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| 1 | Stability improvement under high efficiency—next stage development of perovskite solar cells显示文摘With efficiency of perovskite solar cells(PSCs) overpassing 23%, to realize their commercialization, the biggest challenge now is to boost the stability to the same level as conventional solar cells. Thus, tremendous effort has been directed over the past few years toward improving the stability of these cells. Various methods were used to improve the stability of bulk perovskites,including compositional engineering, interface adjustment, dimensional manipulation, crystal engineering, and grain boundary decoration. Diverse device configurations, carrier transporting layers, and counter electrodes are investigated. To compare the stability of PSCs and clarify the degradation mechanism, diverse characterization methods were developed. Overall stability of PSCs has become one central topic for the development of PSCs. In this review, we summarize the state-of-the-art progress on the improvement of device stability and discuss the directions for future research, hoping it provides an overview of the current status of the research on the stability of PSCs and guidelines for future research. | Danni Yu Yue Hu Jiangjian Shi Haoying Tang Wenhao Zhang Qingbo Meng Hongwei Han Zhijun Ning He Tian | 2019 | Science China Chemistry2019，62，6： | 7 |
| 2 | Indian hedgehog mutations causing brachydactyly type A1 impair Hedgehog signal transduction at multiple levels显示文摘Brachydactyly 打 A1 (BDA1 ) ,第一在人记录了孟德尔的正染色体的主导的混乱,被弄短或中间的指骨的缺席描绘。在印度刺猬(IHH ) 基因的异质接合的错误感觉变化作为 BDA1 的一个原因被识别了;然而,这些变化的生物化学的后果是不清楚的。在这份报纸,我们在印度刺猬(IhhN ) 的 N 终端碎片分析了三个 BDA1 变化(E95K, D100E,和 E131K ) 。结构的分析证明 E95K 变化在一条钙绑定沟把一个否定地控告的区域改变到一个断然控告的区域,并且 D100E 变化改变本地第三级的结构。而且,我们证明 E95K 和 D100E 变化导致了一温度敏感并且 IhhN 的钙依赖者不稳定性,它可能经由 lysosome 贡献变异的蛋白质的提高的细胞内部的降级。尤其是,所有三个变化影响了对受体 Patched1 (PTC1 ) 有约束力的 Hh,减少它的能力导致细胞的区别。我们建议这些是引起 BDA1 的变化的普通特征,影响 Hh 第三级的结构,细胞内部的命运,到受体 / 搭挡的绑定,和到细胞外的部件的绑定。这些特征的联合改变发信号的能力和范围,但是影响是可能的是变量和变化依赖者。在发信号的范围的潜在的变化被和 heparan 硫酸盐的一个提高的相互作用与 E95K 变化,然而并非 E131K 变化为 IHH 描绘。一起拿,我们的结果建议这些 IHH 变化影响在多重层次,引起的反常骨头发展和反常的位形成发信号的 Hh。 | Gang Ma Jiang Yu Yue Xiao Danny Chan Bo Gao Jianxin Hu Yongxing He Shengzhen Guo Jian Zhou Lingling Zhang Linghan Gao Wenjuan Zhang Yan Kang Kathryn SE Cheah Guoyin Feng Xizhi Guo Yujiong Wang Cong-zhao Zhou Lin He | 2011 | Cell Research2011，21，9： | 6 |
| 3 | A single-cell transcriptome of mesenchymal stromal cells to fabricate bioactive hydroxyapatite materials for bone regeneration显示文摘The osteogenic microenvironment of bone-repairing materials plays a key role in accelerating bone regeneration but remains incompletely defined,which significantly limits the application of such bioactive materials.Here,the transcriptional landscapes of different osteogenic microenvironments,including three-dimensional(3D)hydroxyapatite(HA)scaffolds and osteogenic medium(OM),for mesenchymal stromal cells(MSCs)in vitro were mapped at single-cell resolution.Our findings suggested that an osteogenic process reminiscent of endochondral ossification occurred in HA scaffolds through sequential activation of osteogenic-related signaling pathways,along with inflammation and angiogenesis,but inhibition of adipogenesis and fibrosis.Moreover,we revealed the mechanism during OM-mediated osteogenesis involves the ZBTB16 and WNT signaling pathways.Heterogeneity of MSCs was also demonstrated.In vitro ossification of LRRC75A+MSCs was shown to have better utilization of WNT-related ossification process,and PCDH10+MSCs with superiority in hydroxyapatite-related osteogenic process.These findings provided further understanding of the cellular activity modulated by OM conditions and HA scaffolds,providing new insights for the improvement of osteogenic biomaterials.This atlas provides a blueprint for research on MSC heterogeneity and the osteogenic microenvironment of HA scaffolds and a database reference for the application of bioactive materials for bone regeneration. | Peng Guo Xizhe Liu Penghui Zhang Zhongyuan He Zhen Li Mauro Alini RGeoff Richards Sibylle Grad Martin J.Stoddart Guangqian Zhou Xuenong Zou Danny Chan Wei Tian Dafu Chen Manman Gao Zhiyu Zhou Shaoyu Liu | 2022 | Bioactive Materials2022，7，3： | 3 |
| 4 | 3D uniform nitrogen-doped carbon skeleton for ultra-stable sodium metal anode显示文摘Sodium metal batteries are arousing extensive interest owing to their high energy density,low cost and wide resource.However,the practical development of sodium metal batteries is inherently plagued by the severe volume expansion and the dendrite growth of sodium metal anode during long cycles under high current density.Herein,a simple electrospinning method is applied to construct the uniformly nitrogen-doped porous carbon fiber skeleton and used as three-dimensional(3D)current collector for sodium metal anode,which has high specific surface area(1,098 m^2/g)and strong binding to sodium metal.As a result,nitrogen-doped carbon fiber current collector shows a low sodium deposition overpotential and a highly stable cyclability for 3,500 h with a high coulombic effciency of 99.9%at 2 mA/cm^2 and 2 mAh/cm^2.Moreover,the full cells using carbon coated sodium vanadium phosphate as cathode and sodium pre-plated nitrogen-doped carbon fiber skeleton as hybrid anode can stably cycle for 300 times.These results illustrate an effective strategy to construct a 3D uniformly nitrogen-doped carbon skeleton based sodium metal hybrid anode without the formation of dendrites,which provide a prospect for further development and research of high performance sodium metal batteries. | Ben Liu Danni Lei Jin Wang Qingfei Zhang Yinggan Zhang Wei He Hongfei Zheng Baisheng Sa Qingshui Xie Dong-Liang Peng Baihua Qu | 2020 | Nano Research2020，13，8： | 3 |
| 5 | In-situ polymerized cross-linked binder for cathode in lithium-sulfur batteries显示文摘Volume expansion and polysulfide shuttle effect are the main barriers for the commercialization of lithium-sulfur(Li-S) battery.In this work,we in-situ polymerized a cross-linked binder in sulfur cathode to solve the aforementioned problems using a facile method under mild conditions.Polycarbonate diol(PCDL),triethanolamine(TEA) and hexamethylene diisocyanate(HDI) were chosen as precursors to prepare the cross-linked binder.The in-situ polymerized binder(PTH) builds a strong network in sulfur cathode,which could restrain the volume expansion of sulfu r.Moreover,by adopting functional groups of oxygen atoms and nitrogen atoms,the binder could effectively facilitate transportation of Li-ion and adsorb polysulfide chemically.The Li-S battery with bare sulfur and carbon/sulfur composite cathodes and cross-linked PTH binder displays much better electrochemical performance than that of the battery with PVDF.The PTH-bare S cathode with a mass loading of 5.97 mg/cm^2 could deliver a capacity of 733.3 mAh/g at 0.2 C,and remained 585.5 mAh/g after 100 cycles.This in-situ polymerized binder is proved to be quite effective on restraining the volume expansion and suppressing polysulfide shuttle effect,then improving the electrochemical performance of Li-S battery. | Heng Ye Danni Lei Lu Shen Bin Ni Baohua Li Feiyu Kang Yan-Bing He | 2020 | Chinese Chemical Letters2020，31，2： | 2 |
| 6 | Comparison of gut microbiota in autism spectrum disorders and neurotypical boys in China:A case-control study显示文摘Background:Autism spectrum disorders(ASDs)are a set of complex neurobiological disorders.Growing evidence has shown that the microbiota that resides in the gut can modulate brain development via the gut–brain axis.However,direct clinical evidence of the role of the microbiota–gut–brain axis in ASD is relatively limited.Methods:A case-control study of 71 boys with ASD and 18 neurotypical controls was conducted at China-Japan Friendship Hospital.Demographic information and fecal samples were collected,and the gut microbiome was evaluated and compared by 16S ribosomal RNA gene sequencing and metagenomic sequencing.Results:A higher abundance of operational taxonomic units(OTUs)based on fecal bacterial profiling was observed in the ASD group.Significantly different microbiome profiles were observed between the two groups.At the genus level,we observed a decrease in the relative abundance of Escherichia,Shigella,Veillonella,Akkermansia,Provindencia,Dialister,Bifidobacterium,Streptococcus,Ruminococcaceae UCG_002,Megasphaera,Eubacterium_coprostanol,Citrobacter,Ruminiclostridium_5,and Ruminiclostridium_6 in the ASD cohort,while Eisenbergiella,Klebsiella,Faecalibacterium,and Blautia were significantly increased.Ten bacterial strains were selected for clinical discrimination between those with ASD and the neurotypical controls.The highest AUC value of the model was 0.947.Conclusion:Significant differences were observed in the composition of the gut microbiome between boys with ASD and neurotypical controls.These findings contribute to the knowledge of the alteration of the gut microbiome in ASD patients,which opens the possibility for early identification of this disease. | Fang Ye Xinying Gao Zhiyi Wang Shuman Cao Guangcai Liang Danni He Zhitang Lv Liming Wang Pengfei Xu Qi Zhang | 2021 | Synthetic and Systems Biotechnology2021，6，2： | 2 |
| 7 | An ultrathin and continuous Li_4Ti_5O_(12) coated carbon nanofiber interlayer for high rate lithium sulfur battery显示文摘Severe capacity fading and poor high rate performance of lithium sulfur(Li–S) battery caused by 'shuttle effect' and low conductivity of sulfur hampers its further developments and applications. Li_4Ti_5O_(12) (LTO)possesses high lithium ion conductivity, and it is also can be used as an active adsorbent for polysulfide. Herein, fine LTO particle coated carbon nanofibers(CNF) were prepared and a conductive network both for electron and lithium ion was built, which can greatly promote the electrochemical conversion of polysulfide and improve the rate performance of Li–S batteries. Meanwhile, a quantity of adsorption sites is constructed by defects of the surface of LTO-CNF membrane to effectively immobilize polysulfide. The multifunctional LTO-CNF interlayer could impede the shuttle effect and enhance comprehensive electrochemical performance of Li–S batteries, especially high rate performance. With such LTO-CNF interlayer,the Li–S battery presents a specific capacity of 641.9 mAh/g at 5 C rate. After 400 cycles at 1 C, a capacity of 618.0 mAh/g is retained. This work provides a feasible strategy to achieve high performance of Li–S battery for practical utilization. | Decheng An Lu Shen Danni Lei Lehong Wang Heng Ye Baohua Li Feiyu Kang Yan-Bing He | 2019 | Journal of Energy Chemistry2019，28，4： | 2 |
| 8 | Quantitation of covalently closed circular DNA in chronic hepatitis B patients显示文摘 | Danny Ka-Ho Wong Man-Fung Yuen He Jun Yuan | 2004 | Hepatology2004，40，： | 1 |
| 9 | Preparation of lead carbonate from spent lead paste via chemical conversion显示文摘 | Xinfeng Zhu Jiakuan Yang Linxia Gao Jianwen Liu Danni Yang Xiaojuan Sun Wei Zhang Qin Wang Lei Li Dongsheng He R. Vasant Kumar | 2013 | Hydrometallurgy2013，，： | 1 |
| 10 | Study on Intervention of Blood Sugar and Blood Lipid in Diabetic Mice by Abrus Cantoniensis and Armeniaca mume Sieb and Their Compatibility显示文摘Objective:The study aims to explore the interventional effect of Abrus cantonensis and Armeniaca mume Sieb and their compatibility on blood glucose and blood lipid in diabetic mice and to explore the optimal ratio of efficacy of their compatibility.Methods:SPF Kunming male mice were fed with high sugar and high fat diet for 6 weeks and then intraperitoneally injected with STZ solution to establish a diabetes model.The successfully modeled mice were randomly divided into 6 groups according to their body weight:model group,Abrus Cantoniensis group,Armeniaca mume Sieb group,as well as Abrus Cantoniensis and Armeniaca mume Sieb group divided into 1:2,1:1 and 2:1 groups according to volume ratio with 10 mice in each group.Another 10 healthy mice were taken as blank group and intraperitoneally injected with sodium citrate buffer.The corresponding solution was given intragastric administration by body mass once a day for 20 days.After the last administration,fasting was performed for 12 hours.Serum was collected by the method of eyeball blood collection to determine the contents of fasting blood glucose,total cholesterol Triacylglycerol,triglyceride,low density lipoprotein and high-density lipoprotein.Results:Compared with Abrus Cantoniensis and Armeniaca mume Sieb groups,Glu,TG,TC and LDL-C of the three compatibility groups significantly decreased,with the most significant decrease in the compatibility group 1:2,while there was no significant difference in HDL-C among all groups.Conclusion:Abrus Cantoniensis and Armeniaca mume Sieb and their combination have synergistic effects on the improvement of blood glucose and lipid levels in mice with high glucose and high fat combined with STZ-induced diabetes mellitus model.Among all the experimental groups,the compatibility 1:2 group had the best effect. | Yixin Zhang Shibo Zhao Sitong Lu Danni Lu Yedong Shen Changhuan He Zhonggang Wu Suoyi Huang | 2021 | TMR Pharmacology Research2021，1，4： | 1 |
| 11 | GABA Enhances Thermotolerance of Seeds Germination by Attenuating the ROS Damage in Arabidopsis显示文摘Seeds germination is strictly controlled by environment factor such as high temperature(HT)through altering the balance between gibberellin acid(GA)and abscisic acid(ABA).Gama-aminobutyric acid(GABA)is a small molecule with four-carbon amino acid,which plays a crucial role during plant physiological process associated with pollination,wounding or abiotic stress,but its role in seeds germination under HT remains elusive.In this study we found that HT induced the overaccumulation of ROS,mainly H_(2)O_(2) and O_(2)^(-),to suppress seeds germination,meanwhile,HT also activated the enzyme activity of GAD for the rapid accumulation of GABA,hinting the regulatory function of GABA in con-trolling seeds germination against HT stress.Applying GABA directly attenuated HT-induced ROS accumulation,upregulated GA biosynthesis and downregulated ABA biosynthesis,ultimately enhanced seeds germination.Consistently,genetic analysis using the gad1/2 mutant defective in GABA biosynthesis,or pop2-5 mutant with high endogenous GABA content supported the potential function of GABA in improving seeds germination tolerance to HT through scavenging ROS overaccumulation.Based on these data,we propose that GABA acts as a novel signal to enhance thermotolerance of seeds germination through alleviating the ROS damage to seeds viability. | Qili Zhang Danni He Songbei Ying Shiyan Lu Jiali Wei Ping Li | 2020 | Phyton-International Journal of Experimental Botany2020，89，3： | 1 |
| 12 | Carbon Monoxide Signal Breaks Primary Seed Dormancy by Transcriptional Silence of DOG1 in Arabidopsis thaliana显示文摘Primary seed dormancy is an adaptive strategy that prevents germination for viable seeds in harsh environment,ensuring seeds germination under favorable condition.Accurately inducing seeds germination in a controllable manner is important for crop production.Thus searching the chemicals that efficiently breaks seed dormancy is valuable.DOG1 protein abundance in the freshly harvested seed is high,and its level is correlated to seed dormancy intensity,thus DOG1 is regarded as the timer to evaluate the seed dormancy degree.In this study,we found the carbon monoxide(CO)donor treatment,the transgenic line with high CO content,showed lower seed dormancy,while scavenging CO,or the mutant with lower CO level,presented strong primary seed dormancy,genetic analysis showed that DOG1 was targeted by CO signal and was prerequisite for CO-dependent seed dormancy release.Furthermore,we found CO signal activated the expression of ERF/AP2 transcriptional factor ERF12,as well as enhanced the binding of ERF12 to the promoter of DOG1,ultimately transcriptional silence of DOG1 expression to break primary seed dormancy.Meanwhile CO signal reduced the histone acetylation level at the chromatin of DOG1 locus to suppress its expression.Together,our results revealed that CO acts as the novel regulator to suppress DOG1 expression and efficiently break primary seed dormancy through activating the negative factor ERF12. | Danni He Guoli Deng Songpei Ying Wenjuan Yang Jiali Wei Ping Li | 2020 | Phyton-International Journal of Experimental Botany2020，89，3： | 1 |
| 13 | Clinical and Biological Significance of KISS1 Expression in Prostate Cancer显示文摘 | Honghe Wang Jacqueline Jones Timothy Turner Qinghua P. He Shana Hardy William E. Grizzle Danny R. Welch Clayton Yates | 2012 | The American Journal of Pathology2012，，3： | 1 |
| 14 | Leaching of spent lead acid battery paste components by sodium citrate and acetic acid显示文摘 | Xinfeng Zhu Xiong He Jiakuan Yang Linxia Gao Jianwen Liu Danni Yang Xiaojuan Sun Wei Zhang Qin Wang R Vasant Kumar | 2013 | Journal of Hazardous Materials2013，，： | 1 |
| 15 | Leaching of spent lead acid battery paste components by sodium citrate and acetic acid显示文摘 | Xinfeng Zhu Xiong He Jiakuan Yang Linxia Gao Jianwen Liu Danni Yang Xiaojuan Sun Wei Zhang Qin Wang R Vasant Kumar | 2013 | Journal of Hazardous Materials2013，，： | 1 |
| 16 | Notes,outline and divergence times of Basidiomycota显示文摘The Basidiomycota constitutes a major phylum of the kingdom Fungi and is second in species numbers to the Ascomycota.The present work provides an overview of all validly published,currently used basidiomycete genera to date in a single document.An outline of all genera of Basidiomycota is provided,which includes 1928 currently used genera names,with 1263 synonyms,which are distributed in 241 families,68 orders,18 classes and four subphyla.We provide brief notes for each accepted genus including information on classification,number of accepted species,type species,life mode,habitat,distribution,and sequence information.Furthermore,three phylogenetic analyses with combined LSU,SSU,5.8s,rpb1,rpb2,and ef1 datasets for the subphyla Agaricomycotina,Pucciniomycotina and Ustilaginomycotina are conducted,respectively.Divergence time estimates are provided to the family level with 632 species from 62 orders,168 families and 605 genera.Our study indicates that the divergence times of the subphyla in Basidiomycota are 406-430 Mya,classes are 211-383 Mya,and orders are 99-323 Mya,which are largely consistent with previous studies.In this study,all phylogenetically supported families were dated,with the families of Agaricomycotina diverging from 27-178 Mya,Pucciniomycotina from 85-222 Mya,and Ustilaginomycotina from 79-177 Mya.Divergence times as additional criterion in ranking provide additional evidence to resolve taxonomic problems in the Basidiomycota taxonomic system,and also provide a better understanding of their phylogeny and evolution. | Mao-Qiang He Rui-Lin Zhao Kevin D.Hyde Dominik Begerow Martin Kemler Andrey Yurkov Eric H.C.McKenzie Olivier Raspe Makoto Kakishima Santiago Sanchez-Ramırez Else C.Vellinga Roy Halling Viktor Papp Ivan V.Zmitrovich Bart Buyck Damien Ertz Nalin N.Wijayawardene Bao-Kai Cui Nathan Schoutteten Xin-Zhan Liu Tai-Hui Li Yi-Jian Yao Xin-Yu Zhu An-Qi Liu Guo-Jie Li Ming-Zhe Zhang Zhi-Lin Ling Bin Cao Vladimir Antonin Teun Boekhout Bianca Denise Barbosa da Silva Eske De Crop Cony Decock Balint Dima Arun Kumar Dutta Jack W.Fell Jozsef Geml Masoomeh Ghobad-Nejhad Admir J.Giachini Tatiana B.Gibertoni Sergio P.Gorjon Danny Haelewaters Shuang-Hui He Brendan P.Hodkinson Egon Horak Tamotsu Hoshino Alfredo Justo Young Woon Lim Nelson Menolli Jr Armin Mesic Jean-Marc Moncalvo Gregory M.Mueller La szlo G.Nagy RHenrik Nilsson Machiel Noordeloos Jorinde Nuytinck Takamichi Orihara Cheewangkoon Ratchadawan Mario Rajchenberg Alexandre G.S.Silva-Filho Marcelo Aloisio Sulzbacher Zdenko Tkalcec Ricardo Valenzuela Annemieke Verbeken Alfredo Vizzini Felipe Wartchow Tie-Zheng Wei Michael WeiB Chang-Lin Zhao Paul M.Kirk | 2019 | Fungal Diversity2019，，6： | 0 |
| 17 | DEVELOPMENT OF AN AUTOMATIC WEIGHING PLATFORM FOR MONITORING BODYWEIGHT OF BROILER CHICKENS IN COMMERCIAL PRODUCTION显示文摘Bodyweight is a key indicator of broiler production as it measures the production efficiency and indicates the health of a flock.Currently,broiler weight(i.e.,bodyweight)is primarily weighed manually,which is timeconsuming and labor-intensive,and tends to create stress in birds.This study aimed to develop an automatic and stress-free weighing platform for monitoring the weight of floor-reared broiler chickens in commercial production.The developed system consists of a weighing platform,a real-time communication terminal,computer software and a smart phone applet userinterface.The system collected weight data of chickens on the weighing platform at intervals of 6 s,followed by filtering of outliers and repeating readings.The performance and stability of this system was systematically evaluated under commercial production conditions.With the adoption of data preprocessing protocol,the average error of the new automatic weighing system was only 10.3 g,with an average accuracy 99.5%with the standard deviation of 2.3%.Further regression analysis showed a strong agreement between estimated weight and the standard weight obtained by the established live-bird sales system.The variance(an indicator of flock uniformity)of broiler weight estimated using automatic weighing platforms was in accordance with the standard weight.The weighing system demonstrated superior stability for different growth stages,rearing seasons,growth rate types(medium-and slow-growing chickens)and sexes.The system is applicable for daily weight monitoring in floor-reared broiler houses to improve feeding management,growth monitoring and finishing day prediction.Its application in commercial farms would improve the sustainability of poultry industry. | Danni ZHOU Yi ZHOU Pengguang HE Lin YU Jinming PAN Lilong CHAI Hongjian LIN | 2023 | Frontiers of Agricultural Science and Engineering2023，10，3： | 0 |
| 18 | The wheat sucrose synthase gene TaSus1 is a determinant of grain number per spike显示文摘Some haplotypes of the sucrose synthase gene TaSus1 are associated with thousand-grain weight(TGW)in wheat(Triticum aestivum L.).However,no mutations have been identified within the gene to test this association.The effects of TaSus1 on grain number per spike(GNS)also are largely unknown.Our previous genome-wide association study identified TaSus-A1 as a candidate gene controlling fertile spikelet number per spike(FSN).In the present study,we generated two independent mutants for the three TaSus1 homoeologs by CRISPR/Cas9-mediated genome editing.The triple mutants displayed lower FSN,GNS,grain number per spikelet(GNST),and TGW than wild-type plants.In 306 hexaploid wheat accessions,two single-nucleotide polymorphisms in TaSus-A1 contributed differently to GNS.Introgression of the two alleles into a wheat genetic background confirmed their effects.The alleles differed in geographical distribution among the accessions. | Liping Shen Lili Zhang Changbin Yin Xiaowan Xu Yangyang Liu Kuocheng Shen He Wu Zhiwen Sun Ke Wang Zhonghu He Xueyong Zhang Chenyang Hao Jian Hou Aoyue Bi Xuebo Zhao Daxing Xu Botao Ye Xuchang Yu Ziying Wang Danni Liu Yuanfeng Hao Fei Lu Zifeng Guo | 2024 | The Crop Journal2024，12，1： | 0 |
| 19 | Macromolecule’s Orientation in a Nanofiber by Bubble Electrospinning显示文摘In the search for sustainable alternatives to harmful synthetic fibers,an increasing amount of research focuses on biomimicry and natural fibers.Sea silk is an exceptional textile material.It is a kind of natural silk produced using the long silky filaments secreted by a specific bivalve mollusk(Pinna nobilis);now at edge of extinction.This paper suggests a simple but effective way to prepare artificial sea silk from Mytilus edulis.A sea silk solution is prepared using a Mytilus edulis protein,and a polyvinyl alcohol(PVA)solution is mixed with the sea silk solution in order to produce artificial sea silk through a bubble electrospinning technique.The effects of the sea silk concentration on the nanofiber’s morphology and mechanical properties are studied experimentally. | Dan Tian Danni Yu Chunhui He | 2021 | Fluid Dynamics & Materials Processing2021，17，4： | 0 |
| 20 | Sustained release of magnesium and zinc ions synergistically accelerates wound healing显示文摘Skin wounds are a major medical challenge that threaten human health.Functional hydrogel dressings demonstrate great potential to promote wound healing.In this study,magnesium(Mg)and zinc(Zn)are introduced into methacrylate gelatin(GelMA)hydrogel via low-temperature magnetic stirring and photocuring,and their effects on skin wounds and the underlying mechanisms are investigated.Degradation testing confirmed that the GelMA/Mg/Zn hydrogel released magnesium ions(Mg^(2+))and zinc ions(Zn^(2+))in a sustained manner.The Mg^(2+) and Zn^(2+)not only enhanced the migration of human skin fibroblasts(HSFs)and human immortalized keratinocytes(HaCats),but also promoted the transformation of HSFs into myofibroblasts and accelerated the production and remodeling of extracellular matrix.Moreover,the GelMA/Mg/Zn hydrogel enhanced the healing of full-thickness skin defects in rats via accelerated collagen deposition,angiogenesis and skin wound re-epithelialization.We also identified the mechanisms through which GelMA/Mg/Zn hydrogel promoted wound healing:the Mg^(2+) promoted Zn^(2+)entry into HSFs and increased the concentration of Zn^(2+)in HSFs,which effectively induced HSFs to differentiate into myofibroblasts by activating the STAT3 signaling pathway.The synergistic effect of Mg^(2+) and Zn^(2+)promoted wound healing.In conclusion,our study provides a promising strategy for skin wounds regeneration. | Fan Yang Yijia Xue Feilong Wang Danni Guo Yunjiao He Xiao Zhao Fanyu Yan Yuqian Xu Dandan Xia Yunsong Liu | 2023 | Bioactive Materials2023，，8： | 0 |
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