|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Enhanced secondary pollution offset reduction of primary emissions during COVID-19 lockdown in China显示文摘To control the spread of the 2019 novel coronavirus(COVID-19),China imposed nationwide restrictions on the movement of its population(lockdown)after the Chinese New Year of 2020,leading to large reductions in economic activities and associated emissions.Despite such large decreases in primary pollution,there were nonetheless several periods of heavy haze pollution in eastern China,raising questions about the well-established relationship between human activities and air quality.Here,using comprehensive measurements and modeling,we show that the haze during the COVID lockdown was driven by enhancements of secondary pollution.In particular,large decreases in NOx emissions from transportation increased ozone and nighttime NO_(3)radical formation,and these increases in atmospheric oxidizing capacity in turn facilitated the formation of secondary particulate matter.Our results,afforded by the tragic natural experiment of the COVID-19 pandemic,indicate that haze mitigation depends upon a coordinated and balanced strategy for controlling multiple pollutants. | Xin Huang Aijun Ding Jian Gao Bo Zheng Derong Zhou Ximeng Qi Rong Tang Jiaping Wang Chuanhua Ren Wei Nie Xuguang Chi Zheng Xu Liangduo Chen Yuanyuan Li Fei Che Nini Pang Haikun Wang Dan Tong Wei Qin Wei Cheng Weijing Liu Qingyan Fu Baoxian Liu Fahe Chai Steven JDavis Qiang Zhang Kebin He | 2021 | National Science Review2021，8，2： | 47 |
| 2 | Observational evidences for the speed of the gravity based on the Earth tide显示文摘We have found that the current practical Newtonian formula for the gravity tide of the Earth implies a hypothesis that gravity travels at the speed of light; furthermore, we have derived and solved the propagation equation of gravity using the observation data of Earth tides from Shiquanhe and Wushi, after correction of phase lag due to the anelasticity of the Earth, and found that the speeds of gravity are from 0.93 to 1.05 times the speed of light with a relative error of about 5%. This provides first set of strong evidences to show that the speed of gravity is the same as the speed of light. | TANG KeYun HUA ChangCai WEN Wu CHI ShunLiang YOU QingYu YU Dan | 2013 | Chinese Science Bulletin2013，58，4： | 8 |
| 3 | KIF2C:a novel link between Wnt/β-catenin and mTORCI signaling in the pathogenesis of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is the most common primary liver malignancy and is the fourth-leading cause of cancer-related deaths worldwide.HCC is refractory to many standard cancer treatments and the prognosis is often poor,highlighting a pressing need to identify biomarkers of aggressiveness and potential targets for future treatments.Kinesin family member 2C(KIF2C)is reported to be highly expressed in several human tumors.Nevertheless,the molecular mechanisms underlying the role of KIF2C in tumor development and progression have not been investigated.In this study,we found that KIF2C expression was significantly upregulated in HCC,and that KIF2C up-regulation was associated with a poor prognosis.Utilizing both gain and loss of function assays,we showed that KIF2C promoted HCC cell proliferation,migration,invasion,and metastasis both in vitro and in vivo.Mechanistically,we identified TBC1D7 as a binding partner of KIF2C,and this interaction disrupts the formation of the TSC complex,resulting in the enhancement of mammalian target of rapamycin complexl(mTORCI)signal transduction.Additionally,we found that KIF2C is a direct target of the Wnt/β-catenin pathway,and acts as a key factor in mediating the crosstalk between Wnt/β-catenin and mTORCI signaling.Thus,the results of our study establish a link between Wnt/β-catenin and mTORCI signaling,which highlights the potential of KIF2C as a therapeutic target for the treatment of HCC. | Shi Wei Miaomiao Dai Chi Zhang Kai Teng Fengwei Wang Hongbo Li Weipeng Sun Zihao Feng Tiebang Kang Xinyuan Guan Ruihua Xu Muyan Cai Dan Xie | 2021 | Protein & Cell2021，12，10： | 8 |
| 4 | Experimental investigation of propagation mechanisms and fracture morphology for coalbed methane reservoirs显示文摘Fracture propagation mechanisms in coalbed methane(CBM) reservoirs are very complex due to the development of the internal cleat system. In this paper, the characteristics of initiation and propagation of hydraulic fractures in coal specimens at different angles between the face cleat and the maximum horizontal principal stress were investigated with hydraulic fracturing tests. The results indicate that the interactions between the hydraulic fractures and the cleat system have a major effect on fracture networks. 'Step-like'' fractures were formed in most experiments due to the existence of discontinuous butt cleats. The hydraulic fractures were more likely to divert or propagate along the butt cleat with an increase in the angles and a decrease in the horizontal principal stress difference. An increase in the injection rate and a decrease in the fracturing fluid viscosity were more conducive to fracture networks. In addition, the influence on fracture propagation of the residual coal fines in the wellbore was also studied. The existence of coal fines was an obstacle in fracturing, and no effective connection can be formed between fractures. The experimental investigation revealed the fracture propagation mechanisms and can provide guidance for hydraulic fracturing design of CBM reservoirs. | Chi Ai Xiao-Xuan Li Jun Zhang Dan Jia Wen-Jing Tan | 2018 | Petroleum Science2018，15，4： | 5 |
| 5 | 青年型开角型青光眼的中国家系的新型Myocilin基因突变显示文摘目的:探讨某中国家系青年型开角型青光眼(JOAG)的致病基因。
方法:在一个青光眼家系中,三代人中患JOAG或高眼压。我们筛查了6位家族成员Myocilin(MYOC)和 optineurin(OPTN)的突变和apolipoprotein E的多态性,2位患有JOAG,2位患有高眼压,2位无症状。正常对照组包括200位与本家系无关联的受试者。用编码野生型或变异性 MYOC 互补 DNA 的表达载体转染cos-7细胞系。细胞内或分泌的MYOC蛋白用Western法进行检测。 | Bao Jian Fan Dexter Y. L Leung Dan Yi Wang Stéphane Vincent Raymond Pancy O. S. Tam Dennis S. C. Lam Chi Pui Pang 王婷(译) | 2006 | 美国医学会眼科杂志(中文版)2006，18，4： | 5 |
| 6 | Molecular dynamics simulations of the electric double layer capacitance of graphene electrodes in mono-valent aqueous electrolytes显示文摘基于最近,突现的 graphene 材料显示出的电的双层(EDL ) 电容器与常规多孔的碳材料相比的几褶层性能改进,在便携式、可更新的精力驾驶技术突破的一个波浪存储。因此,许多兴趣被产生了追求基础的全面理解还逃犯在电极 / 电解质接口的两倍层结构。在这份报纸,我们执行了全面分子的动力学模拟获得离子类型,溶剂性质,和收费条件怎么在 graphene 电极表面影响 EDL 结构的一幅全面图画,并且从而它对电容的贡献。我们显示出那不同对称的一价的水的电解质 M + X (M += Na +, K +, Rb +, 和 C + ;X = F , Cl , 并且我 ) 确实有特殊 EDL 结构。更大的离子,例如, Rb +, C +, Cl , 并且我 , 经历部分脱水并且在收费下面靠着 graphene 电极表面通过第一水层渗透。因此,通过 EDL 的电的潜在的分发强烈取决于离子类型。有趣地,我们进一步表明水能在决定电容价值起一个关键作用。在不同电解质的水经常的电介质的变化大部分越过不同离子类型的 EDL 在电的潜在的落下抵销变化。我们的模拟打开在溶剂分子和 EDL 结构之间的相互影响怎么合作地贡献电容的新灯,它同意我们的试验性的结果很好。 | Gengping Jiang Chi Cheng Dan Li Jefferson Zhe Liu | 2016 | Nano Research2016，9，1： | 3 |
| 7 | Influence of defect states on the performances of planar tin halide perovskite solar cells显示文摘Although tin halide perovskite has shown excellent photoelectric performance, its efficiency of solar cell is low compared with that of lead halide. In order to enhance the efficiency of tin halide perovskite solar cell, a deep understanding of the role of the defects in the perovskite absorption layer and at the electron transport layer(ETL)/absorber or absorber/hole transport layer(HTL) interface is very necessary. In this work, the planar heterojunction-based CH_3NH_3SnI_3 perovskite solar cells were simulated with the SCAPS-1D program. Simulation results revealed a great dependence of device efficiency on defect density and interface quality of the perovskite absorber. The defect density at the front interface is critical for high efficiency, and the polarity of the interface charge has a different impact on the device efficiency. Strikingly, an efficiency over 29% was obtained under the moderate simulation conditions. | Shihua Huang Zhe Rui Dan Chi Daxin Bao | 2019 | Journal of Semiconductors2019，40，3： | 2 |
| 8 | Antifungal and antiviral products of marine organisms显示文摘 | Randy Chi Fai Cheung Jack Ho Wong Wen Liang Pan Yau Sang Chan Cui Ming Yin Xiu Li Dan He Xiang Wang Evandro Fei Fang Sze Kwan Lam Patrick Hung Kui Ngai Li Xin Xia Fang Liu Xiu Yun Ye Guo Qing Zhang Qing Hong Liu Ou Sha Peng Lin Chan Ki Adnan A Bekhit Alaa | 2014 | Applied Microbiology and Biotechnology2014，，8： | 2 |
| 9 | Engineering microparticles based on solidified stem cell secretome with an augmented pro-angiogenic factor portfolio for therapeutic angiogenesis显示文摘Tissue (re)vascularization strategies face various challenges, as therapeutic cells do not survive long enough in situ, while the administration of pro-angiogenic factors is hampered by fast clearance and insufficient ability to emulate complex spatiotemporal signaling. Here, we propose to address these limitations by engineering a functional biomaterial capable of capturing and concentrating the pro-angiogenic activities of mesenchymal stem cells (MSCs). In particular, dextran sulfate, a high molecular weight sulfated glucose polymer, supplemented to MSC cul-tures, interacts with MSC-derived extracellular matrix (ECM) components and facilitates their co-assembly and accumulation in the pericellular space. Upon decellularization, the resulting dextran sulfate-ECM hybrid material can be processed into MIcroparticles of SOlidified Secretome (MIPSOS). The insoluble format of MIPSOS protects protein components from degradation, while facilitating their sustained release. Proteomic analysis demonstrates that MIPSOS are highly enriched in pro-angiogenic factors, resulting in an enhanced pro-angiogenic bioactivity when compared to naïve MSC-derived ECM (cECM). Consequently, intravital microscopy of full-thickness skin wounds treated with MIPSOS demonstrates accelerated revascularization and healing, far superior to the ther-apeutic potential of cECM. Hence, the microparticle-based solidified stem cell secretome provides a promising platform to address major limitations of current therapeutic angiogenesis approaches. | Thomas Spater Marisa Assunçao Kwok Keung Lit Guidong Gong Xiaoling Wang Yi-Yun Chen Ying Rao Yucong Li Chi Him Kendrick Yiu Matthias W.Laschke Michael D.Menger Dan Wang Rocky S.Tuan Kay-Hooi Khoo Michael Raghunath Junling Guo Anna Blocki | 2022 | Bioactive Materials2022，7，11： | 1 |
| 10 | Potential for nutrient removal by integrated remediation methods in a eutrophicated artificial lake-a case study in Dishui Lake, Lingang New City显示文摘 | Zhang Q Z Chi D Varenyam A Dan S Yang Z Xu Y T Xiang W M | 2014 | China Water Science & Technology2014，70，12： | 1 |
| 11 | Multi-objective optimization of stiffness and workspace for a parallel kinematic machine显示文摘 | Chi Zhongzhe Zhang Dan Xia Lian | 2013 | International Journal of Mechanics and Materials in Design2013，9，3： | 1 |
| 12 | Fabrication and Photocatalytic Activity of Cu_2O Nanobelts on Nanoporous Cu Substrate显示文摘In this paper, we report the fabrication of the photocatalysts composed of Cu_2O nanobelts and nanoporous Cu(NP Cu)substrate, which is obtained by soaking the NP Cu in dehydrated ethanol. The NP Cu substrate is achieved by dealloying of Ti_(40.6)Zr_(9.4)Cu_(40.6)Ni_(6.3)Sn_(3.1) amorphous ribbons in HF solutions. The dealloying process is considered to be a thermally activated process, obeying the Arrhenius law. The surface diffusivity increases with increasing dealloying temperature and concentration of HF solutions. The activation energy of the diffusion of Cu adatoms is estimated to be 76.4 kJ/mol. The Cu_2O nanobelts with the width of 10–15 nm and the length of about 1 lm are formed on the surface of NP Cu after immersion in dehydrated ethanol. The photocatalysts of Cu_2O on nanoporous Cu exhibit superior photocatalytic activity toward the degradation of methyl orange and methylene blue under the irradiation of the sunlight due to the coexistence of Cu_2O semiconductor nanobelts and large amount of heterojunctions as flowing path for photoelectrons. | Yun Li Chuan Ji Yu-Chen Chi Zhen-Hua Dan Hai-Feng Zhang Feng-Xiang Qin | 2019 | Acta Metallurgica Sinica(English Letters)2019，32，1： | 1 |
| 13 | Liquid-Mediated Dense Integration of Graphene Materials for Compact Capacitive Energy Storage显示文摘 | Xiaowei Yang Chi Cheng Yufei Wang Ling Qiu Dan Li | 2013 | Science2013，，6145： | 1 |
| 14 | Multilayered graphene membrane as an experimental platform to probe nano-confined electrosorption | Chi Cheng Julia Uhe Xiaowei Yang Yanzhe Wu Dan Li | 2012 | Progress in Natural Science:Materials International2012，22，6： | 1 |
| 15 | Association of Apolipoprotein E Polymorphisms With Normal Tension Glaucoma in a Chinese Population显示文摘 | Ching Yan Lam Bao Jian Fan Dan Yi Wang Pancy Oi Sin Tam Clement Chee Yung Tham Dexter Yu Lung Leung Dorothy Shu Ping Fan Dennis Shun Chiu Lam Chi Pui Pang | 2006 | Journal of Glaucoma2006，，3： | 1 |
| 16 | An analysis of patients with bulky advanced stage ovarian, tubal, and peritoneal carcinoma treated with primary debulking surgery (PDS) during an identical time period as the randomized EORTC-NCIC trial of PDS vs neoadju-vant chemotherapy (NACT) 显示文摘 | Chi DS Musa F Dan F | 2012 | Gynecol Oncol2012，124，1： | 1 |
| 17 | TNF-α promotes early atherosclerosis by increasing transcytosis of LDL across endothelial cells: Crosstalk between NF-κB and PPAR-γ显示文摘 | Youzhi Zhang Xiaoyan Yang Fang Bian Pinhui Wu Shasha Xing Gao Xu Wenjing Li Jiangyang Chi Changhan Ouyang Tao Zheng Dan Wu Yonghui Zhang Yongsheng Li Si Jin | 2014 | Journal of Molecular and Cellular Cardiology2014，，： | 1 |
| 18 | Dwarf apple MbDREB 1 enhances plant tolerance to low temperature, drought, and salt stress via both ABA-dependent and ABA-independent pathways 显示文摘 | YANG WEI LIU XIAO DAN CHI XIAO JUAN | 2011 | Planta2011，233，2： | 1 |
| 19 | Dynamic phenotypic heterogeneity and the evolution of multiple RNA subtypes in hepatocellular carcinoma:the PLANET study显示文摘Intra-tumor heterogeneity(ITH) is a key challenge in cancer treatment, but previous studies have focused mainly on the genomic alterations without exploring phenotypic(transcriptomic and immune)heterogeneity. Using one of the largest prospective surgical cohorts for hepatocellular carcinoma(HCC)with multi-region sampling, we sequenced whole genomes and paired transcriptomes from 67 HCC patients(331 samples). We found that while genomic ITH was rather constant across stages, phenotypic ITH had a very different trajectory and quickly diversified in stage Ⅱ patients. Most strikingly, 30% of patients were found to contain more than one transcriptomic subtype within a single tumor. Such phenotypic ITH was found to be much more informative in predicting patient survival than genomic ITH and explains the poor efficacy of single-target systemic therapies in HCC. Taken together, we not only revealed an unprecedentedly dynamic landscape of phenotypic heterogeneity in HCC, but also highlighted the importance of studying phenotypic evolution across cancer types. | Weiwei Zhai Hannah Lai Neslihan Arife Kaya Jianbin Chen Hechuan Yang Bingxin Lu Jia Qi Lim Siming Ma Sin Chi Chew Khi Pin Chua Jacob Josiah Santiago Alvarez Pauline Jieqi Chen Mei Mei Chang Lingyan Wu Brian K.P.Goh Alexander Yaw-Fui Chung Chung Yip Chan Peng Chung Cheow Ser Yee Lee Juinn Huar Kam Alfred Wei-Chieh Kow Iyer Shridhar Ganpathi Rawisak Chanwat Jidapa Thammasiri Boon Koon Yoong Diana Bee-Lan Ong Vanessa H.de Villa Rouchelle D.Dela Cruz Tracy Jiezhen Loh Wei Keat Wan Zeng Zeng Anders Jacobsen Skanderup Yin Huei Pang Krishnakumar Madhavan Tony Kiat-Hon Lim Glenn Bonney Wei Qiang Leow Valerie Chew Yock Young Dan Wai Leong Tam Han Chong Toh Roger Sik-Yin Foo Pierce Kah-Hoe Chow | 2022 | National Science Review2022，9，3： | 1 |
| 20 | IL ‐6 in diabetes and cardiovascular complications显示文摘 | Dan Qu Jian Liu Chi Wai Lau Yu Huang | 2014 | Br J Pharmacol2014，，15： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员