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| 1 | Inflammatory bowel disease serology in Asia and the West显示文摘AIM:To study serological antibodies in Caucasians and Asians,in health and inflammatory bowel disease(IBD),in Australia and Hong Kong(HK).METHODS:Anti-glycan antibodies[anti-chitobioside(ACCA),anti-laminaribioside(ALCA)],and anti-mannobioside(AMCA),anti-Saccharomyces cervisiae(gASCA);and atypical perinuclear anti-neutrophil cytoplasmic antibody(pANCA)were tested in IBD patients,their unaffected relatives,and healthy controls in Australia and HK(China).Antibody status(positive or negative)and titre was compared between subjects of different geography,ethnicity and disease state.RESULTS:Ninety subjects were evaluated:21 Crohn’s disease(CD),32 ulcerative colitis(UC),29 healthy controls,and 8 IBD patient relatives.Forty eight subjects were Australian(29 Caucasian and 19 ethnic Han Chinese)and 42 were from HK(all Han Chinese).Caucasian CD patients had a significantly higher antibody prevalence of gASCA(67%vs 3%,P<0.001),ALCA(44%vs 6%,P=0.005),and AMCA(67%vs 15%,P=0.002),whereas HK CD patients had a higher prevalence of only AMCA(58%vs 25%,P=0.035),when compared with UC and healthy subjects in both countries.Caucasian CD had significantly higher gASCA prevalence(67%vs 0%,P<0.001)and titre(median59 vs 9,P=0.002)than HK CD patients.Prevalence and titres of ALCA,ACCA and AMCA did not differ between CD in the two countries.Presence of at least one antibody was higher in Caucasian than HK CD patients(100%vs 58%,P=0.045).pANCA did not differ between countries or ethnicity.CONCLUSION:Serologic CD responses differ between HK Asian and Australian Caucasian patients.Different genetic,environmental or disease pathogenic factors may account for these differences. | Lani Prideaux Michael A Kamm Peter De Cruz Daniel R van Langenberg Siew C Ng Iris Dotan | 2013 | World Journal of Gastroenterology2013，19，37： | 10 |
| 2 | Early-onset colorectal cancer:A separate subset of colorectal cancer显示文摘Colorectal cancer(CRC)has a great impact on the world population.With increasing frequency,CRC is described according to the presenting phenotype,based on its molecular characteristics.Classification of CRC tumors according to their genetic and/or epigenetic alterations is not only important for establishing the molecular bases of the disease,but also for predicting patient outcomes and developing more individualized treatments.Early-onset CRC is a heterogeneous disease,with a strong familial component,although the disease is sporadic in an important proportion of cases.Different molecular alterations appear to contribute to the apparent heterogeneity of the early-onset population and subgroups can be distinguished with distinct histopathologic and familial characteristics.Moreover,compared with late-onset CRC,there are characteristicsthat suggest that early-onset CRC may have a different molecular basis.The purpose of this review was to analyze the current state of knowledge about earlyonset CRC with respect to clinicopathologic,familial and molecular features.Together,these features make it increasingly clear that this subset of CRC may be a separate disease,although it has much in common with late-onset CRC. | Irene Osorio Silla Daniel Rueda Yolanda Rodríguez Juan Luis García Felipe de la Cruz Vigo José Perea | 2014 | World Journal of Gastroenterology2014，20，46： | 4 |
| 3 | Utilizing a novel fiber optic technology to capture the axial responses of fully grouted rock bolts显示文摘Rock bolts are one of the primary support systems utilized in underground excavations within the civil and mining engineering industries. Rock bolts support the weakened rock mass adjacent to the opening of an excavation by fastening to the more stable, undisturbed formations further from the excavation. The overall response of such a support element has been determined under varying loading conditions in the laboratory and in situ experiments in the past four decades; however, due to the limitations with conventional monitoring methods of capturing strain, there still exists a gap in knowledge associated with an understanding of the geomechanical responses of rock bolts at the microscale. In this paper, we try to address this current gap in scientific knowledge by utilizing a newly developed distributed optical strain sensing(DOS) technology that provides an exceptional spatial resolution of 0.65 mm to capture the strain along the rock bolt. This DOS technology utilizes Rayleigh optical frequency domain reflectometry(ROFDR) which provides unprecedented insight into various mechanisms associated with axially loaded rebar specimens of different embedment lengths, grouting materials, borehole annulus conditions, and borehole diameters. The embedment length of the specimens was found to be the factor that significantly affected the loading of the rebar. The critical embedment length for the fully grouted rock bolts(FGRBs) was systematically determined to be430 mm. The results herein highlight the effects of the variation of these individual parameters on the geomechanical responses FGRBs. | Nicholas Vlachopoulos Daniel Cruz Bradley Forbes | 2018 | Journal of Rock Mechanics and Geotechnical Engineering2018，10，2： | 3 |
| 4 | Esophagogastric anastomosis with invagination into stomach:New technique to reduce fistula formation显示文摘AIM: To present a new technique of cervical esophagogastric anastomosis to reduce the frequency of fistula formation. METHODS: A group of 31 patients with thoracic and abdominal esophageal cancer underwent cervical esophagogastric anastomosis with invagination of the proximal esophageal stump into the stomach tube. In the region elected for anastomosis, a transverse myotomy of the esophagus was carried out around the entire circumference of the esophagus. Afterwards, a 4-cm long segment of esophagus was invaginated into the stomach and anastomosed to the anterior and the posterior walls. RESULTS: Postoperative minor complications occurred in 22 (70.9%) patients. Four (12.9%) patients had serious complications that led to death. The discharge of saliva was at a lower region, while attempting to leave the anastomosis site out of the alimentary transit. Three (9.7%) patients had fistula at the esophagogastric anastomosis, with minimal leakage of air or saliva and with mild clinical repercussions. No patients had esophago- gastric fistula with intense saliva leakage from either the cervical incision or the thoracic drain. Fibrotic stenosis of anastomoses occurred in seven (22.6%) patients. All these patients obtained relief from their dysphagia with endoscopic dilatation of the anastomosis.CONCLUSION: Cervical esophagogastric anastomosis with invagination of the proximal esophageal stump into the stomach tube presented a low rate of esophagogastric fistula with mild clinical repercussions. | Alexandre Cruz Henriques Carlos Alberto Godinho Roberto Saad Jr Daniel Reis Waisberg Aline Biral Zanon Manlio Basilio Speranzini Jaques Waisberg | 2010 | World Journal of Gastroenterology2010，16，45： | 2 |
| 5 | FeNb在钢液中的溶化行为及在钢包精炼过程中提高Nb收得率的最佳工艺显示文摘阐述了标准铌铁(FeNb)的微观组织特性及其溶入钢液中的研究结果。在实验室的感应炉中进行了不同温度下的非连续试验,分析了固相FeNb与钢液凝固层界面的微观组织,并与原始FeNb粒子的微观组织进行了对比。这些试验研究结果可以阐释FeNb的溶解机制和它在不同炼钢温度下的融入动力学条件。标准FeNb在钢水中溶解的试验结果证实FeNb颗粒的溶解速率高于有关文献中报告的结果,它们认为FeNb粒子的熔化温度高(>1600℃),所以在其模型中假定FeNb的溶解仅是通过固相粒子的扩散实现。本项工作得到的试验证据为标准FeNb的溶解机理提供了一种新的说法:在1500~1510℃受其共晶区的熔化行为控制,在1530~1575℃温度范围内则由初始板条相的熔化行为所主导,也就是说,均低于1600℃左右的炼钢温度。根据这些研究结果和炼钢厂已有的生产经验,对于微合金化钢在二次精炼阶段加入FeNb推荐了最优的工艺。 | Edmundo Burgos Cruz Daniel Pallos Fridman Marcelo C Carboni Rogério Contato Guimares Marcos A Stuart Nogueira Ferdinando Luiz Cavallante 王厚昕 | 2010 | 世界钢铁2010，，6： | 2 |
| 6 | Vedolizumab for ulcerative colitis: Real world outcomes from a multicenter observational cohort of Australia and Oxford显示文摘BACKGROUND Vedolizumab(VDZ),a humanised monoclonal antibody that selectively inhibits alpha4-beta7 integrins is approved for use in adult moderate to severe ulcerative colitis(UC)patients.AIM To assess the efficacy and safety of VDZ in the real-world management of UC in a large multicenter cohort involving two countries and to identify predictors of achieving remission.METHODS A retrospective review of Australian and Oxford,United Kingdom data for UC patients.Clinical response at 3 mo,endoscopic remission at 6 mo and clinical remission at 3,6 and 12 mo were assessed.Cox regression models and Kaplan Meier curves were performed to assess the time to remission,time to failure and the covariates influencing them.Safety outcomes were recorded.RESULTS Three hundred and three UC patients from 14 centres in Australia and United Kingdom,[60%n=182,anti-TNF naïve]were included.The clinical response was 79%at 3 mo with more Australian patients achieving clinical response compared to Oxford(83%vs 70%P=0.01).Clinical remission for all patients was 56%,62%and 60%at 3,6 and 12 mo respectively.Anti-TNF naive patients were more likely to achieve remission than exposed patients at all the time points(3 mo 66%vs 40%P<0.001,6 mo 73%vs 46%P<0.001,12 mo 66%vs 51%P=0.03).More Australian patients achieved endoscopic remission at 6 mo compared to Oxford(69%vs 43%P=0.01).On multi-variate analysis,anti-TNF naïve patients were 1.8(95%CI:1.3-2.3)times more likely to achieve remission than anti-TNF exposed(P<0.001).32 patients(11%)had colectomy by 12 mo.CONCLUSION VDZ was safe and effective with 60%of UC patients achieving clinical remission at 12 mo and prior anti-TNF exposure influenced this outcome. | Samba Siva Reddy Pulusu Ashish Srinivasan Krupa Krishnaprasad Daniel Cheng Jakob Begun CharlotteKeung Daniel Van Langenberg Lena Thin Tamara Mogilevski Peter De Cruz Graham Radford-Smith Emma Flanagan Sally Bell Soleiman Kashkooli Miles Sparrow Simon Ghaly Peter Bampton Elise Sawyer Susan Connor Quart-ul-ain Rizvi Jane M Andrews Gillian Mahy Paola Chivers Simon Travis Ian Craig Lawrance | 2020 | World Journal of Gastroenterology2020，26，30： | 2 |
| 7 | Antithrombotic treatment in chronic heart failure and sinus rhythm: Systematic review显示文摘AIM: To assess the efficacy and safety of antithrombotic drugs(antiplatelet or anticoagulant drugs) compared to no antithrombotic treatment or placebo in patients with heart failure(HF) and sinus rhythm. METHODS: We searched Medline and Cochrane Library for randomized controlled trials evaluating antithrombotic treatment and no antithrombotic treatment in patients with HF and sinus rhythm. Risk ratio(RR) and 95%CIs were estimated performing meta-analysis with random effects method. RESULTS: Two studies met the inclusion criteria: Heart failure Long-term Antithrombotic Study and Warfarin/Aspirin Study in Heart failure, with 336 patients and mean follow-up 1.8-2.25 years. Stroke risk was not reduced by acetylsalicylic acid(RR = 1.18, 95%CI: 0.17-8.15), oral anticoagulation(RR = 0.30, 95%CI: 0.03-2.65) or overall antithrombotic drugs(RR = 0.52, 95%CI: 0.10-2.74). Acetylsalicylic acid showed a significant increased risk of worsening HF(RR = 1.78, 95%CI: 1.08-2.92), while oral anticoagulation had no impact in this outcome(RR = 1.03, 95%CI: 0.61-1.75). Overall antithrombotic drugs showed a significant risk increase of major bleeding(RR = 6.99, 95%CI: 0.89-54.64). CONCLUSION: Best available evidence does not support the routine use of antithrombotic drugs in patients with HF and sinus rhythm. These drugs, particularly oral anti-coagulation has the hazard of increase significantly major bleeding risk. | Daniel Caldeira Inês Cruz Rita Calé Cristina Martins Helder Pereira Joaquim J Ferreira Fausto J Pinto Joo Costa | 2015 | World Journal of Meta-Analysis2015，3，1： | 1 |
| 8 | Multibeam printed antenna array显示文摘 | CRUZ E M DANIEL J P | 1993 | Electronisc Letters1993，29，1： | 1 |
| 9 | Efficacy and Safety of OnabotulinumtoxinA in Patients with Urinary Incontinence Due to Neurogenic Detrusor Overactivity: A Randomised, Double-Blind, Placebo-Controlled Trial显示文摘 | Francisco Cruz Sender Herschorn Philip Aliotta Mitchell Brin Catherine Thompson Wayne Lam Grace Daniell John Heesakkers Cornelia Haag-Molkenteller | 2011 | European Urology2011，，4： | 1 |
| 10 | E~perlmental Analysis of Comer-fed Printed Square Patch Antenna显示文摘 | Cruz E M Daniel J P | 1991 | Electron Lett1991，27，16： | 1 |
| 11 | Natural antioxidants from residual sources显示文摘 | Moure Andres Cruz Jose Mfraco Franco Daniel | 2001 | Food Chemistry2001，72，2： | 1 |
| 12 | Systemic scleroderma with moderate to severe mitral regurgitation: Unusual three-dimensional echocardiographic features显示文摘 | Rami N. Khouzam Ivan A. D’Cruz Maximiliano Arroyo Daniel Minderman | 2008 | Canadian Journal of Cardiology2008，，2： | 1 |
| 13 | Iron isotope composition of the bulk waters and sediments from the Amazon River Basin显示文摘 | Franck Poitrasson Lucieth Cruz Vieira Patrick Seyler Giana Márcia dos Santos Pinheiro Daniel Santos Mulholland Marie-Paule Bonnet Jean-Michel Martinez Barbara Alcantara Lima Geraldo Resende Boaventura Jér?me Chmeleff Elton Luiz Dantas Jean-Loup Guyot Luiz | 2014 | Chemical Geology2014，，： | 1 |
| 14 | Interactions of primary neuroepithelial progenitor and brain endothelial cells: distinct effect on neural progenitor maintenance and differentiation by soluble factors and direct contact显示文摘神经与血管的相互作用为中枢神经系统的正常发展是关键的。在主要文化学习如此的相互作用,我们开发了一个过程同时从胚胎的老鼠大脑孤立神经祖先和 endothelial 房间部分。取决于文化条件 endothelial 房间被发现通过可溶的因素的生产赞成 theneuroprogenitor 显型的维护,或通过直接接触支持神经祖先的 neuronaldifferentiation。这些显然反对的效果能反映为大脑的合适的发展需要的微分细胞的相互作用。 | Miguel A Gama Sosa Rita De Gasperi Anne B Rocher Gissel M Perez Keila Simons Daniel E Cruz Patrick R Hof Gregory A Elder | 2007 | Cell Research2007，17，7： | 1 |
| 15 | Poster 6 Chal enges As-sociated with the Rehabilitation of a Patient with Acquired Immune Deficiency Syndrome and Advanced Progressive Multifocal Leukoencephalopathy:A Case Report显示文摘 | Stephen Gingrich Ernesto S. Cruz Daniel Moon | | 0，，10： | 1 |
| 16 | Combination Treatment With Curcumin and Quercetin of Adenomas in Familial Adenomatous Polyposis显示文摘 | Marcia Cruz–Correa Daniel A. Shoskes Patricia Sanchez Rhongua Zhao Linda M. Hylind Steven D. Wexner Francis M. Giardiello | 2006 | Clinical Gastroenterology and Hepatology2006，，8： | 1 |
| 17 | Combination Treatment With Curcumin and Quercetin of Adenomas in Familial Adenomatous Polyposis显示文摘 | Marcia Cruz–Correa Daniel A. Shoskes Patricia Sanchez Rhongua Zhao Linda M. Hylind Steven D. Wexner Francis M. Giardiello | 2006 | Clinical Gastroenterology and Hepatology2006，，8： | 1 |
| 18 | Plasma cystatin C for prediction of 1-year cardiac events in Mediterranean patients with non-ST elevation acute coronary syndrome显示文摘 | Nevio Taglieri Daniel J. Fernandez-Berges Wolfgang Koenig Luciano Consuegra-Sanchez José Maria Cruz Fernandez Nicolas Roberto Robles Pedro Luis Sánchez Alfonso Castro Beiras Pedro Maria Montes Orbe Juan Carlos Kaski | 2009 | Atherosclerosis2009，，1： | 1 |
| 19 | Management of the neck after chemoradiotherapy for head and neck cancers in Asia: consensus statement from the Asian Oncology Summit 2009显示文摘 | Joseph T Wee Benjamin O Anderson June Corry Anil D’Cruz Khee C Soo Chao-Nan Qian Daniel T Chua Rodney J Hicks Christopher HK Goh James B Khoo Seng C Ong Arlene A Forastiere Anthony T Chan | 2009 | Lancet Oncology2009，，11： | 1 |
| 20 | Neurobiological mechanisms contributing to alcohol–stress–anxiety interactions显示文摘 | Yuval Silberman Michal Bajo Ann M. Chappell Daniel T. Christian Maureen Cruz Marvin R. Diaz Thomas Kash Anna K. Lack Robert O. Messing George R. Siggins Danny Winder Marisa Roberto Brian A. McCool Jeff L. Weiner | 2009 | Alcohol2009，，： | 1 |
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