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| 1 | Roles of mechanosensitive channel Piezo 1/2 proteins in skeleton and other tissues显示文摘Mechanotransduction is a fundamental ability that allows living organisms to receive and respond to physical signals from both the external and internal environments.The mechanotransduction process requires a range of special proteins termed mechanotransducers to convert mechanical forces into biochemical signals in cells.The Piezo proteins are mechanically activated nonselective cation channels and the largest plasma membrane ion channels reported thus far.The regulation of two family members,Piezol and Piezo2#has been reported to have essential functions in mechanosensation and transduction in different organs and tissues.Recently,the predominant contributions of the Piezo family were reported to occur in the skeletal system,especially in bone development and mechano-stimulated bone homeostasis.Here we review current studies focused on the tissue-specific functions of Piezol and Piezo2 in various backgrounds with special highlights on their importance in regulating skeletal cell mechanotransduction.In this review,we emphasize the diverse functions of Piezol and Piezo2 and related signaling pathways in osteoblast lineage cells and chondrocytes.We also summarize our current understanding of Piezo channel structures and the key findings about PIEZO gene mutations in human diseases. | Lei Qin Tailin He Sheng Chen Dazhi Yang Weihong Yi Huiling Cao Guozhi Xiao | 2021 | Bone Research2021，9，4： | 14 |
| 2 | A flutter-effect-based triboelectric nanogenerator for breeze energy collection from arbitrary directions and self-powered wind speed sensor显示文摘Triboelectric nanogenerators(TENGs)have been developed rapidly into an efficient wind energy collection equipment.Reducing the frictionwear and energy loss in breeze energy collection is a research direction worthy of attention.Herein,a flutter-effect-based triboelectricnanogen erator(FE-TENG)is designed to collect the breeze energy at low wind speed from arbitrary directions.Distinguishing from previouswind-driven TENGs,the wind-driven part of this device is separated from the TENG units,which not only avoids the wear of friction layerscaused by direct wind contact but also reduces the energy loss,therefore,relatively stable electric outputs are obtained with Voc-281 V,Isc-13.4μA,Qsc-143 nC,and output power-4 mW at the wind speed of 4.5 m/s,respectively.In addition,a real-time wind speed monitoringsystem based on LabVIEW software with high sen sitivity and fast response to wind is achieved relying on the excellent linear relation shipbetween wind speed and electrical output signal.Furthermore,it has been successfully applied as power sources for portable electronics,about 170 commercial light-emitting devices(LEDs)are lighted and a digital watch is successfully driven at the wind speed of 2.9 m/s.This worknot only provides a new structure and idea for the future collection of clean and sustainable breeze energy from arbitrary directions but also hasgreat potential in the field of self-powered systems. | Jie Hu Xianjie Pu Hongmei Yang Qixuan Zeng Qian Tang Dazhi Zhang Chenguo Hu Yi Xi | 2019 | Nano Research2019，12，12： | 6 |
| 3 | Simultaneous detection and characterization of toxigenic Clostridium difficile directly from clinical stool specimens显示文摘我们采用了结合的复合聚合酶链反应(PCR ) 指向六的毛状的电气泳动(mPCR-CE ) 在为 toxigenic C 的同时的察觉和描述的 tcdC 的 Clostridium 顽固基因,包括的 tpi, tcdA, tcdB, cdtA, cdtB,和删除。顽固直接从烘便的标本。mPCR-CE 每反应有 10 个形成殖民地的单位的察觉的限制没有与另外的相关细菌的基因跨反应。临床的确认在 354 上被执行连续地与怀疑的 C 从病人收集了凳子标本。顽固感染并且 45 孤立。结果与与 BD 最大 Cdiff,即时房间分析试金(RTCA ) ,和 mPCR-CE 相结合的一个参考标准相比。toxigenic C。顽固种类在 36 被检测孤立并且由 mPCR-CE 的 45 个凳子标本,它提供了 20.3% 的积极的率(81/399 ) 。mPCR-CE 有 97.2% 的特性和 96.0% 的敏感,它比 RTCA 高(x 2= 5.67, P = 0.017 ) 但是比 BD 最大 Cdiff 低(P = 0.245 ) 。在 45 紧张之中,(97.8%) 44 作为 non-ribotype 被决定 027 由 mPCR-CE,它充分被适合于 PCR ribotyping。尽管 ribotypes 017 (n = 8, 17.8%) , 001 (n = 6, 13.3%) ,并且 012 (n = 7, 15.6%) 在这个区域是占优势的, ribotype 027 重要遗传型习惯性地被监视。mPCR-CE 为 toxigenic C 的同时的察觉提供了一个其他的诊断工具。在凳子顽固、在 RT027 和 non-RT027 之间潜在地区分。 | Hanjiang Lai Chen Huang Jian Cai Julian Ye Jun She Yi Zheng Liqian Wang Yelin Wei Weijia Fang Xianjun Wang Yi-Wei Tang Yun Luo Dazhi Jin | 2018 | Frontiers of Medicine2018，12，2： | 2 |
| 4 | Characteristics of Liver Functions in Patients With COVID-19 and Construction of a Prognostic Evaluation Decision Model Based on Liver Functions显示文摘A number of studies have suggested that coronavirus disease 2019(COVID-19)can cause liver damage.However,clinical features and outcome of COVID-19 in patients with liver injury remain to be further investigated.In this study,the clinical data of 265 COVID-19 patients admitted to seven tertiary hospitals were collected.Based on a threshold for transaminase or total bilirubin levels at two times the normal upper limit,patients were divided into mild or moderate/severe liver injury groups.Among the 265 patients,183 patients showed liver injury within 48 hours of admission.Aspartate aminotransferase levels were predominantly elevated in the liver injury group,but albumin levels were reduced.Moreover,fibrinogen and D-dimer were significantly increased.Furthermore,68%of the patients with moderate/severe liver injury had one or more underlying diseases.Almost half of these patients developed acute respiratory distress syndrome(44%)and secondary infections(46%).These patients showed increased interleukin-6 and interleukin-10 levels and a decrease in PaO2 and the oxygenation index.In addition,levels of alanine aminotransferase,aspartate aminotransferase,and albumin were correlated with the oxygenation index,D-dimer and lymphocyte counts.Furthermore,a novel prognostic assessment model based on liver function was established,which accuracy reached 88%and was able to accurately assess the prognosis of COVID-19 patients. | Tongtong Pan Dazhi Chen Chenwei Pan Yi Kang Junping Liu Feifei Su Liang Hong Huili Li Hui Zhao Zhuo Lin Xiaodong Wang Hongwei Lin Qianjing Du Chao Cai Yongping Chen | 2020 | Infectious Microbes & Diseases2020，2，4： | 1 |
| 5 | Accuracy evaluation for in-situ machining reference points binocular measurement based on credibility probability显示文摘Passive binocular measurement systems are being increasingly utilized in the in-situ industries of automobiles,aviation,and aerospace,etc.due to their excellent qualities of accuracy,efficiency,and cost performance.Whereas the barrier of evaluating the accuracy of measured objects resulted from the unequal equivalent focal length and quantization of pixels,has limited their further development and application of high requirements for in-situ machining,e.g.,the measurement of machining reference points for the positioning of robotic drilling in aerospace manufacturing.In this paper,an accuracy evaluation method is proposed to address the problem.Firstly,the unequal equivalent focal length is considered to improve the accuracy of 3D reconstruction.Next,the credibility probability model is developed to calculate the probability of the observed error in the public view of the binocular measurement system and indicates the direction of improvement.Finally,the in-situ experiment is carried out to validate the method within the effective public view range of 300 mm×300 mm.The experiment results show that the RMSs of observed errors are superior to 0.035 mm,and the credibility probabilities are all higher than 0.91;the maximum 3D reconstruction accuracy improvement is 60.3%,with the error reduced from 0.078 mm to 0.031 mm. | Binchao YU Wei LIU Yanze ZHANG Dazhi MA Zhenyuan JIA Yi YUE Jiabo ZHANG | 2024 | Chinese Journal of Aeronautics2024，37，1： | 0 |
| 6 | Achieving desired nodal lines in freely vibrating structures via material-field series-expansion topology optimization显示文摘Accurately controlling the nodal lines of vibrating structures with topology optimization is a highly challenging task.The major difficulties in this type of problem include a large number of design variables,the highly nonlinear and multi-peak characteristics of iteration,and the changeable orders of eigenmodes.In this study,an effective material-field series-expansion(MFSE)-based topology optimization design strategy for precisely controlling nodal lines is proposed.Here,two typical optimization targets are established:(1)minimizing the difference between structural nodal lines and their desired positions,and(2)keeping the position of nodal lines within the specified range while optimizing certain dynamic performance.To solve this complex optimization problem,the structural topology of structures is first represented by a few design variables on the basis of the MFSE model.Then,the problems are effectively solved using a sequence Kriging-based optimization algorithm without requiring design sensitivity analysis.The proposed design strategy inherently circumvents various numerical difficulties and can effectively obtain the desired vibration modes and nodal lines.Numerical examples are provided to validate the proposed topology optimization models and the corresponding solution strategy. | Yi YAN Xiaopeng ZHANG Jiaqi HE Dazhi WANG Yangjun LUO | 2023 | Frontiers of Mechanical Engineering2023，18，3： | 0 |
| 7 | Single-cell analysis reveals the lncRNA-MEG3/miRNA-133a-3p/PRRT2 axis regulates skeletal muscle regeneration and myogenesis显示文摘Skeletal muscle is the largest motor and metabolic organ of the body, which has a robust capacity for regeneration following injury or disease. Delayed regeneration after skeletal muscle injury reduces muscle contractility and leads to dysfunction of innervation. Therefore, identifying the regulation components in skeletal muscle regeneration and determining their molecular mechanisms are important to discover novel therapeutic markers for muscular diseases. Long non-coding RNA (LncRNA) has been implicated in skeletal muscle regeneration. Recent developed single-cell RNA sequencing (scRNA-seq) provides a higher resolution of cellular differences than bulk RNA-seq. Here, we re-analyzed single-cell transcriptomes data of skeletal muscle regeneration and identified lncRNA maternally expressed gene 3 (lncRNA-MEG3) was highly expressed in muscle satellite cells (MuSCs). Further study showed that lncRNA-MEG3 regulates skeletal muscle regeneration via sponging miR-133a-3p to regulate proline-rich transmembrane protein 2 (PRRT2) expression level. These results suggested that lncRNA-MEG3 might be a potential target for skeletal muscle diseases. | Yilong Yao Zishuai Wang Yun Chen Lei Liu Liyuan Wang Guoqiang Yi Yalan Yang Dazhi Wang Kui Li Zhonglin Tang | 2023 | Genes & Diseases2023，10，2： | 0 |
| 8 | Study on Stress-softening Effect in CuZnAl Shape Memory Alloys显示文摘The effect of mechanical cyclings on the stress-strain(S-S) curves was studied systematically using tensile tests over a widetemperature range.Two-stage yielding was observed in the temperature range between M_s and the ultimate temperature to in-duce martensite,denoted by M_d.The first stage was confirmed to be associated with stress-induced martensite(SIM) and the sec-ond stage was associated with the yielding of SIM.When the samples were mechanically cycled between M_s and M_d.astress-softening phenomenon was observed.The cyclings made the martensite amount increase,critical stress σ_c of SIM de-crease according to exponential law,and the entropy(also enthalpy) of the parent to martensite transformation also decrease.Thevariations of SIM relative amount were determined by recording the changes of electrical resistances in the course of tension. | Yi, Huchun Qi, Min Wang, Fengting Yang, Dazhi | 1989 | Rare Metals1989，9，4： | 0 |
| 9 | Construction of monodispersed single-crystalline hierarchical ZSM-5 nanosheets via anisotropic etching显示文摘Hierarchical zeolites and single-crystalline zeolite nanosheets(NSs)have been recognized as two separate types of targeting porous materials to overcome the diffusion limitations of traditional bulk zeolites.The synthesis of uniform single-crystalline hierarchical zeolite NSs featured with NS morphology and interconnected mesoporosity,remains rarely reported.In this work,we prepared ZSM-5 zeolites with the above microstructural features via simple alkaline etching.Moreover,both their microstructure and acid strength could be accurately tuned with this approach,resulting in not only higher conversion rate and BTX selectivity but also superior anti-coking performance in the subsequent methanol aromatization reaction. | Tianli Zhou Dazhi Zhang Yi Liu Yanwei Sun Taotao Ji Shengjun Huang Yi Liu | 2022 | Journal of Energy Chemistry2022，31，9： | 0 |
| 10 | Lightweight design of peanut sowing machine frame based on finite element analysis显示文摘In order to reduce the weight and energy consumption of the whole machine against the heavy mechanical structure and excessive strength redundancy in current small-scale peanut seeders with one ridge and two rows,a finite element model of the frame was established and the static finite element analysis and modal analysis were conducted with ANSYS Workbench.Sensitivity analysis that focuses on the size of intermediate support beams and other components was performed so as to set up a multi-objective optimization model.Then a size optimization and multi-objective optimization collaborative scheme was adopted so that the target was optimized by the Seagull Optimization Algorithm(SOA)to obtain the optimal solution.Based on the results of the finite element analysis,the mechanical structure of the peanut seeder was optimized for lightweight design.Furthermore,response surface plots and static structural analysis were applied for validation.It turned out that the maximum stress of the optimized structure was less than the allowable stress;the weight of the frame reduced by 32.5%after optimization;and the first-order natural frequency did not coincide with the engine input speed or working speed,thus no resonance will occur.Field experiments showed that the qualified rate of row spacing was≥96%when operating at different speeds of different types of seeders;The seeding depth operation performance was stable,with an average qualified rate of seeding depth of≥92%;The performance of the seeders was also stable and reliable due to the lightweight prototype structure.The research outcomes can provide an effective technical reference and theoretical basis for the lightweight design of peanut seeders and for its continuous improvement as well in the future. | Yan Yu Linsong Diao Dongwei Wang Jiasheng Wang Xiaomin Wang Xiaozhi Tan Dazhi Yi | 2023 | International Journal of Agricultural and Biological Engineering2023，16，3： | 0 |
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