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| 1 | Development of the personalized criteria for microscopic review following four different series of hematology analyzer in a Chinese large scale hospital显示文摘 | CUI Wei WU Wei WANG Xin WANG Geng HAO Ying-ying CHEN Yu LUO Dan SHOU Wei-ling ZHANG Shuo XIANG Xue-fang SI Yong-zhen CHEN Qian CAI Hao LI Tan SHEN Han SHANG Kun ZHANG Yong-qiang | 2010 | Chinese Medical Journal2010，，22： | 10 |
| 2 | TET=catalyzed 5-methylcytosine hydroxylation is dynamically regulated by metabolites显示文摘 | Hui Yang Huaipeng Lin Haiyan Xu Lei Zhang Lu Cheng Bo Wen Jianyong Shou Kunliang Guan Yue Xiong Dan Ye | 2014 | Cell Research2014，24，8： | 3 |
| 3 | Panda X-III: Searching for neutrinoless double beta decay with high pressure ^(136)Xe gas time projection chambers显示文摘Searching for the neutrinoless double beta decay(NLDBD)is now regarded as the topmost promising technique to explore the nature of neutrinos after the discovery of neutrino masses in oscillation experiments.Panda X-III(particle and astrophysical xenon experiment III)will search for the NLDBD of136Xe at the China Jin Ping Underground Laboratory(CJPL).In the first phase of the experiment,a high pressure gas Time Projection Chamber(TPC)will contain 200 kg,90%136Xe enriched gas operated at10 bar.Fine pitch micro-pattern gas detector(Microbulk Micromegas)will be used at both ends of the TPC for the charge readout with a cathode in the middle.Charge signals can be used to reconstruct the electron tracks of the NLDBD events and provide good energy and spatial resolution.The detector will be immersed in a large water tank to ensure~5 m of water shielding in all directions.The second phase,a ton-scale experiment,will consist of five TPCs in the same water tank,with improved energy resolution and better control over backgrounds. | Xun Chen Chang Bo Fu Javier Galan Karl Giboni Franco Giuliani Ling Hui Gu Ke Han Xiang Dong Ji Heng Lin Jiang Lai Liu Kai Xiang Ni Hiroki Kusano Xiang Xiang Ren Shao Bo Wang Yong Yang Dan Zhang Tao Zhang Li Zhao Xiang Ming Sun Shou Yang Hu Si Yu Jian Xing Long Li Xiao Mei Li Hao Liang Huan Qiao Zhang Ming Rui Zhao Jing Zhou Ya Jun Mao Hao Qiao Si Guang Wang Ying Yuan Meng Wang Amir N.Khan Neill Raper Jian Tang Wei Wang Jia Ning Dong Chang Qing Feng Cheng Li Jian Bei Liu Shu Bin Liu Xiao Lian Wang Dan Yang Zhu Juan F.Castel Susana Cebri'an Theopisti Dafni Javier G.Garza Igor G.Irastorza Francisco J.Iguaz Gloria Luz ′on Hector Mirallas Stephan Aune Eric Berthoumieux Yann Bedfer Denis Calvet Nicole d'Hose Alain Delbart Maria Diakaki Esther Ferrer-Ribas Andrea Ferrero Fabienne Kunne Damien Neyret Thomas Papaevangelou Franck Sabatie Maxence Vanderbroucke AnDi Tan Wick Haxton Yuan Mei Chinorat Kobdaj Yu-Peng Yan | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，6： | 2 |
| 4 | Therapeutic Effectiveness of Sustained Low‐Efficiency Hemodialysis Plus Hemoperfusion and Continuous Hemofiltration Plus Hemoperfusion for Acute Severe Organophosphate Poisoning显示文摘 | Shou‐liang Hu Dan Wang Hong Jiang Qing‐feng Lei Xiao‐hua Zhu Jun‐zhang Cheng | 2014 | Artificial Organs2014，，2： | 2 |
| 5 | Comparison of two thioxopeptide bond photoswitches in insect kinin显示文摘The photoisomerization abilities of secondary thioxopeptide bond(CS-NH) and thioxo prolyl bond(CS-N) incorporated into the C-terminal pentapeptide of insect kinin were compared.H-Phe-Phe-Ψ[CS-NH]-D-Ala-Trp-Gly-NH_2 and H-Phe-Tyr-Ψ[CS-N]- Pro-Trp-Gly-NH_2 were studied by UV-vis absorption.The isomerization energy barriers of the two segments,Ac-Phe-Ψ[CS-NH]- D-Ala-NH_2 and Ac-Tyr-Ψ[CS-N]-Pro-NH_2 picked from the two peptides,were calculated using ab initio method.The cis isomer of CS-N is more stable than... | Cong, Zhi Yuan Yang, Long Fei Jiang, Ling Ye, Dan Dong, Shou Liang | 2010 | Chinese Chemical Letters2010，21，4： | 1 |
| 6 | Inhibitory effects of matrine on electrical signals and amino acid neurotransmitters in hippocampal brain slices显示文摘<正>BACKGROUND:Studies on electrical signals of hippocampal brain slices in vivo have shown that matrine inhibits benzylpenicillin sodium-induced activation of neuronal signal transduction. OBJECTIVE:To verify the inhibition effect of matrine on activation of electrical signals in rat brain slices and the role matrine plays in hippocampal amino acid transmitter release. DESIGN,TIME AND SEFFING:The in vitro,neurophysiological,controlled experiment was performed in the Zhejiang Province Key Laboratory of Cardio-cerebrovascular Disease and Nerve System Drugs Appraisement and Chinese Traditional Medicine Screening and Research between July 2003 and May 2004.The in vivo,neuronal,biochemical experiment was performed in the Zhejiang Province Key Laboratory of Chinese Traditional Medicine Quality Standardization from July 2005 to December 2006. MATERIALS:Forty healthy,Sprague Dawley rats,7-8 weeks old,and 120 healthy,ICR mice,5-6 weeks old,were included in this study,irrespective of gender.Matrine powder was provided by the National Institute for the Control of Pharmaceutical and Biological Products,China.Matrine injection was purchased from Zhuhai Biochemical Pharmaceutical Factory,China.Penicillin was bought from Shijiazhuang Pharmaceutical Group Co.,Ltd.,China. METHODS:(1) Rats were randomly assigned to four groups:control,penicillin model,and matrine high-dose and low-dose,with 10 rats in each group.The control group was perfused with artificial cerebrospinal fluid.In the remaining three groups,hippocampal brain slices were perfused with normal artificial cerebrospinal fluid containing 1×10~6 U/L penicillin for the first 10 minutes.The penicillin model group received artificial cerebrospinal fluid for an additional 30 minutes,while the matrine high-dose and low-dose groups received 0.1 g/L and 0.05 g/L matrine,respectively,for an additional 30 minutes.(2) Mice were randomly assigned to four groups(n=30).The matrine high-, medium-,and low-dose groups were separately injected with 58.5,39.0,and 19.5 mg/kg matrine via caudal vein,respectively.No intervention was administered to the normal group. MAIN OUTCOME MEASURES:The field potential value in the CA1 region of penicillin-induced rat hippocampal brain slices was analyzed using the evoked field potential technique;chromatography was utilized to determine y-aminobutyric acid and glutamic acid content in the mouse hippocampus. RESULTS:(1) Both 0.1 g/L and 0.05 g/L matrine reduced the number of evoked field potentials in the penicillin-induced rat hippocampal brain slices(P<0.05 or P<0.01).In addition,0.1 g/L matrine led to a reduction of evoked field potential amplitude(P<0.05).(2) Compared with normal mice, y-aminobutyric levels were dramatically increased at 20 minutes after high-dose matrine treatment (P<0.05).In addition,significantly increased y-aminobutyric acid levels were observed at 40 minutes after medium-and low-dose matrine treatments(P<0.05 or P<0.01).The glutamic acid/y-aminobutyric acid ratio was significantly less at 20 minutes after high-dose matrine treatment compared with the normal mice group(P<0.05). CONCLUSION:Matrine exerts a central inhibitory effect via increased inhibitory neurotransmitter y-aminobutyric acid levels in the hippocampus. | Xuping Wang Jiping Chen Guizhi Zhao Dan Shou Xuezhi Hong Jianmin Zhang | 2009 | Neural Regeneration Research2009，4，7： | 1 |
| 7 | Bone Marrow Urokinase Plasminogen Activator Receptor Levels are Associated with the Progress of Multiple Myeloma显示文摘Objective To determine the mRNA and protein levels of urokinase plasminogen activator receptors(u PAR) in bone marrow fluid and bone marrow tissue from multiple myeloma(MM) patients and assess association of u PAR level with prognosis of MM.Methods u PAR levels in bone marrow fluid of 22 MM patients at the stable and progressive stages and 18 iron deficiency anemia patients with normal bone marrow(control) were examined by ELISA.Furthermore,u PAR expression in bone marrow tissue was investigated by RT-PCR and Western blot,respectively.The distribution of u PAR in MM cells was examined using immunofluorescence staining.The pathological changes in different stages of MM patients were studied by HE staining.Results u PAR level in bone marrow fluid of MM patients(1.52±0.32 μg/ml) was found to be higher than that in the control group(0.98±0.15 μg/ml).Interestingly,u PAR protein(0.686±0.075 vs.0.372±0.043,P<0.05) and m RNA(2.51±0.46 vs.4.46±1.15,P<0.05) expression levels of MM patients at the progressive stage were significantly higher than those at the stable stage.The expression of u PAR in MM bone marrow was confirmed by immunofluorescence staining.Moreover,HE staining revealed a great increased number of nucleated cells and severe impairment of hematopoietic function in the bone marrow of patients with progressive-stage myeloma.Conclusion Our study reveals that u PAR expression is positively correlated with the development and progress of MM. | Li-hong Shou Dan Cao Xiao-hui Dong Qiu Fang Bao-lian Xu Ju-ping Fei | 2016 | Chinese Medical Sciences Journal2016，31，3： | 0 |
| 8 | Transmembrane kinase 1-mediated auxin signal regulates membrane-associated clathrin in Arabidopsis roots显示文摘Clathrin-mediated endocytosis(CME)is the major endocytic pathway in eukaryotic cells that directly regulates abundance of plasma membrane proteins.Clathrin triskelia are composed of clathrin heavy chains(CHCs)and light chains(CLCs),and the phytohormone auxin differentially regulates membraneassociated CLCs and CHCs,modulating the endocytosis and therefore the distribution of auxin efflux transporter PIN-FORMED2(PIN2).However,the molecular mechanisms by which auxin regulates clathrin are still poorly understood.Transmembrane kinase(TMKs)family proteins are considered to contribute to auxin signaling and plant development;it remains unclear whether they are involved in PIN transport by CME.We assessed TMKs involvement in the regulation of clathrin by auxin,using genetic,pharmacological,and cytological approaches including live-cell imaging and immunofluorescence.In tmk1 mutant seedlings,auxin failed to rapidly regulate abundance of both CHC and CLC and to inhibit PIN2 endocytosis,leading to an impaired asymmetric distribution of PIN2 and therefore auxin.Furthermore,TMK3 and TMK4 were shown not to be involved in regulation of clathrin by auxin.In summary,TMK1 is essential for auxin-regulated clathrin recruitment and CME.TMK1therefore plays a critical role in the establishment of an asymmetric distribution of PIN2 and an auxin gradient during root gravitropism. | Yutong Wang Xu Yan Mei Xu Weiyang Qi Chunjie Shi Xiaohong Li Jiaqi Ma Dan Tian Jianxin Shou Haijun Wu Jianwei Pan Bo Li Chao Wang | 2023 | Journal of Integrative Plant Biology2023，65，1： | 0 |
| 9 | High-efficient removal of tetracycline in water via porous magnetic Ce/Fe photocomposite under visible light显示文摘Tetracycline is a typical antibiotic commonly used in various industries which is eco-toxic and quickly causes bacterial resistance.Therefo re,studying the efficient removal of tetracycline is necessary to protect the water environment.Herein,a novel Ce/Fe nanoparticle composite(1CCFO)was prepared by the sol-gel method and its removal effects of tetracycline under visible light were performed.The relationship between physicochemical properties of catalyst and photocatalytic degradation effects of tetracycline was analyzed based on a series of characterizations data such as X-ray diffraction(XRD),Raman spectro scopy,a vibrating sample magnetometer(VSM),scanning electron microscopy(SEM),Brunauer-Emmett-Teller(BET)method,X-ray photoelectron spectroscopy(XPS),and ultraviolet-visible(UV-Vis)spectroscopy.The results show that Ce/Fe photocatalyst possesses a large specific surface area,good visible light response,abundant oxygen vacancies and excellent redox performance,exhibiting good adsorption capacity,remarkable catalytic performance and stability.The optimal conditions for tetracycline removal were explored through orthogonal experiments.About 88%of tetracycline can be photodegraded in 1 h under optimal conditions.The possible decomposition pathways,main reactive oxygen species and suitable mechanism of the photocatalytic system were studied by liquid chromatography-mass spectro metry(LC-MS),an electron spin resonance(ESR)spectrometer and free radical quenching experiments.The results show that 1CCFO has an efficient degradation effect on tetracycline under visible light,which provides a feasible method to improve the performance of 1CCFO. | Weihang Han Jingxuan Shou Yifan Yang Liangchen Chen Luping Zhang Yutong Chen Xuewei Tu Dan Jin Shijie Zhang Yurong Chang Hui Zheng | 2023 | Journal of Rare Earths2023，41，10： | 0 |
| 10 | Determination of lisinopril using anion exchange chromatography with integrated pulsed amperometric detection显示文摘为在阴离子交换层析(原子能委员会) 的 lisinopril 的直接察觉的一个快速、实际的方法与综合搏动的安培计的察觉(IPAD ) 被开发了。Dionex AS18 (250 公里? | Yu Xiu Liu Dan Shou Mei Lan Chen Zhi Dong Chen Pei Min Zhang Yan Zhu | 2012 | Chinese Chemical Letters2012，23，3： | 0 |
| 11 | Relationship of Retinal Nerve Fiber Layer Thickness and Retinal Vessel Calibers with Cognitive Impairment in the Asymptomatic Polyvascular Abnormalities Population显示文摘Objective Cognitive impairment(CI)in older individuals has a high morbidity rate worldwide,with poor diagnostic methods and susceptible population identification.This study aimed to investigate the relationship between different retinal metrics and CI in a particular population,emphasizing polyvascular status.Methods We collected information from the Asymptomatic Polyvascular Abnormalities Community Study on retinal vessel calibers,retinal nerve fiber layer(RNFL)thickness,and cognitive function of 3,785participants,aged 40 years or older.Logistic regression was used to analyze the relationship between retinal metrics and cognitive function.Subgroups stratified by different vascular statuses were also analyzed.Results RNFL thickness was significantly thinner in the CI group(odds ratio:0.973,95%confidence interval:0.953–0.994).In the subgroup analysis,the difference still existed in the non-intracranial arterial stenosis,non-extracranial carotid arterial stenosis,and peripheral arterial disease subgroups(P<0.05).Conclusion A thin RNFL is associated with CI,especially in people with non-large vessel stenosis.The underlying small vessel change in RNFL and CI should be investigated in the future. | WANG Dan Dan WANG An Xin ZHANG Xiao Li WEI Wen Bin WU Shou Ling ZHAO Xing Quan | 2024 | Biomedical and Environmental Sciences2024，37，2： | 0 |
| 12 | Commissioning experiment of the high-contrast SILEX-Ⅱ multi-petawatt laser facility显示文摘The results of a commissioning experiment on the SILEX-Ⅱlaser facility(formerly known as CAEP-PW)are reported.SILEX-Ⅱis a complete optical parametric chirped-pulse amplification laser facility.The peak power reached about 1 PWin a 30 fs pulse duration during the experiment.The laser contrast was better than 1010 at 20 ps ahead of the main pulse.In the basic laser foil target interaction,a set of experimental data were collected,including spatially resolved x-ray emission,the image of the coherent transition radiation,the harmonic spectra in the direction of reflection,the energy spectra and beam profile of accelerated protons,hot-electron spectra,and transmitted laser energy fraction and spatial distribution.The experimental results show that the laser intensity reached 531020 W/cm^(2) within a 5.8μm focus(FWHM).Significant laser transmission did not occur when the thickness of theCHfoil was equal to or greater than 50 nm.The maximum energy of the accelerated protons in the target normal direction was roughly unchanged when the target thickness varied between 50 nm and 15μm.The maximum proton energy via the target normal sheath field acceleration mechanism was about 21 MeV.We expect the on-target laser intensity to reach 10^(22) W/cm^(2) in the near future,after optimization of the laser focus and upgrade of the laser power to 3 PW. | Wei Hong Shukai He Jian Teng Zhigang Deng Zhimeng Zhang Feng Lu Bo Zhang Bin Zhu Zenghai Dai Bo Cui Yuchi Wu Dongxiao Liu Wei Qi Jinlong Jiao Faqiang Zhang Zuhua Yang Feng Zhang Bi Bi Xiaoming Zeng Kainan Zhou Yanlei Zuo Xiaojun Huang Na Xie Yi Guo Jingqin Su Dan Han Ying Mao Leifeng Cao Weimin Zhou Yuqiu Gu Feng Jing Baohan Zhang Hongbo Cai Minqing He Wudi Zheng Shaoping Zhu Wenjun Ma Dahui Wang Yinren Shou Xueqing Yan Bin Qiao Yi Zhang Congling Zhong Xiaohui Yuan and Wenqing Wei | 2021 | Matter and Radiation at Extremes2021，6，6： | 0 |
| 13 | Prenatal inflammation exposure-programmed hypertension exhibits multi-generational inheritance via disrupting DNA methylome显示文摘The multi-generation heredity trait of hypertension in human has been reported,but the molecular mechanisms underlying multi-generational inheritance of hypertension remain obscure.Recent evidence shows that prenatal inflammatory exposure(PIE)results in increased incidence of cardiovascular diseases,including hypertension.In this study we investigated whether and how PIE contributed to multi-generational inheritance of hypertension in rats.PIE was induced in pregnant rats by intraperitoneal injection of LPS or Poly(I:C)either once on gestational day 10.5(transient stimulation,T)or three times on gestational day 8.5,10.5,and 12.5(persistent stimulation,P).Male offspring was chosen to study the paternal inheritance.We showed that PIE,irrespectively induced by LPS or Poly(I:C)stimulation during pregnancy,resulted in multi-generational inheritance of significantly increased blood pressure in rat descendants,and that prenatal LPS exposure led to vascular remodeling and vasoconstrictor dysfunction in both thoracic aorta and superior mesenteric artery of adult F2 offspring.Furthermore,we revealed that PIE resulted in global alteration of DNA methylome in thoracic aorta of F2 offspring.Specifically,PIE led to the DNA hypomethylation of G beta gamma(Gβγ)signaling genes in both the F1 sperm and the F2 thoracic aorta,and activation of PI3K/Akt signaling was implicated in the pathologic changes and dysregulated vascular tone of aortic tissue in F2 LPS-P offspring.Our data demonstrate that PIE reprogrammed DNA methylome of cells from the germline/mature gametes contributes to the development of hypertension in F2 PIE offspring.This study broadens the current knowledge regarding the multi-generation effect of the cumulative early life environmental factors on the development of hypertension. | Xiao Guan Guo-rong Dan Yao Yang Yan Ji Wen-jing Lai Fang-jie Wang Meng Meng Bang-hui Mo Pei Huang Ting-ting You Ya-fei Deng Liang Song Wei Guo Ping Yi Jian-hua Yu Yuan Gao Wei-nian Shou Bing-bo Chen You-cai Deng Xiao-hui Li | 2022 | Acta Pharmacologica Sinica2022，43，6： | 0 |
| 14 | Determination of catecholamines by ion chromatography coupled to acidic potassium permanganate chemiluminescence detection显示文摘察觉在这份报纸被描述的为在由有化合光(CL ) 的离子层析(IC ) 的人的尿的 catecholamines 的决心的一个简单、快、敏感、高度选择、 eco 友好的分析方法。用没有是的任何器官的添加剂的 12 mmol/L H2SO4, eluent,包括肾上腺素(EP ) 的三 catecholamines,新肾上素(NE ) 和多巴胺(DA ) 是在阳离子交换列上分开的井。CL 察觉作为 enhancer 面对甲醛与酸的钾高锰酸盐基于 analytes 的反应。在 eluent 的甲醇和 acetonitrile 的缺席使建议方法更敏感、 eco 友好。在最佳的条件下面,建议方法的线性范围在 0.020.5 g/mL 的范围。察觉(LOD ) 的限制在 0.6 和 5.1 g/L 的范围。为 0.1 g/mL 的相对标准差(RSD ) 混合了标准答案在 0.81.9% 的范围(n = 11 ) 。方法成功地在人的尿被用于 catecholamines 的决心。优秀刺的恢复被完成因为 catecholamines 从 91.2% ~ 112.7%。 | Hong Wei Wu Mei Lan Chen Dan Shou Yan Zhu | 2012 | Chinese Chemical Letters2012，23，7： | 0 |
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