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| 1 | GeoScope:Full 3D Geospatial Information System Case Study显示文摘Aiming at the integrative management and comprehensive applications of large-scale 3D geospatial information covering the full 3D space of a city,this paper briefly introduces the design and implementation of a full 3D GIS platform:GeoScope,which provides a professional solution for the massive full three-dimensional geospatial data integration,management,analysis,visualization,and applications.GeoScope is characterized by:(1) extendible software architecture based on the hierarchical message bus,facilitates multimodal integrative applications of 2D GIS and 3D GIS;(2) unified 3D city models,support multiscale semantic representation of outdoor & indoor and aboveground & underground 3D objects;(3) high-efficient 3D geospatial database engine,supports integrated management of massive 3D geospatial data for real-time applications;and (4) high-performance visualization engine exploiting the massively parallel computation architecture of modern GPUs,supports real-time realistic rendering of large-scale complicated 3D geospatial environments.The successful pilot application of GeoScope is also illustrated with the 3D city models of 8494 km2 of the whole Wuhan City,the largest city in middle China. | ZHANG Yeting ZHU Qing LIU Gang ZHENG Wenting LI Zhonghua DU Zhiqiang | 2011 | Geo-Spatial Information Science2011，14，2： | 7 |
| 2 | Possible mechanisms underlying treatment of Alzheimer’s disease with Traditional Chinese Medicine: active components, potential targets and synthetic pathways of Bulao Elixir显示文摘OBJECTIVE: To elucidate the mechanisms underlying the treatment of Alzheimer’s disease(AD) with Traditional Chinese Medicine(TCM), by examining the active components, potential targets and synthetic pathways of Bulao Elixir(BLE).METHODS: The Absorption, Distribution, Metabolism, Excretion(ADME)/Toxicology(T) calculation was used to screen the active components of Bulao Elixir. Based on the TCM Systems Pharmacology Analysis Platform(TCMSP database) and a text mining tool(GoPubMed database), we predicted and screened the active components of Bulao Elixir and its therapeutic targets for AD. Using the Database for Annotation, Visualization and Integrated Discovery(DAVID), we obtained the targets for AD. Cytoscape software was used to establish a network map of the active component-target and target-pathway of Bulao Elixir. Gene function, related biological processes and signaling pathways were analyzed using the DAVID database.RESULTS: Twelve active components were selected from 196 components of Bulao Elixir. Among 2209 targets, 102 effective targets were selected, and 30 important targets were identified via matching with the disease targets. After further analysis, 14 core targets were identified. Enrichment analysis revealed that most of these important targets were involved in multiple biological processes, including apoptosis, inflammatory reactions, and cell regulation cycles. The synthetic pathways for AD treatment were identified after analyzing and confirming the relevant pathways, providing potentially useful information for diagnosis and treatment methods for AD.CONCLUSION: The current study elucidated the potential treatment mechanisms of Bulao Elixir in AD using network pharmacology, providing a foundation for further clarification of its treatment targets. | Ren Beida Cheng Fafeng Wang Xueqian Wan Yuxiang Ji Wenting Du Xin Zhang Shuang Liu Shilling Ma Chongyang Xiong Yiliang Hao Gaoting Wang Qingguo | 2020 | Journal of Traditional Chinese Medicine2020，40，3： | 4 |
| 3 | Treatment of oily sludgeby advanced oxidation process显示文摘 | Guolin Jing Mingming Luan Wenting Du | 2012 | Environ Earth Sci2012，，67： | 1 |
| 4 | Studies on prediction of separation percent in electrodialysis process via BP neural networks and improved BP algorithms显示文摘 | Guolin Jing Wenting Du Yingying Guo | 2012 | Desalination2012，，： | 1 |
| 5 | Wear Behavior of a NiCr/AgVO_3 Self-Lubricating Composite显示文摘NiCr/AgVO3 self-lubricating composite was prepared by powder cold-pressed method with the NiCr alloy as the matrix and 10 wt.% additive of AgVO3 as solid lubricant.The AgVO3 additive powder was synthesized by the precipitation method which exhibits a melting point of 460℃.Microstructure,phase composition and thermal properties of the AgVO3 powder,as well as the composite of NiCr/AgVO3 were analyzed using scanning electron microscopy(SEM),transmission electron microscopy(TEM),X-ray diffraction(XRD) and differential scanning calorimeter(DSC).The friction and wear behavior of the specimens from room temperature(R.T.) to 800℃ was evaluated using a ball-on-disk tribometer and 3D white light interference(WLI).The results showed that the friction coefficient of this material under atmosphere decreases with temperature increasing from R.T.to 800℃.However,the wear rate firstly increases from R.T.to 200℃,almost remains stable from 200℃ to 600℃,and then decreases with further increasing the temperature up to 800℃.It is also found that the prepared composite materials show a better frictional behavior than NiCr alloy over the whole range of temperatures,which is mainly attributed to solid lubrication of AgVO3 exhibiting a lamella-slip structure at temperatures below 460℃ and forms liquid-film at elevated temperatures above the melting point. | Wenting ZHANG Lingzhong DU Hao LAN Chuanbing HUANG Weigang ZHANG | 2013 | Acta Metallurgica Sinica(English Letters)2013，26，4： | 1 |
| 6 | Study of the fragmentation mechanism of novel functionalized macrocycles by Fourier transform ion cyclotron resonance mass spectrometry, 显示文摘 | HUI Chen DU Darning HUA Wenting | 2003 | Mass Spectrom2003，38，： | 1 |
| 7 | Studies on prediction of separation percent in electrodialysis process via BP neural networks and improved BP algorithms显示文摘 | Jing Guolin Du Wenting Guo Yingying | 2012 | Desalination2012，，291： | 1 |
| 8 | Antidepressant-like effect of trans -resveratrol: Involvement of serotonin and noradrenaline system显示文摘 | Ying Xu Zhichao Wang Wenting You Xiuhua Zhang Shan Li Philip A. Barish Matthew M. Vernon Xia Du Gaowen Li Jianchun Pan William O. Ogle | 2010 | European Neuropsychopharmacology2010，，6： | 1 |
| 9 | Synthesis and evaluation of water-soluble docetaxel prodrugs-docetaxel esters of malic acid显示文摘 | Wenting Du Lan Hong Tongwei Yao Xiaochun Yang Qiaojun He Bo Yang Yongzhou Hu | 2007 | Bioorganic & Medicinal Chemistry2007，，18： | 1 |
| 10 | Chromium transformation driven by iron redox cycling in basalt-derived paddy soil with high geological background values显示文摘The flooding and drainage of paddy fields has great effects on the transformation of heavy metals, however, the transformation of Cr in basalt-derived paddy soil with high geological background values was less recognized. The typical basalt-derived paddy soil was incubated under alternating redox conditions. The Cr fractions and the dynamics of Fe/N/S/C were examined. The HCl-extractable Cr increased under anaerobic condition and then decreased during aerobic stage. The UV-vis spectra of the supernatant showed that amounts of colloids were released under anaerobic condition, and then re-aggregated during aerobic phase. The scanning transmission electron microscopy(TEM) and X-ray photoelectron spectroscopy(XPS) revealed that Fe oxides were reduced and became dispersed during anaerobic stage, whereas Fe(Ⅱ) was oxidized and recrystallized under aerobic condition. Based on these results, a kinetic model was established to further distinguish the relationship between the transformation of Cr and Fe. During anaerobic phase, the reduction of Fe(Ⅲ) oxides not only directly released the structurally bound Cr, but also enhanced the breakdown of soil aggregation and dissolution of organic matter causing indirect mobilization of Cr. During aerobic phase, the oxidation of Fe (Ⅱ) and further recrystallization of newly formed Fe(Ⅲ) oxides might induce the re-aggregation of soil colloids and further incorporation of Cr. In addition,the kinetic model of Cr and Fe transformation was further verified in the pot experiment.The model-based findings demonstrated that the Cr transformation in the basalt-derived paddy soil with high geological background values was highly driven by redox sensitive iron cycling. | Ke Zhang Yang Yang Wenting Chi Guojun Chen Yanhong Du Shiwen Hu Fangbai Li Tongxu Liu | 2023 | Journal of Environmental Sciences2023，，3： | 0 |
| 11 | Correlation between human seizure-related gene 6 variants and idiopathic generalized epilepsy in a Southern Chinese Han population显示文摘This study sought to analyze the genotype and gene mutations of human seizure-related gene 6 in 98 patients with idiopathic generalized epilepsy (non-febrile seizures), who were selected from three generations of the Chinese Han population living in Shanghai, Zhejiang Province, Wuxi of Jiangsu Province, and Jiangxi Province of Southern China. Twenty-six patients' parents were available as a first-degree relatives group and 100 biologically unrelated healthy controls were collected as the control group. Based on the age of onset and seizure type, the patients were divided into six subgroups. Polymerase chain reaction and DNA direct sequencing analysis showed that the most frequent mutations c.1249dupC (p.Gly418Argfx31) and c.1636A > G (p.Thr546Ala) were detected in some idiopathic generalized epilepsy patients and their asymptomatic first-degree relatives (30.6% vs. 19.2% and 11.2% vs. 26.9%). A novel mutation c.1807G > A (p.Val603Met) was found in a patient with late-onset idiopathic generalized epilepsy. There was no significant difference in the incidence of these three mutations among the different subgroups of idiopathic generalized epilepsy and controls. Thus, further analysis of a larger population is needed to confirm the assumption that human seizure-related gene 6 is a susceptibility gene for idiopathic generalized epilepsy with various sub-syndromes. | Jianming Jiang Xiao ling Chen Wenting Liu Yan Zhao Yangtai Guan Yan Han FengWang Jiajun Lu Zhiliang Yu Zhenfang Du Xianning Zhang | 2012 | Neural Regeneration Research2012，7，2： | 0 |
| 12 | Influence of epitaxial layer structure and cell structure on electrical performance of 6.5 kV SiC MOSFET显示文摘Silicon carbide(SiC)material features a wide bandgap and high critical breakdown field intensity.It also plays an important role in the high efficiency and miniaturization of power electronic equipment.It is an ideal choice for new power electronic devices,especially in smart grids and high-speed trains.In the medium and high voltage fields,SiC devices with a blocking voltage of more than 6.5 kV will have a wide range of applications.In this paper,we study the influence of epitaxial material properties on the static characteristics of 6.5 kV SiC MOSFET.6.5 kV SiC MOSFETs with different channel lengths and JFET region widths are manufactured on three wafers and analyzed.The FN tunneling of gate oxide,HTGB and HTRB tests are performed and provide data support for the industrialization process for medium/high voltage SiC MOSFETs. | Lixin Tian Zechen Du Rui Liu Xiping Niu Wenting Zhang Yunlai An Zhanwei Shen Fei Yang Xiaoguang Wei | 2022 | Journal of Semiconductors2022，43，8： | 0 |
| 13 | Spatial Distribution of Parvalbumin-Positive Fibers in the Mouse Brain and Their Alterations in Mouse Models of Temporal Lobe Epilepsy and Parkinson’s Disease显示文摘Parvalbumin interneurons belong to the major types of GABAergic interneurons.Although the distribution and pathological alterations of parvalbumin interneuron somata have been widely studied,the distribution and vulnerability of the neurites and fibers extending from parvalbumin interneurons have not been detailly interrogated.Through the Cre recombinase-reporter system,we visualized parvalbumin-positive fibers and thoroughly investigated their spatial distribution in the mouse brain.We found that parvalbumin fibers are widely distributed in the brain with specific morphological characteristics in different regions,among which the cortex and thalamus exhibited the most intense parvalbumin signals.In regions such as the striatum and optic tract,even long-range thick parvalbumin projections were detected.Furthermore,in mouse models of temporal lobe epilepsy and Parkinson’s disease,parvalbumin fibers suffered both massive and subtle morphological alterations.Our study provides an overview of parvalbumin fibers in the brain and emphasizes the potential pathological implications of parvalbumin fiber alterations. | Changgeng Song Yan Zhao Jiajia Zhang Ziyi Dong Xin Kang Yuqi Pan Jinle Du Yiting Gao Haifeng Zhang Ye Xi Hui Ding Fang Kuang Wenting Wang Ceng Luo Zhengping Zhang Qinpeng Zhao Jiazhou Yang Wen Jiang Shengxi Wu Fang Gao | 2023 | Neuroscience Bulletin2023，39，11： | 0 |
| 14 | Correction:Spatial Distribution of Parvalbumin‑Positive Fibers in the Mouse Brain and Their Alterations in Mouse Models of Temporal Lobe Epilepsy and Parkinson’s Disease显示文摘In this article the wrong figure appeared as Fig.3,the figure should have appeared as shown below. | Changgeng Song Yan Zhao Jiajia Zhang Ziyi Dong Xin Kang Yuqi Pan Jinle Du Yiting Gao Haifeng Zhang Ye Xi Hui Ding Fang Kuang Wenting Wang Ceng Luo Zhengping Zhang Qinpeng Zhao Jiazhou Yang Wen Jiang Shengxi Wu Fang Gao | 2023 | Neuroscience Bulletin2023，39，11： | 0 |
| 15 | Microzone-explosion synthesis of porous carbon electrodes for advanced aqueous solid-state supercapacitors with a high-voltage gel electrolyte显示文摘A new microzone-combustion synthesis is proposed for preparing S, N-doped hierarchically porous carbons(CAC-CN) with a novel mixed microstructure of sp~2 short-range order area and sp~3 defective area,achieving a coexistence of high conductivity and high capacitance as well as good access for electrolyte.By engineering ‘‘water in salts' into a polymer matrix, a high-voltage(2.5 V) aqueous gel electrolyte(HGWIS) is prepared and used to construct an aqueous solid-state SCs by in situ polymerization between the electrodes. The good match of CAC-CN electrode and HG-WIS electrolyte endows the assembled devices with superior high energy density and excellent capacitance retention, also a good temperature robustness, as well a high flexibility in 0-180° bending cycles. This study indicates that the collaborative design strategy of electrode materials and electrolyte would be great potential in exploring advanced aqueous solid-state SCs. | Yongxu Du Wei Liu Yongpeng Cui Hongguang Fan Yuan Zhang Tianqi Wang Huanlei Wang Yongcheng Jin Shuang Liu Wenting Feng Ming Chen | 2021 | Journal of Energy Chemistry2021，30，9： | 0 |
| 16 | Large deletions within the spinal muscular atrophy gene region in a patient with spinal muscular atrophy type 3显示文摘Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disorder characterized by degeneration and loss of anterior horn cells in the spinal cord and brain stem nuclei,leading to progressive limb and trunk paralysis and muscular atrophy.Depending on the age of onset and maximum muscular function achieved,SMA is recognized as SMA1,SMA2,SMA3 or SMA4,and most patients have a deletion or truncation of the survival motor neuron 1 (SMN1) gene.In this report,we present a patient with a mild SMA phenotype,SMA3,and define his genetic abnormality.Tetra-primer amplification refractory mutation system PCR combined with restriction fragment length polymorphism analysis and array comparative genomic hybridization were used to determine the genetic variations in this patient.A 500 kb deletion in chromosome 5q13.2,including homozygous deletion of neuronal apoptosis inhibitory protein,and heterozygous deletion of occludin and B-double prime 1 was identified.This SMA region deletion did not involve SMN,indicating that SMN was likely to function normally.The phenotype was dependent of the large deletion and neuronal apoptosis inhibitory protein,occludin and B-double prime 1 may be candidate genes for SMA3. | Wei Wei Chunyue Chen Wenting Liu Zhenfang Du Xiaoling Chen Xianning Zhang | 2011 | Neural Regeneration Research2011，6，23： | 0 |
| 17 | Accelerating hybrid and compact neural networks targeting perception and control domains with coarse-grained dataflow reconfiguration显示文摘Driven by continuous scaling of nanoscale semiconductor technologies,the past years have witnessed the progressive advancement of machine learning techniques and applications.Recently,dedicated machine learning accelerators,especially for neural networks,have attracted the research interests of computer architects and VLSI designers.State-of-the-art accelerators increase performance by deploying a huge amount of processing elements,however still face the issue of degraded resource utilization across hybrid and non-standard algorithmic kernels.In this work,we exploit the properties of important neural network kernels for both perception and control to propose a reconfigurable dataflow processor,which adjusts the patterns of data flowing,functionalities of processing elements and on-chip storages according to network kernels.In contrast to stateof-the-art fine-grained data flowing techniques,the proposed coarse-grained dataflow reconfiguration approach enables extensive sharing of computing and storage resources.Three hybrid networks for MobileNet,deep reinforcement learning and sequence classification are constructed and analyzed with customized instruction sets and toolchain.A test chip has been designed and fabricated under UMC 65 nm CMOS technology,with the measured power consumption of 7.51 mW under 100 MHz frequency on a die size of 1.8×1.8 mm^2. | Zheng Wang Libing Zhou Wenting Xie Weiguang Chen Jinyuan Su Wenxuan Chen Anhua Du Shanliao Li Minglan Liang Yuejin Lin Wei Zhao Yanze Wu Tianfu Sun Wenqi Fang Zhibin Yu | 2020 | Journal of Semiconductors2020，41，2： | 0 |
| 18 | Molecular simulation-based research on antifreeze peptides:advances and perspectives显示文摘Antifreeze protein(AFP)can inhibit the growth of ice crystals to protect organisms from freezing damage,and demonstrates broad application prospects in food industry.Antifreeze peptides(AFPP)are specifi c peptides with functional domains showing antifreeze activity in AFP.Bioinformatics-based molecular simulation technology can more accurately explain the properties and mechanisms of biological macromolecules.Therefore,the binding stability of antifreeze peptides and antifreeze proteins(AFP(P))to ice and the molecular-scale growth kinetics of ice were analyzed by molecular simulation,which can make up for the limitations of experimental technology.This review concludes the molecular simulation-based research in the inhibition’s study of AFP(P)on ice growth,including sequence prediction,structure construction,molecular docking and molecular dynamics(MD)studies of AFP(P)on ice applications in growth inhibition.Finally,the review prospects the future direction of designing new antifreeze biomimetic materials through molecular simulation and machine learning.The information presented in this paper will help enrich our understanding of AFPP. | Wenting Jiang Fujia Yang Xu Chen Xixi Cai Jinhong Wu Ming Du Jianlian Huang Shaoyun Wang | 2022 | Journal of Future Foods2022，2，3： | 0 |
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