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45篇 您的检索式:作者名="Daniel Wright"
    题名 作者 年代 出处 被引量
1基于随机暴雨移置方法的城市设计暴雨分析显示文摘城市地区暴雨洪灾发生频繁,合理计算设计暴雨是解决城市洪涝的重要前提。采用随机暴雨移置方法(Stochastic Storm Transposition,SST),设定暴雨移置区并提取出暴雨目录,通过区域性概率重采样与暴雨空间变换相结合的方式进行降雨频率分析,估计本地化的极端暴雨频率。以上海地区为例,研究发现暴雨移置区内暴雨分布具有空间异质性,暴雨随机移置概率不均,计算得到的设计暴雨方案包含了降雨时空分布信息,在不同重现期下设计暴雨的时空结构存在变异性,说明传统方法中采用的简化雨型和均一化空间分布假设会增加设计暴雨的不确定性。周正正 刘曙光 Daniel B Wright 2020水科学进展2020,31,4:6
2Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure显示文摘Aram V. Chobanian George L. Bakris Henry R. Black William C. Cushman Lee A. Green Joseph L. Izzo Daniel W. Jones Barry J. Materson Suzanne Oparil Jackson T. Wright Edward J. Roccella 2003Hypertension: Journal of The American Heart Association2003,,6:4
3Lgr5 +ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro显示文摘Nick Barker Meritxell Huch Pekka Kujala Marc van de Wetering Hugo J. Snippert Johan H. van Es Toshiro Sato Daniel E. Stange Harry Begthel Maaike van den Born Esther Danenberg Stieneke van den Brink Jeroen Korving Arie Abo Peter J. Peters Nick Wright Richa 2010Cell Stem Cell2010,,1:2
4Chronic kidney disease and prevalent atrial fibrillation: The Chronic Renal Insufficiency Cohort (CRIC)显示文摘Elsayed Z. Soliman Ronald J. Prineas Alan S. Go Dawei Xie James P. Lash Mahboob Rahman Akinlolu Ojo Val L. Teal Nancy G. Jensvold Nancy L. Robinson Daniel L. Dries Lydia Bazzano Emile R. Mohler Jackson T. Wright Harold I. Feldman 2010American Heart Journal2010,,6:2
5肺癌全基因组测序显示文摘肺癌是全球肿瘤发病率和病死率的主因,且预后很差。加强对肿瘤生物学的认识对肺癌研究至关重要。被誉为'下一代测序技术'的NGS技术(next-generation sequencing)是一种针对全基因组鉴定的有力工具,可以对致癌体细胞突变进行全面检测。大多数的NGS技术是基于平台特异性DNA文库进行多重聚合酶链反应(polymerase chain reaction,PCR),从而对目的基因扩增后测序。这种技术适用于高通量测序,可以检测出肿瘤中出现的全部基因组变异。缺点是这种技术需要在时间、实验设备、计算机数据分析、生物信息技术等各方面的大量投入。NGS技术已广泛应用于全基因组、外显子组、转录组和表观基因组的研究中,为肺癌研究和医疗模式带来改变。这项新技术的开展将转变当前对致癌信号通路的认识,可为癌症诊疗提供新的分子靶点。肺癌体细胞突变已有NGS技术的分析报道,但大规模基因组研究仍在进行中。个体化治疗策略将改善那些潜在获益患者的治疗方式,避免'无辜'患者受无效治疗带来的高额费用和不良反应。NGS的组织化、计算机化和生物信息化技术推动了科技的进步,同时,患者知情权和数据发布的相关伦理问题也浮现出来。信号通路中,驱动基因(driver gene)突变和传递基因(passenger gene)突变的区别,需要对测序结果进行细致解读。解读准确与否取决于DNA提取的样本类型、样本处理技术和样本含量。肿瘤异质性也会降低肿瘤基因突变的检测效能。NGS技术将推动对肿瘤基因突变的基础和临床研究,而且,也可应用于单细胞和游离的循环DNA,未来还将用于从体液和肿瘤亚群中获取的DNA样本。如果能进一步降低费用、提高检验速度和精度,NGS技术无疑将会成为肺癌研究的绝佳选择。Marissa Daniels Felicia Goh Casey M. Wright Krishna B. Sriram Vandana Relan Belinda E. Clarke Edwina E. Duhig Rayleen V. Bowman Ian A Yang Kwun M. Fong 孙岚 何建行 2013国际病理科学与临床杂志2013,33,4:2
6An international, multicenter phase II trial of bortezomib in patients with hepatocellular carcinoma显示文摘George P. Kim Michelle R. Mahoney Daniel Szydlo Tony S. K. Mok Robert Marshke Kyle Holen Joel Picus Michael Boyer Henry C. Pitot Joseph Rubin Philip A. Philip Anna Nowak John J. Wright Charles Erlichman 2012Investigational New Drugs2012,,1:2
7Xenon purity analysis for exo-200 via mass spectrometry 显示文摘Dobi A Hall C Slutsky S Yen Y R Aharmin B Auger M Barbeau P S Benitez-Medina C Breidenbach M Cleveland B Conley R Cook J Cook S Counts I Craddock W Daniels T Davis C G Davis J Devoe R Dixit M Dolinski M J Donato K Fairbank Jr W Farine J Fierlinger P Franco D Giroux G Gornea R Graham K Gratta G Green C Hagemann C Hall K Hallman D Hargrove C Herrin S Hughes M Hodgson J Juget F Karelin A Kaufman L J Kuchenkov A Kumar K Leonard D S Lutter G Mackay D Maclellan R Marino M Mong B Montero Diez M Morgan P MUller A R Neilson R Odian A Oullivan K Piepke A Pocar A Prescott C Y Pushkin K Rivas A Rollin E Rowson P C Sabourov A Sinclair D Skarpaas K Stekhanov V Strickland V Swift M Twelker K Vuilleumier J L Vuilleumier J M Weber M Wichoski U Wodin J Wright J D Yang L 2012Nuclear Instruments and Methods in Physics Research Section A: Accelerators Spectrometers Detectors and Associated Equipment2012,675,:1
8Upregulation of prostate-specific membrane antigen after androgen-deprivation therapy显示文摘George L. Wright B. Mayer Grob Cara Haley Katie Grossman Kathy Newhall Daniel Petrylak John Troyer Alice Konchuba Paul F. Schellhammer Richard Moriarty 1996Urology1996,,2:1
9Age Differences in Lineup Identification Accuracy: People Are Better with Their Own Age显示文摘Daniel B. Wright Joanne N. Stroud 2002Law and Human Behavior2002,,6:1
1018Fluorodeoxyglucose-Positron Emission Tomography in the Management of Patients With Suspected Pancreatic Cancer显示文摘D. Michael Rose Dominique Delbeke R. Daniel Beauchamp William C. Chapman Martin P. Sandler Kenneth W. Sharp William O. Richards J. Kelly Wright Maria E. Frexes C. Wright Pinson Steven D. Leach 1999Annals of Surgery1999,,5:1
11Monolithic photorefractive organic glasses with large coupling gain and strong beam fanning 显示文摘Urich Gubler Meng He Daniel Wright 2002Adv Mater2002,14,4:1
12A Practical Criterion for the Rapid Detection of Single‐Loop and Double‐Loop Reentry Tachycardias显示文摘NICK W.F. LINTON STEPHEN B. WILTON DANIEL SCHERR ASHOK J. SHAH NICOLAS DERVAL FREDERIC SACHER MATTHEW WRIGHT MéLèZE HOCINI MARK D. O’NEILL MICHEL HA?SSAGUERRE PIERRE JA?S 2013J Cardiovasc Electrophysiol2013,,5:1
13PLANT ECOLOGICAL STRATEGIES: Some Leading Dimensions of Variation Between Species显示文摘Mark Westoby Daniel S. Falster Angela T. Moles Peter A. Vesk Ian J. Wright 2002Annual Review of Ecology and Systematics2002,,:1
14Cancer Health Empowerment for Living without Pain (Ca-HELP): effects of a tailored education and coaching intervention on pain and impairment显示文摘Richard L. Kravitz Daniel J. Tancredi Tim Grennan Donna Kalauokalani Richard L. Street Christina K. Slee Ted Wun Jennifer Wright Oliver Kate Lorig Peter Franks 2011Pain2011,,7:1
15Whole genome sequencing for lung cancer显示文摘Daniels M Goh F Wright CM 2012J Thorac Dis2012,4,:1
16A Functional Magnetic Resonance Imaging Study of Amygdala Responses to Human Faces in Aging and Mild Alzheimer’s Disease显示文摘Christopher I. Wright Bradford C. Dickerson Eric Feczko Alyson Negeira Danielle Williams 2007Biological Psychiatry2007,,12:1
17Yield and Nitrogen Management of Irrigated Switchgrass Systems in Diverse Ecoregions显示文摘Pedroso Gabriel M Hutmacher Robert B Putnam Daniel Wright Steven D Six Johan van Kessel Chris Linquist Bruce A 2013Agronomy Journal2013,,2:1
18Factors contributing to the successful implementation of technology innovafions显示文摘David Ensminger Daniel Surry Barry Porter Dawn Wright 2004Educafional Technology& Society2004,7,3:1
19Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure显示文摘Aram V. Chobanian George L. Bakris Henry R. Black William C. Cushman Lee A. Green Joseph L. Izzo Daniel W. Jones Barry J. Materson Suzanne Oparil Jackson T. Wright Edward J. Roccella 2003Hypertension: Journal of The American Heart Association2003,,6:1
20The microsporidian parasites Nosema ceranae and Nosema apis are widespread in honeybee ( Apis mellifera ) colonies across Scotland显示文摘Karen A Bollan J. Daniel Hothersall Christopher Moffat John Durkacz Nastja Saranzewa Geraldine A. Wright Nigel E. Raine Fiona Highet Christopher N. Connolly 2013Parasitology Research2013,,2:1
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