expanded(001)plane on rGO for superior Na-ion and K-ion storage显示文摘VS2 with natural layered structure and metallic conductivity is a prospective candidate for sodium-ion batteries(SIBs)and potassium-ion batteries(PIBs).However,due to large radius of Na+and K+,the limited interlayer spacing(0.57 nm)of VS2 generally determines high ion diffusion barrier and large volume variation,resulting in unsatisfactory electrochemical performance of SIBs and PIBs.In this work,flower-like VS_(2)/N-doped carbon(VS_(2)/N-C)with expanded(001)plane is grown on reduced graphene oxide(rGO)via a solvothermal and subsequently carbonization strategy.In the VS_(2)/N-C@rGO nanohybrids,the ultrathin VS2'petals'are alternately intercalated by the N-doped porous carbon monolayers to achieve an expanded interlayer spacing(1.02 nm),which can effectively reduce ions diffusion barrier,expose abundant active sites for Na+/K+intercalation,and tolerate large volume variation.The N-C and rGO carbonous materials can significantly promote the electrical conductivity and structural stability.Benefited from the synergistic effect,the VS2/N-C@rGO electrode exhibits large reversible capacity(Na+:407 mAh·g^(-1) at 1 A·g^(-1);K^(+):334 mAh·g^(-1) at 0.2 A·g^(-1)),high rate capacity(Na+:273 mAh·g^(-1) at 8 A·g^(-1);K+:186 mAh·g^(-1) at 5 A·g^(-1)),and remarkable cycling stability(Na+:316 mAh·g^(-1) at 2 A·g^(-1) after 1,400 cycles;K^(+):216 mAh·g^(-1) at 1 A·g^(-1) after 500 cycles). | Junwei Sun Gang Lian Laiying Jing Di Wu Deliang Cui Qilong Wang Haohai Yu Huaijin Zhang Ching-Ping Wong | 2022 | Nano Research2022，15，5： | 1 |
| 18 | Steroids therapy for eosinophilic esophagitis: Systematic review and meta‐analysis显示文摘 | Nian Di Tan Ying Lian Xiao Min Hu Chen | 2015 | Journal of Digestive Diseases2015，，： | 1 |
| 19 | Phosphorylation of Parkin by Parkinson disease-linked kinase PINKI activates Parkin E3 ligase function and NF-KB signaling显示文摘 | Di Sha Lih-shen Chin Lian Li | 2010 | Hum Mol Genet2010，19，2： | 1 |
| 20 | Study on the structural changes of bovine serum albumin with effects on polydatin binding by a muhitechnique approach 显示文摘 | Peng-Xia Lian Yao Di Bian-He Dong etal | 2011 | Speetrochimiea Aeta Part A2011，81，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员