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| 1 | Natural Variation in the Promoter of GSE5 Contributes to Grain Size Diversity in Rice显示文摘自然基因变化的利用极大地在庄稼贡献重要农学的特点的改进。为谷物尺寸的自然变化理解基因基础能帮助 breeders 开发产量很高的米饭变化。在这研究,我们识别以前未被认出的基因,命名 GSE5,与功能的分析在由联合染色体宽的协会控制米饭谷物尺寸的 qSW5/GW5 地点学习。GSE5 编码血浆有 IQ 领域的联系膜的蛋白质,与米饭 calmodulin 蛋白质交往, OsCaM1-1。我们发现 GSE5 功能的损失引起了宽、重的谷物,当 GSE5 的 overexpression 导致了狭窄的谷物时。我们证明 GSE5 由在小穗状花小穗壳影响房间增长主要调整谷物尺寸。GSE5 的三主要 haplotypes (GSE5, GSE5 DEL1+IN1 , 和 GSE5 在栽培米饭的 DEL2 ) 在它的倡导者区域基于删除 / 插入类型被识别。我们表明了那在带 GSE5 在带 GSE5 haplotype 和 1212-bp 删除(DEL2 )> 与 GSE5 的减少的表示联系的 DEL2 haplotype,导致宽谷物。进一步的分析显示野米饭就职包含 GSE5 的所有三 haplotypes,建议在栽培米饭在场的 GSE5 haplotypes 是可能的从在米饭驯服期间的不同野米饭就职发源。一起拿,我们的结果显示在 qSW5/GW5 地点的以前未被认出的 GSE5 基因,被米饭 breeders 广泛地利用,控制谷物缩放,并且表明在 GSE5 的倡导者区域的那个自然变化在米饭贡献谷物尺寸差异。 | Penggen Duan Jinsong Xu Dali Zeng Baolan Zhang Mufan Geng Guozheng Zhang Ke Huang Luojiang Huang Ran Xu Song Ge Qian Qian Yunhai Li | 2017 | Molecular Plant2017，10，5： | 31 |
| 2 | Diverse modes of clonal evolution in HBV-related hepatocellular carcinoma revealed by single-cell genome sequencing显示文摘Hepatocellular 癌(HCC ) 是癌症实质词法,基因并且 phenotypic 差异。然而,我们不理解在 intratumor 异质和肿瘤的联系词法 / 组织学的特征之间的关系。用介绍 96 个肿瘤房间(30-36 各个) 和 15 个正常的肝房间(5 各个) 的单个房间的整个染色体的定序,与联系 HBV 的 HCC 从三个男病人收集了,我们证实拷贝数字变化在 hepatocarcinogenesis 早发生,但是此后在整个肿瘤仍然保持相对稳定前进。重要地,我们证明特定的 HCC 能具有 monoclonal 或 polyclonal 起源。有汇合的 multinodular 形态学的肿瘤是典型 polyclonal 肿瘤并且显示最高的 intratumor 异质。除了 mutational 和拷贝数字侧面,我们把了用导出 HBV 的外国 genomic 标记的 HCC 的同种细胞的起源。在 monoclonal HCC,所有肿瘤单身者房间展出一样的 HBV 集成,显示 HBV 集成是一个早司机事件并且在肿瘤前进期间仍然保持极其稳定。另外,我们的结果显示那两个都转移,迟了的传播并且早播种当模特儿,在 HCC 有一个角色前进。尤其是,开始的克隆传播的早 intrahepatic 导致同步 multifocal 肿瘤的形成。同时,我们在 HCC 识别了潜在的司机基因 ZNF717,它展出变化的高频率在单个房间并且人口铺平,,通过调整 IL-6/STAT3 小径行动的肿瘤 suppressor。这些调查结果热点多重不同肿瘤在 HCC 的进化机制,它为特定的处理策略建议需要。 | Meng Duan, Shu Zhang, Zhichao Wang, Jieyi Shi, Longzi Liu, Xiaoying Wang, Aiwu Ke, Jian Zhou, Jia Fan, Qiang Gao Junfeng Hao, Chong Li Sijia Cui Daniel L Worthley Ya Cao Ruibin Xi Xiaoming Zhang Jian Zhou, Jia Fan Qiang Gao | 2018 | Cell Research2018，28，3： | 21 |
| 3 | Regulation of OsSPX1 and OsSPX3 on Expression of OsSPX Domain Genes and Pi-starvation Signaling in Rice显示文摘The rice(Oryza sativa L.) genome contains at least six genes exclusively with an SPX(SYG1/PHO81/XPR1) domain at the N-terminal,designated as OsSPX1-6.Here we report the diverse expression patterns of the OsSPX genes in different tissues and their responses to Pi-starvation.Among them,five genes,OsSPX1,2,3,5 and 6 are responsive to Pi-starvation in shoots and/or in roots.The subcellular localization analysis indicates that OsSPX1 and OsSPX2 is exclusively located in nucleus,OsSPX3 in the cytoplasm,and OsSPX4 is a membrane localization protein.OsSPX1 regulates OsSPX2,3 and 5 at the transcription level and is positively involved in the responses of the genes to Pi-starvation.Overexpression of OsSPX3 downregulates OsSPX5 in shoots under Pi-sufficiency.OsSPX3 negatively regulates the PSI(Pi-starvation induced) gene,OsIPS1 and is involved in the responses of miR399 and OsPHO2 to Pi-starvation.Our results suggest that OsSPX1 may be a regulator involved in the transcriptions of OsSPX2,3 and 5.OsSPX3 plays a role in OsIPS1/miR399 mediated long distance regulation on OsPHO2.Our results also indicate that OsSPX3 is involved in plant tolerance to Pi-starvation stress. | Zhiye Wang Han Hu Hongjie Huang Ke Duan Zhong changWu Ping Wu | 2009 | Journal of Integrative Plant Biology2009，51，7： | 18 |
| 4 | Ectopic osteogenesis and angiogenesis regulated by porous architecture of hydroxyapatite scaffolds with similar interconnecting structure in vivo显示文摘The macro-pore sizes of porous scaffold play a key role for regulating ectopic osteogenesis and angiogenesis but many researches ignored the influence of interconnection between macro-pores with different sizes.In order to accurately reveal the relationship between ectopic osteogenesis and macro-pore sizes in dorsal muscle and abdominal cavities of dogs,hydroxyapatite(HA)scaffolds with three different macro-pore sizes of 500–650,750–900 and 1100–1250 mm were prepared via sugar spheres-leaching process,which also had similar interconnecting structure determined by keeping the d/s ratio of interconnecting window diameter to macro-pore size constant.The permeability test showed that the seepage flow of fluid through the porous scaffolds increased with the increase of macro-pore sizes.The cell growth in three scaffolds was not affected by the macro-pore sizes.The in vivo ectopic implantation results indicated that the macro-pore sizes of HA scaffolds with the similar interconnecting structure have impact not only the speed of osteogenesis and angiogenesis but also the space distribution of newly formed bone.The scaffold with macro-pore sizes of 750–900 mm exhibited much faster angiogenesis and osteogenesis,and much more uniformly distribution of new bone than those with othermacro-pore sizes.This work illustrates the importance of a suitable macro-pore sizes in HA scaffolds with the similar interconnecting structure which provides the environment for ectopic osteogenesis and angiogenesis. | Jinyu Li Wei Zhi Taotao Xu Feng Shi Ke Duan JianxinWang Yandong Mu Jie Weng | 2016 | Regenerative Biomaterials2016，3，5： | 16 |
| 5 | Combined application of virtual imaging techniques and three-dimensional computed tomographic angiography in diagnosing intracranial aneurysms显示文摘虚拟成像的诊断价值为 intracranial 动脉瘤与三维的计算 tomographic angiography (3D-CTA ) 相结合的背景还充分没被阐明。这研究试图在在尖锐阶段与动脉瘤的 subarachnoid 出血(SAH ) 诊断病人评估虚拟成像技术和 3D-CTA 的联合申请的价值。有非创伤的 SAH 的八十个病人收到了 3D-CTA 考试的方法。这些病人的未加工的 CT 数据被重建并且基于虚拟现实(VR ) 通过外科的计划系统转了进 3D 模式图象,和 3D 颅骨和大脑血容器的虚拟图象被获得。有邻近的纸巾的动脉瘤和他们的解剖关系的地点,尺寸和形状从许多观点被测量。结果 73 个动脉瘤在 80 个病人中的 68 个被检测,但是 2 个动脉瘤在以前没有动脉瘤被发现了并且一个月以后为第二次收到了 3D-CTA 考试的 5 个病人中的 2 个被检测。虚拟图象由虚拟成像系统生产了的 3D 清楚、生动,并且他们能直接揭示到父母动脉和颅骨的动脉瘤和它的关系的地点和尺寸。3D-CTA 的成像是在诊断方便、可靠、快的 intracranial 动脉瘤和罐头的结论为破裂的 intracranial 动脉瘤的诊断和治疗被认为是第一种选择。基于 VR 图象与外科的计划系统结合了, 3D-CTA 可以关于动脉瘤获得更多的成像信息。 | GUO Yan-wu KE Yi-quan ZHANG Shi-zhong WANG Qiu-jing DUAN Chuan-zhi JIA Hong-shun ZHOU Li XU Ru-xiang | 2008 | Chinese Medical Journal2008，，24： | 14 |
| 6 | The GW2-WG1-OsbZIP47 pathway controls grain size and weight in rice显示文摘Regulation of seed size is a key strategy for improving crop yield and is also a basic biological question.However,the molecular mechanisms by which plants determine their seed size remain elusive.Here,we report that the GW2-WG1-OsbZIP47 regulatory module controls grain width and weight in rice.WG1,which encodes a glutaredoxin protein,promotes grain growth by increasing cell proliferation.Interestingly,WG1 interacts with the transcription factor OsbZIP47 and represses its transcriptional activity by associating with the transcriptional co-repressor ASP1,indicating that WG1 may act as an adaptor protein to recruit the transcriptional co-repressor.In contrary,OsbZIP47 restricts grain growth by decreasing cell proliferation.Further studies reveal that the E3 ubiquitin ligase GW2 ubiquitinates WG1 and targets it for degradation.Genetic analyses confirm that GW2,WG1,and OsbZIP47 function in a comm on pathway to control grain growth.Taken together,ourfindi ngs reveal a genetic and molecular framework for the control of grain size and weight by the GW2-WG1-OsbZIP47 regulatory module,providing new targets for improving seed size and weight in crops. | Jianqin Hao Dekai Wang Yingbao Wu Ke Huang Penggen Duan Na Li Ran Xu Dali Zeng Guojun Dong Baolan Zhang Limin Zhang Dirk Inze Qian Qian Yunhai Li | 2021 | Molecular Plant2021，14，8： | 14 |
| 7 | A population-based survey of gastroesophageal reflux disease in a region with high prevalence of esophageal cancer in China显示文摘Background: The exact relationship between gastroesophageal reflux disease (GERD) and esophageal squamous cell cancer (ESCC) is far from clarification. The aim of this study was to investigate the epidemiology of GERD in a region with high prevalence of ESCC in China. Methods: A population-based, cross-sectional study was conducted in a high ESCC prevalent area, Anyang, Henan, China. All subjects fulfilled questionnaires and underwent gastroendoscopy with routine esophageal biopsy. The subjects were divided into GERD subtypes (reflux esophagitis [RE] and non-erosive reflux disease [NERD]) and controls. Odds ratios (ORs) and 95% confidence intervals (Cis) were calculated to examine risk factors for RE and NERD. Results: A total of 2844 subjects were finally enrolled. The prevalence of GERD (RE + NERD) was 17.3%. Among them, 271 (9.53%) adults were diagnosed with RE. The prevalence of RE increased with age (7.09% in 45-50 years, 8.00% in 51-60 years, and 9.53% in 61-69 years,x^2 = 62.216, P < 0.001). Sixty-seven (2.36%) subjects were diagnosed with the silent RE. A total of 221 (7.77%) subjects were diagnosed with NERD. Frequent liquid food consumption (OR [95% CI]: 1.502 [1.076-2.095]) was independent risk factor for RE as well as age, male gender, high body mass index (BMI), ever smoking. Age was independent risk factor for NERD. For silent RE, age, male gender, and frequent liquid food consumption were risk factors. Conclusions: In the population with high prevalence of ESCC, a high prevalence of GERD and inverted proportion of RE/NERD were presented. Age was an independent risk factor for GERD. The male gender, high BMI, smoking, and frequent liquid food consumption may be risk factors for RE but not for NERD. | Kun Wang Li Zhang Zhong-Hu He Zuo-Jing Liu Lu Zhang Nan Hu Zhu Jin Yang Ke Li-Ping Duan | 2019 | Chinese Medical Journal2019，，13： | 13 |
| 8 | Epidemiological and clinical features of functional dyspepsia in a region with a high incidence of esophageal cancer in China显示文摘Background:Functional dyspepsia(FD)has rarely been investigated in areas with a high prevalence of esophageal squamous cell carcinoma(ESCC).This study aims to reveal the epidemiological and clinical features of FD and organic dyspepsia(OD)in such a population.Methods:A middle-aged and elderly population-based study was conducted in a region with a high incidence of ESCC.All participants completed the Gastroesophageal Reflux Disease Questionnaire and Functional Gastrointestinal Disease Rome III Diagnostic Questionnaire,and they underwent gastroscopy.After exclusion of gastroesophageal reflux disease,uninvestigated dyspepsia(UID)was divided into OD and FD for further analyses.Results:A total of 2916 participants were enrolled from July 2013 to March 2014 in China.We detected 166 UID cases with questionnaires,in which 17 patients with OD and 149 with FD were diagnosed via gastroscopy.OD cases presented as reflux esophagitis(RE),ESCC,and duodenal ulcer.Heartburn(52.94%)and reflux(29.41%)were common in OD,but no symptomatic differences were found between FD and OD.Male sex,low education level,and liquid food were the risk factors for OD,while frequent fresh vegetable consumption was a protective factor.FD included 56(37.58%)cases of postprandial distress syndrome(PDS),52(34.89%)of epigastric pain syndrome(EPS),nine(6.04%)of PDS+EPS,and 32(21.48%)of FD+functional esophageal disorders.The Helicobacter pylori infection rate in FD patients was not higher than that in the control group(34.23%vs.42.26%,P=0.240).Frequent spicy food consumption was associated with PDS(odds ratio[OR]:2.088,95%confidence interval[CI]:1.028–4.243),while consumption of deep well water was protective for PDS(OR:0.431,95%CI:0.251–0.741).Conclusions:The prevalence of FD was 5.11%in the studied population.Gastroscopy should be prescribed for dyspepsia patients in case that ESCC and RE would be missed in UID cases diagnosed solely by the Rome III questionnaire.Trial Registration:ClinicalTrials.gov,NCT01688908;http://gffzzd3f38a9638994581scwoo5ffnxn9v65c0.ffgz.tsg.suse.edu.cn/ct2/show/record/NCT01688908. | Nan Hu Kun Wang Li Zhang Zuo-Jing Liu Zhu Jin Rong-Li Cui He-Jun Zhang Zhong-Hu He Yang Ke Li-Ping Duan | 2021 | Chinese Medical Journal2021，，12： | 9 |
| 9 | Therapeutic effect of Keap1-Nrf2-ARE pathway-related drugs on age-related eye diseases through anti-oxidative stress显示文摘Age-related eye diseases,including cataract,glaucoma,diabetic retinopathy(DR),and age-related macular degeneration(AMD),are the leading causes of vision loss in the world.Several studies have shown that the occurrence and development of these diseases have an important relationship with oxidative stress in the eye.The Keap1-Nrf2-ARE pathway is a classical pathway that resists oxidative stress and inflammation in the body.This pathway is also active in the development of age-related eye diseases.A variety of drugs have been shown to treat agerelated eye diseases through the Keap1-Nrf2-ARE(Kelch-like ECH-Associating protein 1-nuclear factor erythroid 2 related factor 2-antioxidant response element)pathway.This review describes the role of oxidative stress in the development of age-related eye diseases,the function and regulation of the Keap1-Nrf2-ARE pathway,and the therapeutic effects of drugs associated with this pathway on age-related eye diseases. | Zi-Yan Cai Meng-Die Fu Ke Liu Xuan-Chu Duan | 2021 | International Journal of Ophthalmology(English edition)2021，14，8： | 9 |
| 10 | CRISPR/Cas9-mediated correction of human genetic disease显示文摘The clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated(Cas) protein 9 system(CRISPR/Cas9) provides a powerful tool for targeted genetic editing. Directed by programmable sequence-specific RNAs,this system introduces cleavage and double-stranded breaks at target sites precisely. Compared to previously developed targeted nucleases, the CRISPR/Cas9 system demonstrates several promising advantages, including simplicity, high specificity,and efficiency. Several broad genome-editing studies with the CRISPR/Cas9 system in different species in vivo and ex vivo have indicated its strong potential, raising hopes for therapeutic genome editing in clinical settings. Taking advantage of non-homologous end-joining(NHEJ) and homology directed repair(HDR)-mediated DNA repair, several studies have recently reported the use of CRISPR/Cas9 to successfully correct disease-causing alleles ranging from single base mutations to large insertions. In this review, we summarize and discuss recent preclinical studies involving the CRISPR/Cas9-mediated correction of human genetic diseases. | Ke Men Xingmei Duan Zhiyao He Yang Yang Shaohua Yao Yuquan Wei | 2017 | Science China(Life Sciences)2017，60，5： | 7 |
| 11 | Hadron Physics Programs at HIRFL-CSRm: Plan and Status显示文摘 | ZHENG Chuan XIAO Zhi-Gang XU Hu-Shan XIAO Guo-Qing ZHAN Wen-Long LI Zhan-Kui DUAN Li-Min SUN Zhi-Yu YAO Nan YUAN Xiao-Hua ZHANG Xue-Ying WANG Jian-Song CHEN Ruo-Fu FAN Rui-Rui FU Fen HUANG Tian-Heng LIANG Jin-Jie OUYANG Zhen YU Yu-Hong YUE Ke ZHANG Xue-Heng ZHANG Ya-Peng LI Xi-Guo LI Jin | 2007 | 高能物理与核物理2007，31，12： | 5 |
| 12 | Genome wide abnormal DNA methylome of human blastocyst in assisted reproductive technology显示文摘Proper reprogramming of parental DNA methylomes is essential for mammalian embryonic development.However,it is unknown whether abnormal methylome reprogramming occurs and is associated with the failure of embryonic development.Here we analyzed the DNA methylomes of 57 blastocysts and 29 trophectoderm samples with different morphological grades during assisted reproductive technology(ART) practices.Our data reveal that the global methylation levels of high-quality blastocysts are similar(0.30 ± 0.02,mean ± SD).while the methylation levels of low-quality blastocysts are divergent and away from those of high-quality blastocysts.The proportion of blastocysts with a methylation level falling within the range of 0.30 ± 0.02 in different grades correlates with the live birth rate for that grade.Moreover,abnormal methylated regions are associated with the failure of embryonic development.Furthermore,we can use the methylation data of cells biopsied from trophectoderm to predict the blastocyst methylation level as well as to detect the aneuploidy of the blastocysts.Our data indicate that global abnormal methylome reprogramming often occurs in human embryos,and suggest that DNA methylome is a potential biomarker in blastocyst selection in ART. | Guoqiang Li Yang Yu Yong Fan Congru Li Xiaocui Xu Jialei Duan Rong Li Xiangjin Kang Xin Ma Xuepeng Chen Yuwen Ke Jie Yan Ying Lian Ping Liu Yue Zhao Hongcui Zhao Yaoyong Chen Xiaofang Sun Jianqiao Liu Jie Qiao Jiang Liu | 2017 | Journal of Genetics and Genomics2017，44，10： | 5 |
| 13 | Microstructure and Mechanical Properties of High-Nitrogen Austenitic Stainless Steels Subjected to Equal-Channel Angular Pressing显示文摘Three high-nitrogen stainless steels with different N contents were successfully processed by equal-channel angular pressing for one pass, and their microstructures and mechanical properties were investigated. It was found that the microstructure of the billet was heterogeneous across the billet thickness, resulting in the difference in the mechanical properties due to the different deformation conditions. A relatively low strength, high uniform elongation, and high workhardening rate for the samples at the bottom of the billet was achieved in comparison with those processed at the top.Meanwhile, it was observed that the density of deformation twins increased with the content of N; accordingly, the strength and elongation of the alloys increase with the content of N, resulting in a good strength–ductility combination. | Fu-Yuan Dong Peng Zhang Jian-Chao Pang Qi-Qiang Duan Yi-Bin Ren Ke Yang Zhe-Feng Zhang | 2016 | Acta Metallurgica Sinica(English Letters)2016，29，2： | 5 |
| 14 | A Second-Order Sliding Mode Controller of Quad-Rotor UAV Based on PID Sliding Mode Surface with Unbalanced Load显示文摘Quad-rotor unmanned aerial vehicle(UAV)is a typical multiple-input-multiple-output underactuated system with couplings and nonlinearity.Usually,the flying environment is very complex,so that it is impossible for the UAV to avoid effects derived from disturbances and uncertainties.In order to improve the reliability of flight control,we established the dynamic model of quad-rotor UAV by Newton-Euler equation in unbalanced load conditions.Considering external disturbances in the attitude,a second-order sliding mode controller was designed with PID sliding mode surface and Extended State Observer(ESO).The simulation experiments have got good control performance,illustrating the effectiveness of our controller.Meanwhile,the controller was implemented in a quadrotor UAV,which carried a pan-tilt camera for aerial photography.The actual flight experiments proved that this paper dealt with the high stabilization flight control problem for the quad-rotor UAV,which laid a good foundation for autonomous flight of the UAV. | KANG Bing MIAO Yan LIU Fu DUAN Jilu WANG Ke JIANG Shoukun | 2021 | Journal of Systems Science & Complexity2021，34，2： | 5 |
| 15 | Epstein-Barr virus-encoded RNAs as a survival predictor in nasopharyngeal carcinoma显示文摘 | Ke Kengjian Wang Haiyun Fu Sha Zhang Zichen Duan Liping Liu Dabo Ye Jin | 2014 | Chinese Medical Journal2014，，2： | 5 |
| 16 | LRP6 downregulation promotes cardiomyocyte proliferation and heart regeneration显示文摘The adult mammalian heart is thought to be a terminally differentiated organ given the postmitotic nature of cardiomyocytes.Consequently,the potential for cardiac repair through cardiomyocyte proliferation is extremely limited.Low-density lipoprotein receptor-related protein 6(LRP6)is a Wnt co-receptor that is required for embryonic heart development.In this study we investigated the role of LRP6 in heart repair through regulation of cardiomyocyte proliferation.Lrp6 deficiency increased cardiomyocyte cell cycle activity in neonatal,juvenile and adult mice.Cardiomyocyte-specific deletion of Lrp6 in the mouse heart induced a robust regenerative response after myocardial infarction(MI),led to reduced MI area and improvement in left ventricular systolic function.In vivo genetic lineage tracing revealed that the newly formed cardiomyocytes in Lrp6-deficient mouse hearts after MI were mainly derived from resident cardiomyocytes.Furthermore,we found that the pro-proliferative effect of Lrp6 deficiency was mediated by the ING5/P21 signaling pathway.Gene therapy using the adeno-associated virus(AAV)9 miRNAi-Lrp6 construct promoted the repair of heart injury in mice.Lrp6 deficiency also induced the proliferation of human induced pluripotent stem cell-derived cardiomyocytes(iPSC-CMs).Our study identifies LRP6 as a critical regulator of cardiomyocyte proliferation,which may lead to the development of a novel molecular strategy to promote myocardial regeneration and repair. | Yahan Wu Liping Zhou Hongyu Liu Ran Duan Huixing Zhou Fulei Zhang Xiaoyu He Dongbo Lu Ke Xiong Maolin Xiong Jinzhu Zhuang Yi Liu Li Li Dandan Liang Yi-Han Chen | 2021 | Cell Research2021，31，4： | 5 |
| 17 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 18 | Group VB transition metal dichalcogenides for oxygen reduction reaction and strain-enhanced activity governed by p-orbital electrons of chalcogen显示文摘Developi ng alter native oxyge n reducti on reactio n (ORR) catalysts to replace precious Pt-based metals with abundant materials is the key challe nge of commercial application of fuel cells. Owing to their various compositi ons and tun able electronic properties, transition metal dichalcogenides (TMDs) have the great potential to realize high-efficiency catalysts for ORR. Here, various 3R-phase dichalcogenides of group VB and VIB transition metals (MX2, M = Nb, Ta, Mo, W;X = S, Se, Te) are investigated for ORR catalysts by using density functional theory calculations. The computed over-potentials of group VB TMDs are much less than those of group VIB TMDs. For group VB TMDs, a volcano-type plot of ORR catalytic activity is established on the adsorption energies of *OH, and NbS2 and TaTe2 exhibit best ORR activity with an oveepotential of 0.54 V. To achieve even better activity, strain engineering is performed to tune ORR catalytic activity, and the minimum over-potential of 0.43 V can be realized. We further dem on strate that the shift of p orbital center of surface chalcoge n elements under strain is responsible for tuning the catalytic activity of TMDs. | Shuyang Zhao Ke Wang Xiaolong Zou Lin Gan Hongda Du Chengjun Xu Feiyu Kang Wenhui Duan Jia Li | 2019 | Nano Research2019，12，4： | 4 |
| 19 | Comprehensive analysis of chemical constituents in Xingxiong injection by high performance liquid chromatography coupled with mass spectrometry显示文摘Xingxiong injection(XXI) is a widely used Chinese herbal formula prepared by the folium ginkgo extract and ligustrazine for the treatment of cardiovascular and cerebrovascular diseases. Compared with the pharmacological studies, chemical analysis and quality control studies on this formula are relatively limited. In the present study, a high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry(HPLC-QTOF MS) method was applied to comprehensive analysis of constituents in XXI. According to the fragmentation rules and previous reports, thirty ginkgo flavonoids, four ginkgo terpene lactones, and one alkaloid were identified. A high performance liquid chromatography coupled with triple quadrupole mass spectrometry(HPLC-QQQ MS) method was then applied to quantify ten major constituents in XXI. The method validation results indicated that the developed method had desirable specificity, linearity, precision and accuracy. The total contents of ginkgo flavonoids were about 22.05-25.51 μg·mL-1 and the ginkgo terpene lactones amounts were about 4.41-8.70 μg·m L-1 in six batches of XXI samples, respectively. Furthermore, cosine ratio algorithm and distance measurements were employed to evaluate the similarity of XXI samples, and the results demonstrated a high-quality consistency. This work could provide comprehensive information on the quality control of Xingxiong injection, which be helpful in the establishment of a rational quality control standard. | GUO Long DOU Li-Li DUAN Li LIU Ke BI Zhi-Ming LI Ping LIU E-Hu | 2015 | Chinese Journal of Natural Medicines2015，13，9： | 4 |
| 20 | Effect of Rare Earth and Cooling Process on Microstructure and Mechanical Properties of an Ultra-Cleaned X80 Pipeline Steel显示文摘In order to explore the eff ect of a small amount of rare earth addition in ultra-cleaned pipeline steel and the influence of the cooling process on the tensile and impact properties,three API X80 pipeline steels were fabricated by varying RE addition and the cooling process at the same time.Three microstructures with different features for a low C high Nb microalloyed high-strength pipeline steel and the corresponding mechanical properties were investigated.The results showed that even in the ultra-cleaned steel with O and S contents less than 10 ppm,the addition of RE would still cause an increase in the volume fraction of inclusions consisting of complicated RE oxysulfide and RE sulfide.More inclusions formed in the 112 ppm RE steel were harmful to the low temperature toughness,while few inclusions formed in the 47 ppm RE steel had almost no influence on the low temperature toughness.The two RE additions had no effect on strength of the steels.As the finishing cooling temperature was increased and the cooling rate was decreased within a certain range,the volume fractions of polygonal ferrite and quasi-polygonal ferrite as well as the number density and size of martensite–austenite islands were increased.Under such combined effect,the strength of the steels had almost no change.As the finishing cooling temperature was increased from 481 to 584℃and the cooling rate was reduced from 20 to 13℃/s,for the steel with 112 ppm addition of RE,there was an obvious decrease in the low temperature toughness.The reduced value(about 33 J)of the USE of steel consisted of two parts including the influence(about 18 J)of more inclusions formed due to 112 ppm addition of RE and the eff ect(about 15 J)of the lower high-angle grain boundaries. | He Duan Yi-Yin Shan Ke Yang Xian-Bo Shi Wei Yan Yi Ren | 2021 | Acta Metallurgica Sinica(English Letters)2021，34，5： | 4 |
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