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| 1 | Hepatocellular carcinoma in extremely elderly patients:An analysis of clinical characteristics,prognosis and patient survival显示文摘瞄准:80 年或更多与肝细胞癌(HCC ) 识别病人的临床、预示的特征。方法:有 HCC 的 1310 个病人的一个总数在这研究被包括。80 年或更多的 91 个病人在 HCC 的诊断的时候被定义为极其老的组。>
或 = 的 234 个病人 50 年但是不到 60 年被认为是非老的组。结果:两性比率(到女性的男性) 比在非老的组在极其老的组(0.90:1 ) 是显著地更低的(3.9:1, P <
0.001 ) 。为 HBsAg 的积极的率在极其老的组和为显然在极其老的组增加的 HBsAg 和 HCVAb 否定的病人的比例是显著地更低的(P <
0.001 ) 。在下列参数没有有效差量:肿瘤,分级的孩子呸,肿瘤阶段,门静脉血栓形成或腹水的存在,和为 HCVAb 的积极的率的直径和数字。极其老的病人经常没收到外科疗法(P <
0.001 ) 并且他们是更可能的收到保守疗法(P <
0.01 ) 。基于与在二个组之间的全面病人比较的 Kaplan-Meier 方法在幸存曲线没有有效差量。然而,幸存曲线在有阶段 I/II 的极其老的病人是显著地更坏的,上演 I/II,孩子呸分级与非老的组比较的肝硬化。死亡的原因没在病人之中不同,并且大多数盒子甚至在极其老的病人死于肝相关的疾病。结论:在有好肝功能和好表演地位的病人,为 HCC 的好攻击的治疗可能改进幸存率,甚至在极其老的病人。 | Gengo Tsukioka Satoru Kakizaki Naondo Sohara Ken Sato Hitoshi Takagi Hirotaka Arai Takehiko Abe Mitsuo Toyoda Kenji Katakai Akira Kojima Yuichi Yamazaki Toshiyuki Otsuka Yutaka Matsuzaki Fujio Makita Daisuke Kanda Katsuhiko Horiuchi Tetsuya Hamada Mieko Kaneko Hideyuki Suzuki Masatomo Mori | 2006 | World Journal of Gastroenterology2006，12，1： | 7 |
| 2 | Two-week treatment with proton pump inhibitor is sufficient for healing post endoscopic submucosal dissection ulcers显示文摘AIM:To investigate the optimum period of treatment for post endoscopic submucosal dissection(ESD)ulcers.METHODS:Patients who underwent ESD for gastric cancer were randomized to two groups and treated with esomeprazole 20 mg per day for 4 wk(4W group)or 2 wk(2W group).At 4 wk after ESD,we measured the size of the artificial ulcers by endoscopy and determined the ulcer healing rate,compared with the size of the ESD specimens.This randomized controlled trial study was approved by our ethics committee and registered in the UMIN Clinical Trial Registry.RESULTS:A total of 60 consecutive patients were included in the study.All patients received rebamipide 300 mg per day for 4 wk.One patient in 2W group who showed bleeding within two weeks and received endoscopic treatment was excluded from further analysis.The numbers of patients with ulcers in the healing/scar stage in the 2W and 4W groups at 4 wk after ESD were 20/6 and 28/5,respectively,with no significant difference.The ulcer healing rate in the 2W and 4W groups were 96.1%[95%confidence interval(CI):94.6%-97.55]vs 94.8%(95%CI:92.6%-97.1%),respectively,with no statistical difference(UMIN000006951).CONCLUSION:Two-wk treatment with a proton pump inhibitor is as effective as four-week treatment for healing post ESD ulcers. | Makoto Arai Tomoaki Matsumura Kenichiro Okimoto Arata Oyamada Keiko Saito Shoko Minemura Daisuke Maruoka Takeshi Tanaka Tomoo Nakagawa Tatsuro Katsuno Osamu Yokosuka | 2014 | World Journal of Gastroenterology2014，20，43： | 6 |
| 3 | 在有阴暗胃肠的流血的病人的囊内视镜检查法的计算图象修正的功效显示文摘 AIM:To investigate whether flexible spectral color enhancement(FICE) improves diagnostic yields of capsule endoscopy(CE) for obscure gastro-intestinal bleeding(OGIB).METHODS:The study subjects consisted of 81 patients.Using FICE,there were three different sets with different wavelengths.Using randomly selected sets of FICE,images of CE were evaluated again by two individuals who were not shown the conventional CE reports and findings.The difference between FICE and conventional imaging was examined.RESULTS:The overall diagnostic yields in FICE sets 1,2,3 and conventional imaging(48.1%) were 51.9%,40.7%,51.9% and 48.1%,respectively,which showed no statistical difference compared to conventional imaging.The total numbers of detected lesions per examination in FICE imaging and conventional imaging were 2.5 ± 2.1 and 1.8 ± 1.7,respectively,which showed a significant difference(P = 0.01).CONCLUSION:The diagnostic yield for OGIB is not improved by FICE.However,FICE can detect significantly more small bowel lesions compared to conventional imaging. | Tomoaki Matsumura Makoto Arai Toru Sato Tomoo Nakagawa Daisuke Maruoka Masaru Tsuboi Sachio Hata Eiji Arai Tatsuro Katsuno Fumio Imazeki Osamu Yokosuka | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，9： | 4 |
| 4 | Membrane lipid saturation activates IRE 1α without inducing clustering显示文摘 | Yuto Kitai Hiroyuki Ariyama Nozomu Kono Daisuke Oikawa Takao Iwawaki Hiroyuki Arai | 2013 | Genes Cells2013，，9： | 1 |
| 5 | Stent Placement for Atherosclerotic Stenosis of the Vertebral Artery Ostium: Angiographic and Clinical Outcomes in 117 Consecutive Patients显示文摘 | Taketo Hatano Tetsuya Tsukahara Akinori Miyakoshi Daisuke Arai Susumu Yamaguchi Mamoru Murakami | 2011 | Neurosurgery2011，，1： | 1 |
| 6 | CT assessment of breast cancer for pathological involvement of four or more axillary nodes显示文摘 | Ichiro Ogino Yoshibumi Tayama Mito Arai Tomio Inoue Daisuke Shimizu Takashi Ishikawa | 2012 | Breast Cancer2012，，2： | 1 |
| 7 | Device-physics-based analytical model for single-event transients in SO1 CMOS logic显示文摘 | Daisuke Kobayashi Kazuyuki Hirose Veronique Ferlet- Cavrois Dale McMorrow Takahiro Makino Hirokazu Ike- da Yasuo Arai and Morifumi Ohno | 2009 | IEEE Trans Nucl Sci2009，56，6： | 1 |
| 8 | Reclassification of Methylobacterium chloromethanicum and Methylobacterium dichloromethanlcum as later subjective synonyms of Methylobacterlum extorquens and of Methy-lobacterium lusitanum as a later subjective synonym of Methylobacterium rhodesianum显示文摘 | Yuko Kato Mika Asahara Daisuke Arai | 2005 | J Gen Appl Microbioi2005，51，： | 1 |
| 9 | BCR/ABL activates Rap1 and B-Raf to stimulate the MEK/Erk signaling pathway in hematopoietic cells显示文摘 | Daisuke Mizuchi Tetsuya Kurosu Aiko Kida Zhen-Hua Jin Aishun Jin Ayako Arai Osamu Miura | 2004 | Biochemical and Biophysical Research Communications2004，，3： | 1 |
| 10 | Protein-losing enteropathy caused by a jejunal ulcer after an internal hernia in Petersen's space: A case report显示文摘BACKGROUND The incidence of internal hernias has recently increased in concordance with the popularization of laparoscopic surgery.Of particular concern are internal hernias occurring in Petersen's space,a space that is surgically created after treatment for gastric cancer and obesity.These hernias cause devastating sequelae,such as massive intestinal necrosis,fatal Roux limb necrosis,and superior mesenteric vein thrombus.In addition,protein-losing enteropathy(PLE)is a rare syndrome involving gastrointestinal protein loss,although its relationship with internal Petersen’s hernias remains unknown.CASE SUMMARY A 75-year-old man with a history of laparotomy for early gastric cancer developed Petersen's hernia 1 year and 5 mo after surgery.He was successfully treated by reducing the incarcerated small intestine and closure of Petersen’s defect without resection of the small intestine.Approximately 3 mo after his surgery for Petersen’s hernia,he developed bilateral leg edema and hypoalbuminemia.He was diagnosed with PLE with an alpha-1 antitrypsin clearance of 733 mL/24 h.Double-balloon enteroscopy revealed extensive jejunal ulceration as the etiology,and it facilitated minimum bowel resection.Pathological analysis showed extensive jejunal ulceration and collagen hyperplasia with nonspecific inflammation of all layers without lymphangiectasia,lymphoma,or vascular abnormalities.His postoperative course was unremarkable,and his bilateral leg edema and hypoalbuminemia improved after 1 mo.There was no relapse over the 5-year follow-up period.CONCLUSION PLE and extensive jejunal ulceration may occur after Petersen's hernia.Doubleballoon enteroscopy helps identify and resect these lesions. | Tomohiko Yasuda Nobuyuki Sakurazawa Komei Kuge Jun Omori Hiroki Arai Daisuke Kakinuma Masanori Watanabe Hideyuki Suzuki Katsuhiko Iwakiri Hiroshi Yoshida | 2022 | World Journal of Clinical Cases2022，10，1： | 1 |
| 11 | Activation of the FGF2-FGFR1 Autocrine Pathway: A Novel Mechanism of Acquired Resistance to Gefitinib in NSCLC显示文摘 | Hideki Terai Kenzo Soejima Hiroyuki Yasuda Sohei Nakayama Junko Hamamoto Daisuke Arai Kota Ishioka Keiko Ohgino Shinnosuke Ikemura Takashi Sato Satoshi Yoda Ryosuke Satomi Katsuhiko Naoki Tomoko Betsuyaku | 2013 | Molecular Cancer Research2013，，7： | 1 |
| 12 | Expression level of sonic hedgehog correlated with the speed of gastric mucosa regeneration in artificial gastric ulcers显示文摘 | Takeshi Tanaka Makoto Arai Shoko Minemura Arata Oyamada Keiko Saito Xia Jiang Masaru Tsuboi Sayuri Sazuka Daisuke Maruoka Tomoaki Matsumura Tomoo Nakagawa Shigeru Sugaya Tatsuo Kanda Tatsuro Katsuno Kazuko Kita Takashi Kishimoto Fumio Imazeki Atsushi Kane | 2014 | J Gastroenterol Hepatol2014，，4： | 1 |
| 13 | Integrated micro-endeffector for micromanipulation 显示文摘 | Arai Fumihito Andou Daisuke Nonoda Yukio | 1998 | IEEE/ASME Transactions on Mecha-tronics1998，3，1： | 1 |
| 14 | Factors Associated with Inadequate Tissue Yield in EUS-FNA for Gastric SMT显示文摘 | Takuto Suzuki Makoto Arai Tomoaki Matsumura Eiji Arai Sachio Hata Daisuke Maruoka Takeshi Tanaka Shingo Nakamoto Fumio Imazeki Osamu Yokosuka L. Bonavina A. W. Mangel | 2011 | ISRN Gastroenterology2011，，： | 1 |
| 15 | Utility of plasma D-dimer for diagnosis of venous thromboembolism after hepatectomy显示文摘BACKGROUND Venous thromboembolism(VTE)is a potentially fatal complication of hepatectomy.The use of postoperative prophylactic anticoagulation in patients who have undergone hepatectomy is controversial because of the risk of postoperative bleeding.Therefore,we hypothesized that monitoring plasma D-dimer could be useful in the early diagnosis of VTE after hepatectomy.AIM To evaluate the utility of monitoring plasma D-dimer levels in the early diagnosis of VTE after hepatectomy.METHODS The medical records of patients who underwent hepatectomy at our institution between January 2017 and December 2020 were retrospectively analyzed.Patients were divided into two groups according to whether or not they developed VTE after hepatectomy,as diagnosed by contrast-enhanced computed tomography and/or ultrasonography of the lower extremities.Clinicopathological factors,including demographic data and perioperative D-dimer values,were compared between the two groups.Receiver operating characteristic curve analysis was performed to determine the D-dimer cutoff value.Univariate and multivariate analyses were performed using logistic regression analysis to identify significant predictors.RESULTS In total,234 patients who underwent hepatectomy were,of whom(5.6%)were diagnosed with VTE following hepatectomy.A comparison between the two groups showed significant differences in operative time(529 vs 403 min,P=0.0274)and blood loss(530 vs 138 mL,P=0.0067).The D-dimer levels on postoperative days(POD)1,3,5,7 were significantly higher in the VTE group than in the non-VTE group.In the multivariate analysis,intraoperative blood loss of>275 mL[odds ratio(OR)=5.32,95%confidence interval(CI):1.05-27.0,P=0.044]and plasma D-dimer levels on POD 5≥21μg/mL(OR=10.1,95%CI:2.04-50.1,P=0.0046)were independent risk factors for VTE after hepatectomy.CONCLUSION Monitoring of plasma D-dimer levels after hepatectomy is useful for early diagnosis of VTE and may avoid routine prophylactic anticoagulation in the postoperative period. | Taiichiro Miyake Hiroaki Yanagimoto Daisuke Tsugawa Masayuki Akita Riki Asakura Keisuke Arai Toshihiko Yoshida Shinichi So Jun Ishida Takeshi Urade Yoshihide Nanno Kenji Fukushima Hidetoshi Gon Shohei Komatsu Sadaki Asari Hirochika Toyama Masahiro Kido Tetsuo Ajiki Takumi Fukumoto | 2024 | World Journal of Clinical Cases2024，12，2： | 0 |
| 16 | Platelet count and sustained virological response in hepatitis C treatment显示文摘AIM:To examine the epidemiological data,hematological safety and treatment responses of peginterferonalpha 2a plus ribavirin therapy for hepatitis C.METHODS:Between March 2008 and February 2011,196 hepatitis C virus(HCV)genotype 1 infected Japanese(127 treatment-naive and 69 treatment-experienced patients)patients treated with peginterferonalpha 2a plus ribavirin were enrolled.We examined the epidemiological data and treatment responses were retrospectively analyzed in terms of hematological safety.HCV RNA was measured by the COBAS TaqMan HCV test.RESULTS:Overall sustained virological response(SVR)rates of treatment-naive and treatment-experienced patients were 56% and 39%,respectively.Multivariate logistic regression analysis showed that SVR was attained independently of early virological response in both treatment-naive and treatment-experienced patients.SVR rates did not differ between the pretreatment hemoglobin < 13 g/dL and ≥ 13 g/dL groups.However,in treatment-naive patients,the SVR rate of the pretreatment platelet count < 130000/μL group was significantly lower than that of the pretreatment platelet count ≥ 130000/μL group.CONCLUSION:Attention should be paid to potential thrombocytopenia in the treatment of chronic hepatitis C patients. | Tatsuo Kanda Keizo Kato Akihito Tsubota Nobuo Takada Takayoshi Nishino Shigeru Mikami Tatsuo Miyamura Daisuke Maruoka Shuang Wu Shingo Nakamoto Makoto Arai Keiichi Fujiwara Fumio Imazeki Osamu Yokosuka | 2013 | World Journal of Hepatology2013，5，4： | 0 |
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