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| 1 | SIDT1-dependent absorption in the stomach mediates host uptake of dietary and orally administered microRNAs显示文摘Dietary microRNAs have been shown to be absorbed by mammals and regulate host gene expression,but the absorption mechanism remains unknown.Here,we show that SIDT1 expressed on gastric pit cells in the stomach is required for the absorption of dietary microRNAs.SIDT1-deficient mice show reduced basal levels and impaired dynamic absorption of dietary microRNAs.Notably,we identified the stomach as the primary site for dietary microRNA absorption,which is dramatically attenuated in the stomachs of SIDT1-deficient mice.Mechanistic analyses revealed that the uptake of exogenous microRNAs by gastric pit cells is SIDT1 and low-pH dependent.Furthermore,oral administration of plant-derived miR2911 retards liver fibrosis,and this protective effect was abolished in SIDT1-deficient mice.Our findings reveal a major mechanism underlying the absorption of dietary microRNAs,uncover an unexpected role of the stomach and shed light on developing small RNA therapeutics by oral delivery. | Qun Chen Fan Zhang Lei Dong Huimin Wu Jie Xu Hanqin Li Jin Wang Zhen Zhou Chunyan Liu Yanbo Wang Yuyan Liu Liangsheng Lu Chen Wang Minghui Liu Xi Chen Cheng Wang Chunni Zhang Dangsheng Li Ke Zen Fangyu Wang Qipeng Zhang Chen-Yu Zhang | 2021 | Cell Research2021，31，3： | 10 |
| 2 | A high-quality Actinidia chinensis(kiwifruit)genome显示文摘Actinidia chinensis(kiwifruit)is a perennial horticultural crop species of the Actinidiaceae family with high nutritional and economic value.Two versions of the A.chinensis genomes have been previously assembled,based mainly on relatively short reads.Here,we report an improved chromosome-level reference genome of A.chinensis(v3.0),based mainly on PacBio long reads and Hi-C data.The high-quality assembled genome is 653 Mb long,with 0.76%heterozygosity.At least 43%of the genome consists of repetitive sequences,and the most abundant long terminal repeats were further identified and account for 23.38%of our novel genome.It has clear improvements in contiguity,accuracy,and gene annotation over the two previous versions and contains 40,464 annotated protein-coding genes,of which 94.41%are functionally annotated.Moreover,further analyses of genetic collinearity revealed that the kiwifruit genome has undergone two whole-genome duplications:one affecting all Ericales families near the K-T extinction event and a recent genus-specific duplication.The reference genome presented here will be highly useful for further molecular elucidation of diverse traits and for the breeding of this horticultural crop,as well as evolutionary studies with related taxa. | Haolin Wu Tao Ma Minghui Kang Fandi Ai Junlin Zhang Guanyong Dong Jianquan Liu | 2019 | Horticulture Research2019，6，1： | 10 |
| 3 | Study on magnetic memory signals of medium carbon steel specimens with surface crack precut during loading process显示文摘Static tensile test and tensile-tensile fatigue test of medium carbon steel sheet specimens with surface crack precut were performed on MTS810 hydraulic testing machine to clear the meaning of the point of Hp(y) value zero. Magnetic memory signals were measured during the test process. The results show that only one point of Hp(y) zero value exists in all measured magnetic signal curves during the loading process, which should be a sign of intersection of positive-negative magnetic poles after magnetic ordered state appears and does not indicate the position of surface crack precut. The analysis shows that the surface crack precut can not interrupt the magnetic ordered state occurred during the test completely, hence its Hp(y) value is not zero. However, the crack extending to a penetrated defect at the instant of specimen′s fracture leads to the discontinuance of magnetic ordered state. | DONG Lihong XU Binshi DONG Shiyun YE Minghui CHEN Qunzhi | 2006 | Rare Metals2006，25，z1： | 9 |
| 4 | Spatial Pattern Evolution and Casual Analysis of County Level Economy in Changsha-Zhuzhou-Xiangtan Urban Agglomeration, China显示文摘In order to evaluate whether or not the county units′ economy in the Changsha-Zhuzhou-Xiangtan(Chang-Zhu-Tan) Urban Agglomeration was growing as expected, this study analyzed the spatial economy pattern at county-level by using the Exploratory Spatial Data Analysis(ESDA) method. In this process, the global Moran′s I and local Getis-Ord G*i indexes were employed to analyze indicators including per capita GDP and three industrials(i.e. primary, secondary and tertiary industry) from 2000 to 2010. The results show that: 1) the county units′ economy in the Chang-Zhu-Tan Urban Agglomeration has exhibited a strong spatial autocorrelation and an accelerated integration trend since 2008(Moran′ s I increased from 0.26 to 0.56); 2) there is a significant difference in economy development between the northern and southern county units in the Chang-Zhu-Tan Urban Agglomeration: the hotspot zone with high economic level was formed among the northern county units whereas the coldspot zone with low economic level was located in the southern areas. This difference was caused primarily by the increasingly prominent economic radiation effect of Changsha ′upheaval′; 3) town density, secondary industry, and the integration policy are the major contributors driving the evolution of the spatial economy pattern in the Chang-Zhu-Tan Urban Agglomeration. | DONG Minghui ZOU Bin PU Qiang WAN Neng YANG Lingbin LUO Yanqing | 2014 | Chinese Geographical Science2014，24，5： | 8 |
| 5 | Mett13-Mettl14 methyltransferase complex regulates the quiescence of adult hematopoietic stem cells显示文摘 | QiJason Yao Lina Sang Minghui Lin Xiujuan Yin Wenjie Dong Yuping Gong Bo O. Zhou | 2018 | Cell Research2018，28，9： | 8 |
| 6 | CT仿真支气管内窥镜在中央型肺癌诊断中的应用显示文摘目的 评价螺旋CT仿真支气管内窥镜 (CTVB)在中央型肺癌诊断中的作用。方法 对45例经纤维支气管镜检查和病理证实的气管、支气管肿瘤患者进行CT仿真内窥镜检查 ,包括中央型肺癌 33例、肺癌术后 8例、肺癌放疗后 2例及气管恶性肿瘤 2例。用新型螺旋CT机对患者进行扫描后 ,将数据建成CTVB图像进行分析 ,并与纤维支气管镜进行对照 ,2 4例与病理标本进行对照。结果CTVB显示了 10 0 %的段以上支气管和 80 %以上的亚段支气管。肿瘤呈块状或结节状 ,引起管腔狭窄或闭塞。肺癌术后正常的支气管残端呈光滑的盲端 ,肿瘤复发呈结节状突出 ,与纤维支气管镜所见基本一致。肺癌放疗后支气管腔轻度凹凸不平及管腔狭窄。结论 CTVB是一种新的无创性观察气管、支气管腔的方法 ,酷似纤维支气管镜所见 ,结合其他三维重建功能 ,能同时显示管壁的厚度和肿瘤向管腔外侵犯的范围。但与纤维支气管镜相比 ,不易观察支气管黏膜的表浅病变且不能活检。 | Xiong Minghui ZHANG Wanshi WANG Dong 熊明辉 张挽时 王东 宋云龙 | 2001 | 中华肿瘤杂志2001，23，2： | 7 |
| 7 | Mitochondrial uncoupler BAM15 inhibits artery constriction and potently activates AMPK in vascular smooth muscle cells显示文摘Our previous studies found that mitochondrial uncouplers CCCP and niclosamide inhibited artery constriction and the mechanism involved AMPK activation in vascular smooth muscle cells. BAM15 is a novel type of mitochondrial uncoupler. The aim of the present study is to identify the vasoactivity of BAM15 and characterize the BAM15-induced AMPK activation in vascular smooth muscle cells(A10 cells). BAM15 relaxed phenylephrine(PE)-induced constricted rat mesenteric arteries with intact and denuded endothelium. Pretreatment with BAM15 inhibited PEinduced constriction of rat mesenteric arteries with intact and denuded endothelium. BAM15, CCCP,and niclosamide had the comparable IC50 value of vasorelaxation in PE-induced constriction of rat mesenteric arteries. BAM15 was less cytotoxic in A10 cells compared with CCCP and niclosamide.BAM15 depolarized mitochondrial membrane potential, induced mitochondrial fission, increased mitochondrial ROS production, and increased mitochondrial oxygen consumption rate in A10 cells.BAM15 potently activated AMPK in A10 cells and the efficacy of BAM15 was stronger than that of CCCP, niclosamide, and AMPK positive activators metformin and AICAR. In conclusion, BAM15 activates AMPK in vascular smooth muscle cells with higher potency than that of CCCP, niclosamide and the known AMPK activators metformin and AICAR. The present work indicates that BAM15 is a potent AMPK activator. | Yu Tai Lanjun Li Xuan Peng Junxue Zhu Xihai Mao Nan Qin Minghui Ma Rong Huo Yunlong Bai Deli Dong | 2018 | Acta Pharmaceutica Sinica B2018，8，6： | 5 |
| 8 | Development and validation of an analytical method for detecting chlorantraniliprole residues in fresh tea leaves显示文摘An efficient method using multiwalled carbon nanotubes(MWCNTs)as dispersive solid-phase extraction sorbent was established for determining chlorantraniliprole residues in fresh tea leaves,which are known to be a troublesome matrix containing abundant pigments,via gas chromatography with an electron capture detector.Acetonitrile was used as the extraction solvent,with sodium chloride enhancing the analyte partition in the organic phase.The optimal mixture of MWCNTs and primary secondary amine(PSA)was based on the distribution of the target analyte recovery and on the clean-up efficiency;while matrix-matched calibration was recommended to combat the matrix effect.Mean recoveries of 95.2%–108.8%were obtained with intraday and interday precisions of less than 7.9%and 10.3%,respectively.Good linearity was observed for concentrations of 0.02–1.0 mg/kg with a correlation coefficient of 0.9984.The limits of detection and quantification were 0.005 mg/kg and 0.02 mg/kg,respectively.The method was employed to investigate the dissipation dynamics of chlorantraniliprole in fresh tea leaves with real field samples.Consequently,the dissipation rates of chlorantraniliprole in fresh tea leaves followed pseudo-first-order kinetics with a half-life of 1.9 d,and the average chlorantraniliprole residue content was below 0.02 mg/kg with a harvest withholding period of 14 d. | Tengfei Liu Minghui Dong Fengjie Zhou Daifeng Yang Xueming Zhang | 2019 | Food Science and Human Wellness2019，8，4： | 5 |
| 9 | Assessment on critical technologies for conceptual design of blended-wing-body civil aircraft显示文摘Civil aviation faces great challenges because of its robust projected future growth and potential adverse environmental effects. The classical Tube-And-Wing(TAW) configuration following the Cayley’s design principles has been optimized to the architecture’s limit, which can hardly satisfy the further requirements on green aviation. By past decades’ investigations the BlendedWing-Body(BWB) concept has emerged as a potential solution, which can simultaneously fulfill metrics of noise, emission and fuel burn. The purpose of the present work is to analyze the developments of critical technologies for BWB conceptual design from a historical perspective of technology progress. It was found that the high aerodynamic efficiency of BWB aircraft can be well scaled by the mean aerodynamic chord and wetted aspect ratio, and should be realized with the trade-offs among stability and control and low-speed performance. The structure concepts of non-cylinder pressurized cabin are of high risks on weight prediction and weight penalty. A static stability criterion is recommended and further clear and adequate criteria are required by the evaluations of flying and handling qualities. The difficulties of propulsion and airframe integration are analyzed. The energy to revenue work ratios of well-developed BWB configurations are compared,which are 31.5% and 40% better than that of TAW, using state-of-art engine technology and future engine technology, respectively. Finally, further study aspects are advocated. | Zhenli CHEN Minghui ZHANG Yingchun CHEN Weimin SANG Zhaoguang TAN Dong LI Binqian ZHANG | 2019 | Chinese Journal of Aeronautics2019，32，8： | 3 |
| 10 | Effects of stability margin and thrust specific fuel consumption constrains on multi-disciplinary optimization for blended-wing-body design显示文摘Blended-Wing-Body(BWB) configuration, as an innovative transport concept, has become a worldwide research focus in the field of civil transports development. Relative to the conventional Tube-And-Wing(TAW) configuration, the BWB shows integrated benefits and serves as a most promising candidate for future ‘‘green aviation'. The objective of the present work is to figure out the effects of the stability margin and Thrust Specific Fuel Consumption(TSFC) on the BWB design in the framework of Multi-Disciplinary Optimization(MDO). A physically-based platform was promoted to study the effect static stability margin and engine technology level. Low-order physically based models are applied to the evaluation of the weight and the aerodynamic performance. The modules and methods are illustrated in detail, and the validation of the methods shows feasibility and confidence for the conceptual design of BWB aircrafts. In order to find out the relation between planform changes and the selection of stability and engine technology level, two sets of optimizations are conducted separately. The study proves that these two factors have dominant effects towards the optimized BWB designs in both aerodynamic shapes, weight distribution, which needs to be considered during the MDO design process. A balance diagram analysis is applied to find out a reasonable static stability margin range. It can be concluded that a recommended stability margin of a practical BWB commercial aircraft can be half of that of a conventional TAW design. | Minghui ZHANG Zhenli CHEN Zhaoguang TAN Wenting GU Dong LI Changsheng YUAN Binqian ZHANG | 2019 | Chinese Journal of Aeronautics2019，32，8： | 3 |
| 11 | Impact of biodegradable versus durable polymer drug-eluting stents on clinical outcomes in patients with coronary artery disease: a meta-analysis of 15 randomized trials显示文摘 | Zhang Yaojun Tian Nailiang Dong Shengjie Ye Fei Li Minghui Christos V.Bourantas Javaid Iqbal Yoshinobu Onuma Takashi Muramatsu Roberto Diletti Hector M. Garcia-Garcia Xu Bo Patrick W. Serruys Chen Shaoliang | 2014 | Chinese Medical Journal2014，，11： | 3 |
| 12 | Four-protein model for predicting prognostic risk of lung cancer显示文摘Patients with lung cancer at the same stage may have markedly different overall outcome and a lack of specific biomarker to predict lung cancer outcome.Heat-shock protein 90β(HSP90β)is overexpressed in various tumor cells.In this study,the ELISA results of HSP90βcombined with CEA,CA125,and CYFRA21-1 were used to construct a recursive partitioning decision tree model to establish a four-protein diagnostic model and predict the survival of patients with lung cancer.Survival analysis showed that the recursive partitioning decision tree could distinguish the prognosis between high-and low-risk groups.Results suggested that the joint detection of HSP90β,CEA,CA125,and CYFRA21-1 in the peripheral blood of patients with lung cancer is plausible for early diagnosis and prognosis prediction of lung cancer. | Xiang Wang Minghui Wang Lin Feng Jie Song Xin Dong Ting Xiao Shujun Cheng | 2022 | Frontiers of Medicine2022，16，4： | 2 |
| 13 | Reactive oxygen species generation is essential for cisplatininduced accelerated senescence in hepatocellular carcinoma显示文摘因为这个过程涉及肿瘤抑制并且被许多化学疗法的代理人导致了,加速的老朽是重要的。基于铂的化学疗法的代理人 cisplatin 显示大量 antitumor 活动。然而,在 hepatocellular 癌(HCC ) 的导致 cisplatin 的加速的老朽的分子的机制仍然保持不清楚。在现在的学习,生长 HepG2 和 SMMC-7721 细胞上的 cisplatin 的禁止的效果被 3-(4,5-dimethylthiazol-2-yl ) 检测 -2,5-diphenyltetrazolium 溴化物试金。细胞的老朽然后被牛乳糖试金估计。包括 p53, p21,和 p16,老朽相关的因素被量的反向的抄写聚合酶链反应评估。反应的氧种类(ROS ) 被流动 cytometry 分析。我们的结果表明 cisplatin 在一个剂量依赖者和时间依赖者举止减少了 HepG2 和 SMMC-7721 房间的增长。在 cisplatintreated hepatoma 房间观察的衰老的显型依赖于 p53 和 p21 激活然而并非在 p16 激活上。而且, cisplatininduced 加速了取决于的老朽细胞内部的 ROS 产生。ROS scavenger N-acetyl-L-cysteine 显著地也压制了 HepG2 和 SMMC-7721 房间的导致 cisplatin 的老朽。在结论,我们的结果揭示了在细胞内部的 ROS 产生和导致 cisplatin 的加速的老朽之间的一个功能的连接,并且这个连接可以被用作 HCC 的一个潜在的目标。 | Kai Qu Ting Lin Zhixin Wang Sinan Liu Hulin Chang Xinsen Xu Fandi Meng Lei Zhou Jichao Wei Minghui Tai Yafeng Dong Chang Liu | 2014 | Frontiers of Medicine2014，8，2： | 2 |
| 14 | Determination of 18 Kinds of Amino Acids in Fresh Tea Leaves by HPLC Coupled with Pre-column Derivatization显示文摘A rapid and accurate quantitative method of high performance liquid chromatography( HPLC) with fluorescence detector has been developed for the analysis of 18 kinds of amino acids in fresh tea leaves. The samples were minced and mixed,and extracted with ultra pure water at 90℃ for 20 min. The 6-aminoquinolyl N-hydroxy-succinimidyl carbamate( AQC) was used as pre-column derivatization reagent. Gradient HPLC separation was performed on a C_(18) column( Symmetry C_(18),3. 9 mm × 15 cm,4 μm). Good linearity between concentrations and peak areas was achieved in the concentration range of 5. 0-250 μmol/L for 18 kinds of amino acids. The method was validated by the analysis of five replicates. The 18 kinds of amino acid standards were spiked in fresh tea leaf samples and the average recovery rate was 86. 25%-109. 05% with relative standard deviations( n = 5) ranging from 6. 03% to 10. 56%. The limit of detection( LOD) for the analytes was0. 05-1. 27 μmol/L. The method was successfully applied to the analysis of the 18 kinds of amino acids in fresh tea leaves from east Dongting and west Dongting mountains in Suzhou. The results indicate that the method is simple,rapid,precise and reliable. | Shangwen DONG Tengfei LIU Minghui DONG | 2018 | Asian Agricultural Research2018，10，2： | 2 |
| 15 | Three-dimensional ordered hierarchically porous carbon materials for high performance Li-Se battery显示文摘Developing host materials with high specific surface area, good electron conductivity, and fast ion transportation channel is critical for high performance lithium-selenium(Li-Se) batteries. Herein, a series of three dimensional ordered hierarchically porous carbon(3D OHPC) materials with micro/meso/macropores are designed and synthesized for Li-Se battery. The porous structure is tuned by following the concept of the generalized Murray’s law to facilitate the mass diffusion and reduce ion transport resistance.The optimized 3D Se/OHPC cathode exhibits a very high 2 nd discharge capacity of 651 m Ah/g and retains 361 m Ah/g after 200 cycles at 0.2 C. Even at a high current rate of 5 C, the battery still shows a discharge capacity as high as 155 m Ah/g. The improved electrochemical performance is attributed to the synergy effect of the interconnected and well-designed micro, meso and macroporosity while shortened ions diffusion pathways of such Murray materials accelerate its ionic and electronic conductivities leading to the enhanced electrochemical reaction. The diffusivity coefficient in Se/OHPC can reach a very high value of 1.3 × 10^(-11)cm^(2)/s, much higher than those in single pore size carbon hosts. Their effective volume expansion accommodation capability and reduced dissolution of polyselenides ensure the high stability of the battery. This work, for the first time, established the clear relationship between textural properties of cathode materials and their performance and demonstrates that the concept of the generalized Murray’s law can be used as efficient guidance for the rational design and synthesis of advanced hierarchically porous materials and the great potential of 3D OHPC materials as a practical high performance cathode material for Li-Se batteries. | Hongyan Li Wenda Dong Chao Li Tarek Barakat Minghui Sun Yingying Wang Liang Wu Lang Wang Lei Xia Zhi-Yi Hu Yu Li Bao-Lian Su | 2022 | Journal of Energy Chemistry2022，31，5： | 1 |
| 16 | LKB1-AMPK axis negatively regulates ferroptosis by inhibiting fatty acid synthesis显示文摘Dear Editor,Ferroptosis has emerged as a new programmed cell death modality highly relevant to disease.1 Ferroptosis was initially discovered as an iron-dependent non-apoptotic cell death induced by a serial of ferroptosis-inducing agents(FIN),such as erastin and RSL3.Erastin activates ferroptosis by inhibiting the activity of system Xc−,a cystine-glutamate antiporter,resulting in the depletion of cellular cysteine and glutathione(GSH),thus breaking cellular redox homeostasis.Inactivation of glutathione peroxidase 4(GPX4),an enzyme required to remove the toxic lipid hydroperoxides can induce ferroptosis without the depletion of cellular cysteine and GSH. | Changzhi Li Xuan Dong Wenjing Du Xin Shi Kangjie Chen Wei Zhang Minghui Gao | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 17 | Integration of magnetically stabilized bed and amorphous nickel alloy catalyst for CO methanation显示文摘 | Pan Zhiyong Dong Minghui Meng Xiangkun Zhang Xiaoxing Mu Xuhong Zong Baoning | 2007 | Chemical Engineering Science2007，62，： | 1 |
| 18 | The Science of Harmony: A Psychophysical Basis for Perceptual Tensions and Resolutions in Music显示文摘Tis paper attempts to establish a psychophysical basis for both stationary(tension in chord sonorities)and transitional(resolution in chord progressions)harmony.Harmony studies the phenomenon of combining notes in music to produce a pleasing efect greater than the sum of its parts.Being both aesthetic and mathematical in nature,it has bafed some of the brightest minds in physics and mathematics for centuries.With stationary harmony acoustics,traditional theories explaining consonances and dissonances that have been widely accepted are centred around two schools:rational relationships(commonly credited to Pythagoras)and Helmholtz’s beating frequencies.Te frst is more of an attribution than a psychoacoustic explanation while electrophysiological(amongst other)discrepancies with the second still remain disputed.Transitional harmony,on the other hand,is a more complex problem that has remained largely elusive to acoustic science even today.In order to address both stationary and transitional harmony,we frst propose the notion of interharmonic and subharmonic modulations to address the summation of adjacent and distant sinusoids in a chord.Based on this,earlier parts of this paper then bridges the two schools and shows how they stem from a single equation.Later parts of the paper focuses on subharmonic modulations to explain aspects of harmony that interharmonic modulations cannot.Introducing the concept of stationary and transitional subharmonic tensions,we show how it can explain perceptual concepts such as tension in stationary harmony and resolution in transitional harmony,by which we also address the fve fundamental questions of psychoacoustic harmony such as why the pleasing efect of harmony is greater than that of the sum of its parts.Finally,strong correlations with traditional music theory and perception statistics afrm our theory with stationary and transitional harmony. | Paul Yaozhu Chan Minghui Dong Haizhou Li | 2019 | Research2019，，1： | 1 |
| 19 | Aberrant methylation and decreased expression of the TGF‐β/Smad target gene FBXO32 in esophageal squamous cell carcinoma显示文摘 | Wei Guo Minghui Zhang Supeng Shen Yanli Guo Gang Kuang Zhibin Yang Zhiming Dong | 2014 | Cancer2014，，： | 1 |
| 20 | Reconstructing avascular necrotic femoral head through a bioactiveβ-TCP system:From design to application显示文摘A variety of techniques have been used for treating avascular necrosis of the femoral head(ANFH),but have frequently failed.In this study,we proposed aβ-TCP system for the treatment of ANFH by boosting revascularization and bone regeneration.The angio-conductive properties and concurrent osteogenesis of the highly interconnected porousβ-TCP scaffold were revealed and quantified through an in vivo model that simulated the ischemic environment of ANFH.Mechanical test and finite element analysis showed that the mechanical loss caused by tissue necrosis and surgery was immediately partially compensated after implantation,and the strength of the operated femoral head was adaptively increased and eventually returned to normal bone,along with continuous material degradation and bone regeneration.For translational application,we further conducted a multi-center open-label clinical trial to assess the efficacy of theβ-TCP system in treating ANFH.Two hundred fourteen patients with 246 hips were enrolled for evaluation,and 82.1%of the operated hips survived at a 42.79-month median follow-up.The imaging results,hip function,and pain scores were dramatically improved compared to preoperative levels.ARCO stage II disease outperformed stage III in terms of clinical effectiveness.Thus,bio-adaptive reconstruction using theβ-TCP system is a promising hip-preserving strategy for the treatment of ANFH. | Yajie Lu Xiantao Chen Xiao Lu Changning Sun Minghui Li Guojing Chen Zuoyao Long Yuan Gao Haoqiang Zhang Mengquan Huang Chuanlei Ji Hongbin Fan Dong Liu Yuewen Hao Hong Wang Leilei Zhang Hongmei Zhang Jianxi Lu Zhen Wang Jing Li | 2023 | Bioactive Materials2023，，10： | 1 |
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