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| 1 | Analysis of In-hospital Neonatal Death in the Tertiary Neonatal Intensive Care Unit in China: A Multicenter Retrospective Study显示文摘 | Chen-Hong Wang Li-Zhong Du Xiao-Lu Ma Li-Ping Shi Xiao-Mei Tong Hong Liu Guo-Fang Ding Bin Yi Xin-Nian Pan Dan-Ni Zhong Ling Liu Mei Li Cui-Qing Li Shi-Wen Xia Hong-Yun Wang Ling He Kun Liang Xiao-Yu Zhou Shu-Ping Han Qin Lyu Yin-Ping Qiu Ruo-Bing Shan De-Zhi Mu Xiao-Hong Liu Si-Qi Zhuang Jing Guo Li Liu Jia-Jun Zhu Hong Xiong | 2016 | Chinese Medical Journal2016，，22： | 8 |
| 2 | Two congenital coronary abnormalities affecting heart function: anomalous origin of the left coronary artery from the pulmonary artery and congenital left main coronary artery atresia显示文摘 | Xiao Yanyan Jin Mei Han Ling Ding Wenhong Zheng Jianyong Sun Chufan Lyu Zhenyu | 2014 | Chinese Medical Journal2014，，21： | 7 |
| 3 | Detection of periodontal pathogens in the patients with aortic aneurysm显示文摘 | Ding Fang Lyu Yalin Han Xiao Zhang Hai Liu Dongyu Hei Wei Liu Yinhua | 2014 | Chinese Medical Journal2014，，23： | 6 |
| 4 | Optimizing accuracy of a parabolic cylindrical deployable antenna mechanism based on stiffness analysis显示文摘Accuracy of the fitted surface is of great importance to the performance of deployable antennas utilized in space.This paper proposes a stiffness analysis based fitting accuracy optimization method for achieving the optimal parameters of the parabolic cylindrical deployable antenna mechanism.The stiffness matrix of the proposed cylindrical antenna mechanism is established by assembling the stiffness of beams and tension cables.Structural deformations of the mechanism are calculated where the tensioned cable is substituted by a 2-node truss element and an equivalent force acting on the joint.Consideration of the tensity of tension cables,namely tensioned or slack,is transformed into a typical linear complementarity problem.Comparison between structural deformations of the mechanism fixed at different points is performed.Sensitivities of the geometric and structural parameters on fitting accuracy are investigated.Influence of force of the driven cable on structural deformations of antenna operated in different orbits is conducted.A fitting optimization method is proposed to minimize the structural deformations subject to constraints on volume and mass.Simulation result shows that the fitting accuracy of the antenna mechanism is improved significantly through the optimization.The proposed method can be utilized for the optimal design of other deployable mechanisms constructed by joining rigid links. | Hang XIAO Shengnan LYU Xilun DING | 2020 | Chinese Journal of Aeronautics2020，33，5： | 6 |
| 5 | A novel approach for designing efficient broadband photodetectors expanding from deep ultraviolet to near infrared显示文摘Broadband photodetection(PD)covering the deep ultraviolet to near-infrared(200–1000 nm)range is significant and desirable for various optoelectronic designs.Herein,we employ ultraviolet(UV)luminescent concentrators(LC),iodinebased perovskite quantum dots(PQDs),and organic bulk heterojunction(BHJ)as the UV,visible,and near-infrared(NIR)photosensitive layers,respectively,to construct a broadband heterojunction PD.Firstly,experimental and theoretical results reveal that optoelectronic properties and stability of CsPbI3 PQDs are significantly improved through Er3+doping,owing to the reduced defect density,improved charge mobility,increased formation energy,tolerance factor,etc.The narrow bandgap of CsPbI3:Er3+PQDs serves as a visible photosensitive layer of PD.Secondly,considering the matchable energy bandgap,the BHJ(BTP-4Cl:PBDB-TF)is selected as to NIR absorption layer to fabricate the hybrid structure with CsPbI3:Er3+PQDs.Thirdly,UV LC converts the UV light(200–400 nm)to visible light(400–700 nm),which is further absorbed by CsPbI3:Er3+PQDs.In contrast with other perovskites PDs and commercial Si PDs,our PD presents a relatively wide response range and high detectivity especially in UV and NIR regions(two orders of magnitude increase that of commercial Si PDs).Furthermore,the PD also demonstrates significantly enhanced air-and UV-stability,and the photocurrent of the device maintains 81.5%of the original one after 5000 cycles.This work highlights a new attempt for designing broadband PDs,which has application potential in optoelectronic devices. | Nan Ding Yanjie Wu Wen Xu Jiekai Lyu Yue Wang Lu Zi Long Shao Rui Sun Nan Wang Sen Liu Donglei Zhou Xue Bai Ji Zhou Hongwei Song | 2022 | Light(Science & Applications)2022，11，5： | 5 |
| 6 | Control over emissivity of zero-static-power thermal emitters based on phase-changing material GST显示文摘Controlling the emissivity of a thermal emitter has attracted growing interest,with a view toward a new generation of thermal emission devices.To date,all demonstrations have involved using sustained external electric or thermal consumption to maintain a desired emissivity.In the present study,we demonstrated control over the emissivity of a thermal emitter consisting of a film of phase-changing material Ge2Sb2Te5(GST)on top of a metal film.This thermal emitter achieves broad wavelength-selective spectral emissivity in the mid-infrared.The peak emissivity approaches the ideal blackbody maximum,and a maximum extinction ratio of 410 dB is attainable by switching the GST between the crystalline and amorphous phases.By controlling the intermediate phases,the emissivity can be continuously tuned.This switchable,tunable,wavelength-selective and thermally stable thermal emitter will pave the way toward the ultimate control of thermal emissivity in the field of fundamental science as well as for energy harvesting and thermal control applications,including thermophotovoltaics,light sources,infrared imaging and radiative coolers. | Kai-Kai Du Qiang Li Yan-Biao Lyu Ji-Chao Ding Yue Lu Zhi-Yuan Cheng Min Qiu | 2016 | Light(Science & Applications)2016，5，1： | 4 |
| 7 | Association between PTCH1 gene polymorphisms and chronic obstructive pulmonary disease susceptibility in a Chinese Han population:a case-control study显示文摘Background:Chronic obstructive pulmonary disease(COPD)is a leading cause of morbidity and mortality worldwide.Genome-wide association studies in non-Asian population revealed a link between COPD and mutations in the PTCH1 gene encoding Patched1,a receptor in the Hedgehog signaling pathway important for lung morphogenesis and pulmonary function.The aim of this study was to investigate the association between PTCH1 polymorphisms and the COPD risk in the Chinese Han population.Methods:We performed a case-control study including 296 patients with COPD and 300 healthy individuals.Single-nucleotide polymorphisms in the PTCH1 gene were identified and genotyped based on the linkage disequilibrium analysis in all participants.Odds ratios(ORs)and 95%confidence intervals(95%CIs)were estimated using logistic regression analysis after adjustment for age,gender,and smoking.Results:In total,28 single-nucleotide polymorphisms were identified in patients with COPD.Among them,'A'allele of rs28491365(OR:1.388,95%CI:1.055-1.827,P=0.018),and'G'alleles of rs10512248(OR:1.299,95%CI:1.021-1.653,P=0.033)and rs28705285(OR:1.359,95%CI:1.024-1.803,P=0.033;respectively)were significantly associated with an increased COPD risk.Genetic model analysis revealed that the'T/T'genotype of rs34695652 was associated with a decreased COPD risk under the recessive model(OR:0.490,95%CI:0.270-0.880,P=0.010),whereas rs28504650/rs10512248 haplotype CG was significantly associated with an increased COPD risk after adjustment for age,gender,and smoking status(OR:6.364,95%CI:1.220-33.292,P=0.028).Conclusions:The study provides a new insight into the role of PTCH1 polymorphisms in the susceptibility to COPD in the Chinese Han population. | Xi Kang Ting Guo Lyu Liu Shui-Zi Ding Cheng Lei Hong Luo | 2020 | Chinese Medical Journal2020，，17： | 3 |
| 8 | Thalidomide-based Regimens for Elderly and/or Transplant Ineligible Patients with Multiple Myeloma: A Meta-analysis显示文摘 | Wen-Wen Lyu Qing-Chun Zhao De-Hai Song Jin-Jie Zhang Zhao-Xing Ding Bao-Yuan Li Chuan-Mei Wei | 2016 | Chinese Medical Journal2016，，3： | 2 |
| 9 | Review of Rapid Transformation of Floodplain Wetlands in Northeast China: Roles of Human Development and Global Environmental Change显示文摘Northeast China is the region with the largest area of wetlands in China. The Sanjiang Plain and the Songnen Plain are large freshwater marsh distribution regions that are affected by climate warming and by the increasing frequency and density of extreme weather and are the regions most subject to disturbances by human activities in Northeast China. The wetlands of the Sanjiang Plain and the Songnen Plain have shrunk severely in the past 60 years, and wetland functions have been reduced substantially because of climate change, unreasonable land use, fire episodes, engineering and construction works and urbanization. Large-scale agricultural development started in the 1950 s has been the most important driving factor for wetland loss and degradation in the Sanjiang Plain. Water shortage has been the most important factor for degradation and fragmentation of wetlands in the Songnen Plain. To mitigate wetland degradation and better protect wetlands, special regulations, long-term mechanisms and technical support of wetland protection should be established. A wetland compensation program should be implemented, and technologies for increasing the adaptive capacity of wetlands should be developed. Moreover, it is most important to find the balanced threshold between agricultural development and wetland protection. | YU Xiaofei DING Shanshan ZOU Yuanchun XUE Zhenshan LYU Xianguo WANG Guoping | 2018 | Chinese Geographical Science2018，28，4： | 2 |
| 10 | Iron-Imprinted Single-Atomic Site Catalyst-Based Nanoprobe for Detection of Hydrogen Peroxide in Living Cells显示文摘Fe-based single-atomic site catalysts(SASCs),with the natural metalloproteases-like active site structure,have attracted widespread attention in biocatalysis and biosensing.Precisely,controlling the isolated single-atom Fe-N-C active site structure is crucial to improve the SASCs’performance.In this work,we use a facile ion-imprinting method(IIM)to synthesize isolated Fe-N-C single-atomic site catalysts(IIM-Fe-SASC).With this method,the ion-imprinting process can precisely control ion at the atomic level and form numerous well-defined single-atomic Fe-N-C sites.The IIM-Fe-SASC shows better peroxidase-like activities than that of non-imprinted references.Due to its excellent properties,IIM-Fe-SASC is an ideal nanoprobe used in the colorimetric biosensing of hydrogen peroxide(H_(2)O_(2)).Using IIM-Fe-SASC as the nanoprobe,in situ detection of H_(2)O_(2)generated from MDA-MB-231 cells has been successfully demonstrated with satisfactory sensitivity and specificity.This work opens a novel and easy route in designing advanced SASC and provides a sensitive tool for intracellular H_(2)O_(2)detection. | Zhaoyuan Lyu Shichao Ding Maoyu Wang Xiaoqing Pan Zhenxing Feng Hangyu Tian Chengzhou Zhu Dan Du Yuehe Lin | 2021 | Nano-Micro Letters2021，13，9： | 2 |
| 11 | PGE2/EP4 skeleton interoception activity reduces vertebral endplate porosity and spinal pain with low-dose celecoxib显示文摘Skeletal interoception regulates bone homeostasis through the prostaglandin E2(PGE2)concentration in bone.Vertebral endplates undergo ossification and become highly porous during intervertebral disc degeneration and aging.We found that the PGE2 concentration was elevated in porous endplates to generate spinal pain.Importantly,treatment with a high-dose cyclooxygenase 2 inhibitor(celecoxib,80 mg·kg−1 per day)decreased the prostaglandin E2 concentration and attenuated spinal pain in mice with lumbar spine instability.However,this treatment impaired bone formation in porous endplates,and spinal pain recurred after discontinuing the treatment.Interestingly,low-dose celecoxib(20 mg·kg−1 per day,which is equivalent to one-quarter of the clinical maximum dosage)induced a latent inhibition of spinal pain at 3 weeks post-treatment,which persisted even after discontinuing treatment.Furthermore,when the prostaglandin E2 concentration was maintained at the physiological level with low-dose celecoxib,endplate porosity was reduced significantly,which was associated with decreased sensory nerve innervation and spinal pain.These findings suggest that low-dose celecoxib may help to maintain skeletal interoception and decrease vertebral endplate porosity,thereby reducing sensory innervation and spinal pain in mice. | Peng Xue Shenyu Wang Xiao Lyu Mei Wan Xialin Li Lei Ma Neil CFord Yukun Li Yun Guan Wenyuan Ding Xu Cao | 2021 | Bone Research2021，9，3： | 2 |
| 12 | Ultra-thin Piezoelectric Lattice for Vibration Suppression in Pipe Conveying Fluid显示文摘In this paper,an electrically active,ultra-thin,easy-to-implement,and tunable phononic crystal(PC)-based device is proposed to suppress excessive vibration in pipes conveying fluids.We demonstrate that this device can be realized by periodic implementation of piezoelectric patches with shunt circuits on the pipe acting as PCs for vibration suppression.The mathematical model of the pipe structure is simplified to the form of the Euler Bernoulli beam,and the transfer matrix method and the finite element method are used to predict the effective bandgap.Conversion between mechanical vibration energy and electrical energy via the piezoelectric effect is observed.As a result,the pipe vibration is suppressed by combined Bragg and electroelastic bandgaps.The comparison with previous literature shows that this ultra-compact device provides a new solution for vibration and noise control in long-distance fluid-conveying pipe systems. | Xiaofei Lyu Fei Chen Qingquan Ren Ye Tang Qian Ding Tianzhi Yang | 2020 | Acta Mechanica Solida Sinica2020，33，6： | 2 |
| 13 | Direct ink writing of programmable functional silicone-based composites for 4D printing applications显示文摘Polydimethylsiloxane(PDMS)has been widely used in flexible electronics,soft robotics,and bioelectronics.However,the fabrication of PDMS-based devices has mostly relied on conventional approaches,such as casting and molding,thereby limiting their potential.Here we fabricate PDMS-based composites with programmable microstructures by direct ink writing and realize their practical functionalities of four-dimensional(4D)printing.The mechanical,thermomechanical and magnetic properties of the three-dimensional-printed composites can be well tailored by using carbon,metal,or ceramic functional fillers.By taking advantage of the printable,flexible,and magnetic PDMS composites,we demonstrate new practical functionalities of 4D printing by designing programmable architectures,including magnetic-field-driven battery cases and patchworks,as well as arbitrary morphing ceramic structures.In particular,4D-printed batteries are constructed by PDMS-based battery cases for the first time,which can be actuated via external magnetic field.This study broadens the paradigm of 4D printing for prospective applications,such as implant batteries,biomimetic engineering,and customized biomedical devices. | Zhiyang Lyu J.ustin Koh Gwendolyn J.H.Lim Danwei Zhang Ting Xiong Lei Zhang Siqi Liu Junfei Duan Jun Ding John Wang Jinlan Wang Yunfei Chen Chaobin He | 2022 | Interdisciplinary Materials2022，1，4： | 2 |
| 14 | A vision inspection system for the surface defects of strongly reflected metal based on multi-class SVM 显示文摘 | ZHANG X W DING Y Q LYU Y Y | 2011 | Expert Systems with Applications2011，38，5： | 1 |
| 15 | Bio-inspired untethered fully soft robots in liquid actuated by induced energy gradients显示文摘Soft robotics with new designs,fabrication technologies and control strategies inspired by nature have been totally changing our view on robotics.To fully exploit their potential in practical applications,untethered designs are preferred in implementation.However,hindered by the limited thermal/mechanical performance of soft materials,it has been always challenging for researchers to implement untethered solutions,which generally involve rigid forms of high energy-density power sources or high energy-density processes.A number of insects in nature,such as rove beetles,can gain a burst of kinetic energy from the induced surface-energy gradient on water to return to their familiar habitats,which is generally known as Marangoni propulsion.Inspired by such a behavior,we report the agile untethered mobility of a fully soft robot in liquid based on induced energy gradients and also develop corresponding fabrication and maneuvering strategies.The robot can reach a speed of 5.5 body lengths per second,which is 7-fold more than the best reported,0.69(body length per second),in the previous work on untethered soft robots in liquid by far.Further controlling the robots,we demonstrate a soft-robot swarm that can approach a target simultaneously to assure a hit with high accuracy.Without employing any high energy-density power sources or processes,our robot exhibits many attractive merits,such as quietness,no mechanical wear,no thermal fatigue,invisibility and ease of robot fabrication,which may potentially impact many fields in the future. | Liang Xiong Lyu Fen Li Kang Wu Pan Deng Seung Hee Jeong Zhigang Wu Han Ding | 2019 | National Science Review2019，6，5： | 1 |
| 16 | Correlations between the optic nerve head morphology and ocular biometrics in highly myopic eyes显示文摘AIM: To analyze peripapillary atrophy β/γ zone(PPA-β/γ)and the optic disc ovality index, and to assess their associations with the axial length(AL), refractive error,best corrected visual acuity(BCVA), choroidal thickness(CT), and age in highly myopic eyes.METHODS: This was a retrospective observational case series. The study included 667 patients consecutively examined for highly myopic eyes [spherical equivalent≤-6.0 diopters(D) and AL≥26 mm] with or without myopic retinopathy. Each patient went through a comprehensive ophthalmological examination that included spectral domain optical coherence tomography(SD-OCT) of the macula,A-mode ultrasonography, and a cycloplegic refraction test.The ovality index and PPA-β/γ area were measured from optic disc photographs.RESULTS: A significant association was seen between PPA-β/γ area and the ovality index(P=0.000, r=-0.232).The PPA-β/γ area increased significantly with a longer AL,older age, worse BCVA, higher refractive error, and thinner choroid(P<0.01). The oval disc was significantly correlated with a longer AL, older age, worse BCVA, higher refractive error, larger PPA-β/γ area, and thinner choroid(P<0.01).CONCLUSION: The PPA-β/γ zone and ovality index in highly myopic eyes show distinct associations with the AL, refractive error, BCVA, age, and CT. | Xiu-Juan Zhao Huai-Yan Jiang Yong-Hao Li Bing-Qian Liu Hong-Xia Xu Jie Zhou Xiao-Hong Chen Can-Can Lyu Wei Ma Jin Ma Xiao-Ling Liang Chen-Jin Jin Xiao-Yan Ding Lin Lu | 2018 | International Journal of Ophthalmology(English edition)2018，11，6： | 1 |
| 17 | Merging phononic crystals and acoustic black holes显示文摘Phononic crystals(PCs) have recently been developed as effective components for vibration suppression and sound absorption. As a typical design of PCs, wave attenuation occurs in the so-called stop-band. However, the structural response is still significantly large in the pass-band. In this paper, we combine PCs and acoustic black holes(ABHs) in a unique device, achieving a versatile device that can attenuate vibration in the stop-band, while suppress vibration in the pass-band. This approach provides a versatile platform for controlling vibration in a multiband with a simple design. | Xiaofei LYU Qian DING Tianzhi YANG | 2020 | Applied Mathematics and Mechanics(English Edition)2020，41，2： | 1 |
| 18 | An ionizable supramolecular dendrimer nanosystem for effective siRNA delivery with a favorable safety profile显示文摘Gene therapy using small interfering RNA(siRNA)is emerging as a novel therapeutic approach to treat various diseases.However,safe and efficient siRNA delivery still constitutes the major obstacle for clinical implementation of siRNA therapeutics.Here we report an ionizable supramolecular dendrimer vector,formed via self-assembly of a small amphiphilic dendrimer,as an effective siRNA delivery system with a favorable safety profile.By virtue of the ionizable tertiary amine terminals,the supramolecular dendrimer has a low positively charged surface potential and no notable cytotoxicity at physiological pH.Nonetheless,this ionizable feature imparted sufficient surface charge to the supramolecular dendrimer to enable formation of a stable complex with siRNA via electrostatic interactions.The resulting siRNA/dendrimer delivery system had a surface charge that was neither neutral,thus avoiding aggregation,nor too high,thus avoiding cytotoxicity,but was sufficient for favorable cellular uptake and endosomal release of the siRNA.When tested in different cancer cell lines and patient-derived cancer organoids,this dendrimer-mediated siRNA delivery system effectively silenced the oncogenes Myc and Akt2 with a potent antiproliferative effect,outperforming the gold standard vector,Lipofectamine 2000.Therefore,this ionizable supramolecular dendrimer represents a promising vector for siRNA delivery.The concept of supramolecular dendrimer nanovectors via self-assembly is new,yet easy to implement in practice,offering a new perspective for supramolecular chemistry in biomedical applications. | Dinesh Dhumal Wenjun Lan Ling Ding Yifan Jiang Zhenbin Lyu Erik Laurini Domenico Marson Aura Tintaru Nelson Dusetti Suzanne Giorgio Juan Lucio Iovanna Sabrina Pricl Ling Peng | 2021 | Nano Research2021，14，7： | 1 |
| 19 | Recent advances in carbon-supported non-precious metal singleatom catalysts for energy conversion electrocatalysis显示文摘Non-precious metal single-atom catalysts(NPM-SACs)with unique electronic structures and coordination environments have gained much attention in electrocatalysis owing to their low cost,high atomic utilization,and high performance.NPM-SACs on carbon support(NPM-SACs/CS)are promising because of the carbon substrate with a large surface area,excellent electrical conductivity,and high chemical stability.This review provides an overview of recent developments in NPM-SACs/CS for the electrocatalytic field.First,the state-of-the-art synthesis methods and advanced characterization techniques of NPM-SACs/CS are discussed in detail.Then,the structural adjustment strategy of NPM-SACs/CS for optimizing electrocatalytic performance is introduced concisely.Furthermore,we provide a comprehensive summary of recent advances in developing NPM-SACs/CS for important electrochemical reactions,including carbon dioxide reduction reaction,hydrogen evolution reaction,oxygen evolution reaction,oxygen reduction reaction,and nitrogen reduction reaction.In the end,the existing challenges and future opportunities of NPM-SACs/CS in the electrocatalytic field are highlighted. | Li-Xia Liu Yangyang Ding Linan Zhu Jin-Cheng Li Huitong Du Xiang Li Zhaoyuan Lyu Dan Du Fuqiang Liu Yuanyuan Wang Wenlei Zhu Yuehe Lin | 2023 | National Science Open2023，2，2： | 1 |
| 20 | Analysis of retinal vasculature changes in indirect traumatic optic neuropathy using optic coherence tomography angiography显示文摘AIM:To assess the retinal vasculature alterations in indirect traumatic optic neuropathy(ITON)patients following craniofacial trauma by optic coherence tomography angiography(OCTA).METHODS:Patients diagnosed of monocular ITON were recruited from August 2016 to May 2020.OCTA was performed using the Angio Vue OCT-A system for two cube scans centered at the optic nerve head and fovea.OCTA data included thicknesses of peripapillary retinal nerve fiber layer(RNFL)and macular ganglion cell complex(GCC),as well as proportion of capillary perfusion and data were analyzed for correlation with post-injury timepoints:within 7,8-30,31-90,and 91-365d.RESULTS:A total of 73 ITON patients were studied.Significant thinning of RNFL and GCC layers and attenuation of microvascular perfusion were observed in ITON eyes as compared to contralateral unaffected eyes(for most of the analyzed sectors and quadrants,P<0.05).Without respect to surgical intervention and vision recovery,the decrease in retinal layer thicknesses and microvascular perfusion was time-dependent,and most significant within three months(P<0.001).CONCLUSION:ITON presents with time-dependent thinning of retinal layers and attenuation of microvasculature,indicating possible degeneration of retinal ganglion cells due to reduced retinal blood supply. | Huan Ma Yang Gao Jin-Miao Li Yue-Kun Bao Cong Nie Pan Yin Xi Lyu Xiao-Yan Ding Rong Lu | 2022 | International Journal of Ophthalmology(English edition)2022，15，8： | 1 |
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