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| 1 | Focal adhesion protein Kindlin-2 regulates bone homeostasis in mice显示文摘Our recent studies demonstrate that the focal adhesion protein Kindlin-2 is critical for chondrogenesis and early skeletal development. Here, we show that deleting Kindlin-2 from osteoblasts using the 2.3-kb mouse Col1 a1-Cre transgene minimally impacts bone mass in mice, but deleting Kindlin-2 using the 10-kb mouse Dmp1-Cre transgene, which targets osteocytes and mature osteoblasts, results in striking osteopenia in mice. Kindlin-2 loss reduces the osteoblastic population but increases the osteoclastic and adipocytic populations in the bone microenvironment. Kindlin-2 loss upregulates sclerostin in osteocytes,downregulates β-catenin in osteoblasts, and inhibits osteoblast formation and differentiation in vitro and in vivo. Upregulation ofβ-catenin in the mutant cells reverses the osteopenia induced by Kindlin-2 deficiency. Kindlin-2 loss additionally increases the expression of RANKL in osteocytes and increases osteoclast formation and bone resorption. Kindlin-2 deletion in osteocytes promotes osteoclast formation in osteocyte/bone marrow monocyte cocultures, which is significantly blocked by an anti-RANKLneutralizing antibody. Finally, Kindlin-2 loss increases osteocyte apoptosis and impairs osteocyte spreading and dendrite formation.Thus, we demonstrate an important role of Kindlin-2 in the regulation of bone homeostasis and provide a potential target for the treatment of metabolic bone diseases. | Huiling Cao Qinnan Yan Dong Wang Yumei Lai Bo Zhou Qi Zhang Wenfei Jin Simin Lin Yiming Lei Liting Ma Yuxi Guo Yishu Wang Yilin Wang Xiaochun Bai Chuanju Liu Jian QFeng Chuanyue Wu Di Chen Xu Cao Guozhi Xiao | 2020 | Bone Research2020，8，1： | 8 |
| 2 | 3D Seed-Germination-Like MXene with In Situ Growing CNTs/Ni Heterojunction for Enhanced Microwave Absorption via Polarization and Magnetization显示文摘Ti_(3)C_(2)Tx MXene is widely regarded as a potential micro-wave absorber due to its dielectric multi-layered structure.However,missing magnetic loss capability of pure MXene leads to the unmatched electromagnetic parameters and unsatisfied impedance matching condi-tion.Herein,with the inspiration from dielectric-magnetic synergy,this obstruction is solved by fabricating magnetic CNTs/Ni hetero-structure decorated MXene substrate via a facile in situ induced growth method.Ni2+ions are successfully attached on the surface and interlamination of each MXene unit by intensive electrostatic adsorption.Benefiting from the possible“seed-germination”effect,the“seeds”Ni^(2+)grow into“buds”Ni nanoparticles and“stem”carbon nanotubes(CNTs)from the enlarged“soil”of MXene skeleton.Due to the improved impedance matching con-dition,the MXene-CNTs/Ni hybrid holds a superior microwave absorp-tion performance of−56.4 dB at only 2.4 mm thickness.Such a distinctive 3D architecture endows the hybrids:(i)a large-scale 3D magnetic coupling network in each dielectric unit that leading to the enhanced magnetic loss capability,(ii)a massive multi-heterojunction interface structure that resulting in the reinforced polarization loss capability,confirmed by the off-axis electron holography.These outstanding results provide novel ideas for developing magnetic MXene-based absorbers. | Xiao Li Wenbin You Chunyang Xu Lei Wang Liting Yang Yuesheng Li Renchao Che | 2021 | Nano-Micro Letters2021，13，10： | 4 |
| 3 | Effects of electroacupuncture at Zusanli (ST 36) on neurons in the colonic myenteric plexus in rats with irritable bowel syndrome with constipation显示文摘We studied the effects of electroacupuncture at Zusanli (ST 36) on neurons in the colonic myenteric plexus and on defecation in rats with irritable bowel syndrome with constipation (IBS-C). We also used intragastric administration of pinaverium bromide as a positive control treatment to reveal the pathway mediating the onset of IBS-C. Both electroacupuncture and pinaverium bromide greatly improved defecation in rats with IBS-C. Immunohistochemical staining of the enteric nervous system neuronal marker protein gene product 9.5 in the colonic myenteric plexus showed that electroacupuncture by itself, or in combination with pinaverium bromide, increased the number of neurons and the staining intensity of protein gene product 9.5 in the colonic myenteric plexus. We conclude that visceral hypersensitivity is likely to be a primary cause of constipation in IBS-C rats. | Liting Zhu Zhonghan Li Bin Xu Chen Xia Jie Cheng Xiaoren Xiang Yi Zhu | 2011 | Neural Regeneration Research2011，6，33： | 3 |
| 4 | Effect of Roucongrong(Herba Cistanches Deserticolae) decoction on the substantia nigra through Wnt/β-catenin signaling pathway in rats with Parkinson's disease induced by 6-hydroxydopamine hydrochloride显示文摘OBJECTIVE:To investigate the effect of Roucongrong(Herba Cistanches Deserticolae)decoction on the substantia nigra in rats with Parkinson’s disease(PD)induced by 6-hydroxydopamine hydrochloride(6-OHDA).To further determine whether the Wnt/β-catenin signaling pathway is involved in the action.METHODS:A rat model of PD was established by intracranial injection of 6-OHDA.Subsequently,three concentrations of Roucongrong(Herba Cistanches Deserticolae)decoction were prepared and administered to rats by gavage therapy for 14 d.Behavioral changes were measured in PD rats.In vivo tyrosine hydroxylase(TH)levels in the substantia nigra were examined by immunohistochemistry.Additionally,gene and protein expression levels of members of the Wnt/β-catenin signaling pathway were examined by Western blotting and polymerase chain reaction.Lastly,a Wnt/β-catenin inhibitor was used to investigate the mechanism of action in 1-methyl-4-phenylpyridinium(MPP+)-treated MES23.5 cells in vitro.RESULTS:Roucongrong(Herba Cistanches Deserticolae)decoction improved performance in the stride and gait adjustment tests in PD rats.It also increased TH in the substantia nigra and altered the expression of genes and proteins in the Wnt/β-catenin signaling pathway.Wnt/β-catenin inhibitor reduced the effect of Roucongrong(Herba Cistanches Deserticolae)decoction in MPP+-treated MES23.5 cells.CONCLUSION:Roucongrong(Herba Cistanches Deserticolae)decoction may promote neuronal survival in PD in vivo and in vitro by increasing TH content in the substantia nigra and by activating the Wnt/β-catenin signaling pathway. | XU Qian QIN Wei WU Fangzhen LIN Yao HONG Liting CHEN Dan HU Xuefeng CAI Jing | 2021 | Journal of Traditional Chinese Medicine2021，41，5： | 1 |
| 5 | Tuning of Polyarylene Ether Nitrile Emission Profile by Using Red-Emitting Gold Nano- clusters via Fluorescence Resonance Energy Transfer 显示文摘 | Wang Pan Yuan Liting Huang Xu | 2014 | RSC Advances2014，4，46： | 1 |
| 6 | HSCS:a hybrid shared cache scheduling scheme for multiprogrammed workloads显示文摘The traditional dynamic random-access memory (DRAM)storage medium can be integrated on chips via modem emerging 3D-stacking technology to architect a DRAM shared cache in multicore systems.Compared with static random-access memory (SRAM),DRAM is larger but slower.In the existing research,a lot of work has been devoted to improving the workload performance using SRAM and stacked DRAM together in shared cache systems,ranging from SRAM structure improvement to optimizing cache tags and data access.However,little attention has been paid to designing a shared cache scheduling scheme for multiprogrammed workloads with different memory footprints in multicore systems.Motivated by this,we propose a hybrid shared cache scheduling scheme that allows a multicore system to utilize SRAM and 3D-stacked DRAM efficiently, thus achieving better workload performance.This scheduling scheme employs (1)a cache monitor,which is used to collect cache statistics;(2)a cache evaluator,which is used to evaluate the cache information during the process of programs being executed;and (3)a cache switcher,which is used to self-adaptively choose SRAM or DRAM shared cache modules.A cache data migration policy is naturally developed to guarantee that the scheduling scheme works correctly.Extensive experiments are conducted to evaluate the workload performance of our proposed scheme.The experimental resuits showed that our method can improve the multiprogrammed workload performance by up to 25%compared with state-of-the-art methods (including conventional and DRAM cache systems). | Jingyu ZHANG Chentao WU Dingyu YANG Yuanyi CHEN Xiaodong MENG Liting XU Minyi GUO | 2018 | Frontiers of Computer Science2018，12，6： | 1 |
| 7 | Lipase-catalyzed modification of lard to produce human milk fat substitutes显示文摘 | Tiankui Yang Xuebing Xu Chuan He Lite Li | 2002 | Food Chemistry2002，，4： | 1 |
| 8 | 通过鉴定关键靶标蛋白探究青蒿素抗疟机制显示文摘The widespread use of artemisinin(ART)and its derivatives has significantly reduced the global burden of malaria;however,malaria still poses a serious threat to global health.Although significant progress has been achieved in elucidating the antimalarial mechanisms of ART,the most crucial target proteins and pathways of ART remain unknown.Knowledge on the exact antimalarial mechanisms of ART is urgently needed,as signs of emerging ART resistance have been observed in some regions of the world.Here,we used a combined strategy involving mass spectrometry-coupled cellular thermal shift assay(MS-CETSA)and transcriptomics profiling to identify a group of putative antimalarial targets of ART.We then conducted a series of validation experiments on five prospective protein targets,demonstrating that ART may function against malaria parasites by interfering with redox homeostasis,lipid metabolism,and protein synthesis processes.Taken together,this study provides fresh perspectives on the antimalarial mechanisms of ART and identifies several crucial proteins involved in parasite survival that can be targeted to combat malaria. | Peng Gao Jianyou Wang Jiayun Chen Liwei Gu Chen Wang Liting Xu Yin Kwan Wong Huimin Zhang Chengchao Xu Lingyun Dai Jigang Wang | 2023 | Engineering2023，31，12： | 0 |
| 9 | Long noncoding RNA study:Genome-wide approaches显示文摘Long noncoding RNAs(lncRNAs)have been confirmed to play a crucial role in various biological processes across several species.Though many efforts have been devoted to the expansion of the lncRNAs landscape,much about lncRNAs is still unknown due to their great complexity.The development of high-throughput technologies and the constantly improved bioinformatic methods have resulted in a rapid expansion of lncRNA research and relevant databases.In this review,we introduced genome-wide research of lncRNAs in three parts:(i)novel lncRNA identification by high-throughput sequencing and computational pipelines;(ii)functional characterization of lncRNAs by expression atlas profiling,genome-scale screening,and the research of cancer-related lncRNAs;(iii)mechanism research by large-scale experimental technologies and computational analysis.Besides,primary experimental methods and bioinformatic pipelines related to these three parts are summarized.This review aimed to provide a comprehensive and systemic overview of lncRNA genome-wide research strategies and indicate a genome-wide lncRNA research system. | Shuang Tao Yarui Hou Liting Diao Yanxia Hu Wanyi Xu Shujuan Xie Zhendong Xiao | 2023 | Genes & Diseases2023，10，6： | 0 |
| 10 | Carbon Monoxide Promotes the Catalytic Hydrogenation on Metal Cluster Catalysts显示文摘Size effect plays a crucial role in catalytic hydrogenation.The highly dispersed ultrasmall clusters with a limited number of metal atoms are one candidate of the next generation catalysts that bridge the single-atom metal catalysts and metal nanoparticles.However,for the unfavorable electronic property and their interaction with the substrates,they usually exhibit sluggish activity.Taking advantage of the small size,their catalytic property would be mediated by surface binding species.The combination of metal cluster coordination chemistry brings new opportunity.CO poisoning is notorious for Pt group metal catalysts as the strong adsorption of CO would block the active centers.In this work,we will demonstrate that CO could serve as a promoter for the catalytic hydrogenation when ultrasmall Pd clusters are employed.By means of DFT calculations,we show that Pd_(n)(n=2-147)clusters display sluggish activity for hydrogenation due to the too strong binding of hydrogen atom and reaction intermediates thereon,whereas introducing CO would reduce the binding energies of vicinal sites,thus enhancing the hydrogenation reaction.Experimentally,supported Pd_(2)CO catalysts are fabricated by depositing preestablished[Pd_(2)(μ-CO)_(2)Cl_(4)]2-clusters on oxides and demonstrated as an outstanding catalyst for the hydrogenation of styrene.The promoting effect of CO is further verified experimentally by removing and reintroducing a proper amount of CO on the Pd cluster catalysts. | Ruixuan Qin Pei Wang Pengxin Liu Shiguang Mo Yue Gong Liting Ren Chaofa Xu Kunlong Liu Lin Gu Gang Fu Nanfeng Zheng | 2020 | Research2020，，1： | 0 |
| 11 | Metatranscriptomic analysis of host response and vaginal microbiome of patients with severe COVID-19显示文摘Dear Editor,The pandemic of coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-Co V-2)has become a global public health threat.Here we use a TRACE-seq-based metatranscriptomic analysis to compare host responses and vaginal microbiome of postmenopausal female patients with underlying severe COVID-19 disease with those of healthy females,thereby providing insights into the changes in the microenvironment of women's reproductive system. | Meng Xiao Bo Lu Rui Ding Xia Liu Xian Wu Yaqian Li Xudong Liu Lin Qiu Zhibo Zhang Jing Xie Yu Chen Dong Zhang Liting Dong Meiling Zhang Jinying Peng Hua Yang Timothy Kudihna Yingchun Xu Taisheng Li Chengqi Yi Lan Zhu | 2022 | Science China(Life Sciences)2022，65，7： | 0 |
| 12 | Highly Robust and Wearable Facial Expression Recognition via Deep-Learning-Assisted, Soft Epidermal Electronics显示文摘The facial expressions are a mirror of the elusive emotion hidden in the mind,and thus,capturing expressions is a crucial way of merging the inward world and virtual world.However,typical facial expression recognition(FER)systems are restricted by environments where faces must be clearly seen for computer vision,or rigid devices that are not suitable for the time-dynamic,curvilinear faces.Here,we present a robust,highly wearable FER system that is based on deep-learning-assisted,soft epidermal electronics.The epidermal electronics that can fully conform on faces enable high-fidelity biosignal acquisition without hindering spontaneous facial expressions,releasing the constraint of movement,space,and light.The deep learning method can significantly enhance the recognition accuracy of facial expression types and intensities based on a small sample.The proposed wearable FER system is superior for wide applicability and high accuracy.The FER system is suitable for the individual and shows essential robustness to different light,occlusion,and various face poses.It is totally different from but complementary to the computer vision technology that is merely suitable for simultaneous FER of multiple individuals in a specific place.This wearable FER system is successfully applied to human-avatar emotion interaction and verbal communication disambiguation in a real-life environment,enabling promising human-computer interaction applications. | Meiqi Zhuang Lang Yin Youhua Wang Yunzhao Bai Jian Zhan Chao Hou Liting Yin Zhangyu Xu Xiaohui Tan YongAn Huang | 2022 | Research2022，，1： | 0 |
| 13 | Progress in oncolytic viruses modified with nanomaterials for intravenous application显示文摘In oncolytic virus(OV)therapy,a critical component of tumor immunotherapy,viruses selectively infect,replicate within,and eventually destroy tumor cells.Simultaneously,this therapy activates immune responses and mobilizes immune cells,thereby eliminating residual or distant cancer cells.However,because of OVs’high immunogenicity and immune clearance during circulation,their clinical applications are currently limited to intratumoral injections,and their use is severely restricted.In recent years,numerous studies have used nanomaterials to modify OVs to decrease virulence and increase safety for intravenous injection.The most commonly used nanomaterials for modifying OVs are liposomes,polymers,and albumin,because of their biosafety,practicability,and effectiveness.The aim of this review is to summarize progress in the use of these nanomaterials in preclinical experiments to modify OVs and to discuss the challenges encountered from basic research to clinical application. | Liting Chen Zhijun Ma Chen Xu Youbang Xie Defang Ouyang Shuhui Song Xiao Zhao Funan Liu | 2023 | Cancer Biology & Medicine2023，20，11： | 0 |
| 14 | Combined inhibition of Notch and FLT3 produces synergistic cytotoxic effects in FLT3/ITD^(+)acute myeloid leukemia显示文摘Internal tandem duplication(ITD)mutations of FMS-like tyrosine kinase-3(FLT3)are the most frequent genetic alterations in acute myeloid leukemia(AML)and predict a poor prognosis.FLT3 tyrosine kinase inhibitors(TKIs)provide short-term clinical responses,but the long-term prognosis of FLT3/ITD^(+)AML patients remains poor.Notch signaling is important in numerous types of tumors.However,the role of Notch signaling in FLT3/ITD^(+)AML remains to be elucidated.In the current study,we found that Notch signaling was activated upon FLT3-TKI treatment in FLT3/ITD^(+)cell lines and primary cells.As Notch signaling can be blocked byγ-secretase inhibitors(GSIs),we examined the combinatorial antitumor efficacy of FLT3-TKIs and GSIs against FLT3/ITD^(+)AML and explored the underlying molecular mechanisms.As a result,we observed synergistic cytotoxic effects,and the treatment preferentially reduced cell proliferation and induced apoptosis in FLT3/ITD^(+)AML cell lines and in primary AML cells.Furthermore,the combination of FLT3-TKI and GSI eradicated leukemic cells and prolonged survival in an FLT3/ITD^(+)patient-derived xenograft AML model.Mechanistically,differential expression analysis suggested that CXCR3 may be partially responsible for the observed synergy,possibly through ERK signaling.Our findings suggest that combined therapies of FLT3-TKIs with GSI may be exploited as a potential therapeutic strategy to treat FLT3/ITD^(+)AML. | Dan Li Tongjuan Li Zhen Shang Lei Zhao Qian Xu Jiaqi Tan Yun Qin Yuanyuan Zhang Yang Cao Na Wang Liang Huang Xiaojian Zhu Kuangguo Zhou Liting Chen Chunrui Li Ting Xie Yi Yang Jue Wang Jianfeng Zhou | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
| 15 | Palladium nanoplates scotch breast cancer lung metastasis by constraining epithelial-mesenchymal transition显示文摘Metastasis accounts for the majority of cancer deaths in many tumor types including breast cancer.Epithelial-mesenchymal transition(EMT)is the driving force for the occurrence and progression of metastasis,however,no targeted strategies to block the EMT program are currently available to combat metastasis.Diverse engineered nanomaterials(ENMs)have been reported to exert promising anti-cancer effects,however,no ENMs have been designed to target EMT.Palladium(Pd)nanomaterials,a type of ENM,have received substantial attention in nanomedicine due to their favorable photothermal performance for cancer therapeutics.Herein,Pd nanoplates(PdPL)were found to be preferentially biodistributed to both primary tumors and metastatic tumors.Importantly,PdPL showed a significant inhibition of lung metastasis with and without near-infrared(NIR)irradiation.Mechanistic investigations revealed that EMT was significantly compromised in breast cancer cells upon the PdPL treatment,which was partially due to the inhibition of the transforming growth factor-beta(TGF-β)signaling.Strikingly,the PdPL was found to directly interact with TGF-βproteins to diminish TGF-βfunctions in activating its downstream signaling,as evidenced by the reduced phosphorylation of Smad2.Notably,TGF-β-independent pathways were also involved in undermining EMT and other important biological processes that are necessary for metastasis.Additionally,NIR irradiation elicited synergistic effects on PdPL-induced inhibition of primary tumors and metastasis.In summary,these results revealed that the PdPL remarkably curbed metastasis by inhibiting EMT signaling,thereby indicating the promising potential of PdPL as a therapeutic agent for treating breast cancer metastasis. | Shunhao Wang Jingchao Li Mei Chen Liting Ren Wenya Feng Lining Xu Xiaolan Chen Tian Xia Nanfeng Zheng Sijin Liu | 2021 | National Science Review2021，8，7： | 0 |
| 16 | Molecular imaging:design mechanism and bioapplications显示文摘Molecular imaging is a non-invasive method to image and analyze the concentration and activity of functional biomolecules in cells or in vivo at molecular level,and plays an increasing role in deep understanding of biological processes,early and accurate diagnosis of diseases,and evaluation of treatment.Nowadays,numerous novel molecular imaging probes have been developed,involving every biomedical imaging modality,such as optical imaging,photoacoustic imaging,magnetic resonance imaging,single-photon-emission computed tomography,and positron emission tomography.In this review,we summarize the development of current state-of-the-art molecular imaging probes.We introduce the design strategies of molecular probes and detailed imaging modalities,and highlight the properties of probes and biomedical imaging applications in cells and in vivo,including disease diagnosis,drug tracking,and imaging-guided surgery.Then we discuss the perspectives and challenges in this emerging field.We expect this review could inspire more effective molecular imaging probes to be developed,achieving the goal towards clinical practices. | Lanlan Chen Yifan Lyu Xuan Zhang Liting Zheng Qingqing Li Ding Ding Fengming Chen Yihao Liu Wei Li Yutong Zhang Qiuling Huang Zhiqiang Wang Tiantian Xie Qiang Zhang Yingyu Sima Ke Li Shuai Xu Tianbing Ren Mengyi Xiong Ying Wu Jibin Song Lin Yuan Huanghao Yang Xiao-Bing Zhang Weihong Tan | 2023 | Science China Chemistry2023，66，5： | 0 |
| 17 | Investigation into Experimental Conditions and Factors for Cyclohexane Oxidation with VO(acac)2显示文摘 | MA Xitong XING Na WU Qiong XU Liting XING Yongheng | 2014 | Chemical Research in Chinese Universities2014，30，6： | 0 |
| 18 | Highly Robust and Wearable Facial Expression Recognition via Deep-Learning-Assisted,Soft Epidermal Electronics显示文摘The facial expressions are a mirror of the elusive emotion hidden in the mind,and thus,capturing expressions is a crucial way of merging the inward world and virtual world.However,typical facial expression recognition(FER)systems are restricted by environments where faces must be clearly seen for computer vision,or rigid devices that are not suitable for the time-dynamic,curvilinear faces.Here,we present a robust,highly wearable FER system that is based on deep-learning-assisted,soft epidermal electronics.The epidermal electronics that can fully conform on faces enable high-fidelity biosignal acquisition without hindering spontaneous facial expressions,releasing the constraint of movement,space,and light.The deep learning method can significantly enhance the recognition accuracy of facial expression types and intensities based on a small sample.The proposed wearable FER system is superior for wide applicability and high accuracy.The FER system is suitable for the individual and shows essential robustness to different light,occlusion,and various face poses.It is totally different from but complementary to the computer vision technology that is merely suitable for simultaneous FER of multiple individuals in a specific place.This wearable FER system is successfully applied to human-avatar emotion interaction and verbal communication disambiguation in a real-life environment,enabling promising human-computer interaction applications. | Meiqi Zhuang Lang Yin Youhua Wang Yunzhao Bai Jian Zhan Chao Hou Liting Yin Zhangyu Xu Xiaohui Tan YongAn Huang | 2021 | Research2021，，1： | 0 |
| 19 | Temperature-regulation liquid gating membrane with controllable gas/liquid separation显示文摘Membrane separation technology with the ability to regulate gas/liquid transport and separation is critical for environmental fields, such as sewerage treatment, multiphase separation, and desalination. Although numerous membranes can dynamically control liquid-phase fluids transport via external stimuli, the transport and separation of gas-phase fluids remains a challenge. Here, we show a temperature-regulation liquid gating membrane that allows in-situ dynamically controllable gas/liquid transfer and multiphase separation by integrating a thermo-wettability responsive porous membrane with functional gating liquid. Experiments and theoretical analysis have demonstrated the temperature-regulation mechanism of this liquid gating system, which is based on thermo-responsive changes of porous membrane surface polarity, leading to changes in affinity between the porous membrane and the gating liquid. In addition, the sandwich configuration with dense Au-coated surfaces and heterogeneous internal components by a bistable interface design enables the liquid gating system to enhance response sensitivity and maintain working stability. This temperature-regulation gas/liquid transfer strategy expands the application range of liquid gating membranes,which are promising in environmental governance, water treatment and multiphase separation. | Baiyi Chen Huimeng Wang Jiadai Xu Liting Pan Yuan Jing Xu Hou | 2023 | Green Energy & Environment2023，8，6： | 0 |
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