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| 1 | Preoperative neutrophil-to-lymphocyte ratio plus platelet-to-lymphocyte ratioin predicting survival for patients with stage Ⅰ-Ⅱgastric cancer显示文摘Background:The preoperative neutrophil-to-lymphocyte ratio(NLR) and the platelet-to-lymphocyte ratio(PLR) are associated with poor prognosis of gastric cancer.We aimed to determine whether the combination of NLR and PLR(NLR-PLR) could better predict survival of patients after curative resection for stage Ⅰ-Ⅱ gastric cancer.Methods:We collected data from the medical records of patients with stage Ⅰ-Ⅱ gastric cancer undergoing curative resection between December 2000 and November 2012 at the Sun Yat-sen Cancer Center.The preoperative NLRPLR was calculated as follows:patients with both elevated NLR(≥2.1) and PLR(≥ 120) were given a score of 2,and patients with only one or neither were given a score of 1 or 0,respectively.Results:Kaplan-Meier analysis and log-rank tests revealed significant differences in overall survival(OS) among patients with NLR-PLR scores of 0,1 and 2(P < 0.001).Multivariate analysis showed that OS was independently associated with the NLR-PLR score[hazard ratio(HR) = 1.51,95%confidence interval(CI) 1.02-2.24,P = 0.039]and TNM stage(HR = 1.36,95%CI 1.01-1.83,P= 0.041).However,other systemic inflammation-based prognostic scores,including the modified Glasgow prognostic score,the prognostic nutritional index,and the combination of platelet count and NLR,were not.In TNM stage-stratified analysis,the prognostic significance of NLR-PLR was maintained in patients with stage Ⅰ(P < 0.001) and stage Ⅱ cancers(P= 0.022).In addition,the area under the receiver operating characteristic curve for the NLR-PLR score was higher than those of other systemic inflammation-based prognostic scores(P = 0.001).Conclusion:The preoperative NLR-PLR score is a useful predictor of postoperative survival in the patients with stage l-ll gastric cancer and may help identify high-risk patients for rational therapy and timely follow-up. | Xiaowei Sun Xuechao Liu Jianjun Liu Shangxiang Chen Dazhi Xu Wei Li Youqing Zhan Yuanfang Li Yingbo Chen Zhiwei Zhou | 2016 | Chinese Journal of Cancer2016，35，7： | 25 |
| 2 | Roles of mechanosensitive channel Piezo 1/2 proteins in skeleton and other tissues显示文摘Mechanotransduction is a fundamental ability that allows living organisms to receive and respond to physical signals from both the external and internal environments.The mechanotransduction process requires a range of special proteins termed mechanotransducers to convert mechanical forces into biochemical signals in cells.The Piezo proteins are mechanically activated nonselective cation channels and the largest plasma membrane ion channels reported thus far.The regulation of two family members,Piezol and Piezo2#has been reported to have essential functions in mechanosensation and transduction in different organs and tissues.Recently,the predominant contributions of the Piezo family were reported to occur in the skeletal system,especially in bone development and mechano-stimulated bone homeostasis.Here we review current studies focused on the tissue-specific functions of Piezol and Piezo2 in various backgrounds with special highlights on their importance in regulating skeletal cell mechanotransduction.In this review,we emphasize the diverse functions of Piezol and Piezo2 and related signaling pathways in osteoblast lineage cells and chondrocytes.We also summarize our current understanding of Piezo channel structures and the key findings about PIEZO gene mutations in human diseases. | Lei Qin Tailin He Sheng Chen Dazhi Yang Weihong Yi Huiling Cao Guozhi Xiao | 2021 | Bone Research2021，9，4： | 14 |
| 3 | Deformation characteristics and formation mechanism of the Yunmengshan metamorphic core complex显示文摘The Yunmengshan metamorphic core complex in the middle part of the Yanshan Fold and Thrust Belt records crust extension processes of the eastern North China Craton during its peak destruction.Development of the metamorphic core complex was controlled by the generally NNE-striking Dashuiyu Shear Zone.The shear zone dips SE and becomes shallower NE-wards,leading to exposures of a ductile shear zone in the southern and middle parts and brittle faults in the northern part.Exposure structures,microstructures,and quartz C-axis fabrics indicate that the ductile shear zone belongs to an extensional shear zone with a top-to-the-SE shear sense.Deformation temperatures of 300–520°C suggest a midcrustal origin for the ductile shear zone.A ductile deformation belt in the footwall of the shear zone is only as wide as 1–3 km,indicating no widespread mid-crustal ductile flow in the region during the deformation.Zircon U–Pb dating of dykes and plutons as well as hornblende and biotite40Ar/39Ar dating demonstrate that the metamorphic core complex originated at 135 Ma and experienced intense shearing of the Dashuiyu Shear Zone,development of the supradetachment basins,and synkinematic intrusion during 135–125 Ma.The metamorphic core complex was subjected to rapid exhumation during 125–114 Ma when the Dashuiyu Shear Zone suffered continuous activity and passive doming.The shear zone and its hanging wall were cut or replaced by a series of brittle faults when they wereuplifted to a brittle regime,showing that exhumation took place in continuous extensional activities.The metamorphic core complex turned into slow exhumation in an extensional regime in the following latest Early Cretaceous.The evolution history suggests that the Yunmengshan metamorphic core complex was developed by the rolling-hinge model,a common formation mechanism for intraplate metamorphic core complexes in the North China Craton,under the continuous NW–SE extension during the Early Cretaceous(135–100 Ma). | Yin Chen Guang Zhu Dazhi Jiang Shaoze Lin | 2014 | Chinese Science Bulletin2014，59，20： | 10 |
| 4 | Prognostic value of programmed death.1, programmed death-ligand 1, programmed death-ligand 2 expression, and CD8(+) T cell density in primary tumors and metastatic lymph nodes from patients with stage T1.4N+M0 gastric adenocarcinoma显示文摘Background: Anti-programmed death-1/programmed death-ligand 1(PD-1/PD-L1) immunotherapy has been proved to be effective on gastric cancer in ongoing clinical trials. However, the value of PD-L1 in predicting responses of patients with gastric cancer to anti-PD-1/PD-L1 immunotherapy is controversial. Some studies suggested that intra-and inter-tumoral heterogeneity of PD-L1 expression might explain the controversy.This study aimed to analyze the expression of PD-L1, PD-L2, and PD-1 as well as CD8(+) T-cell density in primary tumors and lymph nodes from patients with stage T1-4 N+M0 gastric adenocarcinoma to explore the heterogeneity of PD-1 signaling pathway molecules.Methods: In primary tumors and metastatic as well as non-metastatic lymph nodes from patients with stage T1-4 N+M0 gastric adenocarcinoma, we detected PD-L1 and PD-L2 expression with immunohistochemistry. CD8(+)T-cell density in primary tumors and PD-1 expression on CD8(+)T cells were detected with immunofluorescence. Univariate analysis was used to determine the prognostic values of them. Cox proportional hazard regression model was used to identify independent risk factors that affect patients' overall survival and disease-free survival.Results: Among 119 eligible patients who had undergone surgical resection, the positive rate of PD-L1 was higher in metastatic lymph nodes than in primary tumors(45.4% vs. 38.7%, P = 0.005); the positive rate of PD-1 on CD8(+)T cells was significantly higher in primary tumors and metastatic lymph nodes than in tumor-free lymph nodes(both P < 0.001). The intensity of PD-1 expression on CD8(+) T cells in primary tumors and in metastatic lymph nodes were stronger than that in tumor-free lymph nodes from the same patient. Beside, the positive rate of PD-L2 did not show any differences between primary tumors and metastatic lymph nodes. In multivariate analysis, PD-L1 expression,PD-L2 expression, a low density of CD8(+) T cells in primary tumors, and PD-1 expression on CD8(+) T cells in primary tumors were associated with poor prognosis.Conclusion: The expression of PD-L1 is heterogeneous in primary tumors and in metastatic lymph nodes from patients with stageT1-4 N+M0 gastric adenocarcinoma, which might explain the inconsistent results in assessing the prognostic value of PD-L1 expression in previous studies. | Yuan Gao Su Li Dazhi Xu Shangxiang Chen Yuchen Cai Wenqi Jiang Xinke Zhang Jin Sun Kefeng Wang Boyang Chang Fenghua Wang Minghuang Hong | 2017 | Chinese Journal of Cancer2017，36，11： | 8 |
| 5 | Circular RNA circStag1 promotes bone regeneration by interacting with HuR显示文摘Postmenopausal osteoporosis is a common bone metabolic disorder characterized by deterioration of the bone microarchitecture,leading to an increased risk of fractures.Recently,circular RNAs(circ RNAs)have been demonstrated to play pivotal roles in regulating bone metabolism.However,the underlying functions of circ RNAs in bone metabolism in postmenopausal osteoporosis remain obscure.Here,we report that circ Stag1 is a critical osteoporosis-related circ RNA that shows significantly downregulated expression in osteoporotic bone marrow mesenchymal stem cells(BMSCs)and clinical bone tissue samples from patients with osteoporosis.Overexpression of circ Stag1 significantly promoted the osteogenic capability of BMSCs.Mechanistically,we found that circ Stag1 interacts with human antigen R(Hu R),an RNA-binding protein,and promotes the translocation of Hu R into the cytoplasm.A high cytoplasmic level of Hu R led to the activation of the Wnt signaling pathway by stabilizing and enhancing low-density lipoprotein receptor-related protein 5/6(Lrp5/6)andβ-catenin expression,thereby stimulating the osteogenic differentiation of BMSCs.Furthermore,overexpression of circ Stag1 in vivo by circ Stag1-loaded adeno-associated virus(circ Stag1-AAV)promoted new bone formation,thereby preventing bone loss in ovariectomized rats.Collectively,we show that circ Stag1 plays a pivotal role in promoting the regeneration of bone tissue via Hu R/Wnt signaling,which may provide new strategies to prevent bone metabolic disorders such as postmenopausal osteoporosis. | Gaoyang Chen Canling Long Shang Wang Zhenmin Wang Xin Chen Wanze Tang Xiaoqin He Zhiteng Bao Baoyu Tan Jin Zhao Yongheng Xie Zhizhong Li Dazhi Yang Guozhi Xiao Songlin Peng | 2022 | Bone Research2022，10，3： | 7 |
| 6 | ANALYSIS FOR GENE NETWORKS BASED ON LOGIC RELATIONSHIPS显示文摘 | Shudong WANG Yan CHEN Qingyun WANG Eryan LI Yansen SU Dazhi MENG | 2010 | Journal of Systems Science & Complexity2010，23，5： | 3 |
| 7 | Dispersion–tribological property relationship in mineral oils containing 2D layered α-zirconium phosphate nanoplatelets显示文摘Inorganic nanomaterials exhibit superior friction-reduction and anti-wear properties in oils. In this study, 2D layered α-zirconium phosphate (α-ZrP) nanosheets intercalated with different amines have been synthesized to study their dispersion stabilities in lubricating oil and tribological applications. The intercalated amines should be sufficiently long and lipophilic to provide stabilization to α-ZrP nanosheets in mineral oil. The results of tribological tests illustrate that with the addition of well-dispersed nanosheets, the coefficient of friction (COF) and pin volume loss reduce by ~47% and 75%, respectively. The excellent dispersion stability enables the nanosheets to flow into the contact area at the beginning, and thereby protect the rubbing surface. A reduction in the van der Waals forces between the adjacent layers induced by the intercalated amines transforms the friction between adjacent layers from pin disk to sliding, leading to a decrease in the COF under hydrodynamic lubrication. The study provides a new method to enhance the tribological properties via tuning the dispersion stabilities of nanomaterials in oils. | Feng JIANG Haoyang SUN Lei CHEN Fan LEI Dazhi SUN | 2020 | Friction2020，8，4： | 3 |
| 8 | Isothermal Aging Kinetics in CuZnAl Shape Memory Alloy显示文摘Isothermal aging behaviours of a CuZnAl shape memory alloy have been investigated by means ofdilatometry.The length of the specimens during isothermal aging from 190 to 280℃ increases withthe aging time at each temperature.The isothermal aging kinetics fits in Avrami equation and thetime exponent n decreases with the increase in aging temperature.The apparent activation energyfor the isothermal aging process was measured to be 109.0kJ/mol,which is about equal to that of arelaxation internal friction peak at about 200℃ (f≈1 Hz) in the alloy. | Zengqi ZHAO Lab.of Physics,Baotou Research Institute of Rare Earth,Baotou,014010,ChinaFeixia CHEN Dazhi YANG Dept.of Mater.Eng.,Dalian University of Technology,Dalian,116024,ChinaEr BAO Dept.of Mater.Eng.,Yanshan University,Qinhuangdao,066004,China | 1993 | Journal of Materials Science & Technology1993，9，3： | 2 |
| 9 | Simultaneous detection and characterization of toxigenic Clostridium difficile directly from clinical stool specimens显示文摘我们采用了结合的复合聚合酶链反应(PCR ) 指向六的毛状的电气泳动(mPCR-CE ) 在为 toxigenic C 的同时的察觉和描述的 tcdC 的 Clostridium 顽固基因,包括的 tpi, tcdA, tcdB, cdtA, cdtB,和删除。顽固直接从烘便的标本。mPCR-CE 每反应有 10 个形成殖民地的单位的察觉的限制没有与另外的相关细菌的基因跨反应。临床的确认在 354 上被执行连续地与怀疑的 C 从病人收集了凳子标本。顽固感染并且 45 孤立。结果与与 BD 最大 Cdiff,即时房间分析试金(RTCA ) ,和 mPCR-CE 相结合的一个参考标准相比。toxigenic C。顽固种类在 36 被检测孤立并且由 mPCR-CE 的 45 个凳子标本,它提供了 20.3% 的积极的率(81/399 ) 。mPCR-CE 有 97.2% 的特性和 96.0% 的敏感,它比 RTCA 高(x 2= 5.67, P = 0.017 ) 但是比 BD 最大 Cdiff 低(P = 0.245 ) 。在 45 紧张之中,(97.8%) 44 作为 non-ribotype 被决定 027 由 mPCR-CE,它充分被适合于 PCR ribotyping。尽管 ribotypes 017 (n = 8, 17.8%) , 001 (n = 6, 13.3%) ,并且 012 (n = 7, 15.6%) 在这个区域是占优势的, ribotype 027 重要遗传型习惯性地被监视。mPCR-CE 为 toxigenic C 的同时的察觉提供了一个其他的诊断工具。在凳子顽固、在 RT027 和 non-RT027 之间潜在地区分。 | Hanjiang Lai Chen Huang Jian Cai Julian Ye Jun She Yi Zheng Liqian Wang Yelin Wei Weijia Fang Xianjun Wang Yi-Wei Tang Yun Luo Dazhi Jin | 2018 | Frontiers of Medicine2018，12，2： | 2 |
| 10 | Characteristics of carotid artery disease (CAD) and presenting cerebrovascular symptoms in an aged group显示文摘 | Qingwei Chen Ying Liu Linlin Pei Dazhi Ke Guiqiong Li Wei Deng Wuwei Yao | 2009 | The International Journal of Cardiovascular Imaging2009，，2： | 1 |
| 11 | Mixed monolayers of Gemini surfaetants and stearie acid at the air/water interface显示文摘 | Li Rong Chen Qibin Zhang Dazhi | 2008 | Journal of Colloid and lnterface Science2008，327，： | 1 |
| 12 | Flapping motion weasurement of honeybee bilateral wings using four virtual struc- tured-light sensors 显示文摘 | Zhang Guaniun Sun Junhua Chen Dazhi et at | 2008 | Sensors and Actuators2008，148，： | 1 |
| 13 | A novel hierarchical two-level spectral preconditioning technique for multilevel fast muhipole analysis of elec- tromagnetic wave scattering显示文摘 | Ding Dazhi Chen Rushan Fan Zhenhong | 2008 | IEEE Transactions on Antennas and Propagation2008，56，4： | 1 |
| 14 | Destruction of the eastern North China Craton in a backarc setting: Evidence from crustal deformation kinematics显示文摘 | Guang Zhu Dazhi Jiang Bilong Zhang Yin Chen | 2011 | Gondwana Research2011，，1： | 1 |
| 15 | On-demand Geographic Forwarding for Data Delivery in Wireless Sensor Networks 显示文摘 | Dazhi Chen Pramod K Varshney | 2007 | Computer Communications (S0140-3664)2007，30，6： | 1 |
| 16 | Bayesian statis-tical reconstruction for low-dose X-ray computed tomogra-phy using an adaptive-weighting nonlocal prior 显示文摘 | Chen Yang Gao Dazhi Nie Cong | 2009 | Com-puterized Medical Imaging and Graphics2009，33，7： | 1 |
| 17 | Flapping motion measurement of honeybee bilateral wings using four virtual structured-light sensors显示文摘 | ZHANG Guangjun SUN Junhua CHEN Dazhi | 2008 | Sensors and Actuators A: Physical2008，148，： | 1 |
| 18 | Randomized trial of autologous bone marrow mesenchymal stem cells transplantation for hepatitis B virus cirrhosis: Regulation of T reg/ T h17 cells显示文摘 | Lanman Xu Yuewen Gong Benfu Wang Keqing Shi Yijun Hou Liping Wang Zuo Lin Yixiang Han Lu Lu Dazhi Chen Xiuli Lin Qiqiang Zeng Wenke Feng Yongping Chen | 2014 | J Gastroenterol Hepatol2014，，8： | 1 |
| 19 | Effect of the spac er group on the behavior of the cationic Gemini surfactant monolayer at the air/water interface显示文摘 | Chen Qibin Zhang Dazhi Li Rong et ag | 2008 | Thin Solid Films2008，516，23： | 1 |
| 20 | A New Sub-Pixel Detector for X-Corners in Camera Calibration Targets显示文摘 | CHEN Dazhi ZHANG Guangjun | 2005 | WSCG(ShortPapers)2005，，5： | 1 |
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