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| 1 | Artemisinin mimics calorie restriction to extend yeast lifespan via a dual-phase mode: a conclusion drawn from global transcriptome profiling显示文摘Calorie restriction(CR) promotes longevity among distinct organisms from yeast to mammals. Although CR-prolonged lifespan is believed to associate with enhanced respiratory activity, it is apparently controversial for accelerated energy consumption regardless of insufficient nutrient intake. In reconciling the contradiction of less food supply versus much metabolite dispense, we revealed a CR-based mode of dual-phase responses that encompass a phase of mitochondrial enhancement(ME) and a phase of post-mitochondrial enhancement(PME), which can be distinguished by the expression patterns and activity dynamics of mitochondrial signatures. ME is characterized by global antioxidative activation, and PME is denoted by systemic metabolic modulation. CR-mediated aging-delaying effects are replicated by artesunate, a semi-synthetic derivative of the antimalarial artemisinin that can alkylate heme-containing proteins, suggesting artesunate-heme conjugation functionally resembles nitric oxide-heme interaction. A correlation of artesunate-heme conjugation with cytochrome c oxidase activation has been established from adduct formation and activity alteration. Exogenous hydrogen peroxide also mimics CR to trigger antioxidant responses, affect signaling cascades, and alter respiratory rhythms, implying hydrogen peroxide is engaged in lifespan extension. Conclusively, artesunate mimics CR-triggered nitric oxide and hydrogen peroxide to induce antioxidative networks for scavenging reactive oxygen species and mitigating oxidative stress, thereby directing metabolic conversion from anabolism to catabolism, maintaining essential metabolic functionality, and extending life expectancy in yeast. | WANG DaTing WU Ming LI SiMing GAO Qian ZENG QingPing | 2015 | Science China(Life Sciences)2015，58，5： | 6 |
| 2 | Effect of process parameters on electromagnetic impact welding of aluminum sheets显示文摘 | S.D. Kore P.P. Date S.V. Kulkarni | 2006 | International Journal of Impact Engineering2006，，8： | 3 |
| 3 | Design and evaluation of self-nanoemulsifying drug delivery systems (SNEDDS) for cefpodoxime proxetil显示文摘 | Abhijit A. Date M.S. Nagarsenker | 2006 | International Journal of Pharmaceutics2006，，1： | 2 |
| 4 | Advances in the catalysis of Au nanoparticles显示文摘 | HARUTA M DATE M | 2001 | Applied Catalysis A: General2001，222，： | 1 |
| 5 | Intracerebral transplantation of genetically engineered cells for Parkinson's disease: toward clinical application 显示文摘 | YASUHARA T DATE I | 2007 | Cell Transplant2007，16，2： | 1 |
| 6 | Successful canine bilateral single-lung transplantation after 21-hour lung preservation 显示文摘 | Date I-I Izumi S Miyade Y | 1995 | Ann Thorac Surg1995，59，： | 1 |
| 7 | Ghrelin is a growth hormone releasing acylated peptide from the stomach 显示文摘 | KOJIMA M HOSODA H DATE Y | 1999 | Nature1999，402，6762： | 1 |
| 8 | Hepatic cell lines HeLaand 293 support efficient replication of the hepatitis C virusgenotype 2a subgenomic replicon显示文摘 | Kato T Date T Miyamoto M | 2005 | J Virol2005，79，： | 1 |
| 9 | Ghrelin is a growth-hormone- releasing acylated peptide from stomach 显示文摘 | Kojima M Hosoda H Date Y | 1999 | Nature1999，402，： | 1 |
| 10 | Efficient replication of the genotype 2a hepatitis C virus subgenomic replicon显示文摘 | KATO T DATE T MIYAMOTO M | 2003 | Gastroenterology2003，125，6： | 1 |
| 11 | Visualization of the esophagus throughout left atrial catheter ablation for atrial fibrillation 显示文摘 | Yamane T Matsuo S Date T | 2006 | J Cardiovasc Electrophysiol2006，17，： | 1 |
| 12 | Simple Conditions for Guaranteeing Higher Normal Forms in Relational Databases显示文摘 | Date C J Fagin R | 1992 | ACM Transactions on Database Systems1992，17，3： | 1 |
| 13 | Ghrelin is a growth-hormone-releasing acylated peptide from stomach 显示文摘 | Kojima M Hosoda H Date Y | 1999 | Nature1999，402，6762： | 1 |
| 14 | Heat transfer and pressure drop in a spirally grooved tube with twisted tape insert 显示文摘 | Bharadwaj P Khondge A D Date A W | 2009 | International Journal of Heat and Mass Transfer2009，52，78： | 1 |
| 15 | ghrelin-induce food intake is me- diated via the orexin path way显示文摘 | Toshinai K Date Y Murakami N | 2003 | Endocrinology2003，144，： | 1 |
| 16 | Ghrelin is a growth-hormone-re- leasing acylated peptide from stomach 显示文摘 | Kojim M Hosoda H Date Y | 1999 | Nature1999，402，6762： | 1 |
| 17 | Heat transfer and pressure drop characteristics of laminar flow in a circular tube fitted with regularly spaced twisted-tape elements 显示文摘 | Saha S K Gaitonde U N Date A W | 1989 | Experimental Thermal and Fluid Science1989，2，3： | 1 |
| 18 | Evaluation of lead-free solder balls produced by uniform droplet spray method显示文摘 | Date M Sato K Kuboi T | | 0，，18： | 1 |
| 19 | Changes in plasma ghrelin levels, gastric ghrelin production, and body weight after Helicobacter pylori cure显示文摘 | Hiroyuki Osawa Hiroto Kita Hirohide Ohnishi Masamitsu Nakazato Yukari Date Christopher L. Bowlus Yumiko Ishino Eiko Watanabe Tomomi Shiiya Hiroaki Ueno Hiroko Hoshino Kiichi Satoh Kentaro Sugano | 2006 | Journal of Gastroenterology2006，，10： | 1 |
| 20 | Bone morphogenetic protein-2 induces differentiation of multipotent C3H10T1/2 cells into osteoblasts, chon- drocytes, and adipocytes in vivo and in vitro显示文摘 | DATE T DOIGUCHI Y NOBUTA M | 2004 | J Orthop Sci2004，9，： | 1 |
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